The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation

Proteins: Structure, Function and Genetics

Volumn 71, Issue 4, 2008, Pages 1984-1994

  Xiong, Bing ^a,b   Burk, David L ^a   Shen, Jianhua ^b   Luo, Xiaomin ^b   Liu, Hong ^b   Shen, Jingkang ^b   Berghuis, Albert M ^a  

^a MCGILL UNIVERSITY   (Canada)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Correlation map; MM PBSA; Normal mode; Protein DNA interaction; Steered molecular dynamics; Topoisomerase III

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE 1A; FUNCTIONAL GROUP; TYROSINE;

ARTICLE; BIOCHEMISTRY; BIOPHYSICS; CATALYSIS; CONFORMATION; COVALENT BOND; DNA BINDING; DNA CLEAVAGE; DNA STRAND; ENERGY; GENETIC MANIPULATION; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SECRETION; SIMULATION;

APOPROTEINS; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE I, BACTERIAL; DNA, BACTERIAL; DNA, SINGLE-STRANDED; ESCHERICHIA COLI; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; TIME FACTORS;

ESCHERICHIA COLI;

EID: 44349161735     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21876     Document Type: Article

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