Molecular mechanisms of restenosis after percutaneous peripheral angioplasty and approach to endovascular therapy

Current Drug Targets - Cardiovascular and Haematological Disorders

Volumn 4, Issue 3, 2004, Pages 275-287

  Mongiardo, Annalisa ^a   Curcio, Antonio ^a   Spaccarotella, Carmen ^a   Parise, Simona ^a   Indolfi, Ciro ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE; DEXAMETHASONE; ESTRADIOL; EVEROLIMUS; HEPARIN; INSULIN; MACROLIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITINOL; PACLITAXEL; RAF PROTEIN; RAPAMYCIN; RAS PROTEIN; STREPTOZOCIN; TICLOPIDINE;

AORTA OCCLUSION; ARTERY DISEASE; ARTERY INTIMA PROLIFERATION; ATHEROSCLEROSIS; CLINICAL TRIAL; CONTROLLED DRUG RELEASE; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG ELUTING STENT; DRUG MECHANISM; FEMORAL ARTERY; FEMOROPOPLITEAL BYPASS; HUMAN; ILIAC ARTERY OBSTRUCTION; LEG ARTERY; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERIPHERAL VASCULAR DISEASE; POPLITEAL ARTERY; POSTOPERATIVE COMPLICATION; RECANALIZATION; RESTENOSIS; REVIEW; STENT; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

ANGIOPLASTY, BALLOON; ARTERIOSCLEROSIS; CORONARY RESTENOSIS; FEMORAL ARTERY; HUMANS; ILIAC ARTERY; PERIPHERAL VASCULAR DISEASES; POPLITEAL ARTERY; RANDOMIZED CONTROLLED TRIALS; STENTS; VASCULAR PATENCY;

EID: 4444228717     PISSN: 15680061     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568006043336258     Document Type: Review

References (73)

1. Mukherjee, D.; Lingam, P.; Chetcuti, S.; Grossman, M.; Moscucci, M.; Luciano, A.E.; Eagle, K.A. Missed opportunities to treat atherosclerosis in patients undergoning peripheral vascular interventions. Circulation 2002, 106, 1909-1912.
2. Criqui, M.H.; Langer, R.D.; Fronek, A.; Feigelson, H.S.; Klauber, M.R.; McCann, T.J.; Browner, D. Mortality over a period of 10 years in patients with peripheral arterial disease. N. Engl. J. Med. 1992, 326, 381-386.
3. Vogt, M.T.; Cauley, J.A.; Newman, A.B. Decreased ankle/arm blood pressure index and mortality in elderly women. JAMA 1993, 270, 465-469.
4. Leng, G.C.; Lee, A.J.; Fowkes, F.G. Incidence, natural history and cardiovascular events in symptomatic and symptomatic peripheral arterial disease in the general population. Int. J. Epidemiol. 1996, 25, 1172-1181.
5. Newman, A.B.; Shemanski, L.; Manolio, T.A. Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group. Arterioscler. Thromb. Vasc. Biol. 1999, 19, 538-545.
6. Sheeran, S.R.; Hallisey, M.J.; Ferguson, D. Percutaneous transluminal stent placement in the abdominal aorta. J. Vasc. Interv. Radiol. 1997, 8(1 Pt. 1), 55-60.
7. Diethrich, E.B.; Santiago, O.; Gustafson, G.; Heuser, R.R. Preliminary observations on the use of the Palmaz stent in the distal portion of the abdominal aorta. Am. Heart J. 1993, 125(2 Pt. 1), 490-501.
8. Westcott, M.A.; Bonn, J. Comparison of conventional angioplasty with the Palmaz stent in the treatment of abdominal aortic stenoses from the STAR registry. SCVIR Transluminal Angioplasty and Revascularization. J. Vasc. Interv. Radiol. 1998, 9, 225-31.
9. Yakes, W.F.; Kumpe, D.A.; Brown, S.B.; Parker, S.H.; Lattes, R.G.; Cook, P.S. Percutaneous transluminal aortic angioplasty: techniques and results. Radiology 1989, 172(3 Pt 2), 965-70.
10. Charlebois, N.; Saint-Georges, G.; Hudon, G. Percutaneous transluminal angioplasty of the lower abdominal aorta. Am. J. Roentgenol. 1986, 146, 369-71
11. Audet, P.; Therasse, E.; Oliva, V.L.; Soulez, G.; Cote, G.; Wistaff, R. Infrarenal aortic stenosis: long-term clinical and hemodynamic results of percutaneous transluminal angio-plasty. Radiology 1998, 209, 357-63.
12. Henry, M.; Amor, M.; Henry, I.; Tzvetanov, K.; Chati, Z.; Buniet, J.M. Percutaneous Endovascular Treatment of Aorto-Iliac Occlusive Diseases. In: Tenth international course book of peripheral vascular intervention. Endovascular Therapy Course; 1999 May 18-21; Paris, France. Toulouse: Europa Organisation, 1999, 285-302.
13. Henry, M.; Amor, M.; Henry, I.; Klonaris, C.; Tzvetanov, K.; Chati, Z. Percutaneous endovascular treatment of aortic bifurcation occlusive diseases. Radiology 1999, 213(P), 477.
14. D'Othee, B.J.; Haulon, S.; Mounier-Vehier, C.; Beregi, J.P.; Jabourek, O.; Willoteaux, S. Percutaneous endovascular treatment for stenoses and occlusion of infrarenal aorta and aortoiliac biforcation: midterm results. Eur. J. Vasc. Endovasc. Surg. 2002, 24(6), 516-523
15. Bosch, J.L.; Hunink, M.G. Meta-analysis of the results of percutaneous transluminal angioplasty and stent placement for aortoiliac occlusive disease. Radiology 1997, 204, 87-96.
16. Tetteroo, E.; van der Graaf, Y.; Bosch, J.L.; van Engelen, A.D.; Hunink, M.G.; Eikelboom, B.C. Randomised comparison of primary stent placement versus primary angioplasty followed by selective stent placement in patients with iliacartery occlusive disease. Dutch Iliac Stent Trial Study Group. Lancet 1998, 351, 1153-9.
17. Vorwerk, D.; Gunther, R.W.; Schurmann, K.; Wendt, G. Aortic and iliac stenoses: follow-up results of stent placement after insufficient balloon angioplasty in 118 cases. Radiology 1996, 198, 45-8.
18. Palmaz, J.C.; Laborde, J.C.; Rivera, F.J.; Encarnacion, C.E.; Lutz, J.D.; Moss, J.G. Stenting of the iliac arteries with the Palmaz stent: experience from a multicenter trial. Cardiovasc. Intervent. Radiol. 1992, 15, 291-7.
19. Strecker, E.P.; Hagen, B.; Liermann, D.; Schneider, B.; Wolf, H.R.; Wambsganss, J. Iliac and femoropopliteal vascular occlusive disease treated with flexible tantalum stents. Cardiovasc. Intervent. Radiol. 1993, 16, 158-64.
20. Henry, M.; Amor, M.; Ethevenot, G.; Henry, I.; Amicabile, C.; Beron, R. Palmaz stent placement in iliac and femoropopliteal arteries: primary and secondary patency in 310 patients with 2-4-year follow-up. Radiology 1995, 197, 167-74.
21. Vorwerk, D.; Guenther, R.W.; Schurmann, K.; Wendt, G.; Peters, I. Primary stent placement for chronic iliac artery occlusions: follow-up results in 103 patients. Radiology 1995, 194, 745-9.
22. Henry, M.; Amor, M.; Henry, I.; Klonaris, C.; Mentre, B.; Tzvetanov, K. Percutaneous endoluminal treatment of iliac occlusions. J. Vasc. Interv. Radiol. 2000, 11(Suppl.), 302
23. Dake, M.D.; Semba, C.P.; Kee, S.T.; Razavi, M.K.; Slonim, S.M.; Samuels, S.L. Early results of Hemobahn for the treatment of peripheral arterial disease. In: Ninth international course book of peripheral vascular intervention. Endovascular Therapy Course; 1998 May 5-8; Paris, France. Toulouse: Europa Organisation, 1998, 259-60.
24. Ohki, T.; Veith, F.J. Endovascular grafts for the treatment of arterial lesions. In: Ninth international course book of peripheral vascular intervention. Endovascular Therapy Course; 1998 May 5-8; Paris, France. Toulouse: Europa Organisation.; 1998, 269-82.
25. Sapoval, M.R.; Long, A.L.; Raynaud, A.C.; Beyssen, B.M.; Fiessinger, J.N.; Gaux, J.C. Femoropopliteal stent placement: long-term results. Radiology 1992, 184, 833-9.
26. Sapoval, M.R.; Long, A.L.; Raynaud, A.C.; Beyssen, B.M.; Fiessinger, J.N.; Gaux, J.C. Treatment of femoropopliteal stenoses by means of self-expandable endoprostheses: midterm results. Radiology 1989, 172(3 Pt. 2), 961-4.
27. D Strecker, E.P.; Peters, J. The Strecker stent: indications and results in iliac and femoropopliteal arteries. Cardiovasc. Intervent. Radiol. 1992, 15, 298-305.
28. Damaraju, S.; Cuasay, L.; Le, D.; Strickman, N.; Krajcer, Z. Predictors of primary patency failure in Wallstent selfexpanding endovascular prostheses for iliofemoral occlusive disease. Tex. Heart Inst. J. 1997, 24, 173-8.
29. Gray, B.H.; Sullivan, T.M.; Childs, M.B.; Young, J.R.; Olin, J.W. High incidence of restenosis/reocclusion of stents in the percutaneous treatment of long-segment superficial femoral artery disease after suboptimal angioplasty. J. Vasc. Surg. 1997, 25, 74-83.
30. Henry, M.; Amor, M.; Tzvetanov, K.; Tricoche, O.; Leborgne, E.; Chati, Z. Initial clinical experience with the long medium spiral Palmaz stent. Tenth international course book of peripheral vascular intervention. Endovascular Therapy Course, 1999 May 18-21; Paris, France. Toulouse: Europa Organisation, 1999, 217-221.
31. Henry, M.; Amor, M.; Henry, I.; Klonaris, C.; Tzvetanov, K.; Chati, Z. Femoropopliteal stenting-results, indications: choice of the stent. Radiology 1999, 213(P), 50.
32. Cikrit, D.F.; Dalsing, M.C. Lower-extremity arterial endovascular stenting. Surg. Clin. North Am. 1998, 78, 617-29.
33. Criado, F.J. Endovascular treatment of occlusive lesions in the femoropopliteal territory. In: Criado, F.J.; editor. Endovascular intervention: basic concepts and techniques. Armonk, N.Y: Futura Publishing Company, Inc, 1999: 105-14.
34. Cejna, M.; Schoder, M.; Lammer, J. PTA vs. stent in femoropopliteal obstruction. Radiology 1999, 39, 144-50.
35. Vroegindeweij, D.; Vos, L.D.; Tielbeek, A.V.; Buth, J.; v d Bosch, H.C. Balloon angioplasty combined with primary stenting versus balloon angioplasty alone in femoropopliteal obstructions: a comparative randomized study. Cardiovasc. Intervent. Radiol. 1997, 20, 420-5.
36. Jahnke, T.; Andresen, R.; Muller-Hulsbeck, S.; Schafer, F.K.; Voshage, G.; Heller, M.; Brossmann, J. Hemobahn stent-grafts for treatment of femoropopliteal arterial obstruction: midterm results of a prospective trial. J. Vasc. Interv. Radiol., 2003, 14(1), 41-51).
37. Diethrich, E.B. Endoluminal graft delivery system for femoropopliteal arterial occlusive disease. In: Ninth international course book of peripheral vascular intervention. Endovascular Therapy Course; 1998 May 5-8; Paris, France. Toulouse: Europa Organisation, 998, 283-94.
38. Henry, M.; Amor, M.; Cragg, A.; Porte, J.M.; Henry, I.; Amicabile, C. Occlusive and aneurysmal peripheral arterial disease: assessment of a stent-graft system. Radiology 1996, 201, 717-24.
39. Henry, M.; Amor, M.; Henry, I.; Tzvetanov, K. Role of covered stents in peripheral arterial diseases. Tenth international course book of peripheral vascular intervention. Endovascular Therapy Course; 1999 May 18-21; Paris, France. Toulouse: Europa Organisation, 1999: 229-46.
40. TransAtlantic Inter-Society Consensus (TASC). Management of peripheral arterial disease (PAD), section B: intermittent claudication. Eur. J. Vasc. Endovasc. Surg. 2000, 19(suppl. A), S47-S114.
41. Lofberg, A.M.; Lorelius, L.E.; Karacagil, S.; Westman, B.; Almgren, B.; Berqgvist, D. The use of below-knee percutaneous transluminal angioplasty in arterial occlusive disease causino chronic critical limb ischemia. Cardiovasc. Intervent. Radiol. 1996, 19, 317-22.
42. Dorros, G.; Jaff, M.R.; Murphy, K.J.; Mathiak, L. The acute outcome of tibioperoneal vessel angioplasty in 417 cases with claudication and critical limb ischemia. Cathet. Cardiovasc. Diagn. 1998, 45, 251-6.
43. Duda, S. H.; Pusich, B.; Richter, G.; Landwehr, P.; Oliva, V.L.; Tielbeek, A.; Wiesinger, B.; Hak, J.B.; Tielemans, H.; Ziemer, G.; Cristea, E.; Lansky, A.; Bérégi, J.P. Sirolimus-Eluting Stents for the Treatment of Obstructive Superficial Femoral Artery Disease Six-Month Results. Circulation 2002, 106, 1505-1509.
44. Baumgartner, R.B.I.; Do, D.D.; Alerci, M.; Segatto, J.M.; Tutta, P.; Jager, K.; Aschwanden, M.; Schneider, E.; Amann-Vesti, B.; Greiner, R.; Mahler, F.; Gallino, A. Late Acute Thrombotic Occlusion After Endovascular Brachytherapy and Stenting of Femoropopliteal Arteries. J. Am. Coll. Cardiol. 2003, 41, 409-12
45. Erbel, R.; Haude, M.; Hopp, H.W.. Coronary artery stenting compared with balloon angioplasty for restenosis after initial balloon angioplasty. Restenosis Stent Study Group. N. Engl. J. Med. 1998, 339, 1672-8.
46. Do, D.D.; Triller, J.; Walpoth, B.H.; Stirnemann, P.; Mahler, F. A comparison study of self-expandable stents vs. balloon angioplasty alone in femoropopliteal artery occlusions. Cardiovasc. Intervent. Radiol. 1992, 15, 306-12.
47. Strecker, E.P.; Boos, I.B.; Gottman, D. Femoropopliteal artery stent placement: evaluation of long-term success. Radiology 1997, 205, 375-83.
48. Vroegindeweij, D.; Vos, L.D.; Tielbeek, A.V. Balloon angioplasty combined with primary stenting versus balloon angioplasty alone in femoropopliteal obstructions: a comparative randomized study. Cardiovasc. Intervent. Radiol. 1997, 20, 420-5.
49. Vroegindeweij, D.; Vos, L.D.; Tielbeek, A.V. Peripheral arterial obstruction: prospective study of treatment with a transluminally placed selfexpanding stent graft. Radiology 2000, 217, 95-104.
50. Indolfi, C.; Coppola, C.; Torella, D.; Chiariello, M. Gene therapy for restenosis after balloon angioplasty and stenting. Cardiology in Review. 1999, 7(6), 324-31
51. Indolfi, C.; Torella, D.; Coppola, C.; Stabile, E.; Esposito, G.; Curcio, A.; Pisani, A.; Cavuto, L.; Arcucci, O.; Cireddu, E.; Troncone, G.; Chiariello, M. Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture. Am. J. Physiol. Heart Circ. Physiol. 2002, 283, H760-H767.
52. Indolfi, C.; Esposito, G.; Stabile, E.; Cavuto, L.; Pisani, A.; Coppola, C.; Torella, D.; Perrino, C.; Di Lorenzo, E.; Curcio, A.; Palombini, L.; Chiariello, M. A new rat model of small vessel stenting. Basic Res. Cardiol. 2000, 95, 179-185.
53. Indolfi, C.; Esposito, G.; Stabile, E.; Pisani, A.; Leccia, A.; Chiariello, M. Meccanismi molecolari della restenosi dopo angioplastica e neoangiogenesi terapeutica. Cardiologia 1996, 41, 271-276.
54. Indolfi, C.; Avvedimento, E.V.; Rapacciuolo, A.; Di Lorenzo, E.; Esposito, G.; Stabile, E.; Feliciello, A.; Mele, E.; Giuliano, P.; Condorelli, G.L.; Chiariello M. Inhibition of cellular RAS prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Medicine, 1995, 6, 541-545.
55. Indolfi, C.; Avvedimento, E. V.; Rapacciuolo Esposito, G.; Di Lorenzo Leccia, A.; Pisani, A.; Chieffo, A.; Coppola, A.; Chiariello, M. In vivo gene transfer: prevention of neointima formation by inhibition of mitogen-activated protein kinase kinase. Basic Research in Cardiology 1997, 92, 378-384.
56. Indolfi, C.; Avvedimento, E.V.; Di Lorenzo, E.; Esposito, G.; Rapacciuolo, A.; Giuliano, P.; Grieco, D.; Cavuto, L.; Stingone, A.M.; Ciullo, I.; Condorelli, G.L.; Chiariello, M. Activation of cAMP-PKA Signalling In Vivo Inhibits Smooth Muscle Cell Proliferation induced by Vascular Injury. Nature Medicine 1997, 3, 775-779.
57. Indolfi, C.; Stabile, E.; Coppola, C.; Gallo, A.; Perrino, C.; Allevato, G.; Cavuto, L.; Torella, D.; Di Lorenzo, E.; Troncone, G.; Feliciello, A.; Avvedimento, E.; Chiariello, M. Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals. Circulation Research. 2001, 88(3), 319-24.
58. Indolfi, C.; Di Lorenzo, E.; Rapacciuolo, A.; Stingone, A.M.; Stabile, E.; Leccia, A.; Torella, D.; Caputo, R.; Ciardiello, F.; Tortora, G.; Chiariello, M. 8-Chloro-cAMP inhibits smooth muscle cell poliferation in vitro and neointimal formation induced by balloon injury in vivo. J. Am. Coll. Cardiol, 2000, 36, 288-93.
59. Nabel, E.G. CDKs and CKIs: molecular targets for tissue remodelling. Nat. Rev. Drug Discov. 2002, 1(8), 587-98.
60. Indolfi, C.; Torella, D.; Cavuto, L.; Davalli, A.M.; Coppola, C.; Esposito, G.; Carriero, M.V.; Rapacciuolo, A.; Di Lorenzo, E.; Stabile, E.; Perrino, C.; Chieffo, A.; Pardo, F.; Chiariello, M. Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. Circulation 2001; 103(24), 2980-6.
61. Indolfi, C.; Torella, D.; Coppola, C.; Curcio, A.; Rodriguez, F.; Bilancio, A.; Leccia, A.; Arcucci, O.; Falco, M.; Leosco, D.; Chiariello, M. Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats. Circ. Res. 2002; 91(12), 1190-7.
62. Faraci, F.M.; Sigmund, C.D. Vascular biology in genetically altered mice: smaller vessels, bigger insight. Circ. Res., 1999, 85, 1214-1225
63. Feron, O.; Dessy, C.; Desager, J.P.; Balligand, J.L. Hydroxy-methyglutaryl-coenzyme: a reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001, 103, 113-118.
64. US Department of Health, and Human Services. Physical activity and health: a report of the Surgeon General. Atlanta, Ga: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion; 1996.
65. Lincoff, A.M.; Topol, E.J.; Ellis, S.G. Local drug delivery for the prevention of restenosis: fact, fancy, and future. Circulation 1994, 90, 2070-2084.
66. Van Beusekom, H.M.; Schwartz, R.S.; van der Giessen, W.J. Synthetic polymers. Semin. Interv. Cardiol. 1998, 3(3-4), 145-8
67. Gallo, R.; Padurean, A.; Jayaraman, T. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle. Circulation 1999, 99, 2164-2170.
68. Poon, M.; Marx, S.O.; Gallo, R. Rapamycin inhibits vascular smooth muscle cellmigration. J. Clin. Invest. 1996, 98, 2277-2283.
69. Sun, J.; Marx, S.O.; Chen, H.J. Role for p27 (Kip1) in vascular smooth muscle cell migration. Circulation 2001, 103, 2967-2972.
70. Rowinsky, E.K.; Donehower, R.C. Paclitaxel (taxol). N. Engl. J. Med. 1995, 332, 1004-1014.
71. Axel, D.I.; Kunert, W.; Goggelmann, C. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation 1997, 96, 636-645.
72. Kolodgie, F.D.; John, M.; Khurana, C. Sustained reduction of instent neointimal growth with the use of a novel systemic nanoparticle paclitaxel. Circulation 2002, 106, 1195-1198.
73. Kolodgie, F.D.; John, M.; Khurana, C. Sustained reduction of instent neointimal growth with the use of a novel systemic nanoparticle paclitaxel. Circulation 2002, 106, 1195-1198.