Differing caspase-1 activation states in monocyte versus macrophage models of IL-1β processing and release

Journal of Leukocyte Biology

Volumn 76, Issue 3, 2004, Pages 676-684

  Kahlenberg, J Michelle ^a   Dubyak, George R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AG126; Bromoenol lactone; Inflammation

Indexed keywords

5 (2,2 DICYANOVINYL) 2 NITROPHENOL; BIOLOGICAL FACTOR; BROMOENOL LACTONE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PHOSPHOLIPASE A2 INHIBITOR; PROINTERLEUKIN 1BETA; PROINTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN PRECURSOR; PROTEIN SYNTHESIS INHIBITOR; RECOMBINANT ENZYME; RECOMBINANT INTERLEUKIN 1BETA CONVERTING ENZYME; TRANSFERABLE ACTIVATION FACTOR; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOCATALYSIS; CATALYSIS; CELL LINE; CELL LYSATE; CELL STRAIN BAC1.2F; CELL STRAIN THP 1; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; DEPLETION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNODEPLETION; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MODEL; MOLECULAR STABILITY; MONOCYTE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN PROCESSING; REGULATORY MECHANISM; THERMAL LABILITY; TRANSACTIVATION;

ANIMALS; CASPASE 1; CELL LINE; CHEMOTAXIS, LEUKOCYTE; CULTURE MEDIA, CONDITIONED; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MODELS, BIOLOGICAL; MONOCYTES; NAPHTHALENES; PHOSPHOLIPASES A; PYRONES; TYRPHOSTINS; UP-REGULATION;

ANIMALIA; MURINAE;

EID: 4344700371     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0404221     Document Type: Article

References (30)

1. Dinarello, C. A. (1996) Biologic basis for interleukin-1 in disease. Blood 87, 2095-2147.
2. Rowe, S. J., Allen, L., Ridger, V. C., Hellewell, P. G., Whyte, M. K. (2002) Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. J. Immunol. 169, 6401-6407.
3. Wang, J., Lenardo, M. J. (2000) Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies. J. Cell Sci. 113, 753-757.
4. Jones, M. A., Totemeyer, S., Maskell, D. J., Bryant, C. E., Barrow, P. A. (2003) Induction of proinflammatory responses in the human monocytic cell line THP-1 by Campylobacter jejuni. Infect. Immun. 71, 2626-2633.
5. Aga, M., Johnson, C. J., Hart, A. P., Guadarrama, A. G., Suresh, M., Svaren, J., Bertics, P. J., Darien, B. J. (2002) Modulation of monocyte signaling and pore formation in response to agonists of the nucleotide receptor P2X(7). J. Leukoc. Biol. 72, 222-232.
6. MacKenzie, A., Wilson, H. L., Kiss-Toth, E., Dower, S. K., North, R. A., Surprenant, A. (2001) Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15, 825-835.
7. Yamin, T. T., Ayala, J. M., Miller, D. K. (1996) Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme. J. Biol. Chem. 271, 13273-13282.
8. Poyet, J. L., Srinivasula, S. M., Tnani, M., Razmara, M., Fernandes-Alnemri, T., Alnemri, E. S. (2001) Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276, 28309-28313.
9. Srinivasula, S. M., Poyet, J. L., Razmara, M., Datta, P., Zhang, Z., Alnemri, E. S. (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277, 21119-21122.
10. Grenier, J. M., Wang, L., Manji, G. A., Huang, W. J., Al-Garawi, A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., et al. (2002) Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett. 530, 73-78.
11. Yoo, N. J., Park, W. S., Kim, S. Y., Reed, J. C., Son, S. G., Lee, J. Y., Lee, S. H. (2002) Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. Biochem. Biophys. Res. Commun. 299, 652-658.
12. Thome, M., Hofmann, K., Burns, K., Martinon, F., Bodmer, J. L., Mattmann, C., Tschopp, J. (1998) Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol. 8, 885-888.
13. Martinon, F., Burns, K., Tschopp, J. (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10, 417-426.
14. Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., Tschopp, J. (2004) NALP3 Forms an IL-1beta-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder. Immunity 20, 319-325.
15. Perregaux, D., Gabel, C. A. (1994) Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J. Biol. Chem. 269, 15195-15203.
16. Perregaux, D. G., Laliberte, R. E., Gabel, C. A. (1996) Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response. J. Biol. Chem. 271, 29830-29838.
17. Perregaux, D. G., Gabel, C. A. (1998) Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations. Am. J. Physiol. 275, C1538-C1547.
18. Cheneval, D., Ramage, P., Kastelic, T., Szelestenyi, T., Niggli, H., Hemmig, R., Bachmann, M., MacKenzie, A. (1998) Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. J. Biol. Chem. 273, 17846-17851.
19. 2+ in the regulation of IL-1{beta} secretion by the P2X7 nucleotide receptor in monocytes, macrophages, and HEK293 fibroblasts. Am. J. Physiol. Cell Physiol. 285, C286-C299.
20. Walev, I., Reske, K., Palmer, M., Valeva, A., Bhakdi, S. (1995) Potassium-inhibited processing of IL-1 beta in human monocytes. EMBO J. 14, 1607-1614.
21. Schumann, R. R., Belka, C., Reuter, D., Lamping, N., Kirschning, C. J., Weber, J. R., Pfeil, D. (1998) Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells. Blood 91, 577-584.
22. Grahames, C. B., Michel, A. D., Chessell, I. P., Humphrey, P. P. (1999) Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes. Br. J. Pharmacol. 127, 1915-1921.
23. Perregaux, D. G., McNiff, P., Laliberte, R., Conklyn, M., Gabel, C. A. (2000) ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood. J. Immunol. 165, 4615-4623.
24. Sluyter, R., Shemon, A. N., Wiley, J. S. (2004) Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1{beta} Release from Human Monocytes. J. Immunol. 172, 3399-3405.
25. Humphreys, B. D., Rice, J., Kertesy, S. B., Dubyak, G. R. (2000) Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor. J. Biol. Chem. 275, 26792-26798.
26. Kahlenberg, J. M., Dubyak, G. R. (2003) Mechanisms of Caspase-I Activation by P2X7 Receptor-Mediated K+ Release. Am. J. Physiol. Cell Physiol. 286, C1100-C1108.
27. Walev, I., Klein, J., Husmann, M., Valeva, A., Strauch, S., Wirtz, H., Weichel, O., Bhakdi, S. (2000) Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2. J. Immunol. 164, 5120-5124.
28. Mehta, V. B., Hart, J., Wewers, M. D. (2001) ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J. Biol. Chem. 276, 3820-3826.
29. Hanisch, U. K., Prinz, M., Angstwurm, K., Hausler, K. G., Kann, O., Kettenmann, H., Weber, J. R. (2001) The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol. 31, 2104-2115.
30. Suttles, J., Giri, J. G., Mizel, S. B. (1990) IL-1 secretion by macrophages. Enhancement of IL-1 secretion and processing by calcium ionophores. J. Immunol. 144, 175-182.