8-Chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo

Journal of the American College of Cardiology

Volumn 36, Issue 1, 2000, Pages 288-293

  Indolfi, Ciro ^a   Di Lorenzo, Emilio ^a   Rapacciuolo, Antonio ^a   Stingone, Angela Maria ^a   Stabile, Eugenio ^a   Leccia, Antonio ^a   Torella, Daniele ^a   Caputo, Rosa ^a   Ciardiello, Fortunato ^a   Tortora, Gianpaolo ^a   Chiariello, Massimo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; REGULATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON CATHETER; BLOOD PRESSURE; BLOOD VESSEL INJURY; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY STENT; HEART RATE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RESTENOSIS; SMOOTH MUSCLE FIBER; SURGICAL INJURY; TRANSLUMINAL CORONARY ANGIOPLASTY; VASCULAR SMOOTH MUSCLE;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; AORTA, THORACIC; ARTERIAL OCCLUSIVE DISEASES; BALLOON DILATATION; BLOOD PRESSURE; CELL DIVISION; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; HEART RATE; INJECTIONS, INTRAPERITONEAL; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR; TUNICA INTIMA; UP-REGULATION;

EID: 18144443873     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(00)00679-3     Document Type: Article

References (41)

1. Fischman D., Leon M., Schatz R., et al. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary heart disease. N Engl J Med. 331:1994;496-501.
2. Serruys P, Jaegere P, Kiemenlij F, et al., for the BENESTENT study group. A comparison of balloon expandable stent implantation with balloon angioplasty in patients with coronary heart disease. N Engl J Med 1994;331:489-95.
3. Hoffmann R., Mintz G.S., Dussaillant G.R., et al. Patterns and mechanisms of in-stent restenosis a serial intravascular ultrasound study . Circulation. 94:1996;1247-1254.
4. Dussaillant G.R., Mintz G.S., Pichard A.D., et al. Small stent size and intimal hyperplasia contribute to restenosis a volumetric intravascular ultrasound analysis . J Am Coll Cardiol. 26:1995;720-724.
5. Mintz G.S., Popma J.J., Pichard A.D., et al. Intravascular ultrasound predictors of restenosis after percutaneous transcatheter coronary revascularization. J Am Coll Cardiol. 27:1996;1678-1687.
6. Indolfi C., Stabile E., Perrino C., Chiariello M. Mechanism of restenosis after angioplasty and approach to therapy. Int J Mol Med. 2:1998;143-148.
7. Indolfi C., Avvedimento E.V., Rapacciuolo A., et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nat Med. 1:1995;541-545.
8. Indolfi C., Avvedimento E.V., Di Lorenzo E., et al. Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nat Med. 3:1997;775-779.
9. ++ mobilization, by cyclic AMP and GMP in rabbit aortic smooth muscle cells. Biochem J. 288:1992;527-532.
10. Boynton A.L., Whitfield J.F. The role of cAMP in cell proliferation a critical assessment of the evidence . Adv Cyclic Nucleotide Res. 15:1983;193-294.
11. Cornwell T.L., Arnold E., Boerth N.J., Lincoln T.M. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol. 36:1994;1405-1413.
12. Skalhegg B.S., Landmark B.F., Doskeland S.O., Hansson V., Lea T., Jahnsen T. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3′ 5′-cyclic adenosine monophosphate on cell replication in human T lymphocytes. J Biol Chem. 267:1992;15707-15714.
13. Indolfi C., Chiariello M., Avvedimento E.V. Selective gene therapy for proliferative disorders sense and antisense . Nat Med. 2:1996;634-635.
14. Grieco D., Porcellini A., Avvedimento E.V., Gottesman M.E. Requirement for cAMP-PKA pathway activation by M-phase-promoting factor in the transition from mitosis to interphase. Science. 271:1996;1718-1722.
15. Tortora G., Ciardiello F., Pepe S., et al. Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients. Clin Cancer Res. 1:1995;377-384.
16. Cho-Chung Y.S., Clair T. The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related disease. Pharmacol Ther. 60:1993;265-288.
17. Beebe S., Holloway R., Rannels S.R., Corbin J.D. Two classes of cAMP analogues which are selective for the two different cAMP binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes. J Biol Chem. 259:1984;3539-3547.
18. Beebe S, Corbin JD. Cyclic nucleotide-dependent protein kinases. In: Boyer PD, Krebs EG, editors. The Enzyme: Control by Phosphorilation. New York: Academic Press, 1986:43-111.
19. Taylor S.S., Buechler J.A., Yonemoto W. cAMP-dependent protein kinase framework for a diverse family of regulatory enzyme . Annu Rev Biochem. 59:1990;971-1005.
20. Ally S., Tortora G., Clair T., et al. Selective modulation of protein kinase isoenzyme by site-selective 8-Cl-cAMP provides a biological means for control of human colon cancer cell growth. Proc Natl Acad Sci U S A. 85:1988;6319-6322.
21. β subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem. 268:1993;5774-5782.
22. Ciardiello F., Tortora G., Kim N., et al. 8-Cl-cAMP inhibits transforming growth factor-α transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoform which show disruption upon transformation. J Biol Chem. 265:1990;1016-1020.
23. α subunit of the cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 protooncogenes. Int J Cancer. 53:1993;438-443.
24. Ally S., Clair T., Katsaros D., et al. Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site selective 8-Cl-cAMP. Cancer Res. 49:1989;5650-5655.
25. Tortora G., Yokozaki H., Pepe S., Clair T., Cho-Chung Y.S. Differentiation of HL60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 88:1991;2011-2015.
26. Indolfi C., Esposito G., Di Lorenzo E., et al. Smooth muscle cell proliferation is proportional to the degree of balloon injury in a rat model of angioplasty. Circulation. 92:1995;1230-1235.
27. Indolfi C., Avvedimento E.V., Rapacciuolo A., et al. In vivo gene transfer prevention of neointima formation by inhibition of mitogen-activated protein-kinase-kinase . Basic Res Cardiol. 92:1997;378-384.
28. Indolfi C, Cioppa A, Stabile E, et al. Effects of HMG-CoA reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and in vivo neointimal formation after vascular injury. J Am Coll Cardiol 2000;35:214-21.
29. Gerald M., Tschirky H. Measurement of blood pressure in unanesthetized rats and mice. Drug Res. 18:1969;1285-1287.
30. Groves P.H., Banning A.P., Penny W.J., Lewis M.J., Cheadle H.A., Newby A.C. Kinetics of smooth muscle cell proliferation and intimal thickening in a pig carotid model of balloon injury. Atherosclerosis. 117:1995;83-96.
31. Wilkinson L. SYSTAT, The system for statistics. Evanston, IL: SYSTAT, Inc., 1988.
32. Holmes D.R. Jr, Vliestra R.E., Smith H.C., et al. Restenosis after percutaneous transluminal coronary angioplasty a report from the PTCA registry of the National Heart, Lung and Blood Institute . Am J Cardiol. 53:1984;77C-81C.
33. McBride W., Lange R.A., Hillis L.D. Restenosis after successful coronary angioplasty. N Engl J Med. 318:1988;1734-1737.
34. Palmaz J.C., Laborde J.C., Rivera F.J., Encarnacion C.E., Lutz J.D., Moss J.G. Stenting of the iliac arteries with the Palmaz stent experience from a multicenter trial . Cardiovasc Intervent Radiol. 15:1992;291-297.
35. Joffre F., Rousseau H., Bernadet P., et al. Midterm results of renal artery stenting. Cardiovasc Intervent Radiol. 15:1992;313-318.
36. Savage M.P., Douglas J.S. Jr, Fischman D.L., et al. Stent placement compared with balloon angioplasty for obstructed coronary bypass grafts. Saphenous Vein De Novo Trial Investigators. N Engl J Med. 337:1997;740-747.
37. Chang M.W., Ohno T., Gordon D., et al. Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery. Mol Med. 1:1995;172-181.
38. Indolfi C., Coppola C., Torella D., Arcucci O., Chiariello M. Gene therapy for restenosis after balloon angioplasty and stenting. Cardiol Rev. 6:1999;324-329.
39. Simons M., Edelman E.R., DeKeyser J.L., Langer R., Rosenberg R.D. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 359:1992;67-70.
40. Krebs E.G., Beavo J.A. Phosphorylation and dephosphorylation of enzymes. Annu Rev Biochem. 48:1979;923-939.
41. Cho-Chung Y.S. Role of cAMP receptor proteins in growth differentiation and suppression of malignancy new approaches to therapy . Cancer Res. 50:1990;7093-7100.