The complexity of cytokine treatment in ongoing EAE induced with MBP peptide 68-86 in Lewis rats

Clinical Immunology

Volumn 95, Issue 1 I, 2000, Pages 70-78

  Xu, Ling Yun ^a   Ishikawa, Mikio ^a   Huang, Yu Min ^a   Levi, Michael ^b   Van Der Meide, Peter H ^c   Wahren, Britta ^b   Link, Hans ^a   Xiao, Bao Guo ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Experimental allergic encephalomyelitis; IL 10; Immunotherapy; Nasal administration; TGF 1

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; MYELIN BASIC PROTEIN; RECOMBINANT INTERLEUKIN 10; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; INTERLEUKIN 10; MYELIN BASIC PROTEIN 68 86; MYELIN BASIC PROTEIN 68-86; NITRIC OXIDE; PEPTIDE FRAGMENT; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; DENDRITIC CELL; GENE EXPRESSION; IMMUNOREGULATION; IMMUNOTHERAPY; IN SITU HYBRIDIZATION; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; TARGET CELL; ANIMAL; CD4+ T LYMPHOCYTE; DRUG ADMINISTRATION ROUTE; IMMUNOLOGY; LEWIS RAT; LYMPHOCYTE ACTIVATION; METABOLISM; SECRETION; SPINAL CORD; TH1 CELL; TH2 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DRUG ADMINISTRATION ROUTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERFERON TYPE II; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MYELIN BASIC PROTEINS; NITRIC OXIDE; PEPTIDE FRAGMENTS; RATS; RATS, INBRED LEW; SPINAL CORD; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034169948     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4833     Document Type: Article

References (34)

1. Liblau, R. S., Singer, S. M., and McDevitt, H. O., Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16, 34-38, 1997.
2. Caspi, R. R., IL-12 in autoimmunity. Clin. Immunol. Immunopathol. 88, 4-13, 1998.
3. Hagenbaugh, A., Sharma, S., Dubinett, S. M., Wei, S. H. Y., Aranda, R., Cheroutre, H., Fowell, D. J., Binder, S., Tsao, B., Locksley, R. M., Moore, K. W., and Kronenberg, M., Altered immune responses in interleukin-10 transgenic mice. J. Exp. Med. 185, 2101-2110, 1997.
4. Rott, O., Fleischer, B., and Cash, E., Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24, 1434-1440, 1994.
5. Xiao, B. G., Bai, X. F., Zhang, G. X., and Link, H., Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats. J. Neuroimmunol. 84, 230-237, 1998.
6. Link, H., and Xiao, B. G., Transforming growth factor beta: In "Encyclopedia of Immunology" second ed., Eds. (P. J. Delves and I. Roitt, Eds.), second ed., Vol. 4, pp. 2392-2398, Academic Press, London, 1998.
7. Pratt, B. M., and McPherson, J. M., TGF-beta in the central nervous system: Potential roles in ischemic injury and neurodegenerative diseases. Cytokine Growth Factor Rev. 8, 267-292, 1997.
8. Hohlfeld, R., Biotechnological agents for the immunotherapy of multiple sclerosis. Brain 120, 865-915, 1997.
9. Johns, L. D., and Sriram, S., Experimental allergic encephalomyelitis: Neutralizing antibody to TGF-β1 enhances the clinical severity of the disease. J. Neuroimmunol. 47, 1-7, 1993.
10. Wahl, S. M., Transforming growth factor beta: The good, the bad, and the ugly. J. Exp. Med. 180, 1587-1590, 1994.
11. Kuper, C. F., Koornstra, P. J., Hameleers, D. M. H., Biewenga, J., Spit, B. J., Duijvestijn, A. M., van Breda Vriesman, P. J., and Sminia, T., The role of nasaopharyngeal lymphoid tissue. Immunol. Today 13, 219-224, 1992.
12. Sminia, T., van der Brugge-Gamelkoorn, G. J., and Jeurissen, S. H., Structure and function of bronchus-associated tissue (BALT). Crit. Rev. Immunol. 9, 119-150, 1989.
13. Wu, H. Y., and Russell, M. W., Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system. Immunol. Res. 16, 187-201, 1997.
14. Xiao, B. G., and Link, H., Mucosal tolerance: a two-edged sword to prevent and treat autoimmune diseases. Clin. Immunol. Immunopathol. 85, 119-128, 1997.
15. Holmdahl, R., Olsson, T., Moran, T., and Klareskog, L., In vivo treatment of rats with monoclonal anti-T-cell antibodies: Immunohistochemical and functional analysis in normal rats and in experimental allergic neuritis. Scand. J. Immunol. 22, 157-169, 1985.
16. Zhang, G. X., Ma, C. G., Xiao, B. G., Bakhiet, M., Link, H., and Olsson, T., Depletion of CD8+ T cells suppresses the development of experimental autoimmune myasthenia gravis in Lewin rats. Eur. J. Immunol. 25, 1191-1198, 1995.
17. Olsson, T., Wang, W. Z., Höjieberg, B., Kostulas, V., Jiang, Y. P., Andersson, G., Ekre, H. P., and Link, H., Autoreactive T lymphocytes in multiple sclerosis determined by antigen induced secretion of interferon-gamma. J. Clin. Invest. 86, 981-985, 1990.
18. Dagerlind, Å., Friberg, K., Bean, A. J., and Hokfelt, T., Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 98, 39-49, 1992.
19. Link, J., Fredrikson, S., Soderstrom, M., Olsson, T., Hojeberg, B., Ljungdahl, A., Link, H., Organ-specific autoantigens induce transforming growth factor-beta mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Ann. Neurol. 35, 197-203, 1994.
20. Steinman, R. M., Kaplan, G., Witman, M. D., and Cohn, Z. A., Identification of a novel cell type in peripheral lymphoid organs of mice. J. Exp. Med. 149, 1-16, 1979.
21. Billiau, A., Interferon-gamma in autoimmune diseases. Cytokine Growth Factor Rev. 7, 25-34, 1996.
22. Bettelli, E., Das, M. P., Howard, E. D., Weiner, H. L., Sobel, R. A., and Kuchroo, V. K., IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4-deficient and transgenic mice. J. Immunol. 161, 3299-3306, 1998.
23. Nagelkerken, L., Blauw, B., and Tielemans, M., IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice. Int. Immunol. 9, 1243-1251, 1997.
24. Kroncke, K. D., Fehsel, K., and Kolb-Bachofen, V., Nitric oxide: Cytotoxicity versus cytoprotection - How, why, when and where? Nitric Oxide 1, 107-120, 1997.
25. Kolb, H., and Kolb-Bachofen, V., Nitric oxide in autoimmune disease: Cytotoxic or regulatory mediator? Immunol. Today 19, 556-562, 1998.
26. Röcken, M., Racke, M., and Shevach, E. M., IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17, 225-231, 1996.
27. Chatelain, R., Varkila, K., and Coffman, R. L., IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148, 1182-1187, 1992.
28. O'Garra, A., Steinman, L., and Gijbels, K., CD4+ T cell subsets in autoimmunity. Curr. Opin. Immunol. 9, 872-883, 1997.
29. Segal, B. M., Dwyer, B. K., and Shevach, E. M., An IL-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187, 537-546, 1998.
30. Cannella, B., and Raine, C. S., The adhesion molecules and cytokine profile of multiple sclerosis lesions. Ann. Neurol. 37, 424-435, 1995.
31. Liu, J., Marino, M. W., Wong, G., Grail, D., Dunn, A., Bettadapura, J., Slavin, A. J., Old, L., and Bernard, C. C. A., TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med. 4, 78-83, 1998.
32. Racke, M. K., Bonomo, A., Scott, D. E., Cannella, B., Levine, A., Raine, C. S., Shevach, E. M., and Rocken, M., Cytokine-induced immune deviation as therapy for inflammatory autoimmune disease. J. Exp. Med. 180, 1961-1966, 1994.
33. Tanaka, Y., Otsuka, T., Hotokebuchi, T., Mivahara, H., Nakashima, H., Kuga, S., Nemoto, Y., Niiro, H., and Niho, Y., Effect of IL-10 on collagen-induced arthritis in mice. Inflammation Res. 45, 283-288, 1996.
34. Cannella, B., Gao, Y. L., Brosnan, C., and Raine, C. S., IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45, 735-746, 1996.