Evaluation of the regenerative potential of 25% doxycycline-loaded biodegradable membrane vs biodegradable membrane alone in the treatment of human periodontal infrabony defects: A clinical and radiological study

Indian Journal of Dental Research

Volumn 19, Issue 2, 2008, Pages 116-123

  Chaturvedi, Rashi ^a   Gill, Amarjit ^b   Sikri, Poonam ^c  

^a PANJAB UNIVERSITY   (India)

^b Surendra Dental College and Research Institute   (India)

^c Punjab Government Dental College and Hospital   (India)

Author keywords

Antimicrobial agents; Host modulation; Infection; Microbial colonization; Regeneration

Indexed keywords

EID: 44349102535     PISSN: 09709290     EISSN: 1998359X     Source Type: Journal    
DOI: 10.4103/0970-9290.40465     Document Type: Article

References (51)

1. Nyman S, Gottlow J, Karring T, Lindhe J. The regenerative potential of the periodontal ligament. J Clin Periodontol 1982;9:257-65.
2. Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol 1982;9:290-6.
3. Garrett S. Early wound healing stability and its importance in periodontal regeneration. In: Polson AM, editors. Periodontal regeneration: Current status and directions. Quintessence: Chicago; 1994. p. 41-51.
4. Polson AM, Proye M P. Fibrin linkage: A precursor for new attachment. J Periodontol 1983;54:141-7.
5. Wikesjo UM, Nilveus RE, Selvig KA. Significance of early healing events in periodontal repair: A review. J Periodontol 1992;63:158-65.
6. Selvig KA, Kersten BG, Chamberlain AD, Wikesjo UM, Nilveus RE. Regenerative surgery of intra-bony periodontal defects using e-PTFE barrier membranes: Scanning electron microscopic evaluation of retrieved membranes versus clinical healing. J Periodontol 1992;63:974-8.
7. Nowzari H, Slots J. Micro-organisms in polytetra-fluoroethylene barrier membranes for guided tissue regeneration. J Clin Periodontol 1994;21:203-10.
8. Ling LJ, Hung SL, Lee C F, Chen YT, Wu KM. The influence of membrane exposure on the outcomes of guided tissue regeneration: Clinical and microbiological aspects. J Periodontal Res 2003;38:57-63.
9. Chang C Y, Yamada S. Evaluation of the regenerative effect of a 25% Doxycycline-loaded biodegradable membrane for guided tissue regeneration. J Periodontol 2000;71:1086-93.
10. Gordon JM, Walker CB, Murphy JC, Goodson JM, Socransky SS. Concentration of tetracycline in human gingival fluid after single doses. J Clin Periodontol 1981;8:117-21.
11. Pascale D, Gordon J, Lamster I, Mann P, Seiger M, Amdt W. Concentration of Doxycycline in human gingival fluid. J Clin Periodontol 1986;13:841-4.
12. Walker CB, Gordon JM, McQuilkin SJ, Neibloom TA, Socransky SS. Tetracycline: Levels achievable in gingival crevice fluid and in-vitro effect on sub-gingival organisms, Part II: Susceptibilities of periodontal bacteria. J Periodontol 1981;52:613-6.
13. Baker PJ, Evans RT, Coburn RA, Genco RJ. Tetracycline and its derivates strongly bind to and are released from the tooth surface in active form. J Periodontol 1983;54:580-4.
14. Demirel K, Baer PN, McNamara T F. Topical application of Doxycycline on periodontally involved root surfaces in-vitro: Comparative analysis of substantivity on cementum and dentin. J Periodontol 1991;62:312-6.
15. Golub LM, Ramamurthy N, McNamara T F, Gomes B, Wolff M, Casino A, et al. Tetracyclines inhibit tissue collagenase activity: A new mechanism in the treatment of periodontal disease. J Periodontal Res 1984;19:651-5.
16. 1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: Serpinolytic inhibition by Doxycycline. J Periodontal Res 1997;32:9-19.
17. Yanagimura, Koike F, Hara K. Collagenase activity in gingival crevicular fluid and inhibition by Tetracyclines. J Dent Res 1989;68:1691-3.
18. Galgut PN. Oxidized cellulose mesh used as a biodegradable barrier membrane in the technique of guided tissue regeneration: A case report. J Periodontol 1990;61:766-8.
19. Galgut PN. Oxidized cellulose mesh, I: Biodegradable membrane in periodontal surgery. Biomaterials 1990;11:561-4.
20. Galgut PN. Biodegradable dressing material used in guided tissue regeneration of periodontal tissues: A case report. Quintessence Int 1993;24:25-7.
21. Galgut PN. A technique for treatment of extensive periodontal defects: A case study. J Oral Rehabil 1994;21:27-32.
22. Galgut PN. Radiographic evidence of bone regeneration using oxidized cellulose mesh as a bio-absorbable membrane: Some case studies. Periodontal Clin Investig 1996;18:22-5.
23. Thilander B, Stenstrom S. Maxillary growth after implantation of Surgicel® in clefts of the maxilla. Scand J Plast Reconstr Surg 1974;8:52-7.
24. Dineen P. Antibacterial activity of oxidized regenerated cellulose. Surg Gynaecol Obstet 1976;142:481-6.
25. Everett FG, Fixott HC. Use of an incorporated grid in the diagnosis of oral roentgenograms. Oral Surg Oral Med Oral Pathol 1963;16: 1061-4.
26. Wang HL, McNeil RL. Guided tissue regeneration: Absorbable barriers. Dent Clin North Am 1998;42:505-20.
27. Mombelli A, Lang N P, Nyman S. Isolation of periodontal species after guided tissue regeneration. J Periodontol 1993;64:1171-5.
28. Zucchelli G, Cesari C, Clauser C, DeSanctis M. Early bacterial accumulation on guided tissue regeneration membrane materials: An in-vivo study. J Periodontol 1998;69:1193-202.
29. Slots J. Selection of antimicrobial agents in periodontal therapy. J Periodontal Res 2002;37:389-98.
30. Mombelli A, Samaranayake L P. Topical and systemic antibiotics in the management of periodontal diseases. Int Dent J 2004;54:3-14.
31. Greenstein G, Polson A. The role of local drug delivery in the management of periodontal diseases: A comprehensive review. J Periodontol 1998;69:507-20.
32. Markman C, Fracalanzza SE, Novaes AB Jr, Novaes AB. Slow release of tetracycline hydrochloride from a cellulose membrane used in guided tissue regeneration. J Periodontol 1995;66:978-83.
33. Chung C P, Kim DK, Park YJ, Nam KH, Lee SJ. Biological effects of drug loaded biodegradable membranes for guided bone regeneration. J Periodontal Res 1997;32:172-5.
34. Zarkesh N, Nowzari H, Morrison JL, Slots J. Tetracycline-coated polytetra-fluoroethylene barrier membranes in the treatment of intraosseous periodontal lesions. J Periodontol 1999;70:1008-16.
35. Park YJ, Lee YM, Park SN, Lee JY, Ku Y, Chung C P, et al. Enhanced guided bone regeneration by controlled tetracycline release from poly(L-lactide) barrier membranes. J Biomed Mater Res 2000;51:391-7.
36. Sbordone L, Barone A, Di Genio M, Ramaglia L. Tetracycline fibres used to control bacterial infection during guided tissue regeneration (GTR). Minerva Stomatol 2000;49:27-34.
37. Kurtis B, Unsal B, Cetiner D, Gultekin E, Ozcan G, Celebi N, et al. Effect of polylactide/glycolide (PLGA) membranes loaded with metronidazole on periodontal regeneration following guided tissue regeneration in dogs. J Periodontol 2002;73:694-700.
38. Larsen T. In vitro release of Doxycycline from bio-absorbable materials and acrylic strips. J Periodontol 1990;61:30-4.
39. Caffesse RG, Ramfjord S P, Nasjleti CE. Reverse bevel periodontal flaps in monkeys. J Periodontol 1968;39:219-35.
40. Wilderman MN, Pennel BM, King K, Barron JM. Histogenesis of repair following osseous surgery. J Periodontol 1970;41:551-65.
41. Al-Ali W, Bissada N F, Greenwell H. The effect of local Doxycycline with and without tri-calcium phosphate on the regenerative healing potential of periodontal osseous defects in dogs. J Periodontol 1989;60:582-90.
42. Pepelassi EM, Bissada N F, Greenwell H, Farah C F. Doxycycline tri-calcium phosphate composite graft facilitates osseous healing in advanced periodontal furcation defects. J Periodontol 1991;62:106-15.
43. Takahashi N, Ishihara K, Kimizuka R, Okuda K, Kato T. The effects of tetracycline, minocycline, Doxycycline and ofloxacin on Prevotella intermedia biofilm. Oral Microbiol Immunol 2006;21:366-71.
44. Frank KL, Reichert EJ, Piper KE, Patel R. In vitro effects of antimicrobial agents on planktonic and biofilm forms of staphylococcus lugdunensis clinical isolates. Antimicrobial Agents Chemother 2007;51:888-95
45. Wikesjo UM, Baker PJ, Christersson LA, Genco RJ, Lyall RM, Hic S, et al. A biochemical approach to periodontal regeneration: Tetracycline treatment conditions dentin surfaces. J Periodontal Res 1986;21:322-9.
46. Terranova V P, Franzetti LC, Hic S, DiFlorio RM, Lyall RM, Wikesjo UM, et al. A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth. J Periodontal Res 1986;21:330-7.
47. Gabler WL, Creamer HR. Suppression of human neutrophil functions by tetracyclines. J Periodontal Res 1991;26:52-8.
48. Greenstein G, Lamster I. Efficacy of sub-antimicrobial dosing with doxycycline: Point/counterpoint. J Am Dent Assoc 2001;132:457-66.
49. Novak MJ, Johns L P, Miller RC, Bradshaw MH. Adjunctive benefits of sub-antimicrobial dose Doxycycline in the management of severe, generalized, chronic periodontitis. J Periodontol 2002;73:762-9.
50. Greiner D, Plamondon P, Sorsa T, Lee HM, McNamara T, Ramamurthy NS, et al. Inhibition of proteolytic, serpinolytic and progelatinase-B activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives. J Periodontol 2002;73:79-85.
51. Ramamurthy NS, Rifkin BR, Greenwald RA, Xu J W, Liu Y, Turner G, et al. Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: A comparison of 6 chemically modified Tetracyclines. J Periodontol 2002;73:726-34.