Intracerebroventricular injection of trazodone produces 5-HT receptor subtype mediated anti-nociception at the supraspinal and spinal levels

European Neuropsychopharmacology

Volumn 14, Issue 5, 2004, Pages 419-424

  Zhang, Rihui ^a   Nagata, Tomonari ^a   Hayashi, Takayuki ^a   Miyata, Mariko ^a   Kawakami, Yoriko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

5 HT1A receptor; 5 HT3 receptor; Formalin test; Pain; Trazodone; WAY 100635

Indexed keywords

3 TROPANYLINDOLE 3 CARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; FORMALDEHYDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 3 ANTAGONIST; TRAZODONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HYPERALGESIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MALE; MICE; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; PIPERAZINES; PYRIDINES; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SPINAL CORD; TRAZODONE;

EID: 4344629758     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2003.12.006     Document Type: Article

References (38)

1. 1A receptor gene. J. Biol. Chem. 265:1990;5825-5832
2. 3 receptor-mediated antinocieption: possible release of GABA. J. Neurosci. 11:1991;1881-1888
3. Araneda R., Andrade R. 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 40:1991;399-412
4. 1A receptor-mediated, behaviorally specific analgesia. Eur. J. Pharmacol. 421:2001;109-114
5. Baldessarini R.J. Drugs and treatment of psychiatric depression and anxiety disorders. Hardman J.G., Limbird L.E., Gilman A.G. The Pharmacological Basis of Therapeutics. 2001;447-485 McGraw-Hill, New York
6. 2A receptor ligands. Arch. Parnazie. 329:1996;283-290
7. Claramella A., Grosso S., Poli P. Fluoxetine versus fluvoxamine for treatment of chronic pain. Minerva Anesth. 66:2000;55-61
8. Field H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14:1991;219-245
9. Foster C.A., Bafaloukes J. Paroxetine in the treatment of chronic daily headache. Headache. 34:1994;587-589
10. Frank R.G., Kashani J.H., Parker J.C., Beck N.C., Browniee-Duffeck M., Elliott T.R., Haut A.E., Atwood C., Smith E., Kay D.R. Antidepressant analgesia in rheumatoid arthritis. J. Rheumatol. 15:1988;1632-1638
11. 3 reduced hyperexcitability of dorsal horn neurons after chronic spinal cord hemisection injury in rat. Exp. Brain Res. 149:2003;174-186
12. Halliday G., Harding A., Paxinos G. Serotonin and tachykinin system. Paxinos G. The Rat Nervous System. 1995;929-974 Academic Press, New York
13. 3 receptor binding sites are on capsaicin-sensitive fibbers in the rat spinal cord. Eur. J. Pharmacol. 164:1989;315-322
14. 1A receptors in quiet awake rats, in vivo electrophysiological evidence. Neuropsychopharmacology. 24:2001;141-151
15. Kawamata T., Omote K., Kawamata M., Namiki A. Intracerebroventricular morphine produces antinociception by evoking gamma-aminobutyric acid release through activation of 5-hydroxytryptamine 3 receptor in the spinal cord. Aresthesiology. 96:2002;1175-1182
16. 3 induced anti-nocicption. Br. J. Pharmacol. 127:1999;843-852
17. 1A recptor localization on the axon hillock of cervical spinal motoneurons in primates. J. Comp. Neurol. 355:1995;11-220
18. Khurana R.C. Treatment of painful diabetic neuropathy with trazodone. J. Am. Med. Assoc. 250:1983;1392
19. Kia H.K., Miquel M.-C., Brisorgueh M.J., Daval G., Riad M., Mestikawy S.E., Hamon M., Verge D. Immunocytochemical localization of serotonin1A receptors in the rat central nervous system. J. Comp. Neurol. 365:1996;289-305
20. Kia H.K., Brisorgueil M.J., Hamon M., Calas A., Verge D. Ultrastructural localization of 5-hydroxvtryptamine1A receptors in the rat brain. J. Neurosci. Res. 46:1996;697-708
21. Kinney G.G., Griffith J.C., Hudzik T.J. Antidepressant-like effects of 5-hydroxytryptamine 1A receptor agonists on operant responding under a response duration differentiation schedule. Behav. Pharmacol. 9:1998;309-318
22. 1A receptors: regional distribution and functional characteristics. Nucl. Med. Biol. 27:2000;429-435
23. T2 receptors in the rat spinal cord. Brain Res. 550:1991;15-23
24. 2C receptors-mediating inhibition of the N-methyl-D-aspartate/nitric oxide/cyclic GMP pathway in rat cerebellum. J. Pharmacol. Exp. Ther. 285:1998;983-986
25. 1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice. Pain. 58:1994;45-61
26. Miller K.E., Salvatierra A.T. Apposition of enkephalin and neurotensin -immunoreactive neurons by serotonin-immunoreactive varicosities in the rat spinal. Neuroscience. 85:1998;837-846
27. 3 receptor subtype in the rat brain and spinal cord. J. Comp. Neurol. 385:1998;385-401
28. Onghena P., Houdenhove B.V. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain. 49:1992;205-219
29. 3) receptors mediate spinal 5-HT antinociception: an antisense approach. Pharmacol. Exp. Ther. 298:2001;674-678
30. Pazzagli M., Giovannini M.G., Pepeu G. Trazodone increases extracellular serotonin levels in the frontal cortex. Eur. J. Pharmacol. 383:1999;249-257
31. Ropert N., Guy N. Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampaus in vitro. J. Physiol. 441:1991;121-136
32. Sanchez-Blazquez P., Garcia-Espana A., Garzon J. In vivo injection of antisense oligodeoxynucleotides to G å subunits and supraspinal analgesia evoked by μ and u-opioid agonists. J. Pharmacol. Exp. Ther. 275:1995;1590-1596
33. 3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test. Eur. J. Pharmacol. 424:2001;45-52
34. Schreiber S., Backer M.M., Yanai J., Pick C.G. The antinociceptive effects of fluvoxamine. Eur. Neuropsychopharmacol. 6:1996;281-284
35. Schreiber S., Backer M.M., Herman I., Shamir D., Boniel T., Pick C.G. The antinociceptive effect of trazodone in mice is mediated through both u-opioid and serotonergic mechanisms. Behav. Brain Res. 114:2000;51-56
36. 3 receptors in the spinal cord dorsal horn: single cell RT-PCR analysis. Neuroreport. 10:1999;2749-2753
37. Wilson R.C. The use of low-dose trazodone in the treatment of painful diabetic neuropathy. J. Am. Ped. Med. Assoc. 89:1999;468-471
38. Zhang R., Nagata T., Katayama Y., Oshima T., Kawakami Y. Behavioral and electrophysiological studies on antinociception induced by trazodone, a selective serotonin reuptake inhibitor. Jpn. J. Physiol. 52:2002;S158. (Abstract, 79th Annual Meeting of Physiological Society of Japan)