Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats

Journal of Ethnopharmacology

Volumn 118, Issue 1, 2008, Pages 35-45

  He, Haibo ^a   Shi, Mengqiong ^b   Zeng, Xiaowei ^a   Yang, Jun ^a   Li, Yikui ^c   Wu, Limao ^a   Li, Lianda ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Center of Medical Science Analysis   (China)

^c XIYUAN HOSPITAL   (China)

Author keywords

Cardiac failure; ET ROS pathway; Leptin; PLB; Salvianolic acid B; SERCA2a

Indexed keywords

ENDOTHELIN; LEPTIN; MESSENGER RNA; PHOSPHOLAMBAN; REACTIVE OXYGEN METABOLITE; SALVIANOLIC ACID B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; CORRELATION ANALYSIS; DOWN REGULATION; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART DISEASE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE; HEART PROTECTION; HEMODYNAMICS; HISTOLOGY; HYPERLEPTINEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; BENZOFURANS; CALCIUM-BINDING PROTEINS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELINS; GENE EXPRESSION REGULATION; LEPTIN; MALE; MYOCARDIAL INFARCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

RATTUS;

EID: 44349177410     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.03.006     Document Type: Article

References (45)

1. Abe Y., Ono K., Kawamura T., Wada H., Kita T., Shimatsu A., and Hasegawa K. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. American Journal of physiology. Heart and Circulatory Physiology 292 (2007) H2387-H2396
2. 2-dependant MAPK pathways. The Journal of Biological Chemistry 279 (2004) 4292-4304
3. Chan J., Wang F., Lee F., and Wang X. Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza bunge by high speed counter-current chromatography and ESI-MS analysis. Talanta 69 (2006) 172-179
4. B receptor NADPH oxidase and caveolin-1. British Journal of Pharmacology 145 (2005) 323-333
5. Dong F., Zhang X., and Ren J. Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway. Hypertension 47 (2006) 222-229
6. Dong F., Zhang X., Yang X., Esberg L.B., Yang H., Zhang Z., Culver B., and Ren J. Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice. The Journal of Endocrinology 188 (2006) 25-36
7. Fishbein M.C., Maclean D., and Maroko P.R. Experimental myocardial infarction in the rat: qualitative and quantitative changes during pathologic evolution. The American Journal of Pathology 90 (1978) 57-70
8. B receptors in normal rats and animals with experimental heart failure. Journal of Cardiovascular Pharmacology 44 (2004) S54-S58
9. Gianni D., Chan J., Gwathmey J.K., del Monte F., and Hajjar R.J. SERCA2a in heart failure: role and therapeutic prospects. Journal of Bioenergetics and Biomembranes 37 (2005) 375-380
10. He H.B., Dai D.Z., and Dai Y. CPU0213, a novel endothelin receptor antagonist, ameliorates septic renal lesion by suppressing ET system and NF-kappaB in rats. Acta Pharmacologica Sinica 27 (2006) 1213-1221
11. He H.B., Yu F., Dai D.Z., and Dai Y. Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signaling pathway. Journal of Pharmacy and Pharmacology 59 (2007) 977-984
12. Ji X.Y., Tan B.K., and Zhu Y.Z. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacologica Sinica 21 (2000) 1089-1094
13. Lam F.F., Yeung J.H., Kwan Y.W., Chan K.M., and Or P.M. Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. European Journal of Pharmacology 553 (2006) 240-245
14. Lay I.S., Chiu J.H., Shiao M.S., Lui W.Y., and Wu C.W. Crude extract of Salvia miltiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line. Planta Medica 69 (2003) 26-32
15. Lay I.S., Hsieh C.C., Chiu J.H., Shiao M.S., Lui W.Y., and Wu C.W. Salvianolic acid B enhances in vitro angiogenesis and improves skin flap survival in Sprague-Dawley rats. The Journal of Surgical Research 115 (2003) 279-285
16. Lin Y.L., Wu C.H., Luo M.H., Huang Y.J., Wang C.N., Shiao M.S., and Huang Y.T. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells. Journal of Ethnopharmacology 105 (2006) 215-222
17. Liu Q., and Dai D.Z. Influence of a new endothelin receptor antagonist CPU20213 on expression of mRNA of MMPs and TIMPs in hypertrophic myocardium induced by l-thyroxin in rats. Chinese Journal of Basal & Clinical Pharmacology and Therapeutics 9 (2004) 281-284
18. B receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins. American Journal of physiology. Heart and Circulatory Physiology 287 (2004) H1194-H1199
19. MacLennan D.H., and Kranias E.G. Phospholamban: a crucial regulator of cardiac contractility. Nature Reviews. Molecular Cell Biology 4 (2003) 566-577
20. Madani S., De Girolamo S., Munoz D.M., Li R.K., and Sweeney G. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovascular Research 69 (2006) 716-725
21. Morawietz H., and Bornstein S.R. Leptin, endothelin, NADPH oxidase, and heart failure. Hypertension 47 (2006) e20-e21
22. Morgan E.E., Faulx M.D., McElfresh T.A., Kung T.A., Zawaneh M.S., Stanley W.C., Chandler M.P., and Hoit B.D. Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction. American Journal of physiology. Heart and Circulatory Physiology 287 (2004) H2049-H2053
23. Nagaya N., Uematsu M., Kojima M., Ikeda Y., Yoshihara F., Shimizu W., Hosoda H., Hirota Y., Ishida H., Mori H., and Kangawa K. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104 (2001) 1430-1435
24. Na T., Dai D.Z., Tang X.Y., and Dai Y. Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017. Naunyn-Schmiedeberg's Archives of Pharmacology 375 (2007) 39-49
25. Na T., Huang Z.J., Dai D.Z., Zhang Y., and Dai Y. Abrupt changes in expression of FKBP12 6 & SERCA2a contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017. Acta Pharmacologica Sinica 28 (2006) 773-782
26. Olson E.N. A decade of discoveries in cardiac biology. Nature Medicine 10 (2004) 467-474
27. Purdham D.M., Zou M.X., Rajapurohitam V., and Karmazyn M. Rat heart is a site of leptin production and action. American Journal of physiology. Heart and Circulatory Physiology 287 (2004) H2877-H2884
28. Quehenberger P., Exner M., Sunder-Plassmann R., Ruzicka K., Bieglmayer C., Endler G., Muellner C., Speiser W., and Wagner O. Leptin induces endothelin-1 in endothelial cells in vitro. Circulation Research 90 (2002) 711-718
29. Rajapurohitam V., Gan X.T., Kirshenbaum L.A., and Karmazyn M. The obesity-associted peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circulation Research 93 (2003) 277-279
30. Ren J. Leptin and hyperleptinemia-from friend to foe for cardiovascular function. The Journal of Endocrinology 181 (2004) 1-10
31. Schulze P.C., and Kratzsch J. Leptin as a new diagnostic tool in chronic heart failure. Clinica Chimica Acta 362 (2005) 1-11
32. Schulze P.C., Kratzsch J., Linke A., Schoene N., Adams V., Gielen S., Erbs S., Moebius-Winkler S., and Schuler G. Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. European Journal of Heart Failure 5 (2003) 33-40
33. Shamsuzzaman A.S., Winnicki M., Wolk R., Svatikova A., Phillips B.G., Davison D.E., Berger P.B., and Somers V.K. Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation 109 (2004) 2181-2185
34. Soderberg S., Ahren B., Jansson J.H., Johnson O., Hallmans G., Asplund K., and Olsson T. Leptin is associated with increased risk of myocardial infarction. Journal of Internal Medicine 246 (1999) 409-418
35. Soeki T., Kishimoto I., Okumura H., Tokudome T., Horio T., Mori K., and Kangawa K. C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction. Journal of the American College of Cardiology 45 (2005) 608-616
36. Stanton L.W., Garrard L.J., Damm D., Garrick B.L., Lam A., Kapoun A.M., Zheng Q., Protter A.A., Schreiner G.F., and White R.T. Altered patterns of gene expression in response to myocardial infarction. Circulation Research 86 (2000) 939-945
37. Tang M.K., Ren D.C., Zhang J.T., and Du G.H. Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats. Phytomedicine 9 (2002) 405-409
38. Tsuruda T., Jougasaki M., Boerrigter G., Huntley B.K., Chen H.H., D'Assoro A.B., Lee S.C., Larsen A.M., Cataliotti A., and Burnett J.C. Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor. Circulation Research 90 (2002) 128-134
39. Wallace A.M., McMahon A.D., Packard C.J., Kelly A., Shepherd J., Gaw A., and Satter N. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104 (2001) 3052-3056
40. Wannamethee S.G., Tchernova J., Whincup P., Lowe G.D., Kelly A., Rumley A., Wallace A.M., and Sattar N. Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease. Atherosclerosis 191 (2007) 418-426
41. Wolk R., Berger P., Lennon R.J., Brilakis E.S., Johnson B.D., and Somers V.K. Plasma leptin and prognosis in patients with established coronary atherosclerosis. Journal of the American College of Cardiology 44 (2004) 1819-1824
42. Xiong Y., Tanaka H., Richardson J.A., Williams S.C., Slaughter C.A., Nakamura M., Chen J.L., and Yanagisawa M. Endothelin-1 stimulates leptin production in adipocytes. The Journal of Biological Chemistry 276 (2001) 28471-28477
43. Xu F.P., Chen M.S., Wang Y.Z., Yi Q., Lin S.B., Chen A.F., and Luo J.D. Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation 110 (2004) 1269-1275
44. Zhang H.S., and Wang S.Q. Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-a (TNF-alpha)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species. Journal of Molecular and Cellular Cardiology 41 (2006) 138-148
45. Zhang Y., proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432