Tournefolic acid B attenuates amyloid β protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons

European Journal of Pharmacology

Volumn 586, Issue 1-3, 2008, Pages 35-43

  Chi, Chih Wen ^a   Lin, Yun Lian ^b   Wang, Ying Hsiu ^b   Chen, Chieh Fu ^a   Wang, Chuen Neu ^b   Shiao, Young Ji ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Amyloid protein; Bid; Calcium; Caspase 8; Cytochrome c; Tournefolic acid B

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[25-35]; CALCIUM; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CYTOCHROME C; PLANT EXTRACT; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BID; TOURNEFOLIC ACID B; TOURNEFORTIA SARMENTOSA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LEUKEMIA; BRAIN CELL; BRAIN MITOCHONDRION; CALCIUM BLOOD LEVEL; CELL DEATH; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; MEDICINAL PLANT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RAT; TOURNEFORTIA SARMENTOSA; UPREGULATION;

AMYLOID BETA-PROTEIN; ANIMALS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BLOTTING, WESTERN; CALCIUM; CASPASE 8; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYTOCHROMES C; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HETEROCYCLIC COMPOUNDS, 3-RING; MITOCHONDRIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS;

EID: 43549088757     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.058     Document Type: Article

References (45)

1. Adams J.M., and Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281 (1998) 1322-1326
2. Antonsson B., and Martinou J.C. The Bcl-2 protein family. Exp. Cell Res. 256 (2000) 50-57
3. Buxbaum J.D., and Greengard P. Regulation of APP processing by intra- and intercellular signals. Ann. N.Y. Acad. Sci. 777 (1996) 327-331
4. Chao D.T., and Korsmeyer S.J. BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 16 (1998) 395-419
5. Danial N.N., and Korsmeyer S. Cell death: critical control points. Cell 116 (2004) 205-219
6. Davidson R.M., Shajenko L., and Donta T.S. Amyloid beta-peptide (A beta P) potentiates a nimodipine-sensitive L-type barium conductance in N1E-115 neuroblastoma cells. Brain Res. 643 (1994) 324-327
7. Ekinci F.J., Malik K.U., and Shea T.B. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to β-amyloid. MAP kinase mediates β-amyloid-induced neurodegeneration. J. Biol. Chem. 274 (1999) 30322-30327
8. Estus S., Tucker H.M., van Rooyen C., Wright S., Brigham E.F., Wogulis M., and Rydel R.E. Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J. Neurosci. 17 (1997) 7736-7745
9. Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
10. Gross A., Yin X.M., Wang K., Wei M.C., Jockel J., Milliman C., Erdjument-Bromage H., Tempst P., and Korsmeyer S.J. Caspase cleaved BID targets mitochondria and is required for cytochrome c release while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274 (1999) 1156-1163
11. Hitomi J., Katayama T., Eguchi Y., Kudo T., Taniguchi M., Koyama Y., Manabe T., Yamagishi S., Bando Y., Imaizumi K., Tsujimoto Y., and Tohyama M. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J. Cell Biol. 165 (2004) 347-356
12. Kluck R.M., Bossy-Wetzel E., Green D.R., and Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 (1997) 1132-1136
13. Korsmeyer S.J., Wei M.C., Saito M., Weiler S., Oh K.J., and Schlesinger P.H. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7 (2000) 1166-1173
14. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
15. Lin Y.L., Chang Y.Y., Kuo Y.H., and Shiao M.S. Anti-lipid-peroxidative principles from Tournefortia Sarmentosa. J. Nat. Prod. 65 (2002) 745-747
16. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A.J., and Cotman C.W. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 7951-7955
17. Luo X., Budihardjo I., Zou H., Slaughter C., and Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94 (1998) 481-490
18. 2+ channel activity by β-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1β. J. Biol. Chem. 275 (2000) 4713-4718
19. Mattson M.P., Partin J., and Begley J.G. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites. Brain Res. 807 (1998) 167-176
20. Maurice T., Lockhart B.P., and Privat A. Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction. Brain Res. 706 (1996) 181-193
21. Morais Cardoso S., Swerdlow R.H., and Oliveira C.R. Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. Brain Res. 931 (2002) 117-125
22. Murphy A.N., Fiskum G., and Beal M.F. Mitochondria in neurodegeneration: bioenergetic function in cell life and death. J. Cereb. Blood Flow Metab. 19 (1999) 231-245
23. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., and Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 403 (2000) 98-103
24. Nicholls D.G., and Budd S.L. Mitochondria and neuronal survival. Physiol. Rev. 80 (2000) 315-360
25. Pappolla M.A., Sos M., Omar R.A., Bick R.J., Hickson-Bick D.L.M., Reiter R.J., Efthimiopoulos S., and Robakis N.K. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J. Neurosci. 17 (1997) 1683-1690
26. Paradis E., Douillard H., Koutroumanis M., Goodyer C., and LeBlanc A. Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons. J. Neurosci. 16 (1996) 7533-7539
27. Pivovarova N.B., Nguyen H.V., Winters C.A., Brantner C.A., Smith C.L., and Andrews S.B. Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J. Neurosci. 24 (2004) 5611-5622
28. Polster B.M., and Fiskum G. Mitochondrial mechanisms of neural cell apoptosis. J. Neurochem. 90 (2004) 1281-1289
29. Prehn J.H., Bindokas V.P., Jordán J., Galindo M.F., Ghadge G.D., Roos R.P., Boise L.H., Thompson C.B., Krajewski S., Reed J.C., and Miller R.J. Protective effect of transforming growth factor-β 1 on β-amyloid neurotoxicity in rat hippocampal neurons. Mol. Pharmacol. 49 (1996) 319-328
30. Reed J.C. Double identity for proteins of the Bcl-2 family. Nature 387 (1997) 773-776
31. Reddy P.H. Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease. J. Neurochem. 96 (2006) 1-13
32. Reddy P.H., and Beal M.F. Are mitochondria critical in the pathogenesis of Alzheimer's disease?. Brain Res. Brain Res. Rev. 49 (2005) 618-632
33. Selkoe D.J. Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues. Science 248 (1990) 1058-1060
34. Selkoe D.J. Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271 (1996) 18295-18298
35. Smith M.A. Alzheimer disease. Int. Rev. Neurobiol. 42 (1998) 1-54
36. Tamagno E., Parola M., Guglielmotto M., Santoro G., Bardini P., Marra L., Tabaton M., and Danni O. Multiple signaling events in amyloid-β induced, oxidative stress-dependent neuronal apoptosis. Free Radic. Biol. Med. 35 (2003) 45-58
37. Troy C.M., Rabacchi S.A., Friedman W.J., Frappier T.F., Brown K., and Shelanski M.L. Caspase-2 mediates neuronal cell death induced by β-amyloid. J. Neurosci. 20 (2000) 1386-1392
38. 2+ channels: a possible involvement of free radicals. J. Neurochem. 68 (1997) 265-271
39. Wang C.N., Chi C.W., Lin Y.L., Chen C.F., and Shiao Y.J. The neuroprotective effects of phytoestrogens on amyloid β protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J. Biol. Chem. 276 (2001) 5287-5295
40. Wang C.N., Pan H.C., Lin Y.L., Chi C.W., and Shiao Y.J. Ester derivatives of tournefolic acid B attenuate N-methyl-d-aspartate-mediated excitotoxicity in rat cortical neurons. Mol. Pharmacol. 69 (2006) 950-959
41. Wang K., Yin X.M., Chao D.T., Milliman C.L., and Korsmeyer S.J. BID: A novel BH3 domain-only death agonist. Genes Dev. 10 (1996) 2859-2869
42. Wei H., Leeds P.R., Qian Y., Wei W., Chen R., and Chuang D. β-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. Eur. J. Pharmacol. 392 (2000) 117-123
43. Wolter K.G., Hsu Y.T., Smith C.L., Nechushtan A., Xi X.G., and Youle R.J. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 139 (1997) 1281-1292
44. Yin X.M. Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene 369 (2006) 7-19
45. Zha J., Weiler S., Oh K.J., Wei M.C., and Korsmeyer S.J. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290 (2000) 1761-1765