Differential hTERT mRNA processing between young and older glioma patients

FEBS Letters

Volumn 582, Issue 12, 2008, Pages 1707-1710

  Shervington, A ^a   Patel, R ^a  

^a UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Age; Glioma; hTERT; Telomerase; Telomere length

Indexed keywords

MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; ASTROCYTOMA; CANCER PATIENT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENETIC TRANSCRIPTION; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN TISSUE; MALE; OLIGODENDROGLIOMA; PRIORITY JOURNAL; RNA PROCESSING;

ADULT; AGE FACTORS; AGED; BRAIN NEOPLASMS; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 43749101824     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.04.027     Document Type: Article

References (24)

1. Blackburn E.H. Switching and signalling at the telomere. Cell 106 (2001) 661-673
2. Harley C.B. Telomere loss: mitotic clock or genetic time bomb?. Mutat. Res. 256 (1991) 271-282
3. O'Sullivan J.N., Bronner M.P., Brentnall T.A., et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat. Genet. 32 (2002) 280-284
4. Blackburn E.H. Structure and function of telomeres. Nature 350 (1991) 569-573
5. Sharpless N., and DePinho R. Telomeres, stem cells, senescence and cancer. J. Clin. Invest. 113 (2004) 160-168
6. Galderisi U., Cipollaro M., and Giordano A. Stem cells and brain cancer. Cell Death Differ. 13 (2006) 5-11
7. Reya T., Morrison S.J., Clarke M.F., and Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 414 (2001) 105-111
8. Blasco M.A. Telomeres and human disease: ageing, cancer and beyond. Nat. Rev. Genet. 6 (2005) 611-622
9. Reddle R., Bearss D., and Hurley L. Telomeres and telomerase as drug targets. Curr. Opin. Pharmacol. 2 (2002) 415-423
10. Hakin-Smith V., Jellinek D., Levy D., Carroll T., Teo M., Timperley W., McKay M., Reddel R., and Royds J. Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. The Lancet 361 (2003) 836-838
11. Collins K., and Mitchell J.R. Telomerase in the human organism. Oncogene 21 (2002) 564-579
12. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
13. Siyuan L., Zhu J.J., Anthony D.C., Greider C.W., and Black P.M. Telomerase activity in human gliomas. Neurosurgery 42 (1998) 1120-1121
14. Mergny J., Riou J., Mailliet P., Teulade-Fichou M., and Gilson E. Natural and pharmacological regulation of telomerase. Nucl. Acids Res. 30 (2002) 839-865
15. Yang J., Wang K., Su B., Huang Y., Zhao S., Wang Y., and Si L. The expression of hTER and hTERT mRNA in human tumors with tissue microarray. J. US-China Med. Sci. 3 (2006) 30-35
16. Shervington A., Patel R., Lu C., Cruickshanks N., Lea R., Roberts G., Dawson T., and Shervington L. Telomerase subunits expression variation between biopsy samples and cell lines derived from malignant glioma. Brain Res. 1134 (2007) 45-52
17. Yi X., Shay J.W., and Wright W.E. Quantitation of telomerase components & hTERT mRNA splicing patterns in immortal human cells. Nucl. Acids Res. 29 (2001) 4818-4825
18. Fan Y., Liu Z., Fang X., Ge Z., Ge N., Jia Y., et al. Differential expression of full-length telomerase reverse transcriptase mRNA and telomerase activity between normal and malignant renal tissues. Clin. Cancer Res. 11 (2005) 4331-4337
19. Barclay J.Y., Morris A.G., and Nwokolo C.U. hTERT mRNA partially regulates telomerase activity in gastric adenocarcinoma and adjacent normal gastric mucosa. Digest. Dis. Sci. 50 (2005) 1299-1303
20. Saji M., Xydas S., Westra W.H., et al. Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms. Clin. Cancer Res. 1483 (1999) 1483-1489
21. Potts P., and Yu H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nature Struct. Biol. 14 (2007) 581-590
22. Henson J., Hannay J., McCarthy S., et al. A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin. Cancer Res. 11 (2005) 217-225
23. Masutomi K., and Hahn W. Telomerase & tumorigenesis. Cancer Lett. 194 (2003) 163-172
24. Ahmed A., and Tollefsbol T. Telomeres, telomerase, and telomerase inhibition: clinical implications for cancer. J Am. Geriatr. Soc. 51 (2003) 116-122