In vivo gene transfer: Prevention of neointima formation by inhibition of mitogen-activated protein kinase kinase

Basic Research in Cardiology

Volumn 92, Issue 6, 1997, Pages 378-384

  Indolfi, C ^a   Avvedimento, E V ^b   Rapacciuolo, A ^a   Esposito, G ^a   Di Lorenzo, E ^a   Leccia, A ^a   Pisani, A ^a   Chieffo, A ^a   Coppola, A ^a   Chiariello, M ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Dipto Med Sperimentale e Clinica   (Italy)

Author keywords

Angioplasty; MAPKK; Restenosis; Smooth muscle cells

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL INJURY; CAROTID ARTERY; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; ENZYME INHIBITION; GENE TRANSFER; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; RAT; RESTENOSIS; SMOOTH MUSCLE FIBER; TIME;

EID: 6844236990     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00796211     Document Type: Article

References (49)

1. raf-1. EMBO J 13; 7: 1610-1619
2. Blenis J (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Aead Sci USA 90 (13): 5889-5892
3. Blumer KJ, Johnson GL (1994) Diversity in function and regulation of MAP kinase pathway. Trends Biol Sci 19: 236-240
4. Boguski MS. McCormick F (1993) Protein regulating ras and its relatives. Nature 366: 643-654
5. Bourne HR, Sanders DA, McCormick F (1991) The GTPase superfamily: Conserved structure and molecular mechanism. Nature 349: 117-127
6. Brott BC, Labinaz M, Culp SC, Fortin DF, Virmani R, Phillips HR, Stack RS (1994) Vessel remodeling after angioplasty: comparative anatomic studies. J Am Coll Cardiol 23: 138A. Abstract
7. Califf RM, Fortin DF, Frid DJ, Harlan WR III Ohman EM, Bengtson JR, Nelson CL,Tcheng JE, Mark DB, Stack RS (1991) Restenosis after coronary angioplasty: an overview. J Am Coll 17: 2B-13B
8. Clowes AW, Reidy MA, Clowes MM (1983) Kinetics of cellular proliferation after arterial injury: 1. Smooth muscle growth in the absence of endothelium. Lab Invest 49: 327-333
9. Clowes AW, Reidy MA, Clowes MM (1983) Mechanisms of stenosis after arterial injury. Lab Invest 49: 208-215
10. Cowley S, Paterson H, Kemp P, Marshall CJ (1994) Activation of MAP kinase kinase is necessary and sufficient for PC 12 differentiation and for transformation of NIH 3T3 cells. Cell 77: 841-852
11. Detre K, Holubkov R, Kelsey S, Cowley M, Kent K, Williams D, Myler R, Faxon D, Holmes D, Bourassa M, Block P, Gosselin A, Bentivoglio L, Leatherman L, Dorros G, King SB III, Galichia J, Al-Bassam M, Leon M, Robertson T, Passamani E (1988) Percutaneous transluminal coronary angioplasty in 1985-1986 and 1977-1981 : the National Heart, Lung and Blod Institute Registry. N Engl J Med 318: 265-270
12. Dickson B, Sprenger F, Morrison D, Hafen E (1992) Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360: 600-603
13. DiMario C, Gil R, Camezind E, Ozaki Y, von Birgelen C, Umans V. de Jaegere P, de Feyter PJ, Roelandt JRTC, Serruys PW (1995) Quantitative assessment with intracoronary ultrasound of the mechanism of restenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy. Am J Cardiol 75: 772-777
14. Dixon WJ, Massey J Jr (1969) Introduction to Statistical Analysis. New York. Mc Graw-Hill, pp 231-234
15. Fischmann DL, Leon MB, Baim DS, Schatz RA, Savage MP, Penn I, Detre K, Veltri L, Ricci D, Nobuyoshi M, Cleman M, Heuser R, Almond D, Teirstein PS, Fisch RD, Colombo A, Brinker J, Moses J, Shanknovich A, Hirshfeld J, Bailey S, Ellis S, Rake R, Goldberg S (1994) for the Stent Retsenosis Study Investigators. N Engl J Med 331: 496-501
16. Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53: 557-573
17. Galis Z, Sukhova G, Larck M, Libby P (1994) Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94: 2493-2503
18. Gerald M, Tschirky H (1969) Measurement of blood pressure in unanesthetized rats and mice. Drug Res 18: 1285-1287
19. Gibbons G, Dzau V (1994) The emerging concept of vascular remodeling. N Engl J Med 330: 1431-1438
20. Glagov S (1994) Intimai hyperplasia, vascular remodeling, and the restenosis problem. Circulation 89: 2888-2891
21. Gruentzig AR, King SB, Sclumpf M, Siegenthaler W (1987) Long-term follow-up after percutaneous transluminal coronary angioplasty. N Engl J Med 316: 1127-1132
22. Halberg B, Rayter SI, Downard J (1994) Interaction of ras and raf in intact mammalian cells upon extracellular stimulation. J Biol Chem 269: 3913-3916
23. Hoffmann R, Mintz GS, Dussailant GR, Popma JJ, Pichard AD, Satler LF, Kent KM, Griffin J, Leon MB (1996) Patterns and mechanisms of stent restenosis. Circulation 94: 1247-1254
24. Holmes DR Jr, Vlietstra RE, Smith HC, Vetrovec GW, Kent KM, Cowley MJ, Taxon DP, Gruentzig AR, Kelsey SF, Detre KM, van Raden MJ, Mock MB (1984) Restenosis after percutaneous transluminal coronary angioplasty (PTCA): a report from the PTCA Registry of the National Heart, Lung, and Blood Institute. Am J Cardiol 53: Suppl: 77C-81C
25. Indolfi C, Avvedimento EV, Di Lorenzo E, Esposito G, Rapacciuolo A, Giuliano P, Grieco D, Cavuto L, Stingone AM, Ciullo I, Condorelli GL, Chiariello M (1997) Activation of cAMP-PKA signalling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nature Medicine 3: 775-779
26. Indolfi C, Avvedimento EV, Rapacciuolo A, Di Lorenzo E, Esposito G, Stabile E, Feliciello A, Mele E, Giuliano P, Condorelli GL, Chiariello M (1995) Inhibition of cellular RAS prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Medicine 6: 541-545
27. Indolfi C, Chiariello M, Avvedimento EV (1996) Selective gene therapy for proliferative disorders: sense and antisense. Nature Med 2: 634-635
28. Indolfi C, Esposito G, Di Lorenzo E, Rapacciuolo A, Feliciello A, Porcellini A, Avvedimento EV, Condorelli M, Chiariello M (1995) Smooth muscle cell proliferation is proportional to the degree of balloon injury in a rat model of angioplasty. Circulation 92: 1230-1235
29. Kolch W et al. (1993) Protein kinase C activates Raf-1 by direct phosphorilation. Nature 364: 249-252
30. Lafont A, Guzman L, Whitlow P, Goormastic M, Cornhill J, Chisholm G (1995) Restenosis after experimental angioplasty: intimal, medial, and advential changes associated with constrictive remodeling. Circ Res 76: 996-1002
31. Langille BL, Bendeck MP, Keeley FW (1989) Adaptations of carotid arteries of young and mature rabbits to reduced carotid flow. Am J Physiol 256: H931-H939
32. Langille BL, O'Donnel F (1986) Reductions in arterial diameter produced by cronic decreases in blood flow are endothelium dependent. Science 231: 405-407
33. Liu MW, Roubin GS, King SB III (1989) Restenosis after coronary angoplasty: potential biologic determinants and role of intimai hiperplasia. Circulation 79: 1374-1387
34. Marshall CJ (1995) Specifity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185
35. Mintz GS, Pompa JJ, Pichard AD, Kent KM, Satlcr LF, Wong SC, Hong MK, Kovach JA, Leon MB (1996) Arterial remodeling after coronary angioplasty. A serial intravascular ultrasound study. Circulation 94: 35-43
36. Nobuyoshi M, Kimura T, Nosaka H, Mioka S, Ueno K, Yokoi H, Hamasaki N, Horiuchi H, Ohishi H (1988) Restenosis restenosis after successful percutaneous transluminal coronary angioplasty: serial angiographic followup of 229 patients. J Am Coll 12: 616-623
37. rd, Scott NA (1995) Inhibition of platelet-dependent thrombosis by local delivery of heparin with a hydrogel-coated balloon. Circulation 92: 1697-1700
38. Porras A, Muszyneski K, Rapp UR, Santos E (1994) Dissociaton between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/ 90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/ras pathway of adypocytic differentiation of 3T3 L1 cells. J Biol Chem 269 (17): 12741-12748
39. Post MJ, Borst C, Kuntz RE (1994) The relative importance of arterial remodeling compared with intimai hyperplasia in lumen renar-rowing after ballon angioplasty. Circulation 89: 2816-2821
40. Reidy MA, Fingerle J, Linder V (1992) Factors controlling the development of arterial lesions after injury. Circulation 86 (suppl III): III-43-III-46
41. Roberts TM (1992) Cell biology. A signal chain of events. Nature 360: 534-535
42. Schwartz RS , Holmes DR jr, Topol EJ (1992) The restenosis paradigm revisited: an alternative proposal for cellular mechanism. J Am Coll Cardiol 20: 1284-1293
43. Serruys PW, De Jaegere P, Kiemeneij F, Macaya C, Rutsch W, Heyndrickx G, Emanuelsson H, Marco J, Legrand V, Materne P, Belardi J, Sigwart U, Colombo A, Goy JJ, van den Heuvel P, Delcan J, Morel MA for the Benestent Study Group (1994) A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 331: 489-495
44. Serruys PW, Emanuelsson H, van der Giessen W, Lunn AC, Kiemeney F, Macaya C, Rutsch W, Heyndrickx G, Suryapranata H, Legrand V, Goy JJ, Materne P, Bonnier H, Morice MC, Fajadet J, Belardi J, Colombo A, Garcia E, Ruygrok P, de Jaegere P, Morel MA on behalf of the Benestent II Study Group (1996) Heparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent II pilot study. Circulation 93: 412-422
45. Serruys PW, Luijten HE, Beatt KJ. Jeuskens R, De Feyter PJ, Van den Brand M, Reiher JHC, ten Katen HJ, van Es GA, Hugenoltz PG (1988) Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon: a quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months. Circulation 77: 361-371
46. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD (1992) Antisense c-myb oligonucleotides inhibits intimai arterial smooth muscleell accumulation in vivo. Nature 359: 67-70
47. Strauss BH, Chilsolm RJ, Keeley FW, Gotlieb AI, Logan RA, Armstrong PW (1994) Extracellular matrix remodeling after ballon angioplasty injury in a rabbit model of restenosis. Circ Res 75: 650-658
48. Williams NG, Paradis H, Agarwal S, Charest DL, Pelech SL, Roberts TM (1993) Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc Natl Acad Sci USA 90: 5772-5776
49. Wood KW, Sarnecki C, Roberts TM, Blenis 'J (1992) Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68 (6): 1041-1050