Synthesis, radiosynthesis and preliminary in vivo evaluation of [ 123I]-(4-fluorophenyl) {1-[2-(2-iodophenyl)ethyl]piperidin-4-yl} methanone, a potential 5-HT2A-antagonist for SPECT brain imaging

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 47, Issue 9, 2004, Pages 591-598

  Blanckaert, P ^a,c   Vandecapelle, M ^a   Staelens, L ^a   Burvenich, I ^a   Dierckx, R A ^b   Slegers, G ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Faculty of Pharmaceutical Sciences   (Belgium)

Author keywords

5 HT2A receptor; Radiotracer; Serotonin; SPECT

Indexed keywords

BRAIN MAPPING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

5-HT2A-RECEPTOR; BRAIN IMAGING; IN-VIVO; METHANONE; RADIOSYNTHESIS; RADIOTRACER; SEROTONIN; SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHIES; SYNTHESISED; VIVO EVALUATION;

PARTICLE BEAMS;

4 FLUOROPHENYL [1 [2 (2 IODOPHENYL)ETHYL]PIPERIDIN 4 YL]METHANONE I 123; PIPERIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROMINATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; RADIOCHEMISTRY; RADIOIODINATION; REACTION ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ORYCTOLAGUS CUNICULUS;

EID: 4344661521     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.845     Document Type: Article

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