Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: A functional comparison

Biological Chemistry

Volumn 385, Issue 7, 2004, Pages 597-603

  Balamurugan, Kuppusamy ^a   Egli, Dieter ^a   Selvaraj, Anand ^a   Zhang, Bo ^a   Georgiev, Oleg ^a   Schaffner, Walter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cadmium; Heavy metal load; Mercury; Metallothioneins; Transcriptional regulation; Zinc

Indexed keywords

ANGIOGENIC FACTOR; CADMIUM; COPPER ION; GROWTH FACTOR; HEAVY METAL; MERCURY; METALLOTHIONEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN; ZINC ION;

ANIMAL CELL; ANOXIA; ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETOXIFICATION; DROSOPHILA; EMBRYO DEATH; GENE DISRUPTION; GENETIC CONSERVATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPOXIA; INSECT; LIVER; MAMMAL; MAMMAL CELL; METAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE HOMOLOGY; STRESS; TISSUE DEGENERATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSGENE; VERTEBRATE;

ANIMALS; COPPER; DNA-BINDING PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION TEST; HELA CELLS; HUMANS; MERCURY; METALLOTHIONEIN; METALS, HEAVY; MICE; MICE, KNOCKOUT; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC;

HEXAPODA; MAMMALIA; VERTEBRATA;

EID: 4344681977     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2004.074     Document Type: Article

References (37)

1. Andrews, G.K. (2000). Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem. Pharmacol. 59, 95-104.
2. Apuy, J.L., Chen X., Russell, D.H., Baldwin. T.O., and Giedroc, D.P. (2001). Ratiometric pulsed alkylation/mass spectrometry of the cysteine pairs in individual zinc fingers of MRE-binding transcription factor-1 (MTF-1) as a probe of zinc chelate stability. Biochemistry 40, 15164-15175.
3. Auf der Maur, A., Belser, T., Elgar, G., Georgiev, O., and Schaffner, W. (1999). Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response. Biol. Chem. 380, 175-185.
4. Bittel, D., Dalton, T., Samson, S.L., Gedamu, L., and Andrews, G.K. (1998). The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem. 273, 7127-7133.
5. Brugnera, E., Georgiev, O., Radtke, F., Heuchel, R., Baker, E., Sutherland, G.R., and Schaffner, W. (1994). Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Res. 22, 3167-3173.
6. Chen, X., Zhang, B., Harmon, P.M., Schaffner, W., Peterson, D.O., and Giedroc, D.P. (2004). A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. J. Biol. Chem. 279, 4515-4522.
7. Dalton, T.P., Solis, W.A., Nebert, D.W., and Carvan, M.J 3rd. (2000). Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 126, 325-335.
8. DeMoor, J.M., and Koropatnick, D.J. (2000). Metals and cellular signaling in mammalian cells. Cell Mol. Biol. (Noisy-le-Grand) 46, 367-381.
9. Egli, D., Selvaraj, A., Yepiskoposyan, H., Zhang, B., Hafen, E., Georgiev, O., and Schaffner, W. (2003). Knockout of metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. EMBO J. 22, 100-108.
10. Finney, L.A., and O'Halloran, T.V. (2003). Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. Science 300, 931-936.
11. Giedroc, D.P., Chen, X., and Apuy, J.L. (2001). Metal response element (MRE)-binding transcription factor-1 (MTF-1): structure, function, and regulation. Antioxid. Redox Signal 3, 577-596.
12. Graham, F.L., and van der Eb, A.J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
13. Green, C.J., Lichtlen, P., Huynh, N.T., Yanovsky, M., Laderoute, K.R., Schaffner, W., and Murphy, B.J. (2001). Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1. Cancer Res. 61, 2696-2703.
14. Günes, C., Heuchel, R., Georgiev, O., Muller, K.H., Lichtlen, P., Bluthmann, H., Marino, S., Aguzzi, A., and Schaffner, W. (1998). Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 17, 2846-2854.
15. Heuchel, R., Radtke, F., Georgiev, O., Stark, G., Aguet, M., and Schaffner, W. (1994). The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13, 2870-2875.
16. Kumar, J.P., and Moses, K. (2001). EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. Cell 104, 687-697.
17. Lichtlen, P., and Schaffner, W. (2001). Putting its fingers on stressful situations: the heavy metal regulatory transcription factor MTF-1. Bioessays 23, 1010-1017.
18. Liu, X.D., and Thiele, D.J. (1997). Yeast metallothionein gene expression in response to metals and oxidative stress. Methods 11, 289-299.
19. Palmiter, R.D. (1998). The elusive function of metallothioneins. Proc. Natl. Acad. Sci. USA 95, 8428-8430.
20. Radtke, F., Heuchel, R., Georgiev, O., Hergersberg, M., Gariglio, M., Dembic, Z., and Schaffner, W. (1993). Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J. 12, 1355-1362.
21. Radtke, F., Georgiev, O., Muller, H.P., Brugnera, E and Schaffner, W. (1995). Functional domains of the heavy metal-responsive transcription regulator MTF-1. Nucleic Acids Res. 23, 2277-2286.
22. Saydam, N., Georgiev, O., Nakano, M.Y., Greber, U.F., and Schaffner, W. (2001). Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. J. Biol. Chem. 276, 25487-25495.
23. Saydam, N., Adams, T.K., Steiner, F., Schaffner, W., and Freedman, J.H. (2002). Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription. J. Biol. Chem. 277, 20438-20445.
24. Shukla, G.S., Shukla, A., Potts, R.J., Osier, M., Hart, B.A., and Chiu, J.F. (2000). Cadmium-mediated oxidative stress in alveolar epithelial cells induces the expression of γ-glutamylcysteine synthetase catalytic subunit and glutathione S-transferase α and π isoforms: potential role of activator protein-1. Cell Biol. Toxicol. 16, 347-362.
25. Stuart, G.W., Searle, P.F., Chen, H.Y., Brinster, R.L., and Palmiter, R.D. (1984). A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc. Natl. Acad. Sci. USA 81, 7318-7322.
26. Stuart, G.W., Searle, P.F., and Palmiter, R.D. (1985). Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature 317, 828-831.
27. Tandon, S.K., Singh, S., Prasad, S., Khandekar, K., Dwivedi, V.K., Chatterjee, M., and Mathur, N. (2003). Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol. Lett. 145, 211-217.
28. Tchounwou, P.B., Ayensu, W.K., Ninashvili, N., and Sutton, D. (2003). Environmental exposure to mercury and its toxicopathologic implications for public health. Environ. Toxicol. 18, 149-175.
29. Thiele, D.J.(1988). ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein. Mol. Cell. Biol. 8, 2745-2752.
30. Urani, C., Calini, V., Melchioretto, P., Morazzoni, F., Canevali, C., and Camatini, M. (2003). Different induction of metallothioneins and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc. Toxicol. In Vitro 17, 553-559.
31. Vasak, M., and Hasler, D.W. (2000). Metallothioneins: new functional and structural insights. Curr. Opin. Chem. Biol. 4, 177-183.
32. Wang, Y., Wimmer, U., Lichtlen, P., Inderbitzin, D., Stieger, B., Meier, P.J., Hunziker, L., Stallmach, T., Forrer, R., Rülicke, T., Georgiev, O., and Schaffner, W. (2004). Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. FASEB J., in press.
33. Weaver, R.F., and Weissmann, C. (1979). Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15S β-globin mRNA precursor and mature 10S β-globin mRNA have identical map coordinates. Nucleic Acids Res. 7, 1175-1193.
34. Westin, G., Gerster, T., Muller, M.M., Schaffner, G., and Schaffner, W. (1987). OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res. 15, 6787-6798.
35. Westin, G., and Schaffner, W. (1988). A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. EMBO J. 7, 3763-3770.
36. Zhang, B., Egli, D., Georgiev, O., and Schaffner, W. (2001). The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals. Mol. Cell. Biol. 21, 4505-4514.
37. 2 in vitro is modulated by metallothionein. Mol. Cell. Biol. 23, 8471-8485.