Intracellular receptors use a common mechanism to interpret signaling information at response elements

Genes and Development

Volumn 10, Issue 10, 1996, Pages 1271-1283

  Starr, D Barry ^a   Matsui, William ^b   Thomas, Jay R ^c   Yamamoto, Keith R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Context dependent activity; DNA binding domain; Glucocorticoid receptor; Intracellular receptor; Transcriptional repression

Indexed keywords

GLUCOCORTICOID RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE ISOLATION; HORMONE RESPONSIVE ELEMENT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SIGNAL PROCESSING; TRANSCRIPTION REGULATION; YEAST;

ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; MOLECULAR SEQUENCE DATA; MUTAGENESIS; RATS; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RECEPTORS, RETINOIC ACID; REGULATORY SEQUENCES, NUCLEIC ACID; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS);

EID: 0029894563     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.10.1271     Document Type: Article

References (73)

1. Baichwal, V.R. and R. Tjian. 1990. Control of c-Jun by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun. Cell 63: 815-825.
2. Ballard, P.L. 1989. Hormonal regulation of pulmonary surfactant. Endocrinol. Rev. 10: 165-181.
3. Bohen, S.P. and K.R. Yamamoto. 1993. Isolation of Hsp90 mutants by screening for decreased steroid receptor function. Proc. Natl. Acad. Sci. 90: 11424-11428.
4. Chen, J.D. and R.M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457.
5. Dalman, F.C., L.C. Scherrer, L.P. Taylor, H. Akil, and W.B. Pratt. 1991. Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. J. Biol. Chem. 266: 3482-3490.
6. de Wet, J.R., K.V. Wood, M. DeLuca, D.R. Helinsk, and S. Subramani. 1987. Firefly luciferase gene: Structure and expression in mammalian cells. Mol. Cell. Biol. 7: 725-737.
7. Diamond, M., J.N. Miner, S.K. Yoshinaga, and K.R. Yamamoto. 1990. Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element. Science 249: 1266-1272.
8. Freedman, L.P., B.F. Luisi, Z.R. Korszun, R. Basavappa, P.B. Sigler, and K.R. Yamamoto. 1988. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature 334: 543-546.
9. Freedman, L.P., S.K. Yoshinaga, J.N. Vanderbilt, and K.R. Yamamoto. 1989. In vitro transcriptional enhancement by purified derivatives of the glucocorticoid receptor. Science 245: 298-301.
10. Frenkel, B., M. Montecino, J.L. Stein, J.B. Lian, and G.S. Stein. 1994. A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: Promoter and cell type requirements. Proc. Natl. Acad. Sci. 91: 10923-10927.
11. Fujita, T., G.P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κ B. Genes & Dev. 6: 775-787.
12. Garabedian, M.J. and K.R. Yamamoto. 1992. Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast. Mol. Biol. Cell 3: 1245-1257.
13. Giguere, V., S.M. Hollenberg, M.G. Rosenfeld, and R.M. Evans. 1986. Functional domains of the human glucocorticoid receptor. Cell 46: 645-652.
14. Godowski, P.J., S. Rusconi, R. Miesfeld, and K.R. Yamamoto. 1987. Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325: 365-368.
15. Godowski, P.J., D. Picard, and K.R. Yamamoto. 1988. Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins. Science 241: 812-816.
16. Green, S. and P. Chambon. 1987. Oestradiol induction of a glucocorticoid response gene by a chimeraic receptor. Nature 325: 75-78.
17. Guarente, L. and M. Ptashne. 1981. Fusion of Escherichia coli Lac Z to the cytochrome c gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 78: 2199-2203.
18. Guarente, L., J.S. Nye, A. Hochschild, and M. Ptashne. 1982. A mutant lambda repressor with a specific defect in its positive control function. Proc. Natl. Acad. Sci. 79: 2236-2239.
19. Hard, T., E. Kellenbach, R. Boelens, B.A. Maler, K. Dahlman, L.P. Freedman, J. Carlstedt-Duke, K.R. Yamamoto, J.-A. Gustafsson, and R. Kaptein. 1990. Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249: 157-160.
20. Heck, S., M. Kullman, A. Gast, H. Ponta, H.J. Rahmsdorf, P. Herrlich, and A.C.B. Cato. 1994. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13: 4087-4095.
21. Herrlich, P. and H. Ponta. 1994. Mutual cross-modulation of steroid-retinoic acid receptor and AP-1 transcription factors: A novel property with practical implications. Trends Endocrinol. Metab. 5: 341-346.
22. Hollenberg, S.M. and R.M. Evans. 1988. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell 55: 899-906.
23. Hoopes, B.C., J.F. LeBlanc, and D.K. Hawley. 1992. Kinetic analysis of yeast TFIID-TATA box complex formation suggests a multi-step pathway. J. Biol. Chem. 267: 1539-1547.
24. Hori, R. and M. Carey. 1994. The role of activators in assembly of RNA polymerase II transcription. Curr. Opin. Genet. Dev. 4: 236-244.
25. Horlein, A.J., A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C.K. Glass, and M.G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377: 397-404.
26. Howard, K.J. and C.W. Distelhorst. 1988. Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein. J. Biol. Chem. 263: 3474-3481.
27. Howard, K.J., S.J. Holley, K.R. Yamamoto, and C.W. Distelhorst. 1990. Mapping the Hsp90 binding region of the glucocorticoid receptor. J. Biol. Chem. 265: 11928-11935.
28. Imai, E., J.N. Miner, J.A. Mitchell, K.R. Yamamoto, and D.K. Granner. 1993. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268: 5353-5356.
29. Jantzen, H.M., U. Strahle, B. Gloss, F. Stewart, W. Schmid, M. Boshart, R. Miksicek, and G. Schutz. 1987. Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 49: 29-38.
30. Jonat, C., H.J. Rahmsdorf, K.-K. Park, A.C.B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1189-1204.
31. Keleher, C.A., C. Goutte, and A.D. Johnson. 1988. The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein. Cell 53: 927-936.
32. Komachi, K., M.J. Redd, and A.D. Johnson. 1994. The WD repeats of Tup1 interact with the homeo domain protein α2. Genes & Dev, 8: 2857-2807.
33. Konig, H., H. Ponta, H.J. Rahmsdorf, and P. Herrlich. 1992. Interference between pathway-specific transcription factors: Glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J. 11: 2241-2246.
34. Kunkel, T.A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. 82: 488-492.
35. Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M.G. Rosenfeld, and C.K. Glass. 1995. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377: 451-454.
36. Lefstin, J.A., J.R. Thomas, and K.R. Yamamoto. 1994. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes & Dev. 8: 2842-2856.
37. Leung, D.W., E. Chen, and D.V. Goeddel. 1989. A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction. Technique 1: 11-15.
38. Lucibello, F.C., E.P. Slater, K.U. Jooss, M. Beato, and R. Muller. 1990. Mutual transrepression of fos and the glucocorticoid receptor: Involvement of a functional domain in fos which is absent in fosB. EMBO J. 9: 2827-2834.
39. Luisi, B.F., W.X. Xu, Z. Otwinowski, L.P. Freedman, K.R. Yamamoto, and P.B. Sigler. 1991. Crystallographic analysis of the interaction of the glucocorticoid receptor and DNA. Nature 352: 497-505.
40. McKnight, S.L. and R. Kingsbury. 1982. Transcriptional control signals of a eukaryotic protein-coding gene. Science 217: 316-324.
41. Meyer, B.J., R. Mauer, and M. Ptashne. 1980. λ repressor directly activates gene transcription. J. Mol. Biol. 139: 195-205.
42. Miller, J., A.D. McLachlan, and A. Klug. 1985. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 4: 1609-1614.
43. Miner, J.N., M.I. Diamond, and K.R. Yamamoto. 1991. Joints in the regulatory lattice: Composite regulation by steroid receptor-AP1 complexes. Cell Growth Differ. 2: 525-530.
44. Mittal, R., K.U. Kumar, A. Pater, and M.M. Pater. 1994. Differential regulation by c-jun and c-fos protooncogenes of hormone response from composite glucocorticoid response element in human papilloma virus type 16 regulatory region. Mol. Endocrinol. 8: 1701-1708.
45. Mordacq, J.C. and D.I.H. Linzer. 1989. Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression. Genes & Dev. 3: 760-769.
46. Niu, W., Y. Zhou, Q. Dong, Y.W. Ebright, and R.H. Ebright. 1994. Characterization of the activating region of Escherichia coli catabolite gene activator protein (CAP). I. Saturation and alanine-scanning mutagenesis. J. Mol. Biol. 243: 595-602.
47. Orth, D.N., W.J. Kovacs, and C.R. Debold. 1992. Williams textbook of endocrinology (ed. J.D. Wilson and D.W. Foster). Saunders, Philadelphia, PA.
48. Pearce, D. and K.R. Yamamoto. 1993. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259: 1161-1165.
49. Pedersen, H., L. Sogaard-Andersen, B. Hoist, and P. Valentin-Hansen. 1991. Heterologous cooperativity in Escherichia coli. The CytR repressor both contacts DNA and the cAMP receptor protein when binding to the deoP2 promoter. J. Biol. Chem. 266: 17804-17808.
50. Picard, D. and K.R. Yamamoto. 1987. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J. 6: 3333-3340.
51. Pignoni, F., R.M. Baldarelli, E. Steingrimsson, R.J. Diaz, A. Patapoutian, J.R. Merriam, and J.A. Lengyel. 1990. The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62: 151-163.
52. Pratt, W.B., D.J. Jolly, D.V. Pratt, S.M. Hollenberg, V. Giguere, F.M. Cadepond, G. Schweizer-Groyer, M.-G. Catelli, R.M. Evans, and E.-E. Baulieu. 1988. A region in the steroid binding domain determines the formation of the non-DNA binding, 9 S glucocorticoid receptor complex. J. Biol. Chem. 263: 267-273.
53. Ray, A., K.S. LaForge, and P.B. Sehgal. 1991. Repressor to activator switch by mutations in the first Zn finger of the glucocorticoid receptor: Is direct binding necessary? Proc. Natl. Acad. Sci. 88: 7086-7090.
54. Ray, A. and K.E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. 91: 752-756.
55. Rusconi, S. and K.R. Yamamoto. 1987. Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J. 6: 1309-1315.
56. Saatcioglu, F., F.-X. Claret, and M. Karin. 1994. Negative transcriptional regulation by nuclear receptors. Semin. Cancer Biol. 5: 347-359.
57. Scheinman, R.I., A. Gualberto, C.M. Jewell, J.A. Cidlowski, and A.S. Baldwin. 1995. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol. Cell. Biol. 15: 943-953.
58. Schena, M. and K.R. Yamamoto. 1988. Mammalian glucocorticoid receptor derivatives enhance transcription in yeast. Science 241: 965-967.
59. Schule, R., P. Rangarajan, S. Kliewer, L.J. Ransone, J. Bolado, N. Yang, I.M. Verma, and R.M. Evans. 1990. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62: 1217-1226.
60. Schule, R., P. Rangarajan, N. Yang, S. Kliewer, L.J. Ransone, J. Bolado, I.M. Verma, and R.M. Evans. 1991. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc. Natl. Acad. Sci. 88: 6092-6096.
61. Sheldon, M. and D. Reinberg. 1995. Transcriptional activation. Tuning-up transcription. Curr. Biol. 5: 43-46.
62. Sleigh, M.J. 1986. A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells. Anal. Biochem. 156: 251-256.
63. Tan, S. and T.J. Richmond. 1990. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 62: 367-377.
64. Tjian, R. and T. Maniatis. 1994. Transcriptional activation: A complex puzzle with few easy pieces. Cell 77: 5-8.
65. Tsai, M.-J. and B.W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63: 451-486.
66. Tsai, S.Y., J. Carlstedt-Duke, N.L. Weigel, K. Dahlman, J.A. Gustafsson, M.-J. Tsai, and B.W. O'Malley. 1988. Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation. Cell 63: 361-369.
67. Vivanco, M.d.M., R. Johnson, P.E. Galante, D. Hanahan, and K.R. Yamamoto. 1995. A transition in transcription activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. EMBO J. 14: 2217-2228.
68. Vivanco-Ruiz, M.d.M., T. Bugge, P. Hirschmann, and H.G. Stunnenberg. 1991. Functional characterization of a natural retinoic acid receptor. EMBO J. 10: 3829-3838.
69. Wu, A., J.A. Wemmie, N.P. Edgington, M. Goebel, J.L. Guevara, and W.S. Moye-Rowley. 1993. Yeast bZIP proteins mediate pleiotropic drug and metal resistance. J. Biol. Chem. 268: 18850-18858.
70. Yamamoto, K.R., D. Pearce, J.R. Thomas, and J.N. Miner. 1993. Combinatorial regulation at a mammalian composite element. In Transcriptional regulation (ed. S.L. McKnight and K.R. Yamamoto), pp. 3-32. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
71. Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T.J. Schmidt, J. Drouin, and M. Karin. 1990. Transcriptional interference between c-jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62: 1205-1215.
72. Yang-Yen, H.-F., X.K. Zhang, G. Graupner, M. Tzukerman, B. Sakamoto, M. Karin, and M. Pfahl. 1991. Antagonism between retinoic acid receptors and AP-1: Implications for tumor promotion and inflammation. New Biol. 3: 1206-1219.
73. Yu, R.T., M. McKeown, R.M. Evans, and K. Umesono. 1994. Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx. Nature 370: 375-379.