Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 270, Issue 6 14-6, 1996, Pages

  Poss, W Bradley ^a   Huecksteadt, Thomas R ^c   Panus, Peter C ^c   Freeman, Bruce A ^c   Hoidal, John R ^b  

^a United States Medical Corp   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^c NONE

Author keywords

bovine; endothelium; gene regulation

Indexed keywords

MESSENGER RNA; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

ANIMAL CELL; ANOXIA; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE CONTROL; GENE EXPRESSION; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; SWINE; VASCULAR ENDOTHELIUM;

EID: 0029775793     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.270.6.l941     Document Type: Article

References (31)

1. Aalto, T. K., and K. O. Raivio. Adenine nucleotide depletion from endothelial cells exposed to xanthine oxidase. Am. J. Physiol. 259 (Cell Physiol. 28): C883-C888, 1990.
2. Allison, R. C., J. Kyle, W. K. Adkins, V. R. Prasad, J. M. McCord, and A. E. Taylor. Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance. J. Appl Physiol. 69: 597-603, 1990.
3. Beckman, J. S., D. A. Parks, J. D. Pearson, P. A. Marshall, and B. Freeman. A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Proc. Natl. Acad. Sci. USA 6: 607-615, 1989.
4. Clare, D. A., B. A. Blakistone, H. E. Swaisgood, and H. R. Horton. Sulfhydral oxidase-catalyzed conversion of xanthine dehydrogenase to xanthine oxidase. Arch. Biochem. Biophys. 211: 44-47, 1981.
5. Donahue, D. M., M. E. Lee, H. C. Suen, T. Quertermous, and J. C. Wain. Pulmonary hypoxia increases endothelin-1 gene expression in sheep. J. Surg. Res. 57: 280-283, 1994.
6. Dupont, G. P., T. P. Huecksteadt, B. C. Marshall, U. S. Ryan, J. R. Michael, and J. R. Hoidal. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J. Clin. Invest. 89: 197-202, 1992.
7. Granger, D. N. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am. J. Physiol. 255 (Heart Circ. Physiol. 24): H1269-H1275, 1988.
8. Grosso, M. A., J. M. Brown, D. E. Viders, D. W. Mulvin, A. Banerjee, S. E. Velasco, J. E. Repine, and A. H. Harken. Xanthine oxidase-derived oxygen radicals induce pulmonary edema via direct endothelial cell injury. J. Surg. Res. 46: 355-360, 1989.
9. Harpold, M. M., R. M. Evans, M. Salditt-Georgieff, and J. E. Darnell. Production of mRNA in Chinese hamster ovary cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell 17: 1023-1035, 1979.
10. Harrison, R., S. Abadeh, and M. Benboubetra. Purification of xanthine oxidase from human mills. Biochem. Soc. Trans. 19: 332S, 1991.
11. Hassoun, P. M., P. S. Yu, A. L. Shedd, J. J. Zulueta, V. J. Thannickal, J. J. Lanzillo, and B. L. Fanburg. Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L163-L171, 1994.
12. Kennedy, T. P., N. V. Rao, C. Hopkins, L. Pennington, E. Tolley, and J. R. Hoidal. Role of reactive oxygen species in reperfasion injury of the rabbit lung. J. Clin. Invest. 83: 1326-1335, 1989.
13. Kourembanas, S., R. L. Hannan, and D. V. Faller. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain in human endothelial cells. J. Clin. Invest. 86: 670-674, 1990.
14. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of baeteriophage T4. Nature Lond. 227: 680-685, 1970.
15. Maeda, Y., M. Matsumoto, O. Hori, K. Kuwabara, S. Ogawa, S. D. Yan, T. Ohtsuki, T. Kinoshita, T. Kamada, and D. M. Stern. Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism of potentially enhancing neuron survival. J. Exp. Med. 180: 2297-2308, 1994.
16. McCord, J. M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312: 158-163, 1985.
17. Millhorn, D. E., M. Czyzk-Kreska, D. A. Bayliss, and E. E. Lawson. Regulation of gene expression by hypoxia. Sleep 16: S44-S48, 1993.
18. Panus, P. C., S. A. Wright, P. H. Chumley, R. Radi, and B. A. Freeman. The contribution of vascular endothelial xanthine dehydrogenase/oxidase to oxygen-mediated cell injury. Arch. Biochem. Biophys. 294: 695-702, 1992.
19. Partridge, C. A., F. A. Blumenstock, and A. B. Malik. Pulmonary microvascular endothelial cells constitutively release xanthine oxidase. Arch. Biochem. Biophys. 294: 184-187, 1992.
20. Pfeffer, K. D., T. P. Huecksteadt, and J. R. Hoidal. Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells: cytokine and steroid regulation. J. Immunol. 153: 1789-1797, 1994.
21. 2 metabolites inactivate xanthine oxidase. J. Appl. Physiol. 65: 2349-2353, 1988.
22. Terada, L. S., J. A. Leff, D. M. Guidot, I. R. Willingham, and J. E. Repine. Inactivation of xanthine oxidase by hydrogen peroxide involves site-directed hydroxyl radical formation. Free Radical Biol. Med. 10: 61-68, 1991.
23. Terada, L. S., D. M. Guidot, J. A. Leff, I. R. Willingham, M. E. Hanley, D. Piermattei, and J. E. Repine. Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity. Proc. Natl. Acad. Sci. USA 89: 3362-3366, 1992.
24. Towbin, H., T. Staehelin, and J. Gordon. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76: 4350-4354, 1979.
25. 2-dependent form (type O). Arch. Biochem. Biophys. 172: 365-379, 1976.
26. Wiezorek, J. S., D. H. Brown, D. E. Kupperman, and C. A. Brass. Rapid conversion to high xanthine oxidase activity in viable Kupffer cells during hypoxia. J. Clin. Invest. 94: 2224-2230, 1994.
27. Wiles, M. E., H. B. Hechtman, N. M. Morel, and D. Shepro. Hypoxia reoxygenation-induced injury of cultured pulmonary microvessel endothelial cells. J. Leukocyte Biol. 53: 490-497, 1993.
28. Yang, W. B., and E. R. Block. Effect of hypoxia on the formation and release of reactive oxygen species by cultured pulmonary artery endothelial cells. Am. Rev. Respir. Dis. 147: A298, 1994.
29. 2 by bovine pulmonary artery endothelial cells. Am. Rev. Respir. Dis. 147: A270, 1994.
30. Zweir, J. L., P. Kuppusamy, S. Thompson-Gorman, D. Klunk, and G. Lutty. Measurement and characterization of free radical generation in reoxygenated human endothelial cells. Am. J. Physiol. 266 (Cell Physiol. 35): C700-C708, 1994.
31. Zweir, J. L., R. Broderick, P. Kuppusamy, S. Thompson-Gorman, and G. A. Lutty. Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. J. Biol. Chem. 269: 24156-24162, 1994.