Modulation of signal transduction pathways in lymphocytes due to sub-lethal toxicity of chlorinated phenol

Toxicology Letters

Volumn 179, Issue 1, 2008, Pages 23-28

  Limaye, Amita ^a   Kashyap, Rajpal S ^b   Kapley, Atya ^c   Galande, Sanjeev ^a   Purohit, Hemant J ^c   Daginawala, Hatim F ^b   Taori, Giridhar M ^b  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

^b CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^c NATIONAL ENVIRONMENTAL ENGINEERING RESEARCH INSTITUTE   (India)

Author keywords

Chlorophenol; Cytotoxicity; Immune response; Signaling pathway

Indexed keywords

CHEMOKINE; CHLOROPHENOL; CYTOKINE; INTERLEUKIN 21; INTERLEUKIN 9; PENTACHLOROPHENOL;

ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; LETHAL DOSE; LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLLUTANT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHLOROPHENOLS; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION; HUMANS; INTERLEUKIN-9; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PENTACHLOROPHENOL; SIGNAL TRANSDUCTION; UNCOUPLING AGENTS;

EID: 44149116416     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.03.016     Document Type: Article

References (35)

1. Beach T.M. Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Hum. Exp. Toxicol. 25 (2006) 651-659
2. Boyum A. Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 97 (1968) 1-109
3. Carnaud C., Lee D., Donnars O., Park S.H., Beavis A., Koezuka Y., and Bendelac A. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163 (1999) 4647-4650
4. Carson D.A., and Seegmiller J.E. Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. J. Clin. Invest. 57 (1976) 274-282
5. Chen X. Pentachlorophenol reduces B lymphocyte function through proinflammatory cytokines in Carassius auratus. Food Chem. Toxicol. 43 (2005) 239-245
6. Dong Q., Louahed J., Vink A., Sullivan C.D., Messler C.J., Zhou Y., Haczku A., Huaux F., Arras M., Holroyd K.J., Renauld J.C., Levitt R.C., and Nicolaides N.C. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur. J. Immunol. 29 (1999) 2130-2139
7. Esteban V.M., Falk K., and Rötzschke O. Small-molecular compounds enhance the loading of APC with encephalitogenic MBP protein. J. Autoimmun. 20 (2003) 63-69
8. Falk K., Lau J.M., Santambrogio L., Esteban V.M., Puentes F., Rotzschke O., and Strominger J.L. Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules. J. Biol. Chem. 277 (2002) 2709-2715
9. Finiasz M.R., Franco M.C., Barrera S., Rutitzky L., Pizzariello G., Sasiain M.C., Renauld J.C., Snick J.V., and Fink S. IL-9 promotes anti-mycobacterium leprae cytotoxicity: involvement of IFNγ. Clin. Exp. Immunol. 147 (2007) 139-147
10. Giblett E.R., Anderson J.E., Cohen F., Pollaraand B., and Meuwissen H.J. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 2 (1972) 1067-1069
11. Giusti G., and Galanti B. Adenosine deaminase: colorimetric method. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis. 3rd ed. Vol. 4 (1984), Verlac Chemie, Weinheim 315-323
12. Gounni A.S., Gregory B., Nutku E., Aris F., Latifa K., Minshall E., North J., Tavernier J., Levit R., Nicolaides N., Robinson D., and Hamid Q. Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Blood 96 (2000) 2163-2171
13. Hirose M., Tanaka H., Takahashi S., Futakuchi M., Fukushima S., and Ito N. Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer Res. 53 (1993) 32-37
14. Jacoby E., Davies J., and Blommers M.J. Design of small molecule libraries for NMR screening and other applications in drug discovery. Curr. Top. Med. Chem. 3 (2003) 11-23
15. Kainthla R.P., Kashyap R.S., Prasad S., Purohit H.J., Taori G.M., and Daginawala H.F. Evaluation of Adenosine deaminase assay for analyzing T-lymphocytes density in vitro. In Vitro Cell. Develop. Biol. 42 (2006) 287-289
16. Kashyap R.S., Kainthla R.P., Mudaliar A.V., Purohit H.J., Taori G.M., and Daginawala H.F. Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis. Cerebrospinal Fluid (BMC) 30 (2006) 3-5
17. Kobayashi K., Yamazaki J., Kasama T., Katsura T., Kasahara K., Wolf S.F., and Shimamura T. Interleukin (IL)-12 deficiency in susceptible mice infected with Mycobacterium avium and amelioration of established infection by IL-12 replacement therapy. J Infect Dis. 174 (1996) 564-573
18. Leach A.R., and Hann M.M. The in silico world of virtual libraries. Drug. Discov. Today 5 (2000) 326-336
19. Lin P.H., Nakamura J., and Swenberg J.A. Quantitative analysis of DNA adducts and abasic sites induced by pentachlorophenol-derived quinone and hydrquinone in calf thymus DNA. Toxicologist 48 (1999) 232-233
20. Lin P.H., La D.K., Upton P.B., and Swenberg J.A. Analysis of DNA adducts in rats exposed to pentachlorophenol. Carcinogenesis 23 (2002) 365-369
21. Ma Q., Kinneer K., Ye J., and Chen B.J. Inhibition of nuclear factor kappaB by phenolic antioxidants: interplay between antioxidant signaling and inflammatory cytokine expression. Mol. Pharmacol. 64 (2003) 211-219
22. Parrish-Novak J., Foster D.C., Holly R.D., and Clegg C.H. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukoc. Biol. 72 (2002) 856-863
23. Reed A., Dzon L., Loganathan B.G., and Whalen M.M. Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides. Hum. Exp. Toxicol. 23 (2004) 463-471
24. Roman J., de Arriba A.F., Barron S., Michelena P., Giral M., Merlos M., Bailon E., Comalada M., Galvez J., Zarzuelo A., and Ramis I. UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells. Mol. Pharmacol. 72 (2007) 269-279
25. Sai K., Kang K.S., Hirose A., Hasegawa R., Trosko J.E., and Inoue T. Inhibition of apoptosis by pentachlorophenol in v-myc-transfected rat liver epithelial cells: relation to down-regulation of gap junctional intercellular communication. Cancer Lett. 173 (2001) 163-174
26. Seiler J.P. Pentachlorophenol. Mutat. Res. 257 (1991) 27-47
27. Shen J., Xu X., Cheng F., Liu H., Luo X., Shen J., Chen K., Zhao W., Shen X., and Jiang H. Virtual screening on natural products for discovering active compounds and target information. Curr. Med. Chem. 10 (2003) 2327-2342
28. Siegel M.G., and Vieth M. Drugs in other drugs: a new look at drugs as fragments drug. Discov. Today 12 (2007) 71-79
29. Snyder F.F., Mendelsohn J., and Seegmiller J.E. Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes. J. Clin. Invest. 58 (1976) 654-666
30. Sondergaard H., Frederiksen K.S., Thygesen P., Galsgaard E.D., Skak K., Kristjansen P.E., Odum N., and Kragh M. Interleukin 21 therapy increases the density of tumor infiltrating CD8(+)T cells and inhibits the growth of syngeneic tumors. Cancer. Immunol. Immunother. 56 (2007) 1417-1428
31. Strengell M., Matikainen S., Siren J., Lehtonen A., Foster D., Julkunen I., and Sareneva T. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J. Immunol. 170 (2003) 5464-5469
32. Townsend M.J., Fallon G.P., Matthews J.D., Smith P., Jolin E.H., and McKenzie A.N.J. IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 13 (2000) 573-583
33. WHO. Pentachlorophenol. Environmental Health Criteria 71 (1987), World Health Organization, Geneva
34. Wispriyono B., Matsuoka M., and Igisu H. Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells. Environ. Health Perspect. 110 (2002) 139-143
35. Zeng R., Spolski R., Casas E., Zhu W., Levy D.E., and Leonard W.J. The molecular basis of IL-21-mediated proliferation. Blood 109 (2007) 4135-4142