A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interaction with a modulating repressor

Nuclear Receptor

Volumn 2, Issue , 2004, Pages

  Uht, Rosalie M ^a   Webb, Paul ^b   Nguyen, Phuong ^b   Price Jr , Richard H ^c   Valentine, Cathleen ^d   Favre, Helene ^d   Kushner, Peter J ^d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AMGEN INC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; DNA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LIGAND; LYSINE; MIFEPRISTONE; PROGESTERONE RECEPTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA BINDING; ESTROGEN RESPONSIVE ELEMENT; GENE ACTIVATION; GENE MUTATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 4344645892     PISSN: 14781336     EISSN: None     Source Type: Journal    
DOI: 10.1186/1478-1336-2-2     Document Type: Article

References (30)

1. Webb Paul, Lopez Gabriela N., Uht Rosalie M., Kushner Peter J.: Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 1995, 9:443-456.
2. Liu MM, Albanese C, Anderson CM, Hilty K, Webb P, Uht RM, Price R. H., Jr., Pestell RG, Kushner PJ: Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 2002, 277:24353-24360.
3. Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM, Webb P: Estrogen receptor pathways to AP-1. Steroid Biochemistry & Molecular Biology 2000, 74:311-317.
4. Umayahara Y, Kawamori R, Watada H, Imano E, Iwama N, Morishima T, Yamasaki Y, Kajimoto Y, Kamada T: Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J Biol Chem 1994, 269:16433-16442.
5. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites [see comments]. Science 1997, 277:1508-1510.
6. Philips Alexandre, Teyssier Catherine, Galtier Florence, Rivier-Covas Corinne, Rey Jean-Marc, Rochefort Henri, Chalbos Dany: FRA-1 Expression Level Modulates Regulation of Activator protein-1 Activity by Estradiol in Breast Cancer Cells. Mol Endocrinol 1998, 12:973-985.
7. Shang Y, Brown M: Molecular determinants for the tissue specificity of SERMs. [see comments.]. Science 2002, 295:2465-2468.
8. Webb P, Nguyen P, Valentine C, Lopez GN, Kwok GR, McInerney E, Katzenellenbogen BS, Enmark E, Gustafsson J-Å, Nilsson S, Kushner PJ: The Estrogen Receptor Enhances AP-1 Activity by two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions. Mol Endocrinol 1999, 13:1672-1685.
9. Webb P, Nguyen P, Kushner PJ: Differential SERM effects on corepressor binding dictate ERalpha activity in vivo. J Biol Chem 2003, 278:6912-6920.
10. Yang-Yen Hsin-Fang, Chambard Jean-Claude, Sun Yu-Lin, Smeal Tod, Schmidt Thomas J., Drouin Jacques, Karin Michael: Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990, 62:1205-1215.
11. Starr D.Barry, Matsui William, R. Thomas Jay, Yamamoto Keith R.: Intracellular receptors use a common mechanism to interpret signaling information at response elements. Genes & Dev 1996, 10:1271-1283.
12. Tora L, Mullick A, Metzger D, Ponglikitmongkol M, Park I, Chambon P: The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J 1989, 8:1981-1986.
13. Danielian PS, White R, Lees JA, Parker MG: Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J 1992, 11:1025-1033.
14. Webb P, Valentine C, Nguyen P, Price R. H., Jr., Marimuthu A, West BL, Baxter JD, Kushner PJ: ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus. Nucl Recept 2003, 1:4.
15. Zhang Xun, Jeyakumar M, Petukhov Sergei, Bagchi Milan K.: A Nuclear Receptor Corepressor Modulates Transcriptional Activity of Antagonist-Occupied Steroid Hormone Receptor. Mol Endocrinol 1998, 12:513-524.
16. Lopez G, Schaufele F, Webb P, Holloway JM, Baxter JD, Kushner PJ: Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site. Mol Cell Biol 1993, 13:3042-3049.
17. Jaaskelainen Tiina, Pirskanen Asta, Ryhanen Sanna, Palvimo Jorma J., Deluca Hector F., Maenpaa Pekka: Functional interference between AP-1 and the vitamin D receptor on osteocalcin gene expression in human osteosarcoma cells. Eur J Biochem 1994, 224:11-20.
18. Bjornstrom L, Sjoberg M: Mutations in the estrogen receptor DNA-binding domain discriminate between the classical mechanism of action and cross-talk with Stat5b and activating protein 1 (AP-1). J Biol Chem 2002, 277:48479-48483.
19. Wardell SE, Boonyaratanakornkit V, Adelman JS, Aronheim A, Edwards DP: Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. Mol Cell Biol 2002, 22:5451-5466.
20. Janne OA, Moilanen AM, Poukka H, Rouleau N, Karvonen U, Kotaja N, Hakli M, Palvimo JJ: Androgen-receptor-interacting nuclear proteins. Biochem Soc Trans 2000, 28:401-405.
21. Mathur Mukul, Tucker Philip W., Samuels Herbert H.: PSF is a Novel Corepressor that Mediates its Effect through Sin3A and the DNA Binding Domain of Nuclear Hormone Receptors. Mol Cell Biol 2001, 21:2298-2311.
22. Oesterreich S, Zhang QP, Hopp T, Fuqua SAW, Michaelis M, Zhao HH, Davie JR, Osborne CK, Lee AV: Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation. Mol Endocrinol 2000, 14:369-381.
23. Wang C, Fu M, Angeletti RH, Siconolfi-Baez L, Reutens AT, Albanese C, Lisanti MP, Katzenellenbogen BS, Kato S, Hopp T, Fuqua SA, Lopez GN, Kushner PJ, Pestell RG: Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. J Biol Chem 2001, 276:18375-18383.
24. Kahlen J-P, Carlberg C: Allosteric interaction of the 1a,25-dihydroxyvitamin D3 receptor and the retinoid X receptor on DNA. NAR 1997, 25:4307-4313.
25. Green Stephen, Walter Philippe, Kumar Vijay, Krust Andree, Bornert Jean-Marc, Argos Patrick, Chambon Pierre: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986, 320:134-139.
26. Uht Rosalie M., Anderson Carol M., Webb Paul, Kushner Peter J.: Transcriptional Activities of Estrogen and Glucocorticoid Receptors Are Functionally Integtrated at the AP-1 Response Element. Endocrinology 1997, 138:2900-2908.
27. Kunkel TA: Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natt Acad Sci, U S A 1985, 82:488-492.
28. Lopez GN, Webb P, Shinsako JH, Baxter JD, Greene GL, Kushner PJ: Titration by estrogen receptor activation function-2 of targets that are downstream from coactivators. Mol Endocrinol 1999, 13:897-909.
29. Webb P, Nguyen P, Shinsako J, Anderson C, Feng W, Nguyen MP, Chen D, Huang SM, Subramanian S, McKinerney E, Katzenellenbogen BS, Stallcup MR, Kushner PJ: Estrogen receptor activation function 1 works by binding p160 coactivator proteins. Mol Endocrinol 1998, 12:1605-1618.
30. Iniguez-Lluhi JA, Pearce D: A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol 2000, 20:6040-6050.