The hydrogenosome as a drug target

Current Pharmaceutical Design

Volumn 14, Issue 9, 2008, Pages 872-881

  Benchimol, Marlene ^a,b  

^a UNIVERSIDADE SANTA ÚRSULA   (Brazil)

^b NONE   (Brazil)

Author keywords

Anaerobic protozoa; Drug target; Hydrogenosomes; Protist; Trichomonas

Indexed keywords

1,4 DIAMINO 2 BUTANONE; ADENOSINE TRIPHOSPHATE; ANTIPROTOZOAL AGENT; BETA LAPACHONE; CALCIUM; CARDIOLIPIN; COLCHICINE; CYTOCHALASIN; CYTOCHALASIN B; CYTOCHALASIN D; CYTOCHROME; FIBRONECTIN; FLUNIDAZOLE; GRISEOFULVIN; HYDROGEN; HYDROGENOSOME PROTEIN; HYDROXYUREA; METRONIDAZOLE; NIMORAZOLE; NITROIMIDAZOLE DERIVATIVE; NOCODAZOLE; ORNIDAZOLE; PACLITAXEL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTOZOAL PROTEIN; PYRUVIC ACID; SECNIDAZOLE; TINIDAZOLE; UNINDEXED DRUG; ZINC;

ANTIPROTOZOAL ACTIVITY; AUTOPHAGY; CALCIUM TRANSPORT; CARBOHYDRATE METABOLISM; CELL CYCLE PHASE; CELL MEMBRANE; CELL METABOLISM; CELL ORGANELLE; CELL SHAPE; CELL SIZE; CITRIC ACID CYCLE; CYTOSKELETON; DRUG TARGETING; ENDOPLASMIC RETICULUM; EXTRACELLULAR MATRIX; FLAGELLATE; GLYCOLYSIS; HUMAN; HYDROGENOSOME; LYSOSOME; MICROBIAL MORPHOLOGY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PSEUDOCYST; RESPIRATORY CHAIN; REVIEW; TRICHOMONAS FOETUS; TRICHOMONAS VAGINALIS; TRICHOMONIASIS; UROGENITAL TRACT INFECTION;

ANIMALS; ANTITRICHOMONAL AGENTS; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE; HUMANS; ORGANELLES; TRICHOMONAS; TRICHOMONAS INFECTIONS;

EID: 44349092082     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161208784041114     Document Type: Review

References (37)

1. Müller M. In: Honigberg BM Ed, Trichomonads Parasitic in human. Springer-Verlag, 1990; 53-83.
2. Diaz JAM, De Souza W. Purification and biochemical characterization of the hydrogenosomes of the flagellate protist Tritrichomonas foetus. Eur J Cell Biol 1997; 74: 85-91.
3. Benchimol M, Almeida JCA, De Souza W. Further studies on the organization of the hydrogenosome in Tritrichomonas foetus. Tiss Cell 1996a; 28: 287-99.
4. Pereira-Neves NA, Benchimol M. Phagocytosis by T. vaginalis: New insights. Biol Cell 2007; 99: 87-101.
5. Granger BL, Warwood SJ, Benchimol M, De Souza W. Transient invagination of flagella by Tritrichomonas foetus. Parasitol Res 2000; 86: 699-709.
6. Pereira-Neves A, Ribeiro KC, Benchimol M. Pseudocysts in trichomonads - New insights. Protist 2003; 154: 313-27.
7. Benchimol M, De Souza W. Fine structure and cytochemistry of the hydrogenosome of Tritrichomonas foetus. J Protozool 1983; 30: 422-5.
8. Benchimol M, Johnson PJ, De Souza W. Morphogenesis of the hydrogenosome: an ultrastructural study. Biol Cell 1996b; 87: 197-205.
9. Johnson PJ, Lahti CJ, Bradley PJ. Biogenesis of the hydrogenosome: An unusual organelle in the anaerobic protist Trichomonas vaginalis. J Parasitol 1993; 79: 664-70.
10. Lindmark DG, Müller M. Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate, Tritrichomonas foetus, and its role in pyruvate metabolism. J Biol Chem 1973; 248: 7724-28.
11. Rosa AI, Einicker-Lamas M, Bemardo RR, Previatto LM, Mohana-Borges R, Morgado-Diaz J, et al. Cardiolipin in hydrogenosomes: Evidence of symbiotic origin. Euk Cell 2006; 5: 784-7.
12. Akhmanova A, Voncken F, van Alen T, van Hoek A, Boxma B, Vogels G, et al. A hydrogenosome with a genome. Nature 1998; 10: 396: 527-8.
13. Müller M. The Hydrogenosome. J Gen Microbriol 1993; 139: 2879-89.
14. Clemens DL, Johnson PJ. Failure to detect DNA in hydrogenosomes of Trichomonas vaginalis by nick translation and immunomicroscopy. Mol Biochem Parasitol 2000; 106: 307-13.
15. Benchimol M, Durand R, Almeida J. A double memebrane surounds the hydrogenosomes of the anaerobic fungus Neocallimastix frontalis. FEMS Microbiol 1997; 154: 277-82.
16. Finlay BJ, Fenchel T. Hydrogenosomes in some anaerobic protozoa resemble mitochondria. FEMS Microb Lett 1989; 65: 311-4.
17. Benchimol M. Hydrogenosome autophagy in Tritrichomonas foetus: An ultrastructural and cytochemical study. Biol Cell 1999; 91: 165-74.
18. Benchimol M. Hydrogenosome morphological variation induced by fibronectin and other drugs in Tritrichomonas foetus and Trichomonas vaginalis. Parasitol Res 2001; 87: 215-22.
19. Madeiro RF, Benchimol M. The effect of drugs in cell structure of Tritrichimonas foetus. Parasitol Res 2004; 92: 159-70.
20. Benchimol M, Elias CA, Dee Souza W. Ultrastructural localization of calcium in the plasma membrane and in the hydrogenosome of Tritrichomonas foetus. Exp Parasitol 1982; 54: 277-84.
21. Benchimol M. Ultrastructural Characterization of the isolated hydrogenosome in Tritrichomonas foetus. Tiss Cell 2000; 32: 1-9
22. Honigberg MB, Brugerolle G. In: Honigberg, BM Ed, Trichomonads parasitic in human. Springer-Verlag, 1990; 5-35.
23. Quon DV, d'Oliveira CE, Johnson PJ. Reduced transcription of the ferredoxin gene in metronidazole-resistant Trichomonas vaginalis. Proc Natl Acad Sci USA 1992; 89: 4402-6.
24. Hrdý 1, Cammack R, Stopka P, Kulda J, Tachezy J. Alternative pathway of metronidazole activation in Trichomonas vaginalis hydrogenosomes. Antimicrob Agents Chemother 2005; 49: 5033-6.
25. Reis IA, Martinez MP, Yarlett N, Johnson PJ, Silva-Filho FC, Vannier-Santos MA. Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes. Antimicrob Agents Chemother 1999; 43: 1919-23.
26. Garcia AF, Benchimol M, Alderete JF. Trichomonas vaginalis polyamine metabolism is linked to host cell adherence and cytotoxicity. Infect Immun 2005; 73: 2602-10.
27. De Moura KC, Salomão K, Menna-Barreto RF, Emery FS, Pinto MC, Pinto AV, et al. Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: A review from an interdisciplinary study. Eur J Med Chem 2004; 39: 639-45.
28. Tagliarino C, Pink JJ, Dubyak GR, Nieminen AL, Boothman DA. Calcium is a key signaling molecule in beta-lapachone-mediated cell death. J Biol Chem 2001; 276:19150-9.
29. Neves-Pinto C, Malta VR, Pinto MC, Santos RH, de Castro SL, Pinto A. Trypanocidal phenazine derived from beta-lapachone. J Med Chem 2002; 45: 2112-15.
30. Menna-Barreto RF, Henriques-Pons A, Pinto AV, Morgado-Diaz JA, Soares MJ, De Castro SL. Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: Identification of target orgnelles. J Antimicrob Chemother 2005; 56: 1034-41.
31. Benchimol M, Almeida JC, Lins U, Gonçalves NR, de Souza W. Electron microscopic study of the effect of zinc on Tritrichomonas foetus. Antimicrob Agents Chemother 1993; 37: 2722-6.
32. Ribeiro KC, Vetö Amholdt AC, Benchimol M. Tritrichomonas foetus: Induced division synchrony by hydroxyurea. Parasitol Res 2002; 88: 627-31.
33. Mariante RM, Guimarães CA, Linden R, Benchimol M. Hydrogen peroxide induces caspase activation and programmed cell death in the amitochondrial Tritrichomonas foetus. Histochem Cell Biol 2003; 120: 129-41.
34. Mariante, RM, Vancini, RG, Benchimol M. (2006) Cell death in Trichomonas: New insights. Histochem Cell Biol 2006; 5: 545-56
35. Vabáacová S, Rasoloson D, Rázga J, Hrdý I, Kulda J, Tachezy J. Iron-induced changes in pyruvate metabolism of Tritrichomonas foetus and involvement of iron in expression of hydrogenosomal proteins. Microbiology 2001; 147: 53-62.
36. Kulda J. Trichomonads, hydrogenosomes and drug resistance. Int J Parasitol 1999; 29: 199-12.
37. Land KM, Clemens DL, Johnson PJ. Loss of multiple hydrogenosomal proteins associated with organelle metabolism and high-level drug resistance in trichomonads. Exp Parasitol 2001; 97: 102-10.