Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms

European Journal of Pharmacology

Volumn 586, Issue 1-3, 2008, Pages 332-339

  Chang, Han Lin ^a   Chang, Fang Rong ^b   Chen, Jin Shan ^c   Wang, Hui Po ^d   Wu, Yi Hsiu ^a   Wang, Chien Chiao ^a   Wu, Yang Chang ^b   Hwang, Tsong Long ^d  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Clerodane diterpenoid; Elastase; Neutrophil; Polyalthia longifolia; Superoxide anion

Indexed keywords

16 HYDROXYCLERODA 3,13(14)DIEN 15 OIC ACID; CLERODANE DERIVATIVE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ELASTASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; THAPSIGARGIN;

ADULT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM MOBILIZATION; CELL ISOLATION; CELL RESPIRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IC 50; LEUKOCYTE ACTIVATION; NEUTROPHIL; POLYALTHIA; POLYALTHIA LONGIFOLIA; PRIORITY JOURNAL; RESPIRATORY BURST; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADULT; ANTIOXIDANTS; CALCIUM; CYCLIC AMP; DITERPENES; HUMANS; LEUKOCYTE ELASTASE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NADPH OXIDASE; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORIC DIESTER HYDROLASES; PICRATES; POLYALTHIA; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 43549104687     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.041     Document Type: Article

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