CD8α+ dendritic cells and immune protection from experimental allergic encephalomyelitis

Clinical and Experimental Immunology

Volumn 137, Issue 3, 2004, Pages 486-495

  Pettersson, A ^a   Wu, X C ^a   Ciumas, C ^a   Lian, H ^c   Chirsky, V ^a   Huang, Y M ^a   Bjelke, B ^a   Link, H ^a   Xiao, Bao Guo ^a,b  

^a FUDAN UNIVERSITY   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NONE

Author keywords

CD8 subset; Dendritic cells; Encephalomyelitis; Experimental allergic immunotherapy tolerance

Indexed keywords

INTERLEUKIN 10; NITRIC OXIDE; CD8 ANTIGEN; CD8ALPHA ANTIGEN; GAMMA INTERFERON;

ADOPTIVE IMMUNOTHERAPY; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; RAT; SPINAL CORD; SPLEEN; T LYMPHOCYTE; ANIMAL; BRAIN; IMMUNOLOGY; IMMUNOPHENOTYPING; LEWIS RAT; METHODOLOGY; PASSIVE IMMUNIZATION; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION; TRANSPLANTATION;

ANIMALS; ANTIGENS, CD8; BRAIN; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNE TOLERANCE; IMMUNIZATION, PASSIVE; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-10; MAGNETIC RESONANCE IMAGING; RATS; RATS, INBRED LEW; SPINAL CORD; T-LYMPHOCYTE SUBSETS;

EID: 4344664091     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2004.02556.x     Document Type: Article

References (46)

1. Bai XF, Li HL, Shi FD et al. Complexities of applying nasal tolerance induction as a therapy for ongoing relapsing experimental autoimmune encephalomyelitis in DA rats. Clin Exp Immunol 1998; 111:205-10.
2. Xu LY, Ishikawa M, Huang YM et al The complexity of cytokine treatment in ongoing EAE induced with MBP68-86 in Lewis rats. Clin Immunol 2000; 95:70-8.
3. Xiao BG, Wu XC, Yang JS et al. Therapeutic potential of IFN-γ-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis. Int Immunol 2004; 16:13-22.
4. Reis e Sousa C, Hieny S, Scharton-Kersten T et al. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med 1997; 186:1819-29.
5. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med 1999; 189:587-92.
6. Vremec D, Shortman K. Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J Immunol 1997; 159:565-73.
7. Kronin V, Wu L, Gong S, Nussenzweig MC, Shortman K. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses. Int Immunol 2000; 12:731-5.
8. α+ dendritic cells are responsible for inducing self-tolerance to tissue-associated antigens. J Exp Med 2002; 196:1099-104.
9. Kronin V, Winkel K, Suss G et al. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J Immunol 1996; 157:3819-27.
10. Suss G, Shortman K. A subclass of dendritic cells kills CD4T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med 1996; 183:1789-96.
11. McLellan AD, Kapp M, Eggert A et al. Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets by CD4 and CD8 expression. Blood 2002; 99:2084-93.
12. Hawiger D, Inaba K, Dorsett Y et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001; 194:769-79.
13. 8- dendritic cells. J Exp Med 2002; 196:817-27.
14. Voisine C, Hubert FX, Trinite B, Heslan M, Josien R. Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity. J Immunol 2002; 169:2284-91.
15. Crowley M, Inaba K, Witmer-Pack M, Steinman RM. The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell Immunol 1989; 118:108-25.
16. McLaren AJ, Marshall SE, Haldar NA et al. Adhesion molecule polymorphisms in chronic renal allograft failure. Kidney Int 1999; 55:1977-82.
17. Stober D, Schirmbeck R, Reimann J. IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells. J Immunol 2001; 167:957-65.
18. Brenan M, Puklavec M. The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin. J Exp Med 1992; 175:1457-65.
19. de la Mata M, Riera CM, Iribarren P. Identification of a CD8alpha (+) dendritic cell subpopulation in rat spleen and evaluation of its OX-62 expression. Clin Immunol 2001; 101:371-8.
20. + DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology 2003; 108:481-92.
21. Trinite B, Voisine C, Yagita H, Josien R. A subset of cytolytic dendritic cells in rat. J Immunol 2000; 165:4202-8.
22. O'Keeffe M, Hochrein H, Vremec D et al. Mouse plasmacytoid cells; long-lived cells, heterogeneous in phenotype and function, that differentiate into CD8 (+) dendritic cells only after microbial stimulus. J Exp Med 2002; 196:1307-19.
23. Vecchione A, Catchpole B, D'Mello F, Kanellos T, Hamblin A. Modulating immune responses with dendritic cells: an attainable goal in veterinary medicine? Vet Immunol Immunopathol 2002; 87:215-21.
24. Kronin V, Fitzmaurice CJ, Caminschi I, Shortman K, Jackson DC, Brown LE. Differential effect of CD8 (+) and CD8 (-) dendritic cells in the stimulation of secondary CD4 (+) T cells. Int Immunol 2001; 13:465-73.
25. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 2002; 23:445-9.
26. Roelen DL, Schuurhuis DH, van den Boogaardt DE et al. Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation 2003; 76:1608-15.
27. Zhang GX, Kishi M, Xu H, Rostami A. Mature bone marrow-derived dendritic cells polarize Th2 response and suppress experimental autoimmune encephalomyelitis. Multiple Sclerosis 2002; 8:463-8.
28. Fallarino F, Grohmann U, Vacca C, Bianchi R, Fioretti MC, Puccetti P. CD40 ligand and CTLA-4 are reciprocally regulated in the Th1 cell proliferative response sustained by CD8 (+) dendritic cells. J Immunol 2002; 169:1182-8.
29. Willenborg DO, Fordham SA, Staykova MA, Ramshaw IA, Cowden WB. IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J Immunol 1999; 163:5278-86.
30. Chu CQ, Wittmer S, Dalton DK. Failure to suppress the expansion of the activated CD4 T cell population in IFN-γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 2000; 192:123-8.
31. Tran EH, Prince EN, Owens T. IFN-γ shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 2000; 164:2759-68.
32. Weishaupt A, Jander S, Bruck W et al. Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: rapid induction of Th1-type cytokines and inducible nitric oxide synthase. J Immunol 2000; 165:7157-63.
33. Eriksson U, Kurrer MO, Bingisser R et al. Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction. Circulation 2001; 103:18-21.
34. Vermeire K, Thielemans L, Matthys P, Billiau A. The effects of NO synthase inhibitors on murine collagen-induced arthritis do not support a role of NO in the protective effect of IFN-gamma. J Leukoc Biol 2000; 68:119-24.
35. Refaeli YPL, Alexander SI, Abbas AK. Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med 2002; 196:999-1005.
36. Mullbacher A, Lobigs M, Hla RT, Tran T, Stehle T, Simon MM. Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis. J Immunol 2002; 169:145-50.
37. Yoshikawa H, Nakajima Y, Tasaka K. IFN-gamma induces the apoptosis of WEHI 279 and normal pre-B cell lines by expressing direct inhibitor of apoptosis protein binding protein with low pI. J Immunol 2001; 167:2487-95.
38. van der Veen RC. Nitric oxide and T helper cell immunity. Int Immunopharmacol 2001; 1:1491-500.
39. Shimamura H, Cumberland R, Hiroishi K, Watkins SC, Lotze MT, Baar J. Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide. J Immunother 2002; 25:226-34.
40. Fallarino F, Vacca C, Orabona C et al. Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha (+) dendritic cells. Int Immunol 2002; 14:65-8.
41. + subset. J Immunol 2000; 165:1357-63.
42. + regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003; 198:235-47.
43. Wakkach A, Fournier N, Brun V, Breittmayer JP, Cottrez F, Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003; 18:605-17.
44. den Haan JM, Lehar SM, Bevan MJ. CD8 (+) but not CD8 (-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 2000; 192:1685-96.
45. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994; 12:991-1045.
46. Bennett SR, Carbone FR, Karamalis F, Flavell RA, Miller JF, Heath WR. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 1998; 393:478-80.