Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 5, 2008, Pages 738-741

  Miyaoka, Hiroaki ^a   Yamanishi, Makoto ^a   Hoshino, Ayako ^a   Mitome, Hidemichi ^a,b   Kawashima, Etsuko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b MATSUYAMA UNIVERSITY   (Japan)

Author keywords

substituted amino acid; Chiral building block; Formal synthesis; Lactacystin; Proteasome inhibitor

Indexed keywords

4 HYDROXYMETHYL 2 PHENYL 4,5 DIHYDROOXAZOL 4 YLMETHYL ACETATE; ACETIC ACID DERIVATIVE; LACTACYSTIN; PROTEASOME INHIBITOR;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETYLCYSTEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE PROTEINASE INHIBITORS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; OXAZOLES; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 43449091296     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.738     Document Type: Article

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