A caspase active site probe reveals high fractional inhibition needed to block DNA fragmentation

Journal of Biological Chemistry

Volumn 279, Issue 27, 2004, Pages 27905-27914

  Méthot, Nathalie ^a   Vaillancourt, John P ^a   Huang, JingQi ^a   Colucci, John ^a   Han, Yongxin ^a   Ménard, Stéphane ^a   Zamboni, Robert ^a   Toulmond, Sylvie ^a   Nicholson, Donald W ^a   Roy, Sophie ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CELL CULTURE; DNA; ENZYME INHIBITION; ENZYMES;

DNA FRAGMENTATION; PHENOTYPIC CHANGES;

BIOCHEMISTRY;

CASPASE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE INHIBITOR; DNA; INTERLEUKIN 1BETA CONVERTING ENZYME; IODINE 125; M 808; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; DNA CONTENT; DNA DAMAGE; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RADIOIODINATION; RAT; THYMOCYTE; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CASPASES; CECUM; COCULTURE TECHNIQUES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; IODINE RADIOISOTOPES; JURKAT CELLS; KINETICS; MICE; MODELS, CHEMICAL; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SEPSIS; THYMUS GLAND; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 3142616523     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400247200     Document Type: Article

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