Microfilament-dependent modulation of cytoplasmic protein binding to TNFα mRNA AU-rich instability element in human lymphoid cells

Cell Biology International

Volumn 23, Issue 8, 1999, Pages 561-570

  Henics, Tamás ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

ARE binding proteins (AUBP); AU rich sequence elements (ARE); Cytoskeleton; Lymphokine mRNA; T lymphocytes; Tumour necrosis factor (TNF )

Indexed keywords

ADENINE; CYTOCHALASIN; CYTOPLASM PROTEIN; F ACTIN; INTERLEUKIN 2; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; URACIL;

3' UNTRANSLATED REGION; ARTICLE; CYTOPLASM; CYTOSKELETON; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICROFILAMENT; PROTEIN RNA BINDING; REGULATORY MECHANISM; RNA METABOLISM; RNA SEQUENCE; T LYMPHOCYTE;

EID: 0033502098     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.1999.0418     Document Type: Article

References (34)

1. Benderdour M, Hess K, Dzondo-Gadet M, Nabet P, Belleville F, Dousset B. Boron modulates extracellular matrix and TNFα synthesis in human fibroblasts. Biochem Biophys Res Commun. 246:1998;746-751.
2. Bohjanen PR, Petryniak B, June CH, Thompson CB, Lindsten T. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA. Mol Cell Biol. 11:1991;3288-3295.
3. Brewer G. An AU-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol. 11:1991;2460-2466.
4. Cervera M, Dreyfuss G, Penman S. Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected cells. Cell. 23:1981;113-120.
5. De Kossodo S, Grau GE, Daneva T, Pointaire P, Fossati L, Ody C, Zapf J, Piquet P-F, Gaillard RC, Vassalli P. Tumor necrosis factor α is involved in mouse growth and lymphoid tissue development. J Exp Med. 176:1992;1259-1264.
6. Furse RK, Kodys K, Zhu D, Miller-Graziano CL. Increased monocyte TNF-α message stability contributes to trauma patients' increased TNF production. J Leukocyte Biol. 62:1997;524-534.
7. Giroir BP, Brown T, Beutler B. Constitutive synthesis of tumor necrosis factor in the thymus. Proc Natl Acad Sci U S A. 89:1992;4864-4868.
8. Gueydan C, Houzet L, Marchant A, Sels A, Huez G, Kruys V. Engagement of tumor necrosis factor mRNA by an endotoxin-inducible cytoplasmic protein. Mol Med. 2:1996;479-488.
9. Han J, Beutler B. The essential role of the AU-rich sequence in endotoxin-induced cachectin/TNF synthesis. Eur Cytokine Netw. 1:1990;71-75.
10. Han JH, Beutler B, Huez G. Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages. Biochim Biophys Acta. 1090:1991;22-28.
11. Han J, Brown T, Beutler B. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med. 171:1990;465-475.
12. Hel Z, Skamene E, Radzioch D. Two distinct regions in the 3′ untranslated region of tumor necrosis factor alpha mRNA form complexes with macrophage proteins. Mol Cell Biol. 16:1996;5579-5590.
13. Henics T, Nagy E, Rigby WFC. Combined application of in vivo UV-crosslinking and in vitro label transfer in the examination of AU-rich sequence binding protein-RNA interactions. Cell Biol Internatl. 19:1995;791-801.
14. Henics T, Nagy E, Szekeres-Bartho J. Interaction of AU-rich sequence binding proteins with actin: Possible involvement of the actin cytoskeleton in lymphokine mRNA turnover. J Cell Physiol. 173:1997;19-27.
15. Hesketh JE, Pryme IF. Interaction between mRNA, rybosomes and the cytoskeleton. Biochem J. 277:1991;1-10.
16. Hirch HH, Nair APK, Backenstoss V, Moroni C. Interleukin-3 mRNA stabilization by a trans-acting mechanism in autocrine tumors lacking interleukin-3 gene rearrangements. J Biol Chem. 270:1995;20,629-20,635.
17. Jacob CO, Tashman N. Disruption of the AU motif of the mouse TNF-α 3′ UTR correlates with reduced TNF production by macrophagesin vitro. Nucl Acids Res. 21:1993;2761-2766.
18. Katz DA, Theodorakis NG, Cleveland DW, Lindsten T, Thopson CB. AU-A, an RNA-binding activity distinct from hnRNP A1 is selective for AUUUA repeats and shuttles between the nucleus and cytoplasm. Nucleic Acid Res. 22:1994;238-246.
19. Kislauskis EH, Li Z, Singer RH, Taneja KL. Isoform-specific 3′-untranslated sequences sort α-cardiac and β-cytoplasmic actin messenger RNAs to different cytoplasmic compartments. J Cell Biol. 123:1993;165-172.
20. Kim Y, Rus HG, Fisher SN, Pitha PM, Shin ML. Binding of a protein to an AU-rich domain of tumor necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes. Biochem J. 316:1996;455-460.
21. Kruys V, Kemmer K, Shakhov A, Jongeneel V, Beutler B. Constitutive activity of the tumor necrosis factor promoter is canceled by the 3′ untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect. Proc Natl Acad Sci U S A. 89:1992;673-677.
22. Lagnado CA, Brown CY, Goodall GJ. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A). Mol Cell Biol. 14:1994;7984-7995.
23. Leverkus M, Yaar M, Eller MS, Tang EH, Gilchrest BA. Post-transcriptional regulation of UV induced TNF-α expression. J Invest Dermatol. 110:1998;353-357.
24. Lewis T, Gueydan C, Huez G, Toulme J-J, Kruys V. Mapping of a minimal AU-rich sequence required for lipopolysaccharide-induced binding of a 55-kDa protein on tumor necrosis factor-α mRNA. J Biol Chem. 273:1998;13,781-13,786.
25. Mijatovic T, Kruys V, Caput D, Defrance P, Huez G. Interleukin-4 and -13 inhibit tumor necrosis factor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages. J Biol Chem. 272:1997;14,394-14,398.
26. Raabe T, Bukrinsky M, Currie RA. Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharide. J Biol Chem. 273:1998;974-980.
27. Ross J. mRNA stability in mammalian cells. Microbiol Rev. 59:1995;423-450.
28. Ross HJ, Sato N, Ueyama Y, Koeffler HP. Cytokine messenger RNA stability is enhanced in tumor cells. Blood. 8:1991;1787-1795.
29. Sirenko OI, Lofquist AK, DeMaria CT, Morris J, Brewer G, Haskill JS. Adhesion-dependent regulation of an A+U-rich element binding activity associated with AUF1. Mol Cell Biol. 17:1997;3898-3906.
30. Soós H, Bujáky Cs, Kiss Á, Kovács É, Somoskeöy Sz, Henics T. Distribution profile and in vivo RNA association of cytoplasmic AU-rich sequence binding proteins in various mammalian cells: effect of the organizational state of cellular architecture. Physiol Chem Phys Med NMR. 30:1998;163-174.
31. Tracey KJ, Cerami A. Tumor necrosis factor: a pleiotropic cytokine and therapeutic agent. Annu Rev Med. 45:1994;491-503.
32. Wang E, Ma W-J, Aghajanian C, Spriggs DR. Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3′-untranslated region of tumor necrosis factor-α messenger RNA. Cancer Res. 57:1997;5426-5433.
33. Zambetti G, Wilming L, Fey EG, Penman S, Stein J, Stein G. Differential association of membrane-bound and non-membrane-bound polysomes with the cytoskeleton. Exp Cell Res. 191:1990;246-255.
34. Zubiaga AM, Belasco JG, Greenberg ME. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol. 15:1995;2219-2230.