6- and 7-substituted 2-[2′-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3- diones: Synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships

Journal of Medicinal Chemistry

Volumn 39, Issue 8, 1996, Pages 1609-1618

  Sami, Salah M ^a   Dorr, Robert T ^a   Sólyom, Anikó M ^a   Alberts, David S ^a   Iyengar, Bhashyam S ^b   Remers, William A ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (DIMETHYLAMINO)ETHYL] 1,2 DIHYDRO 3H DIBENZ[DE,H]ISOQUINOLINE 1,3 DIONE DERIVATIVE; 6 ETHOXYAZONAFIDE; AZONAFIDE; DOXORUBICIN; ISOQUINOLINE DERIVATIVE; MITOXANTRONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARDIOTOXICITY; CONTROLLED STUDY; CROSS RESISTANCE; DNA DENATURATION; DRUG RESISTANCE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA L 1210; MALE; MELANOMA; MELANOMA B16; MOUSE; NONHUMAN; OVARY CANCER; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SOLID TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; ISOQUINOLINES; MALE; MICE; MICE, INBRED DBA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029862703     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950742g     Document Type: Article

References (15)

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