Utility of the ammonia-free birch reduction of electron-deficient pyrroles: Total synthesis of the 20S proteasome inhibitor, clasto-lactacystin β-lactone

Chemistry - A European Journal

Volumn 11, Issue 14, 2005, Pages 4227-4238

  Donohoe, Timothy J ^a   Sintim, Herman O ^a   Sisangia, Leena ^a   Ace, Karl W ^b   Guyo, Paul M ^b   Cowley, Andrew ^a   Harling, John D ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Lactacystin; Natural products; Pyrroles; Total synthesis

Indexed keywords

BENZENE; ELECTRONS; MOLECULAR STRUCTURE; POLYPEPTIDES; REDUCTION; SYNTHESIS (CHEMICAL);

LACTACYSTIN; NATURAL PRODUCTS; PYRROLES; TOTAL SYNTHESIS;

AMMONIA;

AMMONIA; CLASTO-LACTACYSTIN BETA-LACTONE; LACTACYSTIN BETA LACTONE; LACTONE; PROTEASOME; PYRROLE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ELECTRON; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMMONIA; ELECTRONS; LACTONES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22044438998     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200401119     Document Type: Article

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