Inhibition of the protein kinase C pathway promotes anti-CD95-induced apoptosis in jurkat T cells

International Immunology

Volumn 10, Issue 7, 1998, Pages 877-889

  Drew, Lisa ^a   Kumar, Rakesh ^b   Bandyopadhyay, Debdutta ^b   Gupta, Sudhir ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; Caspase; Caspase substrates; CD95; Protein kinase C; T cells

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; FAS ANTIGEN; LAMIN B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

APOPTOSIS; ARTICLE; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; BCL-X PROTEIN; CARBAZOLES; CASPASE 3; CASPASES; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; INDOLES; MALEIMIDES; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-BCL-2; SENSITIVITY AND SPECIFICITY; SUBCELLULAR FRACTIONS; T-LYMPHOCYTES;

EID: 0031813604     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.7.877     Document Type: Article

References (69)

1. Cohen, D. A , Duke, R. C., Fadok, V. A. and Sellins, K. S. 1992. Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:267.
2. Steller, H. 1995. Mechanisms and genes of cellular suicide. Science 267:1145.
3. White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1.
4. Cohen, J. J. 1996. Apoptosis and its regulation. In Gupta, S. and Cohen, J. J., eds, Mechanisms of Lymphocyte Activation and Immune Regulation VI, p. 11. Plenum Press, New York.
5. Ramachandra, S. and Studzinski, G. P. 1995. Morphological and biochemical criteria of apoptosis. In Studzinski, G. P., ed., Cell Growth and Apoptosis: A Practical Approach, p. 119. IRL Press, New York.
6. Nagata, S. and Golstein, P. 1995. The Fas death factor. Science 267:1449.
7. Nagata, S, 1996. Fas-mediated apoptosis. In Gupta, S. and Cohen, J. J., eds, Mechanisms of Lymphocyte Activation and Immune Regulation VI, p. 119. Plenum Press, New York
8. Whyte, M. 1996. A link between cell-surface receptors and ICE proteases, Trends Cell Biol. 6:245.
9. Zhivotovsky, B., Burgess, D, H., Vanags, D. M. and Orenius, S. 1997. Involvement of cellular proteolytic machinery in apoptosis. Biochem. Biophys. Res. Commun. 230:481.
10. Boldin, M. P., Gonbcharov, T. M., Goltsev, Y. V. and Wallach, D. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell 85:803
11. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, D., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P H., Peter, M. E. and Dixit, V. M. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817.
12. Enari, M., Talanian, R. V., Wong, W. W. and Nagata, S. 1996. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723.
13. Mandai, M. and Kumar, R. 1996 Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells. Cell Growth Different. 7:311
14. Kaufmann, S. C. 1989. Induction of endonucleolytic DNA cleavage in acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res. 49:5870.
15. Mandai, M., Maggirwar, S. B., Sharma, N., Kaufmann, S. H., Sun S. C. and Kumar, R 1996. Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly (ADP-ribose) polymerase and restores the NF-kappa-B signaling pathway, J. Biol. Chem. 271:30354.
16. Casciola-Rosen, L. A., Anhalt, G. J. and Rosen, A. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved during apoptosis. J. Exp. Med. 182:1625.
17. Han, Z., Malik, N., Carter, T, Reeves, W. H., Wyche, J. H. and Hendrickson, E. A. 1996. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J. Biol. Chem. 271:25035.
18. McConnel, I K. R., Dynan, W. S., Hardin, J. A. 1997. The DNA-dependent protein kinase C catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells, J. Immunol. 158:2083.
19. Dou, Q. P., An, B., Antoku, K. and Johnson, D. E. 1997 Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family. J. Cell Biochem. 64:586.
20. Jackson, S. P. 1996. The recognition of DNA damage. Curr. Opin. Genet. Dev. 6:19.
21. Reeves, W. H. J., Wang, A. K., Ajmani, A. K., Stojanov, L. and Satoh, H. 1997. The Ku autoantigen. In Zanetti, M. and Capra, J. D., eds, The Antibodies, p. 33. Harwood, Amsterdam.
22. Itoh, N., Tsujimoto, Y. and Nagata, S. 1993. Effect of Bcl-2 on Fas-antigen-mediated cell death. J. Immunol. 151:621.
23. Boise, L. H., Gotlschalk, A. R., Quaintans, J. and Thompson, C. B. 1995. Bcl-2 and Bcl-2-related proteins in apoptosis regulation. Curr. Topics Microbiol. Immunol. 200:107.
24. Sato T. S., Irie, S., Kitada, S. and Reed, J. C. 1995. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science 268:411.
25. Gagliardini, V. P., Fernandez, P., Lee, R. K. K., Drexler, H. C. A., Rotello, R. J., Fishman, M. C. and Yuan, J. 1994. Prevention of vertebrate neuronal cell death by the crmA gene. Science 263:826.
26. Bump, N. J., Hackett, M., Hugunin, M. and Seshagiri, S. 1995. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269:1885.
27. Maeker, H. T., Hedjbeli, S., Alzona, M. and Le, P. T. 1996. Comparison of apoptosis signaling through T cell receptor, Fas, and calcium ionophore. Exp. Cell Res. 222:95.
28. 2. Eur J. Immunol. 26:3119.
29. Liu, J. P. 1996. Protein kinase C and its substrates. Mol Cell Endocrinol. 116:1.
30. Nishizuka,Y 1989. Studies and prospectives of the protein kinase C family for cellular regulation. Cancer 63:1892.
31. Del Carmen Ruiz-Ruiz, M., Izquierdo, M., De Murcia, G. and Lopez-Rivas, A. 1997. Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis. J. Immunol. 27:1442.
32. Aggarwal, S., Gupta, A., Nagata, S. and Gupta, S. 1997. Programmed cell death (apoptosis) in cord blood lymphocytes. J. Clin. Immunol. 17:63.
33. Kumar, R. and Atlas, I. 1992. Modulation of expression of retinoblastoma gene product in human Burkitt's lymphoma Daudi cells by interferon-alpha. Proc. Natl Acad Sci. USA 89:6599.
34. Lamarre, D., Talbot, T., De Murcia, G., Laplante, C., Leduc, Y., Mazen, A. and Poirier, G. G. 1988. Structural and functional analysis of poly (ADP ribose) polymerase: an immunological study. Biochim. Biophys. Acta 950:147.
35. Schlottmann, K. E., Gulbins, E., Lau, S. M. and Coggeshall, K. M. 1996. Activation of Src-family tyrosine kinases during Fasinduced apoptosis. J. Leuk. Biol. 60:546.
36. Friesen, C., Herr, I., Krammer, P. and Depatin, K. 1996. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med. 2:574.
37. Lenczowski, J. M., Dominguez, L., Eder, A. M., King, L. B., Zacharchuk, C. M. and Ashwell, J. D. 1997. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol. Cell. Biol. 17:170.
38. Jarvis, W. D., Turner, A. J., Povirk, L. F., Traylor, R. S. and Grant, S. 1994. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 54:1707.
39. Bertrand, R., Solary, E., O'Connor, P., Kohn, K. W. and Pommier, Y 1994. Induction of a common pathway of apoptosis by staurosporine. Exp. Cell Res. 211:314.
40. Schwartz, G. K., Haimovitz-Friedman, A., Dhupar, S. K., Ehleiter, D., Maslak, P., Lai, L., Loganzo, F., Kelsen, D. P., Fuks, Z. and Albino, A. P. 1995. Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. J. Natl Cancer Inst. 87:1394.
41. Cagnoli, C. M., Kharlamov, E., Alabay, C., Uz, T. and Manev, H. 1996. Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor stauropsorine is attenuated by isoquiniline sulfonamides H-7, H-8, and H-9. J. Mol. Neurosci. 7:65.
42. Geier, A., Bar-Shalom, I., Beery, R., Haimsohn, M., Hemi, R., Mailk, Z., Lunenfeld, A. and Karasik, B. 1996. Induction of apoptosis in MDA-231 cells by protein synthesis inhibitors is suppressed by multiple agents. Cancer Invest. 14:435.
43. Dooley, N. P. and Yong, V. W. 1996. Protein kinase C α antisense and cycloheximide synergize in the induction of apoptosis in the A172 human glioma cell line. Proc. Am. Ass. Cancer Res. 37:2411.
44. Zhu, W.-H. and Loh, T.-T. 1996. Differential effects of phorbol ester on apoptosis in HL-60 promyelocylic leukemia cells Biochem. Pharmacol. 51:1229.
45. Tepper, C, G., Jayadev, S., Liu, B., Bielawska, A., Wolff, R., Yonehara, S., Hannun, Y. A. and Seldin, M. F. 1996. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl Acad. Sci. USA 93:8443.
46. Grant, S. and Jarvis, W. D. 1996. Modulation of drug-induced apoptosis by interruption of the protein kinase C signal transduction pathway: a new therapeutic strategy. Clin. Cancer Res. 2:1915.
47. Ni, R., Tomita, Y, Matsuda, K., Ichihara, A., Ishimura, K., Ogasawara, J. and Nagata, S. 1994. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp. Cell Res. 215:332.
48. Chmura, S. J., Nodenski, E., Crane, M. A., Virudachalam, S., Hallahan, D. E., Weichselbaum, R R. and Quintans, J, 1996. Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. In Gupta, S. and Cohen, J. J., eds, Mechanisms of Lymphocyte Activation and Immune Regulation Vl, p. 49. Plenum Press, New York.
49. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V, Boissin, P., Boursier, E., Loriolle, F., et al. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. biol. Chem. 266:15771.
50. Martiny-Baron, G., Kazanietz, M. G., Mischak, H., Blumberg, P. M., Kochs, G., Hug, H., Marme, D. and Schachtele, C. 1993. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J. Biol. Chem. 268:9194.
51. Kiss, Z., Crilly, K. S. and Anderson, W. B. 1996. Protein kinase C inhibitors enhance the synergistic mitogenic effects of ethanolamine analogues and insulin in NIH 3T3 fibroblasts. Biochem. Biophys. Res. Commun. 220:125.
52. Harris, T. E., Persaud, S. J. and Jones, P. M. 1996. Atypical isoforms of PKC and insulin secretion from pancreatic β cells: evidence using Go 6976 and Ro 31-8220 as PKC inhibitors. Biochem. Biophys. Res. Commun. 227:672.
53. Tsutsumi, A., Kubo, M., Fijii, H., Freire-Moar, J., Turck, C. W. and Ransom, J. T. 1993. Regulation of protein kinase C isoforms in phorbol ester-stimulated Jurkat T lymphoma cells. J. Immunol 150:1746.
54. Ghayur, T. Hugunin, M., Talanian, R. V, Ratnofsky, S., Quinlan, C., Emoto, Y, Pandey, P., Datta, R., Huang, Y. and Kharbanda S. 1996. Proteolytic activation of protein kinase C delta by an ICE-CED-3-like protease induces characteristics of apoptosis. J. Exp. Meet. 184:2399.
55. Sawai, H., Okazaki, T, Takeda, Y, Tashima, M., Sawada, H., Okuma, M., Kishi, S., Umehara, H. and Domae, N. 1996. Ceramide-induced translocation of protein kinase C-δ and ε to the cytosol. J. Biol. Chem. 272:2452.
56. Datta. R., Kojima, H., Yoshida, K. and Kufe, D. 1997. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J. Biol. Chem. 272:20317.
57. Janicke, R. U., Walkerr, P. A., Lin, X. Y. and Porter, A. G. 1996. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 15:6969.
58. Zhang, J. and Winoto, A. 1996. A mouse Fas-associated protein with homology to the human Mort1-FADD protein is essential for Fas-induced apoptosis. Mol. Cell. Biol. 6:2756.
59. Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schroeter, M., Burns, K., Mattmann, et al. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388:190.
60. + antiporter in suppression of apoptosis by granulocyte macrophage colony stimulating-factor and interleukin-3. J. biol. Chem. 267:9980.
61. Furlong, I. J., Ascaso, R., Lopez Rivas, A. and Collins, M. K. 1997. lntracellular acidification induces apoptosis by stimulating ICE-like protease activity. J. Cell Sci. 110:653.
62. Gottlieb, R. A., Nordberg, J., Skowronski, E. and Babior, B. M. 1996. Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc. Natl Acad. Sci. USA 93:654.
63. Yang, E. and Korsmeyer, S. J. 1996. Molecular thanatopsis: a discourse on the Bcl-2 family and cell death. Blood 88:386.
64. Monney, L., Otter, I., Olivier, R., Ravn, U., Mirzasaleh, H., Fellay, I., Poirier, G. G. and Borner, C. 1996. Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/Apopain. Biochem. Biophys. Res. Commun. 221:340.
65. May, W. S., Tyler. G., Ito, I, Armstrong, D K., Qatsha. K. A. and Davidson, N. E. 1994. Interleukin-3 and bryostatin 1 mediate hyperphosphorylation of Bcl-2 in association with suppression of apoptosis. J. Biol. Chem. 269:26865.
66. Blagosklonny, M. V. Schulte, T., Nguyen, P., Trepel, J. and Neckers, L. M. 1996. Taxol-induced apoptosis and phosphorylation of bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res. 56:1851.
67. Hu, Z.-B., Minden, M. D. and McCulloch. E. A. 1996. Posttranscriptional regulation of bcl-2 in acute myeloid leukemia: significance for response to chemotherapy. Leukemia 10:410.
68. Blagsklonny, M. V, Alvarez, M., Fojo, A, and Neckers, L. M. 1996. Bcl-2 protein downregulation is not required for differentiation of multidrug resistant HL-60 leukemia cells. Leukemia Res. 20:101.
69. L during apoptosis. Proc. Natl Acad. Sci. USA 94:3668.