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Slade MJ, Singh A, Smith BM, et al. Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: results at 4 years. Int J Cancer 2005; 114:94-100. Bone marrow samples from 51 non-metastatic breast cancer patients were tested at four time points for the presence of disseminated tumor cells. All of them were positive at least once, pointing to their persistence during therapy. The question remains unanswered whether these cells exhibit any oncogenic or metastatic potential.
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Benoy IA, Salgado R, Elst H, et al. Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer. Breast Cancer Res 2005; 7:R210-R219. The association between disseminated tumor cells in bone marrow and vascularization of the primary tumor might be of biological importance.
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