Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy

Mechanisms of Ageing and Development

Volumn 125, Issue 8, 2004, Pages 563-573

  Leach, Natalia T ^a,b   Rehder, Catherine ^a   Jensen, Keith ^a   Holt, Shawn ^a,c   Jackson Cook, Colleen ^a,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Med Coll Virginia Camp V   (United States)

Author keywords

Acquired somatic cell aneuploidy; Chromosomes; Telomere length

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; AUTOSOME; CHEEK MUCOSA; CHROMOSOME 17; CHROMOSOME LOSS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROCHROMATIN; HUMAN; HUMAN CHROMOSOME; HUMAN TISSUE; LYMPHOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; SOMATIC CELL; TELOMERE; TRISOMY; X CHROMOSOME;

ADULT; ANEUPLOIDY; CHROMOSOMES; CHROMOSOMES, HUMAN, X; DNA; FEMALE; FLOW CYTOMETRY; HETEROCHROMATIN; HUMANS; LYMPHOCYTES; METAPHASE; MIDDLE AGED; MOUTH MUCOSA; PEPTIDE NUCLEIC ACIDS; TELOMERE;

EID: 4344680935     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2004.06.006     Document Type: Article

References (48)

1. M. Abruzzo, M. Mayer, and P. Jacobs Aging and aneuploidy: evidence for the preferential involvement of the inactive X chromosome Cytogenet. Cell. Genet. 39 1985 275 278
2. R. Allsopp, H. Vaziri, C. Patterson, S. Goldstein, E. Younglai, A. Futcher, C. Greider, and C. Harley Telomere length predicts replicative capacity of human fibroblasts Proc. Natl. Acad. Sci. U.S.A. 89 1992 10114 10118
3. M.J. Barch Giemsa-banding Technique using Trypsin GTG in the ACT Cytogenetics Laboratory Manual second ed. 1991 Raven Press New York
4. A. Bodnar, M. Ouellette, M. Frolkis, S. Holt, C. Chiu, G. Morin, C. Harley, J. Shay, S. Lichtsteiner, and W. Wright Extension of the life-span by introduction of telomerase into normal human cells Science 279 1998 349 352
5. T. Brown, D. Fox, F. Robertson, and I. Bullock Non-random chromosome loss in PHA-stimulated lymphocytes from normal individuals Mutat. Res. 122 1983 403 406
6. J. Catalan, K. Autio, M. Wessman, C. Lindholm, S. Knuutila, M. Sorsa, and H. Norppa Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women Cytogenet. Cell Genet. 68 1995 11 16
7. J. Catalan, G. Falck, and H. Norppa The X chromosome frequently lags behind in female lymphocyte anaphase Am. J. Hum. Genet. 66 2000 687 691
8. J. Catalan, J. Surralles, G. Falck, K. Autio, and H. Norppa Segregation of sex-chromosomes in human lymphocytes Mutagenesis 15 2000 251 255
9. W. Deng, S.W. Tsao, X.Y. Guan, J.N. Lucas, and A.L. Cheung Role of sort telomeres in inducing preferential chromosomal aberrations in human ovarian surface epithelial cells: a combined telomerere quantitative fluorescence in situ hybridization and whole-chromosome painting study Genes Chromosomes Cancer 37 2003 92 97
10. E. Fauth, and H. Zankl Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting Mutat. Res. 440 1999 147 156
11. P. Fitzgerald, and C. McEwan Total aneuploidy and age-related sex chromosome aneuploidy in cultured lymphocytes of normal men and women Hum. Genet. 39 1977 329 337
12. J. Ford, and P. Lester Factors affecting the displacement of human chromosomes from the metaphase plate Cytogenet. Cell Genet. 33 1982 327 332
13. J. Ford, and J. Russell Differences in the error mechanisms affecting sex and autosomal chromosomes in women of different ages within the reproductive age group Am. J. Hum. Genet. 37 1985 973 983
14. J. Ford, and A. Correl Chromosome errors at mitotic anaphase Genome 35 1992 702 705
15. S. Galloway, and K. Buckton Aneuploidy and ageing: chromosomes studies on a random sample of the population using G-banding Cytogenet. Cell. Genet. 20 1978 78 95
16. J. Ford, C.L. Schultz, and A. Correll Chromosome elimination in micronuclei: a common cause of hypoploidy Am. J. Hum. Genet. 43 1988 733 740
17. V. Galy, J.-C. Olivo-Marin, H. Scherthan, V. Doye, N. Rascalou, and U. Nehrbass Nuclear pore complexes in the organization of silent telomeric chromatin Nature 403 2000 108 112
18. J. Graakjaer, C. Bischoff, L. Korsholm, S. Holstebroe, W. Vach, V.A. Bohr, K. Christensen, and S. Kolvraa The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life Mech. Age. Dev. 124 2003 629 640
19. M. Guttenbach, R. Schakowski, and M. Schmid Aneuploidy and aging: sex chromosome exclusion into micronuclei Hum. Genet. 94 1994 295 298
20. M. Guttenbach, B. Koschorz, U. Bernthaler, T. Grimm, and M. Schmid Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei Am. J. Hum. Genet. 57 1995 1143 1150
21. C. Harley, A. Futcher, and C. Greider Telomeres shorten during aging of human fibroblasts Nature 345 1990 458 460
22. N. Hastie, M. Dempster, M. Dunlop, A. Thompson, D. Green, and R. Allshire Telomere reduction in human colorectal carcinoma and with ageing Nature 346 1990 866 868
23. P. Jacobs, W. Court Brown, and R. Doll Distribution of human chromosome counts in relation to age Nature 191 1961 1178 1180
24. M. Jeanpierre, C. Turleau, A. Aurias, M. Prieur, F. Ledeist, A. Fischer, and E. Viegas-Pequignot An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome Hum. Mol. Genet. 2 1993 731 735
25. K. Kirk, B. Harmon, I. Reichardt, J. Sedat, and E. Blackburn Block in anaphase chromosome separation caused by a telomerase template mutation Science 275 1997 1478 1481
26. K. Krejí, and J. Koch Improved detection and comparative sizing of human chromosomal telomeres in situ Chromosoma 107 1998 198 203
27. P. Lansdorp, N. Verwoerd, F. Van de Rijke, V. Dragowska, M. Little, R. Dirks, A. Raap, and H. Tanke Heterogeneity in telomere length of human chromosomes Hum. Mol. Genet. 5 5 1996 685 691
28. V. Lundblad, and J. Szostak A mutant with a defect in telomere elongation leads to senescence in yeast Cell 57 1989 633 643
29. U. Martens, J. Zijlmans, S. Poon, W. Dragowska, J. Yui, E. Chavez, R. Ward, and P. Lansdorp Short telomeres on human chromosome 17p Nat. Genet. 18 1998 76 80
30. R.S. Maser, and R.A. DePinho Connecting chromosomes, crisis, and cancer Science 297 2002 565 569
31. n, present at the telomeres of human chromosomes Proc. Natl. Acad. Sci. U.S.A. 85 1998 6622 6626
32. A. Mukherjee, J. Alejandro, S. Payne, and S. Thomas Age-related aneuploidy analysis of human blood cells in vivo by fluorescence in situ hybridization (FISH) Mech. Age. Dev. 90 1996 145 156
33. J. Nath, J. Tucker, and J. Hando Y chromosome aneuploidy, micronuclei, kinetochores and aging in men Chromosoma 103 1995 725 731
34. P. Neurath, K. DeRemer, B. Bell, L. Javrik, and T. Kato Chromosome loss compared with chromosome size, age ans sex of subjects Nature 225 1970 281 282
35. G. Nowinski, D. Van Dyke, B. Tilley, G. Jacobsen, V. Babu, M. Worsham, G. Wilson, and L. Weiss The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history Am. J. Hum. Genet. 46 1990 1101 1111
36. J.N. O'Sullivan, M.P. Bronner, T.A. Brentnall, J.C. Finley, W.T. Shen, S. Emerson, M.J. Emond, K.A. Gollahon, A.H. Moskovitz, D.A. Crispin, J.D. Potter, and P.S. Rabinovitch Chromosomal instability in ulcerative colitis is related to telomere shortening Nat. Genet. 32 2002 280 284
37. R. Pierre, and H. Hoagland Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with aging Cancer 30 1972 889 894
38. F. Richard, A. Aurias, J. Couturier, A. Dutrillaux, A. Flury-Herard, M. Gerbault-Seureau, F. Hoffschir, E. Lamoliatte, D. Lefrancois, M. Lombard, M. Muleris, M. Prieur, M. Ricoul, L. Sabatier, E. Viegas-Pequignot, V. Volobouev, and B. Dutrillaux Aneuploidy in human lymphocytes: an extensive study of eight individuals of various age Mutat. Res. 295 1993 71 80
39. D.E. Rooney, and B.H. Czepulkowski Prenatal Diagnosis and Tissue Culture in Human Cytogenetics: A Practical Approach 1992 Oxford University Press New York
40. L. Sandell, and V. Zakian Loss of a yeast telomere: arrest, recovery, and chromosome loss Cell 75 1993 729 739
41. J.W. Shay, D. Brasiskyte, M. Ouellette, M.A. Piatyszek, H. Werbin, Y. Ying, and W.E. Wright Analysis of telomerase and telomeres Meth. Mol. Gen. 5 1994 263 280
42. M. Stacey, M.S. Bennett, and M. Hulten FISH analysis on spontaneously arising micronuclei in the ICF syndrome J. Med. Genet. 32 1995 502 508
43. J. Surralles, M. Hande, R. Marcos, and P. Lansdorp Accelerated shortening in the human inactive X chromosome Am. J. Hum. Genet. 65 1999 1617 1622
44. M. Tavassoli, C. Ruhrberg, V. Beaumont, K. Reynolds, N. Kirkham, W.P. Collins, and F. Farzaneh Whole chromosome 17 loss in ovarian cancer Genes Chromosomes Cancer 8 1993 195 198
45. J. Tucker, J. Nath, and J. Hando Activation status of the X chromosome in human micronucleated lymphocytes Hum. Genet. 97 1996 471 475
46. H. Vaziri, F. Schachter, I. Uchida, L. Wei, X. Zhu, R. Effros, D. Cohen, and C. Harley Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes Am. J. Hum. Genet. 52 1993 661 667
47. H. Vaziri, W. Dragowska, R. Allsopp, T. Thomas, C. Harley, and P. Landsdorp Evidence for a mitotic clock in humans hematopoietic stem cells: loss of telomeric DNA with age Proc. Natl. Acad. Sci. U.S.A. 91 1994 9857 9860
48. S. Wenger, W. Golden, S. Dennis, and M. Steele Are the occasional aneuploid cells in peripheral blood cultures significant? Am J Med Genet. 19 1984 715 719