Effects of organochlorine pesticides on interleukin secretion from lymphocytes

Human and Experimental Toxicology

Volumn 25, Issue 11, 2006, Pages 651-659

  Beach, T M ^a   Whalen, Margaret M ^a  

^a TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Cytotoxicity; Immunomodulation; Interleukins; NK cells; Organochlorine pesticides

Indexed keywords

CHLORDANE; CHLORPHENOTANE; CYTOKINE; HEPTACHLOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; ORGANOCHLORINE PESTICIDE; OXYCHLORDANE; PENTACHLOROPHENOL;

ADULT; ARTICLE; CELL FUNCTION; CONCENTRATION (PARAMETERS); CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOMODULATION; LYMPHOCYTE; MALE; NATURAL KILLER T CELL; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR CELL;

ADULT; AGED; CELLS, CULTURED; FEMALE; HUMANS; HYDROCARBONS, CHLORINATED; INTERLEUKINS; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; MONOCYTES; PESTICIDES; T-LYMPHOCYTES;

EID: 33845926495     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327106070072     Document Type: Article

References (35)

1. Lotzova E. Definition and function of natural killer cells. Nat Immunol 1993; 12: 169-76.
2. Kiessling R, Haller O. Natural killer cells in the mouse: an alternative surveillance mechanism? Contemp Top Immunobiol 1978; 8: 171-201.
3. Hanna N. Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural-killer-cell mediated cytotoxicity. Int J Cancer 1980; 26: 675-80.
4. Fleisher G, Starr S, Koven N, Kamiya H, Douglas SD, Henle W. A non-X-linked syndrome with susceptibility to severe Epstein-Barr virus infections. J Pediatr 1982; 100: 727-30.
5. Biron CA, Byron KS, Sullivan JL. Severe herpes virus infection in an adolescent without natural killer cells. N Engl J Med 1989; 320: 1731-35.
6. US Environmental Protection Agency (US EPA). Ground water and drinking water. Heptachlor and heptachlor epoxide, technical fact sheet, 2003.
7. Radon K, Wegner R, Heinrich-Ramm R, Baur X, Poschadel B, Szadkowski D. Chlorophenol exposure in harbor workers exposed to river silt aerosols. Am J Ind Med 2004; 45: 440-45.
8. Svensson B-G, Hallberg T, Nilsson A, Schütz A, Hagmar L. Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health 1994; 65: 351-58.
9. McConnachie PR, Zahalsky AC. Immunological consequences of exposure to pentachlorophenol. Arch Environ Health 1991; 46: 249-53.
10. US Environmental Protection Agency (US EPA). Restricted use product file. 25 October 2001.
11. Hardell L, Eriksson M, Lindstrom G, Van Bavel B, Linde A, Carlberg M, Liljegren G. Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus in the etiology of non-Hodgkin lymphoma. Leuk Lymphoma 2001; 42: 619-29.
12. Huber DV, Bauer K, Suesal C, Conradt C, Opelz G. Associations of dichlorophenyltrichloroethane (DDT) 4.4. and dichlorodiphenyldichloroethylene (DDE) 4.4 blood levels with plasma IL-4. Arch Environ Health 2002; 57: 541-47.
13. Centers for Disease Control and Prevention (CDC). Second National Report on Human Exposure to Environmental Chemicals, 2003.
14. Thornton JW, McCally M, Houlihan J. Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden. Public Health Rep 2002; 117: 315-23.
15. Dearth MA, Hites RA. Complete analysis of technical chlordane using negative ionization mass spectrometry. Environ Sci Technol 1991; 25: 245-54.
16. Epstein SS, Ozonoff D. Leukemia and blood dyscrasias following exposure to chlordane and heptachlor. Teratog Carcinogen Mutagen 1987; 7: 527-40.
17. Blaylock BL, Soderberg LS, Gandy J, Menna JH, Denton R, Barnett JB. Cytotoxic T-lymphocyte and NK responses in mice treated prenatally with chlordane. Toxicol Lett 1990; 51: 41-49.
18. Johnson KW, Kaminski NE, Munson AE. Direct suppression of cultured spleen cell responses by chlordane and the basis for differential effects on in vivo and in vitro immunocompetence. J Toxicol Environ Health 1987; 22: 497-515.
19. Reed A, Dzon L, Loganathan BG, Whalen MM. Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides. Hum Exp Toxicol 2004; 23: 463-71.
20. Denis MC, Huber BT. Native and recombinant interleukin-2, two functionally distinct molecules. Mol Immunol 2003; 40: 279-86.
21. Whalen MM, Williams TB, Green SA, Loganathan BG. Interleukins 2 and 12 produce recovery of cytotoxic function in tributyltin-exposed human natural killer cells. Environ Res 2002; 88: 199-209.
22. Marcenaro E, Della Chiesa M, Bellora F, Parolini S, Millo R, Morretta L, Morretta A. IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors. J Immunol 2005; 174: 3992-98.
23. Nagler A, Lanier LL, Phillips JH. The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation. J Immunol 1988; 141: 2349-51.
24. Brown MA, Hural J. Functions of IL-4 and control of its expression. Crit Rev Immunol 1997; 17: 1-32.
25. Cai G, Kastelein RA, Hunter CA. IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18. Eur J Immunol 1999; 29: 2658-65.
26. Whalen MM, Loganathan BG, Kannan K. Immunotoxicity of environmentally relevant concentrations of butyltins on human natural killer (NK) cells in vitro. Environ Res 1999; 81: 108-16.
27. Whalen MM. Inhibition of human natural killer cell function, in vitro, by glucose concentrations seen in poorly controlled diabetes. Cell Physiol Biochem 1997; 7: 53-60.
28. Whalen MM, Ghazi S, Loganathan BG, Hatcher F. Expression of CD16, CD18 and CD56 in tributyltin-exposed human natural killer cells. Chemico-Biol Interact 2002; 139: 159-76.
29. Doherty DG, Norris S, Madrigal-Estebas L, McEntee G, Traynor O, Hegarty JE, O'Farrelly C. The human liver contains multiple populations of NK cells, T cells, and CD3+ CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, Th0 cytokine secretion patterns. J Immunol 1999; 163: 2314-21.
30. Neill WA, Halliday KE, Norval M. Differential effect of phototherapy on human natural killer cells and cytotoxic T cells. J Photochem Photobiol B 1998; 47: 129-35.
31. Norris S, Doherty DG, Collins C, McEntee G, Traynor O, Hegarty JE, O'Farrelly C. Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer phenotype and function are phenotypically heterogeneous and include Vα24-JαQ and γδ T cell receptor bearing cells. Hum Immunol 1999; 60: 20-31.
32. Whalen MM, Walker L, Loganathan BG. Interleukins 2 and 12 produce significant recovery of cytotoxic function in dibutyltin-exposed human natural killer cells. Environ Res 2002; 88: 103-15.
33. Naume B, Gately M, Espevik T. A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells. J Immunol 1992; 148: 2429-36.
34. Retini C, Casadevall A, Pietrella D, Monari C, Palazzetti B, Vecchiarelli A. Specific activated T cells regulate IL-12 production by human monocytes stimulated with Cryptococcus neoformans. J Immunol 1999; 162: 1618-23.
35. Begley J, Reichert EL, Rashad MN, Klemmer HW. Association between renal function tests and pentachlorophenol exposure. Clin Toxicol 1977; 11: 97-106.