Variation in the ovine cortisol response to systemic bacterial endotoxin challenge is predominantly determined by signalling within the hypothalamic-pituitary-adrenal axis

Toxicology and Applied Pharmacology

Volumn 230, Issue 1, 2008, Pages 1-8

  You, Qiumei ^a   Karrow, Niel A ^a   Cao, Honghe ^a   Rodriguez, Alexander ^b   Mallard, Bonnie A ^b   Boermans, Herman J ^b  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

ACTH; AVP; CRF; Endotoxin; Hepatic gene expression; Pro inflammatory cytokines; Variation in cortisol response

Indexed keywords

ARGIPRESSIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; ESCHERICHIA COLI ENDOTOXIN; HYDROCORTISONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENE TARGETING; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIVER BIOPSY; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEEP; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PITUITARY-ADRENAL SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHEEP;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; OVIS; OVIS ARIES;

EID: 43649101034     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.01.033     Document Type: Article

References (47)

1. Barr M., MacKenzie S.M., Friel E.C., Holloway C.D., Wilkinson D.M., Brain N.J., Ingram M.C., Fraser R., Brown M., Samani N.J., Caulfield M., Munroe P.B., Farrall M., Webster J., Clayton D., Dominiczak A.F., Connell J.M., and Davies E. Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension 49 (2007) 113-119
2. Bartels M., Berg M.V.D., Sluyter F., Boomsma D.I., and Geus E.J.D. Heritability of cortisol levels: review and simultaneous analysis of twin studies. Psychoneuroendocrinology 28 (2003) 121-137
3. Bowtell, D., Sambrook, J. (2003). DNA Microarrays: a Molecular Cloning Manual. Edited By David Bowtell and Joseph Sambrook. Peter MacCallum Cancer Institute and The University of Melbourne, Australia. In: Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York.
4. Candore G., Aquino A., Balistreri C.R., Bulati M., Carlo D.D., Grimaldi M.P., Listì F., Orlando V., Vasto S., Caruso M., Colonna-Romano G., Lio D., and Caruso C. Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. Ann. N.Y. Acad. Sci. 1067 (2006) 282-287
5. Cao H., Kabaroff L.C., You Q., Rodriguez A., Boermans H.J., and Karrow N.A. Characterization of ovine hepatic gene expression profiles in response to Escherichia coli lipopolysaccharide using a bovine cDNA microarray. BMC Vet. Res. 2 (2006) 34
6. DeRijk R., and Kloet E.D. Corticosteroid receptor genetic polymorphisms and stress responsivity. Endocrine 28 (2005) 263-270
7. Dinan T.G., and Scott L.V. Anatomy of melancholia: focus on hypothalamic-pituitary-adrenal axis overactivity and the role of vasopressin. J. Anat. 207 3 (2005) 259-264 (Sep)
8. Dobbin K., Shih J.H., and Simon R. Questions and answers on design of dual-label microarrays for identifying differentially expressed genes. J. Natl. Cancer Inst. 95 18 (2003) 1362-1369
9. Emptoz-Bonneton A., Cousin P., Seguchi K., Avvakumov G.V., Bully C., Hammond G.L., and Pugeat M. Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J. Clin. Endocrinol. Metab. 85 (2000) 361-367
10. Federenko I.S., Nagamine M., Hellhammer D.H., Wadhwa P.D., and Wust S. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent. J. Clin. Endocrinol. Metab. 89 (2004) 6244-6250
11. Fish E.W., Shahrokh D., Bagot R., Caldji C., Bredy T., Szyf M., and Meaney M.J. Epigenetic programming of stress responses through variations in maternal care. Ann. N.Y. Acad. Sci. 1036 (2004) 167-180
12. Flint M.S., Depree K.M., Rich B.A., and Tinkle S.S. Differential regulation of sensitizer-induced inflammation and immunity by acute restraint stress in allergic contact dermatitis. J. Neuroimmunol. 140 1-2 (2003) 28-40 (Jul)
13. Guimont F.S., and Wynne-Edwards K.E. Individual variation in cortisol responses to acute "on-back" restraint in an outbred hamster. Horm. Behav. 50 (2006) 252-260
14. Harbuz M.S., Richards L.J., Chover-Gonzalez A.J., Marti-Sistac O., and Jessop D.S. Stress in autoimmune disease models. Ann. N.Y. Acad. Sci. 1069 (2006) 51-61
15. Heesen C., Gold S.M., Huitinga I., and Reul J.M. Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis-a review. Psychoneuroendocrinology 32 (2007) 604-618
16. Hirose M., Nishikawa M., Qian W., Haque A., Mashimo M., and Inoue M. Mannose-conjugated alendronate selectively depletes Kupffer cells and inhibits endotoxemic shock in the mice. Hepatol. Res. 36 (2006) 3-10
17. Islam Z., Moon Y.S., Zhou H.R., King L.E., Fraker P.J., and Pestka J.J. Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. Toxicol. Appl. Pharmacol. 180 1 (2002) 43-55 (April 1)
18. Kabaroff L.C., Rodriguez A., Quinton M., Boermans H., and Karrow N.A. Assessment of the ovine acute phase response and hepatic gene expression in response to Escherichia coli endotoxin. Vet. Immunol. Immunopathol. 113 (2006) 113-124
19. Karrow N.A. Activation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system during inflammation and altered programming of the neuroendocrine-immune axis during fetal and neonatal development: lessons learned from the model inflammagen, lipopolysaccharide. Brain Behav. Immun. 20 (2006) 144-158
20. Lange F., Aigner B., Muller M., and Claus R. Porcine 11beta-hydroxysteroid dehydrogenase type 2 isoform: complete coding sequence and polymorphisms. Anim. Biotechnol. 14 (2003) 13-17
21. Larionov A., Krause A., and Miller W. A standard curve based method for relative real time PCR data processing. BMC Bioinformatics 6 (2005) 62
22. 2 triggers the febrile response of guinea pigs to intravenously injected LPS. Am. J. Physiol., Regul. Integr. Comp. Physiol. 290 (2006) R1262-R1270
23. Liu S., Gallo D.J., Green A.M., Williams D.L., Gong X., Shapiro R.A., Gambotto A.A., Humphris E.L., Vodovotz Y., and Billiar T.R. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect. Immun. 70 (2002) 3433-3442
24. Mariniello B., Ronconi V., Sardu C., Pagliericcio A., Galletti F., Strazzullo P., Palermo M., Boscaro M., Stewart P.M., Mantero F., and Giacchetti G. Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension. Am. J. Hypertens. 18 (2005) 1091-1098
25. Meaney M.J., and Szyf M. Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin. Neurosci. 7 (2005) 103-123
26. Muller-Steinhardt M., Ebel B., and Hartel C. The impact of interleukin-6 promoter-597/-572/-174genotype on interleukin-6 production after lipopolysaccharide stimulation. Clin. Exp. Immunol. 147 (2007) 339-345
27. Nijm J., Kristenson M., Olsson A.G., and Jonasson L. Impaired cortisol response to acute stressors in patients with coronary disease. Implications for inflammatory activity. J. Intern. Med. 262 (2007) 375-384
28. Pestka J., and Zhou H.R. Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. Toxicol. Sci. 92 (2006) 445-455
29. Quervain D.J.F.D., Poirier R., Wollmer M.A., Grimaldi L.M.E., Tsolaki M., Streffer J.R., Hock C., Nitsch R.M., Mohajeri M.H., and Papassotiropoulos A. Glucocorticoid-related genetic susceptibility for Alzheimer's disease. Hum. Mol. Genet. 13 (2004) 47-52
30. Rivalland E.T., Clarke I.J., Turner A.I., Pompolo S., and Tilbrook A.J. Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheep. Neuroscience 145 3 (2007) 1048-1058 (30)
31. SAS. SAS User's Guide (2002), SAS Institute, Inc., Cary, NC, USA
32. Simon R.M., and Dobbin K. Experimental design of DNA microarray experiments. Biotechniques (2003) 16-21 (Suppl)(March 1)
33. Skoog T., Hamsten A., and Eriksson P. Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter. Biochem. Biophys. Res. Commun. 351 (2006) 777-783
34. Slawik M., Reisch N., Zwermann O., Maser-Gluth C., Stahl M., Klink A., Reincke M., and Beuschlein F. Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH. J. Clin. Endocrinol. Metab. 89 (2004) 3131-3137
35. Stewart J.D., Lou Y., Squires E.J., and Coussens P.M. Using human microarrays to identify differentially expressed genes associated with increased steroidogenesis in boars. Anim. Biotechnol. 16 (2005) 139-151
36. Strandberg Y., Gray C., Vuocolo T., Donaldson L., Broadway M., and Tellam R. Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells. Cytokine 31 (2005) 72-86
37. Tao W., Mallard B., Karrow N.A., and Bridle B. Construction and application of a bovine immune-endocrine cDNA microarray. Vet. Immunol. Immunopathol. 101 (2004) 1-17
38. Turnbull A.V., Prehar S., Kennedy A.R., Little R.A., and Hopkins S.J. Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology 144 (2003) 1894
39. Vandesompele J., Preter K.D., Pattyn F., Poppe B., Roy N.V., Paepe A.D., and Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 (2002) (RESEARCH0034)
40. Vodovotz Y., Liu S., McCloskey C., Shapiro R., Green A., and Billiar T.R. The hepatocyte as a microbial product-responsive cell. J. Endotoxin Res. 7 (2001) 365-373
41. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., and Meaney M.J. Epigenetic programming by maternal behavior. Nat. Neurosci. 7 (2004) 847-854
42. Webster J.I., and Sternberg E.M. Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products. J. Endocrinol. 181 (2004) 207-221
43. Wen A.Q., Wang J., Feng K., Zhu P.F., Wang Z.G., and Jiang J.X. Effects of haplotypes in the interleukin 1beta promoter on lipopolysaccharide-induced interleukin 1beta expression. Shock 26 (2006) 25-30
44. Wong M.L., and Medrano J.F. Real-time PCR for mRNA quantitation. BioTechniques 39 (2005) 75-85
45. Wüst S., Rossum E.F.C.V., Federenko I.S., Koper J.W., Kumsta R., and Hellhammer D.H. Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J. Clin. Endocrinol. Metab. 89 (2004) 565-573
46. Wurfel M.M., Park W.Y., Radella F., Ruzinski J., Sandstrom A., Strout J., Bumgarner R.E., and Martin T.R. Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J. Immunol. 175 4 (2005 Aug) 2570-2578 (15)
47. Xu D., Buehner A., Xu J., Lambert T., Nekl C., Nielsen M.K., and Zhou Y. A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors. FASEB J. 20 (2006) 2414-2416