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Volumn 61, Issue 5, 2008, Pages 570-576

Bone marrow micrometastasis in breast cancer: Review of detection methods, prognostic impact and biological issues

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW BIOPSY; BONE MARROW METASTASIS; BREAST CANCER; CANCER STEM CELL; DISSEMINATED CANCER; HUMAN; IMMUNOHISTOCHEMISTRY; MICROMETASTASIS; PRIORITY JOURNAL; PROGNOSIS; QUALITY CONTROL; REVIEW; TUMOR CELL;

EID: 43549083683     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2007.046649     Document Type: Review
Times cited : (60)

References (97)
  • 1
    • 23944466427 scopus 로고    scopus 로고
    • A pooled analysis of bone marrow micrometastasis in breast cancer
    • Braun S, Vogl FD, Naume B, et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 2005;353:793-802.
    • (2005) N Engl J Med , vol.353 , pp. 793-802
    • Braun, S.1    Vogl, F.D.2    Naume, B.3
  • 2
    • 36849069347 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • Harris L, Fritsche H, Mennel R, et al. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol 2007;25:5287-312.
    • (2007) J Clin Oncol , vol.25 , pp. 5287-5312
    • Harris, L.1    Fritsche, H.2    Mennel, R.3
  • 3
    • 33747893501 scopus 로고    scopus 로고
    • A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation
    • Fehm T, Braun S, Muller V, et al. A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer 2006;107:885-92.
    • (2006) Cancer , vol.107 , pp. 885-892
    • Fehm, T.1    Braun, S.2    Muller, V.3
  • 4
    • 0037240269 scopus 로고    scopus 로고
    • Detection of isolated tumor cells in BM from breast-cancer patients: Significance of anterior and posterior iliac crest aspirations and the number of mononuclear cells analyzed
    • Wiedswang G, Borgen E, Karesen R, et al. Detection of isolated tumor cells in BM from breast-cancer patients: significance of anterior and posterior iliac crest aspirations and the number of mononuclear cells analyzed. Cytotherapy 2003;5:40-5.
    • (2003) Cytotherapy , vol.5 , pp. 40-45
    • Wiedswang, G.1    Borgen, E.2    Karesen, R.3
  • 5
    • 2442589602 scopus 로고    scopus 로고
    • The prognostic value of isolated tumor cells in bone marrow in breast cancer patients: Evaluation of morphological categories and the number of clinically significant cells
    • Naume B, Wiedswang G, Borgen E, et al. The prognostic value of isolated tumor cells in bone marrow in breast cancer patients: evaluation of morphological categories and the number of clinically significant cells. Clin Cancer Res 2004;10:3091-7.
    • (2004) Clin Cancer Res , vol.10 , pp. 3091-3097
    • Naume, B.1    Wiedswang, G.2    Borgen, E.3
  • 6
    • 21544473185 scopus 로고    scopus 로고
    • Standardization of the immunocytochemical detection of cancer cells in BM and blood. I: Establishment of objective criteria for the evaluation of immunostained cells. The European ISHAGE Working Group for Standardization of Tumor Cell Detection
    • Borgen E, Naume B, Nesland JM, et al. Standardization of the immunocytochemical detection of cancer cells in BM and blood. I: Establishment of objective criteria for the evaluation of immunostained cells. The European ISHAGE Working Group for Standardization of Tumor Cell Detection. Cytotherapy 1999;1:377-88.
    • (1999) Cytotherapy , vol.1 , pp. 377-388
    • Borgen, E.1    Naume, B.2    Nesland, J.M.3
  • 7
    • 33750464863 scopus 로고    scopus 로고
    • A European interlaboratory testing of three well-known procedures for immunocytochemical detection of epithelial cells in bone marrow. Results from analysis of normal bone marrow
    • Borgen E, Pantel K, Schlimok G, et al. A European interlaboratory testing of three well-known procedures for immunocytochemical detection of epithelial cells in bone marrow. Results from analysis of normal bone marrow. Cytometry B Clin Cytom 2006;70:400-9.
    • (2006) Cytometry B Clin Cytom , vol.70 , pp. 400-409
    • Borgen, E.1    Pantel, K.2    Schlimok, G.3
  • 8
    • 38549140196 scopus 로고    scopus 로고
    • Bone marrow micrometastasis are a powerful prognostic factor in stage I to III breast cancer patients
    • Abstract S460, 14-18 April
    • Bidard FC, Vincent-Salomon A, Gomme S, et al. Bone marrow micrometastasis are a powerful prognostic factor in stage I to III breast cancer patients. Abstract S460. AACR Annual Meeting, Proceedings, 14-18 April 2007.
    • (2007) AACR Annual Meeting, Proceedings
    • Bidard, F.C.1    Vincent-Salomon, A.2    Gomme, S.3
  • 9
    • 24944534497 scopus 로고    scopus 로고
    • Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer
    • Schardt JA, Meyer M, Hartmann CH, et al. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell 2005;8:227-39.
    • (2005) Cancer Cell , vol.8 , pp. 227-239
    • Schardt, J.A.1    Meyer, M.2    Hartmann, C.H.3
  • 10
    • 0038271868 scopus 로고    scopus 로고
    • From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
    • Schmidt-Kittler O, Ragg T, Daskalakis A, et al. From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci USA 2003;100:7737-42.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7737-7742
    • Schmidt-Kittler, O.1    Ragg, T.2    Daskalakis, A.3
  • 11
    • 0033996457 scopus 로고    scopus 로고
    • Braun S, Pantel K, Muller P, et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 2000;342:525-33.
    • Braun S, Pantel K, Muller P, et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 2000;342:525-33.
  • 12
    • 0033578276 scopus 로고    scopus 로고
    • Outcome of primary-breast-cancer patients with micrometastases: A long-term follow-up study
    • Mansi JL, Gogas H, Bliss JM, et al. Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet 1999;354:197-202.
    • (1999) Lancet , vol.354 , pp. 197-202
    • Mansi, J.L.1    Gogas, H.2    Bliss, J.M.3
  • 13
    • 0742323734 scopus 로고    scopus 로고
    • Circulating tumour cells in breast cancer
    • Ring A, Smith IE, Dowsett M. Circulating tumour cells in breast cancer. Lancet Oncol 2004;5:79-88.
    • (2004) Lancet Oncol , vol.5 , pp. 79-88
    • Ring, A.1    Smith, I.E.2    Dowsett, M.3
  • 14
    • 0035672967 scopus 로고    scopus 로고
    • Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: Comparison with preoperative clinical parameters and primary tumor characteristics
    • Naume B, Borgen E, Kvaheim G, et al. Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: comparison with preoperative clinical parameters and primary tumor characteristics. Clin Cancer Res 2001;7:4122-9.
    • (2001) Clin Cancer Res , vol.7 , pp. 4122-4129
    • Naume, B.1    Borgen, E.2    Kvaheim, G.3
  • 15
    • 0033889333 scopus 로고    scopus 로고
    • Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction
    • de Crémoux P, Extra JM, Denis MG, et al. Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction. Clin Cancer Res 2000;6:3117-22.
    • (2000) Clin Cancer Res , vol.6 , pp. 3117-3122
    • de Crémoux, P.1    Extra, J.M.2    Denis, M.G.3
  • 16
    • 13244251086 scopus 로고    scopus 로고
    • Real-time quantitative PCR determination of urokinase-type plasminogen activator receptor (uPAR) expression of isolated micrometastatic cells from bone marrow of breast cancer patients
    • Pierga JY, Bonneton C, Magdelenat H, et al. Real-time quantitative PCR determination of urokinase-type plasminogen activator receptor (uPAR) expression of isolated micrometastatic cells from bone marrow of breast cancer patients. Int J Cancer 2005;114:291-8.
    • (2005) Int J Cancer , vol.114 , pp. 291-298
    • Pierga, J.Y.1    Bonneton, C.2    Magdelenat, H.3
  • 17
    • 34247871453 scopus 로고    scopus 로고
    • A new comprehensive gene expression panel to study tumor micrometastasis in patients with high-risk breast cancer
    • Ferrucci PF, Rabascio C, Gigli F, et al. A new comprehensive gene expression panel to study tumor micrometastasis in patients with high-risk breast cancer. Int J Oncol 2007;30:955-62.
    • (2007) Int J Oncol , vol.30 , pp. 955-962
    • Ferrucci, P.F.1    Rabascio, C.2    Gigli, F.3
  • 18
    • 33847198956 scopus 로고    scopus 로고
    • HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: A possible tool for anti-HER2 therapy management?
    • Vincent-Salomon A, Pierga JY, Couturier J, et al. HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management? Br J Cancer 2007;96:654-9.
    • (2007) Br J Cancer , vol.96 , pp. 654-659
    • Vincent-Salomon, A.1    Pierga, J.Y.2    Couturier, J.3
  • 19
    • 33845914033 scopus 로고    scopus 로고
    • The clinical significance of disseminated tumor cells in breast cancer
    • Slade MJ, Coombes RC. The clinical significance of disseminated tumor cells in breast cancer. Nat Clin Pract Oncol 2007;4:30-41.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 30-41
    • Slade, M.J.1    Coombes, R.C.2
  • 20
    • 0035865153 scopus 로고    scopus 로고
    • Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors
    • Gerber B, Krause A, Muller H, et al. Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors. J Clin Oncol 2001;19:960-71.
    • (2001) J Clin Oncol , vol.19 , pp. 960-971
    • Gerber, B.1    Krause, A.2    Muller, H.3
  • 21
    • 0035880943 scopus 로고    scopus 로고
    • Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: Clinical outcome during long-term follow-up
    • Gebauer G, Fehm T, Merkle E, et al. Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: clinical outcome during long-term follow-up. J Clin Oncol 2001;19:3669-74.
    • (2001) J Clin Oncol , vol.19 , pp. 3669-3674
    • Gebauer, G.1    Fehm, T.2    Merkle, E.3
  • 22
    • 0035045393 scopus 로고    scopus 로고
    • Clinical significance of occult metastatic cells in bone marrow of breast cancer patients
    • Braun S, Pantel K. Clinical significance of occult metastatic cells in bone marrow of breast cancer patients. Oncologist 2001;6:125-32.
    • (2001) Oncologist , vol.6 , pp. 125-132
    • Braun, S.1    Pantel, K.2
  • 23
    • 33646710101 scopus 로고    scopus 로고
    • Tumor cell detection in peripheral blood and bone marrow
    • Zach O, Lutz D. Tumor cell detection in peripheral blood and bone marrow. Curr Opin Oncol 2006;18:48-56.
    • (2006) Curr Opin Oncol , vol.18 , pp. 48-56
    • Zach, O.1    Lutz, D.2
  • 24
    • 33751317764 scopus 로고    scopus 로고
    • Recent translational research: Circulating tumor cells in breast cancer patients
    • Muller V, Hayes DF, Pantel K. Recent translational research: circulating tumor cells in breast cancer patients. Breast Cancer Res 2006;8:110.
    • (2006) Breast Cancer Res , vol.8 , pp. 110
    • Muller, V.1    Hayes, D.F.2    Pantel, K.3
  • 25
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004;351:781-91.
    • (2004) N Engl J Med , vol.351 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 26
    • 33947286218 scopus 로고    scopus 로고
    • Circulating tumor cells in metastatic breast cancer: Biologic staging beyond tumor burden
    • Cristofanilli M, Broglio KR, Guarneri V, et al. Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden. Clin Breast Cancer 2007;7:471-9.
    • (2007) Clin Breast Cancer , vol.7 , pp. 471-479
    • Cristofanilli, M.1    Broglio, K.R.2    Guarneri, V.3
  • 27
    • 36849047716 scopus 로고    scopus 로고
    • Different prognostic value of cytokeratin-19 mRNA-positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer
    • Ignatiadis M, Xenidis N, Perraki M, et al. Different prognostic value of cytokeratin-19 mRNA-positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer. J Clin Oncol 2007;25:5194-202.
    • (2007) J Clin Oncol , vol.25 , pp. 5194-5202
    • Ignatiadis, M.1    Xenidis, N.2    Perraki, M.3
  • 28
    • 33751249337 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Advanced tools for "tailored" therapy?
    • Cristofanilli M, Mendelsohn J. Circulating tumor cells in breast cancer: advanced tools for "tailored" therapy? Proc Natl Acad Sci USA 2006;103:17073-4.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17073-17074
    • Cristofanilli, M.1    Mendelsohn, J.2
  • 29
    • 18844450688 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity
    • Muller V, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res 2005;11:3678-85.
    • (2005) Clin Cancer Res , vol.11 , pp. 3678-3685
    • Muller, V.1    Stahmann, N.2    Riethdorf, S.3
  • 30
    • 1642270632 scopus 로고    scopus 로고
    • Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients
    • Pierga JY, Bonneton C, Vincent-Salomon A, et al. Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients. Clin Cancer Res 2004;10:1392-400.
    • (2004) Clin Cancer Res , vol.10 , pp. 1392-1400
    • Pierga, J.Y.1    Bonneton, C.2    Vincent-Salomon, A.3
  • 31
    • 33745908227 scopus 로고    scopus 로고
    • Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer
    • Benoy IH, Elst H, Philips M, et al. Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer. Clin Breast Cancer 2006;7:146-52.
    • (2006) Clin Breast Cancer , vol.7 , pp. 146-152
    • Benoy, I.H.1    Elst, H.2    Philips, M.3
  • 32
    • 33645221871 scopus 로고    scopus 로고
    • Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer
    • Wiedswang G, Borgen E, Schirmer C, et al. Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer. Int J Cancer 2005;118:2013-9.
    • (2005) Int J Cancer , vol.118 , pp. 2013-2019
    • Wiedswang, G.1    Borgen, E.2    Schirmer, C.3
  • 33
    • 13944259758 scopus 로고    scopus 로고
    • The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence
    • Janni W, Rack B, Schindlbeck C, et al. The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence. Cancer 2005;103:884-91.
    • (2005) Cancer , vol.103 , pp. 884-891
    • Janni, W.1    Rack, B.2    Schindlbeck, C.3
  • 34
    • 4143134311 scopus 로고    scopus 로고
    • Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome
    • Wiedswang G, Borgen E, Karesen R, et al. Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome. Clin Cancer Res 2004;10:5342-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 5342-5348
    • Wiedswang, G.1    Borgen, E.2    Karesen, R.3
  • 35
    • 19944431837 scopus 로고    scopus 로고
    • Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: Results at 4 years
    • Slade MJ, Singh A, Smith BM, et al. Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: results at 4 years. Int J Cancer 2005;114:94-100.
    • (2005) Int J Cancer , vol.114 , pp. 94-100
    • Slade, M.J.1    Singh, A.2    Smith, B.M.3
  • 36
    • 33846815517 scopus 로고    scopus 로고
    • Significance, detection and markers of disseminated breast cancer cells
    • Lacroix M. Significance, detection and markers of disseminated breast cancer cells. Endocr Relet Cancer 2006;13:1033-67.
    • (2006) Endocr Relet Cancer , vol.13 , pp. 1033-1067
    • Lacroix, M.1
  • 37
    • 33747079859 scopus 로고    scopus 로고
    • Breast cancer-specific mRNA transcripts presence in peripheral blood after adjuvant chemotherapy predicts poor survival among high-risk breast cancer patients treated with high-dose chemotherapy with peripheral blood stem cell support
    • Quintela-Fandino M, Lopez JM, Hitt R, et al. Breast cancer-specific mRNA transcripts presence in peripheral blood after adjuvant chemotherapy predicts poor survival among high-risk breast cancer patients treated with high-dose chemotherapy with peripheral blood stem cell support. J Clin Oncol 2006;24:3611-8.
    • (2006) J Clin Oncol , vol.24 , pp. 3611-3618
    • Quintela-Fandino, M.1    Lopez, J.M.2    Hitt, R.3
  • 38
    • 0033986270 scopus 로고    scopus 로고
    • Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients
    • Braun S, Kentenich C, Janni W, et al. Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J Clin Oncol 2000;18:80-6.
    • (2000) J Clin Oncol , vol.18 , pp. 80-86
    • Braun, S.1    Kentenich, C.2    Janni, W.3
  • 39
    • 0033398990 scopus 로고    scopus 로고
    • Monoclonal antibody therapy with edrecolomab in breast cancer patients: Monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow
    • Braun S, Hepp F, Kentenich CR, et al. Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res 1999;5:3999-4004.
    • (1999) Clin Cancer Res , vol.5 , pp. 3999-4004
    • Braun, S.1    Hepp, F.2    Kentenich, C.R.3
  • 40
    • 11144248359 scopus 로고    scopus 로고
    • Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer
    • Bozionellou V, Mavroudis D, Perraki M, et al. Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer. Clin Cancer Res 2004;10:8185-94.
    • (2004) Clin Cancer Res , vol.10 , pp. 8185-8194
    • Bozionellou, V.1    Mavroudis, D.2    Perraki, M.3
  • 41
    • 34247481531 scopus 로고    scopus 로고
    • Tumor dormancy and cancer stem cells: Implications for the biology and treatment of breast cancer metastasis
    • Allan AL, Vantyghem SA, Tuck AB, et al. Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis. Breast Dis 2006;26:87-98.
    • (2006) Breast Dis , vol.26 , pp. 87-98
    • Allan, A.L.1    Vantyghem, S.A.2    Tuck, A.B.3
  • 42
    • 33748937854 scopus 로고    scopus 로고
    • Dormancy of solitary metastatic cells
    • Townson JL, Chambers AF. Dormancy of solitary metastatic cells. Cell Cycle 2006;5:1744-50.
    • (2006) Cell Cycle , vol.5 , pp. 1744-1750
    • Townson, J.L.1    Chambers, A.F.2
  • 43
    • 0142026060 scopus 로고    scopus 로고
    • Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer
    • Wiedswang G, Borgen E, Karesen R, et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol 2003;21:3469-78.
    • (2003) J Clin Oncol , vol.21 , pp. 3469-3478
    • Wiedswang, G.1    Borgen, E.2    Karesen, R.3
  • 44
    • 2542474181 scopus 로고    scopus 로고
    • Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients
    • Gangnus R, Langer S, Breit E, et al. Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients. Clin Cancer Res 2004;10:3457-64.
    • (2004) Clin Cancer Res , vol.10 , pp. 3457-3464
    • Gangnus, R.1    Langer, S.2    Breit, E.3
  • 45
    • 0142259756 scopus 로고    scopus 로고
    • Methylation-specific PCR for DNA-based detection of occult tumor cells in lymph nodes of prostate cancer patients
    • Kollermann J, Muller M, Goessl C, et al. Methylation-specific PCR for DNA-based detection of occult tumor cells in lymph nodes of prostate cancer patients. Eur Urol 2003;44:533-8.
    • (2003) Eur Urol , vol.44 , pp. 533-538
    • Kollermann, J.1    Muller, M.2    Goessl, C.3
  • 46
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 47
    • 33846058844 scopus 로고    scopus 로고
    • The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
    • Wang J, Loberg R, Taichman RS. The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis. Cancer Metastasis Rev 2006;25:573-87.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 573-587
    • Wang, J.1    Loberg, R.2    Taichman, R.S.3
  • 48
    • 29844445176 scopus 로고    scopus 로고
    • Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer
    • Kaifi JT, Yekebas EF, Schurr P, et al. Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J Natl Cancer Inst 2005;97:1840-7.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1840-1847
    • Kaifi, J.T.1    Yekebas, E.F.2    Schurr, P.3
  • 49
    • 33646261865 scopus 로고    scopus 로고
    • Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells
    • Holland JD, Kochetkova M, Akekawatchai C, et al. Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells. Cancer Res 2006;66:4117-24.
    • (2006) Cancer Res , vol.66 , pp. 4117-4124
    • Holland, J.D.1    Kochetkova, M.2    Akekawatchai, C.3
  • 50
    • 17144410313 scopus 로고    scopus 로고
    • Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cells
    • Peng SB, Peek V, Zhai Y, ef al. Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cells. Mol Cancer Res 2005;3:227-36.
    • (2005) Mol Cancer Res , vol.3 , pp. 227-236
    • Peng, S.B.1    Peek, V.2    Zhai, Y.3    ef al4
  • 51
    • 0037147145 scopus 로고    scopus 로고
    • Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation
    • Sun Y, Cheng Z, Ma L, et al. Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation. J Biol Chem 2002;277:49212-9.
    • (2002) J Biol Chem , vol.277 , pp. 49212-49219
    • Sun, Y.1    Cheng, Z.2    Ma, L.3
  • 52
    • 33646867374 scopus 로고    scopus 로고
    • Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer
    • Andre F, Cabioglu N, Assi H, et al. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Ann Oncol 2006;17:945-51.
    • (2006) Ann Oncol , vol.17 , pp. 945-951
    • Andre, F.1    Cabioglu, N.2    Assi, H.3
  • 53
    • 34249059285 scopus 로고    scopus 로고
    • Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells
    • Kallergi G, Mavroudis D, Georgoulias V, et al. Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells. Mol Med 2007;13:79-88.
    • (2007) Mol Med , vol.13 , pp. 79-88
    • Kallergi, G.1    Mavroudis, D.2    Georgoulias, V.3
  • 54
    • 28144440871 scopus 로고    scopus 로고
    • Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells
    • Willipinski-Stapelfeldt B, Riethdorf S, Assmann V, et al. Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clin Cancer Res 2005;11:8006-14.
    • (2005) Clin Cancer Res , vol.11 , pp. 8006-8014
    • Willipinski-Stapelfeldt, B.1    Riethdorf, S.2    Assmann, V.3
  • 55
    • 33644818987 scopus 로고    scopus 로고
    • Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer
    • Benoy IH, Salgado R, Eist H, et al. Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer. Breast Cancer Res 2005;7:R210-9.
    • (2005) Breast Cancer Res , vol.7
    • Benoy, I.H.1    Salgado, R.2    Eist, H.3
  • 56
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast. 1889
    • Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 1989;8:98-101.
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 57
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436:518-24.
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3
  • 58
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49.
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 59
    • 33746620430 scopus 로고    scopus 로고
    • Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency
    • Suzuki M, Mose ES, Montel V, et al. Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am J Pathol 2006;169:673-81.
    • (2006) Am J Pathol , vol.169 , pp. 673-681
    • Suzuki, M.1    Mose, E.S.2    Montel, V.3
  • 60
    • 0032953810 scopus 로고    scopus 로고
    • Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: Establishment of working models for human micrometastases
    • Putz E, Witter K, Offner S, et al. Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases. Cancer Res 1999;59:241-8.
    • (1999) Cancer Res , vol.59 , pp. 241-248
    • Putz, E.1    Witter, K.2    Offner, S.3
  • 61
    • 0042477565 scopus 로고    scopus 로고
    • Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer
    • Pierga JY, Bonneton C, Magdelenat H, et al. Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer. Br J Cancer 2003;89:539-45.
    • (2003) Br J Cancer , vol.89 , pp. 539-545
    • Pierga, J.Y.1    Bonneton, C.2    Magdelenat, H.3
  • 62
    • 19944426264 scopus 로고    scopus 로고
    • Circulating tumor cells in patients with breast cancer dormancy
    • Meng S, Tripathy D, Frenkel EP, et al. Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res 2004;10:8152-62.
    • (2004) Clin Cancer Res , vol.10 , pp. 8152-8162
    • Meng, S.1    Tripathy, D.2    Frenkel, E.P.3
  • 63
    • 0037206022 scopus 로고    scopus 로고
    • Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
    • Klein CA, Blankenstein TJ, Schmidt-Kittler O, et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002;360:683-9.
    • (2002) Lancet , vol.360 , pp. 683-689
    • Klein, C.A.1    Blankenstein, T.J.2    Schmidt-Kittler, O.3
  • 64
    • 33644800080 scopus 로고    scopus 로고
    • Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice
    • Jenkins DE, Hornig YS, Oei Y, et al. Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res 2005;7:R444-54.
    • (2005) Breast Cancer Res , vol.7
    • Jenkins, D.E.1    Hornig, Y.S.2    Oei, Y.3
  • 65
    • 0027173889 scopus 로고
    • Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ
    • Kurebayashi J, McLeskey SW, Johnson MD, et al. Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. Cancer Res 1993;53:2178-87.
    • (1993) Cancer Res , vol.53 , pp. 2178-2187
    • Kurebayashi, J.1    McLeskey, S.W.2    Johnson, M.D.3
  • 66
    • 0036532065 scopus 로고    scopus 로고
    • Persistence of solitary mammary carcinoma cells in a secondary site: A possible contributor to dormancy
    • Naumov GN, MacDonald IC, Weinmeister PM, et al. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res 2002;62:2162-8.
    • (2002) Cancer Res , vol.62 , pp. 2162-2168
    • Naumov, G.N.1    MacDonald, I.C.2    Weinmeister, P.M.3
  • 67
    • 0018123323 scopus 로고
    • Dormancy and spontaneous recurrence of human breast cancer in vitro
    • Yuhas JM, Tarleton AE. Dormancy and spontaneous recurrence of human breast cancer in vitro. Cancer Res 1978;38(11 Pt 1):3584-9.
    • (1978) Cancer Res , vol.38 , Issue.11 PART 1 , pp. 3584-3589
    • Yuhas, J.M.1    Tarleton, A.E.2
  • 68
    • 3042819503 scopus 로고    scopus 로고
    • Integrin alpha5beta1 promotes survival of growth-arrested breast cancer cells: An in vitro paradigm for breast cancer dormancy in bone marrow
    • Koran R, Boots M, Wieder R. Integrin alpha5beta1 promotes survival of growth-arrested breast cancer cells: an in vitro paradigm for breast cancer dormancy in bone marrow. Cancer Res 2004;64:4514-22.
    • (2004) Cancer Res , vol.64 , pp. 4514-4522
    • Koran, R.1    Boots, M.2    Wieder, R.3
  • 69
    • 33748924308 scopus 로고    scopus 로고
    • Systemic cancer progression and tumor dormancy: Mathematical models meet single cell genomics
    • Klein CA, Holzel D. Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomics. Cell Cycle 2006;5:1788-98.
    • (2006) Cell Cycle , vol.5 , pp. 1788-1798
    • Klein, C.A.1    Holzel, D.2
  • 70
    • 24044520722 scopus 로고    scopus 로고
    • Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process
    • Demicheli R, Miceli R, Moliterni A, et al. Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process. Ann Oncol 2005;16:1449-57.
    • (2005) Ann Oncol , vol.16 , pp. 1449-1457
    • Demicheli, R.1    Miceli, R.2    Moliterni, A.3
  • 71
    • 0037061762 scopus 로고    scopus 로고
    • Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo
    • Aguirre-Ghiso JA. Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo. Oncogene 2002;21:2513-24.
    • (2002) Oncogene , vol.21 , pp. 2513-2524
    • Aguirre-Ghiso, J.A.1
  • 72
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)
    • Aguirre-Ghiso JA, Estrada Y, Liu D, et al. ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res 2003;63:1684-95.
    • (2003) Cancer Res , vol.63 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3
  • 73
    • 33750339604 scopus 로고    scopus 로고
    • Cancer stem cells and metastasis: Lethal seeds
    • Wicha MS. Cancer stem cells and metastasis: lethal seeds. Clin Cancer Res 2006;12:5606-7.
    • (2006) Clin Cancer Res , vol.12 , pp. 5606-5607
    • Wicha, M.S.1
  • 74
    • 34247162662 scopus 로고    scopus 로고
    • An alternative model of cancer cell growth and metastasis
    • Vaidya JS. An alternative model of cancer cell growth and metastasis. Int J Surg 2007;5:73-5.
    • (2007) Int J Surg , vol.5 , pp. 73-75
    • Vaidya, J.S.1
  • 75
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, et al. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005;5:744-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3
  • 76
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • Balic M, Lin H, Young L, et al. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 2006;12:5615- 21.
    • (2006) Clin Cancer Res , vol.12 , pp. 5615-5621
    • Balic, M.1    Lin, H.2    Young, L.3
  • 77
    • 33749853670 scopus 로고    scopus 로고
    • Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells
    • Hill A, McFarlane S, Mulligan K, et al. Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Oncogene 2006;25:6079-91.
    • (2006) Oncogene , vol.25 , pp. 6079-6091
    • Hill, A.1    McFarlane, S.2    Mulligan, K.3
  • 78
    • 33751346643 scopus 로고    scopus 로고
    • CD44+/CD24 - breast cancer cells exhibit enhanced invasive properties: An early step necessary for metastasis
    • Sheridan C, Kishimoto H, Fuchs RK, et al. CD44+/CD24 - breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 2006;8:R59.
    • (2006) Breast Cancer Res , vol.8
    • Sheridan, C.1    Kishimoto, H.2    Fuchs, R.K.3
  • 79
    • 0021023549 scopus 로고
    • Detection of micrometastases in patients with primary breast cancer
    • Redding WH, Coombes RC, Monaghan P, et al. Detection of micrometastases in patients with primary breast cancer. Lancet 1983;2:1271-4.
    • (1983) Lancet , vol.2 , pp. 1271-1274
    • Redding, W.H.1    Coombes, R.C.2    Monaghan, P.3
  • 80
    • 0023696579 scopus 로고
    • The value of bone marrow examination for tumor staging in breast cancer
    • Manegold C, Krempien B, Kaufmann M, et al. The value of bone marrow examination for tumor staging in breast cancer. J Cancer Res Clin Oncol 1988;114:425-8.
    • (1988) J Cancer Res Clin Oncol , vol.114 , pp. 425-428
    • Manegold, C.1    Krempien, B.2    Kaufmann, M.3
  • 81
    • 0031867454 scopus 로고    scopus 로고
    • Prognostic value of bone marrow biopsy in operable breast cancer patients at the time of initial diagnosis: Results of a 20-year median follow-up
    • Landys K, Persson S, Kovarik J, et al. Prognostic value of bone marrow biopsy in operable breast cancer patients at the time of initial diagnosis: results of a 20-year median follow-up. Breast Cancer Res Treat 1998;49:27-33.
    • (1998) Breast Cancer Res Treat , vol.49 , pp. 27-33
    • Landys, K.1    Persson, S.2    Kovarik, J.3
  • 82
    • 0025242550 scopus 로고
    • Use of monoclonal antibody MBr1 to detect micrometastases in bone marrow specimens of breast cancer patients
    • Salvadori B, Squicciarini P, Rovini D, et al. Use of monoclonal antibody MBr1 to detect micrometastases in bone marrow specimens of breast cancer patients. Eur J Cancer 1990;26:865-7.
    • (1990) Eur J Cancer , vol.26 , pp. 865-867
    • Salvadori, B.1    Squicciarini, P.2    Rovini, D.3
  • 83
    • 0025305611 scopus 로고
    • Immunohistochemical staining of bone marrow biopsies for detection of occult metastasis in breast cancer
    • Mathieu MC, Friedman S, Bosq J, et al. Immunohistochemical staining of bone marrow biopsies for detection of occult metastasis in breast cancer. Breast Cancer Res Treat 1990;15:21-6.
    • (1990) Breast Cancer Res Treat , vol.15 , pp. 21-26
    • Mathieu, M.C.1    Friedman, S.2    Bosq, J.3
  • 84
    • 0025674663 scopus 로고
    • The prognostic significance of marrow micrometastases in women with early breast cancer
    • Kirk SJ, Cooper GG, Hoper M, et al. The prognostic significance of marrow micrometastases in women with early breast cancer. Eur J Surg Oncol 1990;16:481-5.
    • (1990) Eur J Surg Oncol , vol.16 , pp. 481-485
    • Kirk, S.J.1    Cooper, G.G.2    Hoper, M.3
  • 85
    • 0025818398 scopus 로고
    • Detection of micrometastatic tumor cells in bone marrow of breast carcinoma patients
    • Singletary SE, Larry L, Tucker SL, et al. Detection of micrometastatic tumor cells in bone marrow of breast carcinoma patients. J Surg Oncol 1991;47:32-6.
    • (1991) J Surg Oncol , vol.47 , pp. 32-36
    • Singletary, S.E.1    Larry, L.2    Tucker, S.L.3
  • 86
    • 0026003325 scopus 로고
    • Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases
    • Cote RJ, Rosen PP, Lesser ML, et al. Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol 1991;9:1749-56.
    • (1991) J Clin Oncol , vol.9 , pp. 1749-1756
    • Cote, R.J.1    Rosen, P.P.2    Lesser, M.L.3
  • 87
    • 0001214668 scopus 로고
    • Prognostic significance of disseminated tumor cells detected in bone marrow of patients with breast and colorectal cancer: A multivariate analysis
    • Abstract 102
    • Schlimok G, Lindemann F, Holzmann K, et al. Prognostic significance of disseminated tumor cells detected in bone marrow of patients with breast and colorectal cancer: a multivariate analysis. Abstract 102. Proc Am Soc Clin Oncol 1992;11.
    • (1992) Proc Am Soc Clin Oncol , vol.11
    • Schlimok, G.1    Lindemann, F.2    Holzmann, K.3
  • 88
    • 0028331149 scopus 로고
    • Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: Results of a 3-year median follow-up
    • Harbeck N, Unten M, Pache L, et al. Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up. Br J Cancer 1994;69:566-71.
    • (1994) Br J Cancer , vol.69 , pp. 566-571
    • Harbeck, N.1    Unten, M.2    Pache, L.3
  • 89
    • 0028260626 scopus 로고
    • Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumour prognostic features
    • Menard S, Squicciarini P, Luini A, et al. Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumour prognostic features. Br J Cancer 1994;69:1126- 9.
    • (1994) Br J Cancer , vol.69 , pp. 1126-1129
    • Menard, S.1    Squicciarini, P.2    Luini, A.3
  • 90
    • 8044237715 scopus 로고    scopus 로고
    • Bone marrow micrometastases in 109 breast cancer patients: Correlations with clinical and pathological features and prognosis
    • Molino A, Pelosi G, Turazza M, et al. Bone marrow micrometastases in 109 breast cancer patients: correlations with clinical and pathological features and prognosis. Breast Cancer Res Treat 1997;42:23-30.
    • (1997) Breast Cancer Res Treat , vol.42 , pp. 23-30
    • Molino, A.1    Pelosi, G.2    Turazza, M.3
  • 91
    • 0029928712 scopus 로고    scopus 로고
    • Comparative analyses of bone marrow micrometastases in breast and gastric cancer
    • Funke I, Fries S, Rolle M, et al. Comparative analyses of bone marrow micrometastases in breast and gastric cancer. Int J Cancer 1996;65:755-61.
    • (1996) Int J Cancer , vol.65 , pp. 755-761
    • Funke, I.1    Fries, S.2    Rolle, M.3
  • 92
    • 0029804573 scopus 로고    scopus 로고
    • Micrometastatic breast cancer cells in bone marrow at primary surgery: Prognostic value in comparison with nodal status
    • Diel IJ, Kaufmann M, Costa SD, et al. Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J Natl Cancer Inst 1996;88:1652-8.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1652-1658
    • Diel, I.J.1    Kaufmann, M.2    Costa, S.D.3
  • 93
    • 0035674836 scopus 로고    scopus 로고
    • Time independence of the prognostic impact of tumor cell detection in the bone marrow of primary breast cancer patients
    • Solomayer EF, Diel IJ, Salanti G, et al. Time independence of the prognostic impact of tumor cell detection in the bone marrow of primary breast cancer patients. Clin Cancer Res 2001;7:4102-8.
    • (2001) Clin Cancer Res , vol.7 , pp. 4102-4108
    • Solomayer, E.F.1    Diel, I.J.2    Salanti, G.3
  • 94
    • 0023900354 scopus 로고
    • The relationship between micrometastases in the bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis
    • Berger U, Bettelheim R, Mansi JL, et al. The relationship between micrometastases in the bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis. Am J Clin Pathol 1988;90:1-6.
    • (1988) Am J Clin Pathol , vol.90 , pp. 1-6
    • Berger, U.1    Bettelheim, R.2    Mansi, J.L.3
  • 95
    • 0033647319 scopus 로고    scopus 로고
    • Keratin immunohistochemistry detects clinically significant metastases in bone marrow biopsy specimens in women with lobular breast carcinoma
    • Lyda MH, Tetef M, Carter NH, et al. Keratin immunohistochemistry detects clinically significant metastases in bone marrow biopsy specimens in women with lobular breast carcinoma. Am J Surg Pathol 2000;24:1593-9.
    • (2000) Am J Surg Pathol , vol.24 , pp. 1593-1599
    • Lyda, M.H.1    Tetef, M.2    Carter, N.H.3
  • 96
    • 0003269011 scopus 로고    scopus 로고
    • Detection of cytokeratin (CK) 18 positive cells in the bone marrow (BM) of breast cancer patients-no prediction of bad outcome. (Abstract 2472)
    • Untch M, Kahlert S, Funke I, et al. Detection of cytokeratin (CK) 18 positive cells in the bone marrow (BM) of breast cancer patients-no prediction of bad outcome. (Abstract 2472). Proc Am Soc Clin Oncol 1999;18:693a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Untch, M.1    Kahlert, S.2    Funke, I.3
  • 97
    • 0035161787 scopus 로고    scopus 로고
    • Evaluation of different methods for the detection of minimal residual disease in blood and bone marrow of patients with primary breast cancer: Importance for clinical use?
    • Kasimir-Bauer S, Oberhoff C, Sliwinska K, et al. Evaluation of different methods for the detection of minimal residual disease in blood and bone marrow of patients with primary breast cancer: importance for clinical use? Breast Cancer Res Treat 2001;69:123-32.
    • (2001) Breast Cancer Res Treat , vol.69 , pp. 123-132
    • Kasimir-Bauer, S.1    Oberhoff, C.2    Sliwinska, K.3


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