Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis

Journal of Dental Research

Volumn 82, Issue 12, 2003, Pages 987-992

  Lohinai, Z ^a,b   Mabley, J G ^b   Feher E ^a   Marton, A ^b   Komjati K ^a,b   Szabo C ^a,b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INOTEK CORPORATION   (United States)

Author keywords

DNA breaks; Gingiva; Gut; Inflammation; Knockout; Mice; Nitric oxide; Periodontal disease; Peroxynitrite; Poly(ADP ribose) polymerase; Rat

Indexed keywords

N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NUCLEAR PROTEIN; PHENANTHRENE DERIVATIVE; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ANIMAL; ARTICLE; CELL NUCLEUS; COMPARATIVE STUDY; CONNECTIVE TISSUE; DISEASE MODEL; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYMOLOGY; GINGIVA; LIGATION; MALE; MOUSE; MOUSE MUTANT; MOUTH MUCOSA; OSTEOLYSIS; PATHOLOGY; PERIODONTITIS; PLASMA; RAT; WISTAR RAT;

ALVEOLAR BONE LOSS; ANIMALS; CELL NUCLEUS; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GINGIVA; LIGATION; MALE; MICE; MICE, KNOCKOUT; MOUTH MUCOSA; NUCLEAR PROTEINS; PERIODONTITIS; PHENANTHRENES; PLASMA; POLY ADENOSINE DIPHOSPHATE RIBOSE; RATS; RATS, WISTAR;

EID: 4344640211     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910308201210     Document Type: Article

References (30)

1. Atici K, Yamalik N, Eratalay K, Etikan I (1998). Analysis of gingival crevicular fluid intracytoplasmic enzyme activity in patients with adult periodontitis and rapidly progressive periodontitis. A longitudinal study model with periodontal treatment. J Periodontol 69:1155-1163.
2. Bang J, Cimasoni G, Rosenbusch C, Duckert A (1973). Sodium, potassium and calcium contents of crevicular exudate: their relations to gingivitis and periodontitis. J Periodontol 44:770-774.
3. Berger NA, Berger SJ (1986). Metabolic consequences of DNA damage: the role of poly (ADP-ribose) polymerase as mediator of the suicide response. Basic Life Sci 38:357-363.
4. Buzina R (1976). Early signs of niacin deficiency. Bibl Nutr Dieta 23:88-94.
5. Cheraskin E, Ringsdorf WM Jr (1969). Effect of regular versus sustained-release multivitamin supplementation upon periodontal parameters. II. Sulcus depth and clinical tooth mobility. Int Z Vitaminforsch 39:476-485.
6. Crawford JM, Wilton JM, Richardson P (2000). Neutrophils die in the gingival crevice, periodontal pocket, and oral cavity by necrosis and not apoptosis. J Periodontol 71:1121-1129.
7. Cosi C (2002). New inhibitors of poly(ADP-ribose) polymerase and their potential therapeutic targets. Expert Opin Ther Patents 12:1047-1071.
8. Darveau RP, Arbabi S, Garcia I, Bainbridge B, Maier RV (2002). Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation. Infect Immun 70:1867-1873.
9. Dreizen S, Levy BM, Bernick S (1977). Studies on the biology of the periodontium of marmosets. XIII. Histopathology of niacin deficiency stomatitis in the marmoset. J Periodontol 48:452-455.
10. Ehrlich W, Huser H, Kroger H (1995). Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide. Rheumatol Int 15:171-172.
11. Ghani QP, Armitage GC, Hussain MZ (1996). Biochemical alterations in inflammatory periodontal diseases I. Poly (ADP-ribose) synthetase activity in gingiva and gingival fibroblasts from humans with periodontitis. J Periodontal Res 31:445-452.
12. Hussain MZ, Ghani QP, Zhang JC, Enriquez B, Hayashi C, Wirthlin MR (1994). Alterations of fibroblast metabolism in early ligature-induced periodontitis in the cynomolgus monkey. J Periodontol 65:771-775.
13. Jagtap P, Soriano FG, Virag L, Liaudet L, Mabley J, Szabo E, et al. (2002). Novel phenanthridinone inhibitors of poly (adenosine 5′ - diphosphate-ribose) synthetase: potent cytoprotective and antishock agents. Crit Care Med 30:1071-1082.
14. Le Page C, Sanceau J, Drapier JC, Wietzerbin J (1998). Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation. Biochem Biophys Res Commun 243:451-457.
15. rd ed. Copenhagen: Munksgaard.
16. Lohinai Z, Szabo C (1998). Role of nitric oxide in periodontal tissues in health and disease (review). Med Sci Monit 4:1089-1095.
17. Lohinai Z, Benedek P, Feher E, Györfi A, Rosivall L, Fazekas A, et al. (1998). Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase in ligature-induced periodontitis in the rat (published erratum appears in Br J Pharmacol 123:1741, 1998). Br J Pharmacol 123:353-360.
18. Lohinai Z, Stachlewitz R, Szekely AD, Feher E, Dezsi L, Szabo C (2001a). Evidence for the expression of cyclooxygenase-2 enzyme in periodontitis. Life Sci 70:279-290.
19. Lohinai Z, Stachlewitz R, Virag L, Székely AD, Hasko G, Szabo C (2001b). Evidence for reactive nitrogen species formation in the gingivomucosal tissue. J Dent Res 80:470-475.
20. Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virag L, et al. (2001). Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res 50:561-569.
21. Oliver FJ, Menissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, et al. (1999). Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 18:4446-4454.
22. Salvemini D, Mazzon E, Dugo L, Serraino I, De Sarro A, Caputi AP, et al. (2001). Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic. Arthritis Rheum 44:2909-2921.
23. Soriano FG, Pacher P, Mabley J, Liaudet L, Szabo C (2001). Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 89:684-691.
24. Sugita N, Kimura A, Matsuki Y, Yamamoto T, Yoshie H, Hara K (1998). Activation of transcription factors and IL-8 expression in neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis. Inflammation 22:253-267.
25. Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL (1997). Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 100:723-735.
26. Taguchi S, Wada T, Kijima S, Yoshie H, Hara K, Tonomura M, et al. (1989). Effects of nicotinate ethyl ester treatment on gingival blood circulation of experimental gingivitis in monkeys. Nippon Shishubyo Gakkai Kaishi 31:184-199.
27. Virag L, Szabo C (2002). The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54:375-429.
28. Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, et al. (1995). Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 9:509-520.
29. Wu X, Molinaro C, Johnson N, Casiano CA (2001). Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for systemic autoimmunity. Arthritis Rheum 44:2642-2652.
30. Yoneda K, Yamamoto T, Ueta E, Osaki T (1997). Suppression by azelastine hydrochloride of NF-kappa B activation involved in generation of cytokines and nitric oxide. Jpn J Pharmacol 73:145-153.