-
1
-
-
0038637317
-
Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?
-
Litvinov IV, De Marzo AM, Isaacs JT. Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling? J Clin Endocrinol Metab 2003;88:2972-82.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2972-2982
-
-
Litvinov, I.V.1
De Marzo, A.M.2
Isaacs, J.T.3
-
2
-
-
0031922434
-
Relation between Bcl-2, cell proliferation, and the androgen receptor status in prostate tissue and precursors of prostate cancer
-
Bonkhoff H, Fixemer T, Remberger K. Relation between Bcl-2, cell proliferation, and the androgen receptor status in prostate tissue and precursors of prostate cancer. Prostate 1998;34:251-8.
-
(1998)
Prostate
, vol.34
, pp. 251-258
-
-
Bonkhoff, H.1
Fixemer, T.2
Remberger, K.3
-
3
-
-
0035392953
-
Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells
-
Gao J, Arnold JT, Isaacs JT. Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Cancer Res 2001;61:5038-44.
-
(2001)
Cancer Res
, vol.61
, pp. 5038-5044
-
-
Gao, J.1
Arnold, J.T.2
Isaacs, J.T.3
-
4
-
-
0025298231
-
Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation
-
Kyprianou N, English HF, Isaacs JT. Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation. Cancer Res 1990;50:3748-53.
-
(1990)
Cancer Res
, vol.50
, pp. 3748-3753
-
-
Kyprianou, N.1
English, H.F.2
Isaacs, J.T.3
-
5
-
-
0036219874
-
Mechanisms involved in the progression of androgen-independent prostate cancers: It is not only the cancer cell's fault
-
Arnold JT, Isaacs JT. Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault. Endocr Relat Cancer 2002;9:61-73.
-
(2002)
Endocr Relat Cancer
, vol.9
, pp. 61-73
-
-
Arnold, J.T.1
Isaacs, J.T.2
-
6
-
-
1842612442
-
Androgen receptor outwits prostate cancer drugs
-
Isaacs JT, Isaacs WB. Androgen receptor outwits prostate cancer drugs. Nat Med 2004;10:26-7.
-
(2004)
Nat Med
, vol.10
, pp. 26-27
-
-
Isaacs, J.T.1
Isaacs, W.B.2
-
7
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111:293-303.
-
(2002)
Cell
, vol.111
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
8
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science (Wash DC) 2002;298:1911-2.
-
(2002)
Science (Wash DC)
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
9
-
-
0031782132
-
Mitogen-activated protein kinases and apoptosis in PIN
-
Magi-Galluzzi C, Montironi R, Cangi MG, Wishnow K, Loda M. Mitogen-activated protein kinases and apoptosis in PIN. Virchows Arch 1998;432:407-13.
-
(1998)
Virchows Arch
, vol.432
, pp. 407-413
-
-
Magi-Galluzzi, C.1
Montironi, R.2
Cangi, M.G.3
Wishnow, K.4
Loda, M.5
-
10
-
-
0035848705
-
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
-
Paweletz CP, Charboneau L, Bichsel VE, et al. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene 2001;20:1981-9.
-
(2001)
Oncogene
, vol.20
, pp. 1981-1989
-
-
Paweletz, C.P.1
Charboneau, L.2
Bichsel, V.E.3
-
11
-
-
0036554734
-
Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer
-
Malik SN, Brattain M, Ghosh PM, et al. Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. Clin Cancer Res 2002;8:1168-71.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1168-1171
-
-
Malik, S.N.1
Brattain, M.2
Ghosh, P.M.3
-
12
-
-
0034742120
-
AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
Sun M, Wang G, Paciga JE, et al. AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 2001;159:431-7.
-
(2001)
Am J Pathol
, vol.159
, pp. 431-437
-
-
Sun, M.1
Wang, G.2
Paciga, J.E.3
-
13
-
-
0032574718
-
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
-
Whang YE, Wu X, Suzuki H, et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci USA 1998;95:5246-50.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
Wu, X.2
Suzuki, H.3
-
15
-
-
0032819983
-
Activation of extracellular signal-regulated kinase in human prostate cancer
-
Price DT, Rocca GD, Guo C, Ballo MS, Schwinn DA, Luttrell LM. Activation of extracellular signal-regulated kinase in human prostate cancer. J Urol 1999;162:1537-42.
-
(1999)
J Urol
, vol.162
, pp. 1537-1542
-
-
Price, D.T.1
Rocca, G.D.2
Guo, C.3
Ballo, M.S.4
Schwinn, D.A.5
Luttrell, L.M.6
-
16
-
-
0033555967
-
Activation of mitogen-activated protein kinase associated with prostate cancer progression
-
Gioeli D, Mandell JW, Petroni GR, Frierson HF Jr, Weber MJ. Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res 1999;59:279-84.
-
(1999)
Cancer Res
, vol.59
, pp. 279-284
-
-
Gioeli, D.1
Mandell, J.W.2
Petroni, G.R.3
Frierson Jr., H.F.4
Weber, M.J.5
-
17
-
-
0037404983
-
Differential expression and/or activation of p38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer
-
Uzgare AR, Kaplan PJ, Greenberg NM. Differential expression and/or activation of p38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer. Prostate 2003;55:128-39.
-
(2003)
Prostate
, vol.55
, pp. 128-139
-
-
Uzgare, A.R.1
Kaplan, P.J.2
Greenberg, N.M.3
-
18
-
-
0036235788
-
Regulation of proliferation/apoptosis equilibrium by mitogen-activated protein kinases in normal, hyperplastic, and carcinomatous human prostate
-
Royuela M, Arenas MI, Bethencourt FR, Sanchez-Chapado M, Fraile B, Paniagua R. Regulation of proliferation/apoptosis equilibrium by mitogen-activated protein kinases in normal, hyperplastic, and carcinomatous human prostate. Hum Pathol 2002;33:299-306.
-
(2002)
Hum Pathol
, vol.33
, pp. 299-306
-
-
Royuela, M.1
Arenas, M.I.2
Bethencourt, F.R.3
Sanchez-Chapado, M.4
Fraile, B.5
Paniagua, R.6
-
19
-
-
0033559698
-
Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells
-
Ravi RK, McMahon M, Yangang Z, et al. Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells. J Cell Biochem 1999;72:458-69.
-
(1999)
J Cell Biochem
, vol.72
, pp. 458-469
-
-
Ravi, R.K.1
McMahon, M.2
Yangang, Z.3
-
20
-
-
3242743136
-
In vitro culturing and characteristics of transit amplifying epithelial cells from human prostate tissue
-
Uzgare AR, Xu Y, Isaacs JT. In vitro culturing and characteristics of transit amplifying epithelial cells from human prostate tissue. J Cell Biochem 2004;91:196-205.
-
(2004)
J Cell Biochem
, vol.91
, pp. 196-205
-
-
Uzgare, A.R.1
Xu, Y.2
Isaacs, J.T.3
-
21
-
-
0033044376
-
Assessment and validation of a microinjection method for kinetic analysis of [Ca2+]I in individual cells undergoing apoptosis
-
Tornbal B, Denmeade SR, Isaacs JT. Assessment and validation of a microinjection method for kinetic analysis of [Ca2+]I in individual cells undergoing apoptosis. Cell Calcium 1999;25:19-28.
-
(1999)
Cell Calcium
, vol.25
, pp. 19-28
-
-
Tornbal, B.1
Denmeade, S.R.2
Isaacs, J.T.3
-
22
-
-
0037382797
-
c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration
-
Schwabe RF, Bradham CA, Uehara T, et al. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003;37:824-32.
-
(2003)
Hepatology
, vol.37
, pp. 824-832
-
-
Schwabe, R.F.1
Bradham, C.A.2
Uehara, T.3
-
23
-
-
0035413616
-
Cyclin-dependent kinases
-
Harper JW, Adams PD. Cyclin-dependent kinases. Chem Rev 2001;101:2511-26.
-
(2001)
Chem Rev
, vol.101
, pp. 2511-2526
-
-
Harper, J.W.1
Adams, P.D.2
-
24
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata MF, Horiuchi KY, Manos EJ, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 1998;273:18623-32.
-
(1998)
J Biol Chem
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
-
25
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett BL, Sasaki DT, Murray BW, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001;98:13681-6.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
-
26
-
-
0028988138
-
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
-
Cuenda A, Rouse J, Doza YN, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995;364:229-33.
-
(1995)
FEBS Lett
, vol.364
, pp. 229-233
-
-
Cuenda, A.1
Rouse, J.2
Doza, Y.N.3
-
27
-
-
0034632791
-
3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth
-
Hu Y, Qiao L, Wang S, et al. 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. J Med Chem 2000;43:3045-51.
-
(2000)
J Med Chem
, vol.43
, pp. 3045-3051
-
-
Hu, Y.1
Qiao, L.2
Wang, S.3
-
28
-
-
0032589380
-
Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: Novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade
-
Lian JP, Huang R, Robinson D, Badwey JA. Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade. J Immunol 1999;163:4527-36.
-
(1999)
J Immunol
, vol.163
, pp. 4527-4536
-
-
Lian, J.P.1
Huang, R.2
Robinson, D.3
Badwey, J.A.4
-
29
-
-
0036715005
-
Epithelial barrier function: Assembly and structural features of the cornified cell envelope
-
Kalinin AE, Kajava AV, Steinert PM. Epithelial barrier function: assembly and structural features of the cornified cell envelope. Bioessays 2002;24:789-800.
-
(2002)
Bioessays
, vol.24
, pp. 789-800
-
-
Kalinin, A.E.1
Kajava, A.V.2
Steinert, P.M.3
-
30
-
-
0036319364
-
Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner
-
Tucholski J, Johnson GV. Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner. J Neurochem 2002;81:780-91.
-
(2002)
J Neurochem
, vol.81
, pp. 780-791
-
-
Tucholski, J.1
Johnson, G.V.2
-
31
-
-
0042308774
-
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
-
Denmeade SR, Jakobsen CM, Janssen S, et al. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst (Bethesda) 2003;95:990-1000.
-
(2003)
J Natl Cancer Inst (Bethesda)
, vol.95
, pp. 990-1000
-
-
Denmeade, S.R.1
Jakobsen, C.M.2
Janssen, S.3
-
33
-
-
0034978803
-
Pharmacologic or genetic manipulation of glutathione S-transferase P1-1(GSTpi) influences cell proliferation pathways
-
Ruscoe JE, Rosario LA, Wang T, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1(GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther 2001;298:339-45.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 339-345
-
-
Ruscoe, J.E.1
Rosario, L.A.2
Wang, T.3
-
34
-
-
0033105414
-
Regulation of JNK signaling by GSTp
-
Adler V, Yin Z, Fuchs SY, et al. Regulation of JNK signaling by GSTp. EMBO J 1999;18:1321-34.
-
(1999)
EMBO J
, vol.18
, pp. 1321-1334
-
-
Adler, V.1
Yin, Z.2
Fuchs, S.Y.3
-
35
-
-
0020025844
-
Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system
-
Isaacs JT, Wake N, Coffey DS, Sandberg AA. Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system. Cancer Res 1982;42:2353-71.
-
(1982)
Cancer Res
, vol.42
, pp. 2353-2371
-
-
Isaacs, J.T.1
Wake, N.2
Coffey, D.S.3
Sandberg, A.A.4
-
36
-
-
0032827420
-
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
-
Peruzzi F, Prisco M, Dews M, et al. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol 1999;19:7203-15.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7203-7215
-
-
Peruzzi, F.1
Prisco, M.2
Dews, M.3
-
37
-
-
0035090634
-
Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor
-
Navarro M, Baserga R. Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor. Endocrinology 2001;142:1073-81.
-
(2001)
Endocrinology
, vol.142
, pp. 1073-1081
-
-
Navarro, M.1
Baserga, R.2
-
38
-
-
0142075168
-
Molecular characterization of human prostate carcinoma cell lines
-
van Bokhoven A, Varella-Garcia M, Korch C, et al. Molecular characterization of human prostate carcinoma cell lines. Prostate 2003;57:205-25.
-
(2003)
Prostate
, vol.57
, pp. 205-225
-
-
Van Bokhoven, A.1
Varella-Garcia, M.2
Korch, C.3
-
39
-
-
0025068887
-
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene
-
Bookstein R, Shew JY, Chen PL, Scully P, Lee WH. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 1990;247:712-25.
-
(1990)
Science
, vol.247
, pp. 712-725
-
-
Bookstein, R.1
Shew, J.Y.2
Chen, P.L.3
Scully, P.4
Lee, W.H.5
-
40
-
-
0037369090
-
Dissociation between androgen responsiveness for malignant growth vs. expression of prostate specific differentiation markers PSA, hK2, and PSMA in human prostate cancer models
-
Denmeade SR, Sokoll LJ, Dalrymple S, et al. Dissociation between androgen responsiveness for malignant growth vs. expression of prostate specific differentiation markers PSA, hK2, and PSMA in human prostate cancer models. Prostate 2003;54:249-57.
-
(2003)
Prostate
, vol.54
, pp. 249-257
-
-
Denmeade, S.R.1
Sokoll, L.J.2
Dalrymple, S.3
|