NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage

Biochemical and Biophysical Research Communications

Volumn 371, Issue 4, 2008, Pages 829-833

  Inoue, Ken ichi ^a,b   Nakanjishi, Mitsuru ^a   Kikuchi, Hironobu ^a   Yamamoto, Hideki ^a   Todo, Satoru ^b   Nakagawara, Akira ^a   Ozaki, Toshinori ^a  

^a CHIBA CANCER CENTER   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Adriamycin; Apoptosis; BRCT domain; DNA damage; MDM2; NFBD1 MDC1

Indexed keywords

DNA; DOXORUBICIN; MDC1 PROTEIN; NFBD1 PROTEIN; PROTEIN DERIVATIVE; PROTEIN MDM2; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASSAY; CELL FATE; CELL SURVIVAL; DNA DAMAGE; DOWN REGULATION; EMBRYO; FEMALE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ENZYME STABILITY; HUMANS; IMMUNOPRECIPITATION; NUCLEAR PROTEINS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; UP-REGULATION;

EID: 44149090004     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.155     Document Type: Article

References (22)

1. Nagase T., Seki N., Ishikawa K., Tanaka A., and Nomura N. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 3 (1996) 17-24
2. Ozaki T., Nagase T., Ichimiya S., Seki N., Ohira M., Nomura N., Takada N., Sakiyama S., Weber B.L., and Nakagawara A. NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain. DNA Cell Biol. 19 (2000) 475-485
3. Stewart G.S., Wang B., Bignell C.R., Taylor A.M., and Elledge S.J. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421 (2003) 961-966
4. Goldberg M., Stucki M., Falck J., D'Amours D., Rahman D., Pappin D., Bartek J., and Jackson S.P. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421 (2003) 952-956
5. Lou Z., Minter-Dykhouse K., Wu X., and Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421 (2003) 957-961
6. Bassing C.H., Chua K.F., Sekiguchi J., Suh H., Whitlow S.R., Fleming J.C., Monroe B.C., Ciccone D.N., Yan C., Vlasakova K., Livingston D.M., Ferguson D.O., Scully R., and Alt F.W. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl. Acad. Sci. USA 99 (2002) 8173-8178
7. Celeste A., Petersen S., Romanienko P.J., Fernandez-Capetillo O., Chen H.T., Sedelnikova O.A., Reina-San-Martin B., Coppola V., Meffre E., Difilippantonio M.J., Redon C., Pilch D.R., Olaru A., Eckhaus M., Camerini-Otero R.D., Tessarollo L., Livak F., Manova K., Bonner W.M., Nussenzweig M.C., and Nussenzweig A. Genomic instability in mice lacking histone H2AX. Science 296 (2002) 922-927
8. Fernandez-Capetillo O., Chen H.T., Celeste A., Ward I., Romanienko P.J., Morales J.C., Naka K., Xia Z., Camerini-Otero R.D., Motoyama N., Carpenter P.B., Bonner W.M., Chen J., and Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4 (2002) 993-997
9. Kobayashi J. Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain. J. Radiat. Res. 45 (2004) 473-478
10. Lou Z., Minter-Dykhouse K., Franco S., Gostissa M., Rivera M.A., Celeste A., Manis J.P., van Deursen J., Nussenzweig A., Paull T.T., Alt F.W., and Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21 (2006) 187-200
11. Peng A., and Chen P.L. NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J. Biol. Chem. 278 (2003) 8873-8876
12. Xu X., and Stern D.F. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 17 (2003) 1842-1848
13. Nakanishi M., Ozaki T., Yamamoto H., Hanamoto T., Kikuchi H., Furuya K., Asaka M., Delia D., and Nakagawara A. NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage. J. Biol. Chem. 282 (2007) 22993-23004
14. Bu Y., Suenaga Y., Ono S., Koda T., Song F., Nakagawara A., and Ozaki T. Sp1-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway. Genes Cells 13 (2008) 55-66
15. H. Wang, T. Ozaki, M. Shamim Hossain, Y. Nakamura, T. Kamijo, X. Xue, A. Nakagawara, A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53, Biochem. Biophys. Res. Commun. in press.
16. Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2 (2002) 594-604
17. Leach F.S., Tokino T., Meltzer P., Burrell M., Oliner J.D., Smith S., Hill D.E., Sidransky D., Kinzler K.W., and Vogelstein B. p53 mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res. 53 (1993) 2231-2234
18. Guo W., Ahmed K.M., Hui Y., Guo G., and Li J.J. siRNA-mediated MDM2 inhibition sensitizes human lung cancer A549 cells to radiation. Int. J. Oncol. 30 (2007) 1447-1452
19. Meng L.H., Kohn K.W., and Pommier Y. Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene 26 (2007) 4806-4816
20. Bork P., and Koonin E.V. Protein sequence motifs. Curr. Opin. Struct. Biol. 6 (1996) 366-376
21. Iwabuchi K., Bartel P.L., Li B., Marraccino R., and Fields S. Two cellular proteins that bind to wild-type but not mutant p53. Proc. Natl. Acad. Sci. USA 91 (1994) 6098-6102
22. Chai Y.L., Cui J., Shao N., Shyam E., Reddy P., and Rao V.N. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene 18 (1999) 263-268