Mannose-conjugated alendronate selectively depletes Kupffer cells and inhibits endotoxemic shock in the mice

Hepatology Research

Volumn 36, Issue 1, 2006, Pages 3-10

  Hirose, Masaki ^a   Nishikawa, Manabu ^a   Qian, Wei ^a   Haque, Anwarul ^a   Mashimo, Masayuki ^a   Inoue, Masayasu ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Alendronate; Bisphosphonate; Endotoxcemia; Endotoxin; Inflammation; Kupffer cell; Liver; Macrophage; Mannose; Reticulo endothelial system; Shock

Indexed keywords

ALANINE AMINOTRANSFERASE; ALENDRONIC ACID; ASPARTATE AMINOTRANSFERASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MANNOSE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG SELECTIVITY; DRUG STRUCTURE; ENDOTOXEMIA; FEMALE; HOST RESISTANCE; KUPFFER CELL; LIVER INJURY; MOUSE; NICK END LABELING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SURVIVAL;

EID: 33748138849     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2006.06.002     Document Type: Article

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