Du-zhong (Eucommia ulmoides Oliver) leaf extract mediates hypolipidemic action in hamsters fed a high-fat diet

American Journal of Chinese Medicine

Volumn 36, Issue 1, 2008, Pages 81-93

  Choi, Myung Sook ^a   Jung, Un Ju ^b   Kim, Hye Jin ^a   Do, Gyeong Min ^a   Jeon, Seon Min ^a   Kim, Myung Joo ^c   Lee, Mi Kyung ^d  

^a Kyungpook National University   (South Korea)

^b Columbia University ^*  (United States)

^c Daegu Polytechnic College   (South Korea)

^d Sunchon National University   (South Korea)

Author keywords

Cholesterol; Du zhong Leaf; Hamster; Lipid Metabolism; Lipoprotein; Triglyceride

Indexed keywords

ANTILIPEMIC AGENT; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; EUCOMMIA ULMOIDES EXTRACT; FATTY ACID SYNTHASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; EPIDIDYMIS; EUCOMMIACEAE; FATTY ACID BLOOD LEVEL; FATTY ACID SYNTHESIS; HYPERLIPIDEMIA; LIPID DIET; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PLANT LEAF; SYRIAN HAMSTER; TRIACYLGLYCEROL BLOOD LEVEL; TU CHUNG;

ANIMALS; ANTILIPEMIC AGENTS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CRICETINAE; DIETARY FATS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; EUCOMMIACEAE; FATTY ACIDS, NONESTERIFIED; LIPIDS; LIVER; MALE; MESOCRICETUS; PLANT EXTRACTS; PLANT LEAVES; TRIGLYCERIDES;

EID: 44049092637     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X08005606     Document Type: Article

References (41)

1. American Institute of Nutrition. Report of the American Institute of Nutrition. Ad hoc committee on standards for nutritional studies. J. Nutr. 107: 1340-1348, 1977.
2. American Institute of Nutrition. Report of ad hoc committee on standards for nutritional studies. J. Nutr. 110: 1717-1726, 1980.
3. Bieber, L.L., T. Abraham and T. Helmrath. A rapid spectrophotometric assay for carnitine palmitoyltransferase. Anal. Biochem. 50: 509-518, 1972.
4. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
5. Chang, S.C., C.A. Baumann, M. Kanzaki, D.C. Thurmond, R.T. Watson, C.L. Neudauer, I.G. Macara, J.E. Pessin and A.R. Saltiel. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 410: 944-948, 2001.
6. Chen, J., W. Song and R.N. Redinger. Effect of dietary cholesterol on hepatic production of lipids and lipoproteins in isolated hamster liver. Hepatology 24: 424-434, 1996.
7. de Silva, P.P., P.J. Davis and S.K. Cheema. Hyperlipidaemic effect of fish oil in Bio F1B hamsters. Br. J. Nutr. 91: 341-349, 2004.
8. Dulloo, A.G., C. Duret, D. Rohrer, L. Girardier, N. Mensi, M. Fathi, P. Chantre and J. Vandermander. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clin. Nutr. 70: 1040-1045, 1999.
9. Dulloo, A.G., J. Seydoux, L. Girardier, P. Chantre and J. Vandermander. Green tea and thermogenesis: Interactions between catechin-polyphenols, caffeine and sympathetic activity. Int. J. Obes. Relat. Metab. Disord. 24: 252-258, 2000.
10. Erickson, S.K., M.A. Schrewsbery, C. Brooks and D.J. Meyer. Rat liver acyl-coenzyme A: Cholesterol acyltransferase: Its regulation in vivo and some of properties in vitro. J. Lipid Res. 21: 930-941, 1980.
11. Folch, J., M. Lees and G.H. Sloan-Stanley. A simple method for isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509, 1957.
12. Ghatak, A. and O.P. Asthana. Recent trends in hyperlipopreoteinemias as pharmacotherapy. Ind. J. Pharmacol. 27: 14-29, 1995.
13. Gillies, P.J., K.A. Rathgeb, M.A. Perri and C.S. Robinson. Regulation of acyl-CoA: Cholesterol acyltransferase activity in normal control and atherosclerotic rabbit aortas: Role of a cholesterol substrate pool. Exp. Mol. Pathol. 44: 320-339, 1986.
14. Hayek, T., B. Fuhrman, J. Vaya, M. Rosenblat, P. Belinky, R. Coleman, A. Elis and M. Aviram. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arteriscler. Throm. Vasc. Biol. 17: 2744-2752, 1997.
15. Hertog, M.G., E.J. Feskens, P.C. Hollman, M.B. Katan and D. Kromhout. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 342: 1007-1011, 1993.
16. Hillgartner, F.B., L.M. Salati and A.G. Goodridge. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol. Rev. 75: 47-76, 1995.
17. Hong, N.D., Y.S. Rho, D.H. Won, N.J. Kim and B.S. Cho. Studies on the anti-diabetic activity of Eucommia ulmoides Oliver. Kor. J. Pharmacog. 18: 112-117, 1987.
18. Hulcher, F.H. and W.H. Oleson. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme. A. J. Lipid Res. 14: 625-631, 1973.
19. Kavitha, R. and N. Nalini. Hypolipidemic effect of green and red chilli extract in rats fed a high-fat diet. Med. Sci. Res. 28: 17-21, 2000.
20. Kawasaki, T., K. Uezono and Y. Nakazawa. Antihypertensive mechanism of food for specified health use: "Eucommia leaf glycoside" and its clinical application. J. Health Sci. 22: 29-36, 2000.
21. Knekt, P., R. Jarvinen, A. Reunanen and J. Maatela. Flavonoid intake and coronary mortality in Finland: A cohort study. Br. Med. J. 312: 478-481, 1996.
22. Kuhajda, F.P., E.S. Pizer, J.N. Li, N.S. Mani, G.L. Frehywot and C.A. Townsend. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc. Natl. Acad. Sci. USA 97: 3450-3454, 2000.
23. Kukita, H., K. Hiwada and T. Kokubu. Serum apolipoprotein A-I, A-II and B levels and their discriminative values in relative of patients of coronary artery disease. Atherosclerosis 51: 261-267, 1984.
24. Kwan, C.Y., W.B. Zhang, T. Deyama and S. Nishibe. Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels. Naunyn-Schmiedeberg's Arch. Pharmacol. 369: 206-211, 2004.
25. Lazarow, P.B. Assay of peroxisomal β-oxidation of fatty acids. Methods Enzymol. 72: 315-319, 1981.
26. Lin, J.K and S.Y. Lin-Shiau. Mechanism of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol. Nutr. Food Res. 50: 211-217, 2006.
27. Memon, R.A., C. Grunfeld, A.H. Moser and K.R. Feinglod. Fatty acid synthesis in obese insulin resistant diabetic mice. Horm. Metab. Res. 26: 85-87, 1994.
28. Miura, Y., T. Chibal I. Tomita, H. Koizumi, S. Miura, K. Umegakr, Y. Hara, M. Ikeda and T. Tomita Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J. Nutr. 131: 27-32, 2001.
29. Mustad, V.A., T.D. Etherton, A.D. Cooper, A.M. Mastro, T.A. Pearson, S.S. Jonnalagadda and P.M. Kris-Etherton. Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women. J. Lipid Res. 38: 459-468, 1997.
30. Nakachi, K., S. Matsuyama, S. Miyake, M. Suganuma and K. Imai. Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention. Biofactors 13: 49-54, 2000.
31. Nakazawa, Y. Functional and healthy properties of Du-Zhong tea and their utilization. Food Ind. 40: 6-15, 1997.
32. Nepokroeff, C.M., M.R. Lakshmanan and J.W. Poter. Fatty acid synthase from rat liver. Methods Enzymol. 35: 37-44, 1975.
33. Park, S.A., M.S. Choi, M.J. Kim, U.J. Jung, H.J. Kim, K.K. Park, H.J. Noh, H.M, Park, Y.B. Park, J.S. Lee and M.K. Lee. Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL/KsJ-db/db mice. J. Ethnopharmacol. 107: 412-417, 2006.
34. Parthasarathy, S., M.T. Quinn and D.C. Schwenke. Oxidative modification of beta-very low density lipoprotein potential role in monocyte recruitment and foam cell formation. Atherosclerosis 9: 393-399, 1995.
35. Peters, U., C. Poole and L. Arab. Does tea affect cardiovascular disease? A meta-analysis. Am. J. Epidemiol. 154: 495-503, 2001.
36. Shapiro, D.J., J.L. Nordstrom, J.J. Mitschelen, V.W. Rodwell and R.T. Schimke. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim. Biophys. Acta 370: 369-377, 1974.
37. Smith, S. The animal fatty acid synthase: One gene, one polypeptide, seven enzymes. FASEB J. 8: 1248-1259, 1994.
38. Stangl, V., M. Lorenz and K. Stangl. The role of tea and tea flavonoids in cardiovascular health. Mol. Nutr. Food Res. 50: 218-228, 2006.
39. Tian, W.X. Inhibition of fatty acid synthase by polyphenols. Curr Med. Chem. 13: 967-977, 2006.
40. Xu, R., W.H. Yokoyama, D. Irving, D. Rein, R.L. Walzem and J.B. German. Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. Atherosclerosis 137: 29-36, 1998.
41. Zulet, M.A., A. Barber, H. Garcin, P. Higueret and J.A. Martinez. Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model. J. Am. Coll. Nutr. 18: 36-42, 1999.