Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy

Journal of Membrane Biology

Volumn 222, Issue 2, 2008, Pages 55-63

  Uehara, Akira ^a   Nakamura, Yuki ^a   Shioya, Takao ^b   Hirose, Shinichi ^a   Yasukochi, Midori ^a   Uehara, Kiyoko ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Brain neuron; Channelopathy; Delayed rectifier potassium channel; Patch clamp; Pore helix; Selectivity filter

Indexed keywords

POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL INTERACTION; EPILEPSY; GENE MUTATION; GENE REPRESSION; HUMAN; HYDROGEN BOND; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; BRAIN; CELL LINE; ELECTROPHYSIOLOGY; EPILEPSY; HETEROZYGOTE; HUMANS; HYDROGEN BONDING; ION CHANNEL GATING; KCNQ3 POTASSIUM CHANNEL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 43549119011     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-008-9097-5     Document Type: Article

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