Inhibition of proteolytic, serpinolytic, and progelatinase-B activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives

Journal of Periodontology

Volumn 73, Issue 1, 2002, Pages 79-85

  Grenier, D ^a   Plamondon, P ^a   Sorsa, T ^a   Lee, H M ^a   McNamara, T ^a   Ramamurthy, N S ^a   Golub, L M ^a   Teronen, O ^a   Mayrand, D ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Collagenase; Metalloproteinases, matrix; Periodontal diseases prevention and control; Porphyromonas gingivalis; Proteinase inhibitors; Proteinases; Tetracycline therapeutic use; Treponema denticola

Indexed keywords

ALPHA 1 ANTITRYPSIN; ARGININE; CATION; CHROMOGENIC SUBSTRATE; CHYMOTRYPSIN; COLLAGEN TYPE 1; DOXYCYCLINE; GELATINASE B; GINGIPAIN R; HUMAN SERUM ALBUMIN; LYSINE; MATRIX METALLOPROTEINASE; PROTEINASE; TETRACYCLINE DERIVATIVE; TRYPSIN;

ANIMAL CELL; ARTICLE; CHELATION; CHEMICAL MODIFICATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; INCUBATION TIME; INHIBITION KINETICS; NEUTROPHIL; NONHUMAN; PATHOGENICITY; PERIODONTAL DISEASE; PERIODONTITIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PORPHYROMONAS GINGIVALIS; PROTEIN DEGRADATION; TISSUE INJURY; TREPONEMA DENTICOLA; WESTERN BLOTTING;

ADHESINS, BACTERIAL; ALPHA 1-ANTITRYPSIN; ANTI-BACTERIAL AGENTS; BLOTTING, WESTERN; CHROMOGENIC COMPOUNDS; CHYMOTRYPSIN; COLLAGENASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DOXYCYCLINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ENZYME PRECURSORS; GELATINASES; HEMAGGLUTININS; HUMANS; METALLOENDOPEPTIDASES; NEUTROPHILS; PORPHYROMONAS GINGIVALIS; PROTEASE INHIBITORS; SERINE PROTEINASE INHIBITORS; SERPINS; SERUM ALBUMIN; TETRACYCLINE; TETRACYCLINES; TREPONEMA; TRYPSIN INHIBITORS;

EID: 0036198409     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2002.73.1.79     Document Type: Article

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