Bone regeneration after topical BMP-2-gene delivery in circumferential peri-implant bone defects

Clinical Oral Implants Research

Volumn 19, Issue 6, 2008, Pages 590-599

  Lutz, Rainer ^a   Park, Jung ^a   Felszeghy, Endre ^b   Wiltfang, Jörg ^c   Nkenke, Emeke ^a   Schlegel, Karl Andreas ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Animal experiments; Bone regeneration; Bone implant interactions; Genetics; Growth factors; Guided tissue regeneration

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; COMPLEMENTARY DNA; LIPOSOME; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; AUTOTRANSPLANTATION; BONE DEVELOPMENT; BONE REGENERATION; BONE TRANSPLANTATION; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; FEMALE; FRONTAL BONE; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; METABOLISM; METHODOLOGY; NONPARAMETRIC TEST; PHYSIOLOGY; PLASMID; SWINE; TOOTH IMPLANTATION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE TRANSPLANTATION; COLLAGEN; DENTAL IMPLANTS; DNA, COMPLEMENTARY; DRUG DELIVERY SYSTEMS; FEMALE; FRONTAL BONE; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LIPOSOMES; OSSEOINTEGRATION; OSTEOGENESIS; PLASMIDS; STATISTICS, NONPARAMETRIC; SUS SCROFA; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, AUTOLOGOUS;

EID: 43449131847     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2007.01526.x     Document Type: Article

References (45)

1. Baltzer, A.W., Lattermann, C., Whalen, J.D., Braunstein, S., Robbins, P.D. Evans, C.H. (1999) A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model. Knee Surgery, Sports Traumatology, Arthroscopy 7 : 197 202.
2. Baltzer, A.W., Lattermann, C., Whalen, J.D., Wooley, P., Weiss, K., Grimm, M., Ghivizzani, S.C., Robbins, P.D. Evans, C.H. (2000) Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Therapy 7 : 734 739.
3. Banfi, A., Muraglia, A., Dozin, B., Mastrogiacomo, M., Cancedda, R. Quarto, R. (2000) Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy. Experimental Hematology 28 : 707 715.
4. Barboza, E.P., de Souza, R.O., Caula, A.L., Neto, L.G., Caula Fde, O. Duarte, M.E. (2002) Bone regeneration of localized chronic alveolar defects utilizing cell binding peptide associated with anorganic bovine-derived bone mineral: a clinical and histological study. Journal of Periodontology 73 : 1153 1159.
5. Bebok, Z., Abai, A.M., Dong, J.Y., King, S.A., Kirk, K.L., Berta, G., Hughes, B.W., Kraft, A.S., Burgess, S.W., Shaw, W., Felgner, P.L. Sorscher, E.J. (1996) Efficiency of plasmid delivery and expression after lipid-mediated gene transfer to human cells in vitro. The Journal of Pharmacology and Experimental Therapeutics 279 : 1462 1469.
6. Blum, J.S., Barry, M.A., Mikos, A.G. Jansen, J.A. (2003) In vivo evaluation of gene therapy vectors in ex vivo-derived marrow stromal cells for bone regeneration in a rat critical-size calvarial defect model. Human Gene Therapy 14 : 1689 1701.
7. Botticelli, D., Berglundh, T. Lindhe, J. (2004) Hard-tissue alterations following immediate implant placement in extraction sites. Journal of Clinical Periodontology 31 : 820 828.
8. Breitbart, A.S., Mason, J.M., Urmacher, C., Barcia, M., Grant, R.T., Pergolizzi, R.G. Grande, D.A. (1999) Gene-enhanced tissue engineering: applications for wound healing using cultured dermal fibroblasts transduced retrovirally with the pdgf-b gene. Annals of Plastic Surgery 43 : 632 639.
9. Donath, K. Breuner, G. (1995) A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique 20. The International Journal of Oral & Maxillofacial Implants 10 : 312 334.
10. Fang, J., Zhu, Y.Y., Smiley, E., Bonadio, J., Rouleau, J.P., Goldstein, S.A., McCauley, L.K., Davidson, B.L. Roessler, B.J. (1996) Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proceedings of the National Academy of Sciences of the United States of America 93 : 5753 5758.
11. Finkemeier, C.G. (2002) Bone-grafting and bone-graft substitutes. The Journal of Bone and Joint Surgery American 84-A : 454 464.
12. Franceschi, R.T., Wang, D., Krebsbach, P.H. Rutherford, R.B. (2000) Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing bmp7. Journal of Cellular Biochemistry 78 : 476 486.
13. Goldstein, S.A. (2000) In vivo nonviral delivery factors to enhance bone repair. Clinical Orthopaedics and Related Research 379 : S113 S119.
14. Gysin, R., Wergedal, J.E., Sheng, M.H., Kasukawa, Y., Miyakoshi, N., Chen, S.T., Peng, H., Lau, K.H., Mohan, S. Baylink, D.J. (2002) Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the bmp4 gene completely heals critical size calvarial defect in rats. Gene Therapy 9 : 991 999.
15. Hannallah, D., Peterson, B., Lieberman, J.R., Fu, F.H. Huard, J. (2003) Gene therapy in orthopaedic surgery. Instructional Course Lectures 52 : 753 768.
16. Heraeus-Kulzer, A.K.W.G. (2000) Verarbeitungshinweise zu Technovit 9100 neu.
17. Hönig, J.F. Merten, H.A. (1993) Das Göttinger Miniaturschwein (GMS) als Versuchstier in der human-medizinischen osteologischen Grundlagenforschung. Zeitschrift für Zahnärztliche Implantologie 9 : 244 245.
18. Jovanovic, S.A., Spiekermann, H. Richter, E.J. (1992) Bone regeneration around titanium dental implants in dehisced defect sites: a clinical study. The International Journal of Oral & Maxillofacial Implants 7 : 233 245.
19. Kirker-Head, C.A. (2000) Potential applications and delivery strategies for bone morphogenetic proteins. Advanced Drug Delivery Reviews 43 : 65 92.
20. Lee, J.Y., Musgrave, D., Pelinkovic, D., Fukushima, K., Cummins, J., Usas, A., Robbins, P., Fu, F.H. Huard, J. (2001) Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice. The Journal of Bone and Joint Surgery American 83-A : 1032 1039.
21. Lee, R.J. Huang, L. (1997) Lipidic vector systems for gene transfer. Critical Reviews in Therapeutic Drug Carrier Systems 14 : 173 206.
22. Lieberman, J.R., Daluiski, A., Stevenson, S., Wu, L., McAllister, P., Lee, Y.P., Kabo, J.M., Finerman, G.A., Berk, A.J. Witte, O.N. (1999) The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. The Journal of Bone and Joint Surgery 81 : 905 917.
23. Loser, P., Huser, A., Hillgenberg, M., Kumin, D., Both, G.W. Hofmann, C. (2002) Advances in the development of non-human viral DNA-vectors for gene delivery. Current Gene Therapy 2 : 161 171.
24. Mehrara, B.J., Saadeh, P.B., Steinbrech, D.S., Dudziak, M., Spector, J.A., Greenwald, J.A., Gittes, G.K. Longaker, M.T. (1999) Adenovirus-mediated gene therapy of osteoblasts in vitro and in vivo. Journal of Bone and Mineral Research 14 : 1290 1301.
25. Miller, A.D. (2003) The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy. Current Medicinal Chemistry 10 : 1195 1211.
26. Mori, S., Sawai, T., Teshima, T. Kyogoku, M. (1988) A new decalcifying technique for immunohistochemical studies of calcified tissue, especially applicable to cell surface marker demonstration. The Journal of Histochemistry and Cytochemistry 36 : 111 114.
27. Nagao, H., Tachikawa, N., Miki, T., Oda, M., Mori, M., Takahashi, K. Enomoto, S. (2002) Effect of recombinant human bone morphogenetic protein-2 on bone formation in alveolar ridge defects in dogs. International Journal of Oral and Maxillofacial Surgery 31 : 66 72.
28. Ono, I., Yamashita, T., Jin, H.Y., Ito, Y., Hamada, H., Akasaka, Y., Nakasu, M., Ogawa, T. Jimbow, K. (2004) Combination of porous hydroxyapatite and cationic liposomes as a vector for bmp-2 gene therapy. Biomaterials 25 : 4709 4718.
29. Park, J., Lutz, R., Felszeghy, E., Wiltfang, J., Nkenke, E., Neukam, F.W. Schlegel, K.A. (2007) The effect on bone regeneration of a liposomal vector to deliver bmp-2 gene to bone grafts in peri-implant bone defects. Biomaterials 28 : 2772 2782.
30. Park, J., Ries, J., Gelse, K., Kloss, F., von der Mark, K., Wiltfang, J., Neukam, F.W. Schneider, H. (2003) Bone regeneration in critical size defects by cell-mediated bmp-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Therapy 10 : 1089 1098.
31. Reddi, A.H. (2001) Bone morphogenetic proteins: from basic science to clinical applications. The Journal of Bone and Joint Surgery American 83-A (Suppl. 1) : S1 S6.
32. Saeki, Y., Matsumoto, N., Nakano, Y., Mori, M., Awai, K. Kaneda, Y. (1997) Development and characterization of cationic liposomes conjugated with hvj (sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Human Gene Therapy 8 : 2133 2141.
33. Schlegel, K.A., Lang, F.J., Donath, K., Kulow, J.T. Wiltfang, J. (2006) The monocortical critical size bone defect as an alternative experimental model in testing bone substitute materials. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 102 : 7 13.
34. Schliephake, H. Kracht, D. (1997) Vertical ridge augmentation using polylactic membranes in conjunction with immediate implants in periodontally compromised extraction sites: an experimental study in dogs. The International Journal of Oral & Maxillofacial Implants 12 : 325 334.
35. Schmitz, J.P. Hollinger, J.O. (1986) The critical size defect as an experimental model for craniomandibulofacial nonunions. Clinical Orthopaedics and Related Research 205 : 299 308.
36. Takeshita, S., Gal, D., Leclerc, G., Pickering, J.G., Riessen, R., Weir, L. Isner, J.M. (1994) Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury. The Journal of Clinical Investigation 93 : 652 661.
37. Takita, H., Tsuruga, E., Ono, I. Kuboki, Y. (1997) Enhancement by bfgf of osteogenesis induced by rhbmp-2 in rats. European Journal of Oral Sciences 105 : 588 592.
38. Thorwarth, M., Schlegel, K.A., Wiltfang, J., Rupprecht, S. Park, J.H. (2004) Experimental pilot study on surface activation of implants with liposomal vectors. Mund-, Kiefer- und Gesichtschirurgie 8 : 250 255.
39. Urist, M. (1965) Bone: formation by autoinduction. Science 150 : 893 899.
40. Urist, M.R. Mikulski, A.J. (1979) A soluble bone morphogenetic protein extracted from bone matrix with a mixed aqueous and nonaqueous solvent. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, NY) 162 : 48 53.
41. Urist, M.R., Sato, K., Brownell, A.G., Malinin, T.I., Lietze, A., Huo, Y.K., Prolo, D.J., Oklund, S., Finerman, G.A. DeLange, R.J. (1983) Human bone morphogenetic protein (hbmp). Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, NY) 173 : 194 199.
42. Wang, E.A., Rosen, V., D'Alessandro, J.S., Bauduy, M., Cordes, P., Harada, T., Israel, D.I., Hewick, R.M., Kerns, K.M., LaPan, P., Luxenberg, D.P., McQuaid, D., Moutsatsos, I.K., Nove, J. Wozney, J.M. (1990) Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America 87 : 2220 2224.
43. Wozney, J.M., Rosen, V., Celeste, A.J., Mitsock, L.M., Whitters, M.J., Kriz, R.W., Hewick, R.M. Wang, E.A. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 : 1528 1534.
44. Yang, R., Davies, C.M., Archer, C.W. Richards, R.G. (2003) Immunohistochemistry of matrix markers in technovit 9100 new-embedded undecalcified bone sections. European Cells and Materials 6 : 57 71 discussion 71.
45. Yoshikawa, T., Ohgushi, H., Nakajima, H., Yamada, E., Ichijima, K., Tamai, S. Ohta, T. (2000) In vivo osteogenic durability of cultured bone in porous ceramics: a novel method for autogenous bone graft substitution. Transplantation 69 : 128 134.