-
1
-
-
0031847470
-
Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: A comparison of haematological toxicity and drug metabolite concentrations
-
Lancaster DL, Lennard L, Rowland K, et al. Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: a comparison of haematological toxicity and drug metabolite concentrations. Br J Haematol 1998; 102: 439-43
-
(1998)
Br J Haematol
, vol.102
, pp. 439-443
-
-
Lancaster, D.L.1
Lennard, L.2
Rowland, K.3
-
2
-
-
0028054901
-
Kinetics of mercaptopurine and thioguanine nucleotides in renal transplant recipients during azathioprine treatment
-
Bergan S, Rugstad HE, Bentdal O, et al. Kinetics of mercaptopurine and thioguanine nucleotides in renal transplant recipients during azathioprine treatment. Ther Drug Monit 1994; 16: 13-20
-
(1994)
Ther Drug Monit
, vol.16
, pp. 13-20
-
-
Bergan, S.1
Rugstad, H.E.2
Bentdal, O.3
-
4
-
-
0029134702
-
Azathioprine and 6-mercaptopurine in Crohn disease: A meta-analysis
-
Pearson DC, May GR, Fick GH, et al. Azathioprine and 6-mercaptopurine in Crohn disease: a meta-analysis. Ann Intern Med 1995; 123 (2): 132-42
-
(1995)
Ann Intern Med
, vol.123
, Issue.2
, pp. 132-142
-
-
Pearson, D.C.1
May, G.R.2
Fick, G.H.3
-
5
-
-
0029923360
-
A review of immune modifier therapy for inflammatory bowel disease: Azathioprine, 6-mercaptopurine, cyclosporine and methotrexate
-
Sandborn WJ. A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine and methotrexate. Am J Gastroenterol 1996; 91 (3): 423-33
-
(1996)
Am J Gastroenterol
, vol.91
, Issue.3
, pp. 423-433
-
-
Sandborn, W.J.1
-
6
-
-
0024457688
-
6-Mercaptopurine in the management of inflammatory bowel disease: Short- and long-term toxicity
-
Present DH, Meltzer SJ, Krumholz MP, et al. 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann Intern Med 1989; 111 (8): 641-9
-
(1989)
Ann Intern Med
, vol.111
, Issue.8
, pp. 641-649
-
-
Present, D.H.1
Meltzer, S.J.2
Krumholz, M.P.3
-
7
-
-
0025330168
-
The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis
-
Adler DJ, Korelitz BI. The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis. Am J Gastroenterol 1990; 85 (6): 717-22
-
(1990)
Am J Gastroenterol
, vol.85
, Issue.6
, pp. 717-722
-
-
Adler, D.J.1
Korelitz, B.I.2
-
8
-
-
0034888112
-
6-Thioguanine: A naked bullet? (or how pharmacogenomics can make old drugs brand new)
-
Baert F, Rutgeerts P. 6-Thioguanine: a naked bullet? (or how pharmacogenomics can make old drugs brand new). Inflamm Bowel Dis 2001; 7(3): 190-1
-
(2001)
Inflamm Bowel Dis
, vol.7
, Issue.3
, pp. 190-191
-
-
Baert, F.1
Rutgeerts, P.2
-
9
-
-
0026758498
-
The clinical pharmacology of 6-mercaptopurine
-
Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992; 43 (4): 329-39
-
(1992)
Eur J Clin Pharmacol
, vol.43
, Issue.4
, pp. 329-339
-
-
Lennard, L.1
-
10
-
-
0030896836
-
Management of Crohn's disease in adults
-
Hanauer SB, Meyers SM. Management of Crohn's disease in adults. Am J Gastroenterol 1997; 92 (4): 559-66
-
(1997)
Am J Gastroenterol
, vol.92
, Issue.4
, pp. 559-566
-
-
Hanauer, S.B.1
Meyers, S.M.2
-
11
-
-
0028790186
-
A controlled double blind study of azathioprine in the management of Crohn's disease
-
Candy S, Wright J, Gerber M, et al. A controlled double blind study of azathioprine in the management of Crohn's disease. Gut 1995; 37: 674-8
-
(1995)
Gut
, vol.37
, pp. 674-678
-
-
Candy, S.1
Wright, J.2
Gerber, M.3
-
12
-
-
0018888679
-
Treatment of Crohn's disease with 6-mercaptopurine: A long-term randomised double-blind study
-
Present DH, Korelitz BI, Wisch N, et al. Treatment of Crohn's disease with 6-mercaptopurine: a long-term randomised double-blind study. N Engl J Med 1980; 302: 981-7
-
(1980)
N Engl J Med
, vol.302
, pp. 981-987
-
-
Present, D.H.1
Korelitz, B.I.2
Wisch, N.3
-
13
-
-
0035037703
-
Rational dosing of azathioprine and 6-mercaptopurine
-
Sandborn WJ. Rational dosing of azathioprine and 6-mercaptopurine. Gut 2001; 48: 591-2
-
(2001)
Gut
, vol.48
, pp. 591-592
-
-
Sandborn, W.J.1
-
14
-
-
0034067784
-
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
-
Dubinsky MC, Lamothe S, Yang HY, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000; 118: 705-13
-
(2000)
Gastroenterology
, vol.118
, pp. 705-713
-
-
Dubinsky, M.C.1
Lamothe, S.2
Yang, H.Y.3
-
15
-
-
0035037706
-
Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease
-
Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease. Gut 2001; 48 (5): 642-6
-
(2001)
Gut
, vol.48
, Issue.5
, pp. 642-646
-
-
Cuffari, C.1
Hunt, S.2
Bayless, T.3
-
16
-
-
0029794073
-
6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity
-
Cuffari C, Theoret Y, Latour S, et al. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut 1996; 39: 401-6
-
(1996)
Gut
, vol.39
, pp. 401-406
-
-
Cuffari, C.1
Theoret, Y.2
Latour, S.3
-
17
-
-
0034771188
-
Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
-
Lowry PW, Franklin CL, Weaver AL, et al. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut 2001; 49: 665-70
-
(2001)
Gut
, vol.49
, pp. 665-670
-
-
Lowry, P.W.1
Franklin, C.L.2
Weaver, A.L.3
-
18
-
-
0035186469
-
6-Mercaptopurine (6MP) metabolite levels in children with IBD
-
Gupta P, Gokhale R, Kirschner B. 6-Mercaptopurine (6MP) metabolite levels in children with IBD. J Pediatr Gastroenterol Nutr 2001; 33 (4): 450-4
-
(2001)
J Pediatr Gastroenterol Nutr
, vol.33
, Issue.4
, pp. 450-454
-
-
Gupta, P.1
Gokhale, R.2
Kirschner, B.3
-
19
-
-
0033862234
-
Enhanced bioavailability of azathioprine compared to 6-mercaptopurine therapy in inflammatory bowel disease: Correlation with treatment efficacy
-
Cuffari C, Hunt S, Bayless T. Enhanced bioavailability of azathioprine compared to 6-mercaptopurine therapy in inflammatory bowel disease: correlation with treatment efficacy. Aliment Pharmacol Ther 2000; 14: 1009-14
-
(2000)
Aliment Pharmacol Ther
, vol.14
, pp. 1009-1014
-
-
Cuffari, C.1
Hunt, S.2
Bayless, T.3
-
20
-
-
0034891450
-
An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy
-
Dubinsky MC, Hassard PV, Seidman EG, et al. An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy. Inflamm Bowel Dis 2001; 7 (3): 181-9
-
(2001)
Inflamm Bowel Dis
, vol.7
, Issue.3
, pp. 181-189
-
-
Dubinsky, M.C.1
Hassard, P.V.2
Seidman, E.G.3
-
21
-
-
0037250161
-
6-Thioguanine seems promising in azathioprine- Or 6-mercaptopurine- intolerant inflammatory bowel disease patients: A short-term safety assessment
-
Derijks LJJ, De Jong DJ, Gilissen LPL, et al. 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment. Eur J Gastroenterol Hepatol 2003; 15 (1): 63-7
-
(2003)
Eur J Gastroenterol Hepatol
, vol.15
, Issue.1
, pp. 63-67
-
-
Derijks, L.J.J.1
De Jong, D.J.2
Gilissen, L.P.L.3
-
22
-
-
0038805258
-
Thioguanine: A potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine
-
Dubinsky MC, Feldman EJ, Abreu MT, et al. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol 2003; 98 (5): 1058-63
-
(2003)
Am J Gastroenterol
, vol.98
, Issue.5
, pp. 1058-1063
-
-
Dubinsky, M.C.1
Feldman, E.J.2
Abreu, M.T.3
-
23
-
-
0242464926
-
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
-
Tiede I, Fritz G, Strand S, et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest 2003; 111 (8): 133-45
-
(2003)
J Clin Invest
, vol.111
, Issue.8
, pp. 133-145
-
-
Tiede, I.1
Fritz, G.2
Strand, S.3
-
24
-
-
0036076821
-
TPMT in the treatment of Crohn's disease with azathioprine
-
Lennard L. TPMT in the treatment of Crohn's disease with azathioprine. Gut 2002; 51: 143-6
-
(2002)
Gut
, vol.51
, pp. 143-146
-
-
Lennard, L.1
-
25
-
-
0034093057
-
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
-
Colombel JF, Ferrari N, Debuysere H, et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000; 188: 1025-30
-
(2000)
Gastroenterology
, vol.188
, pp. 1025-1030
-
-
Colombel, J.F.1
Ferrari, N.2
Debuysere, H.3
-
26
-
-
0031680256
-
Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease
-
Kirschner BS. Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease. Gastroenterology 1998; 115(4): 813-21
-
(1998)
Gastroenterology
, vol.115
, Issue.4
, pp. 813-821
-
-
Kirschner, B.S.1
-
27
-
-
0027164795
-
Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience
-
Connell WR, Kamm MA, Ritchie JK, et al. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut 1993; 34 (8): 1081-5
-
(1993)
Gut
, vol.34
, Issue.8
, pp. 1081-1085
-
-
Connell, W.R.1
Kamm, M.A.2
Ritchie, J.K.3
-
28
-
-
0043168014
-
6-Thioguanine can cause serious liver injury in inflammatory bowel disease patients
-
Dubinsky MC, Vasiliauskas EA, Singh H, et al. 6-Thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology 2003; 125: 298-303
-
(2003)
Gastroenterology
, vol.125
, pp. 298-303
-
-
Dubinsky, M.C.1
Vasiliauskas, E.A.2
Singh, H.3
-
29
-
-
0008690916
-
Cortisone in ulcerative colitis: Final report on a therapeutic trial
-
Truelove SC, Witts LJ. Cortisone in ulcerative colitis: final report on a therapeutic trial. BMJ 1955; 4947: 1041-8
-
(1955)
BMJ
, vol.4947
, pp. 1041-1048
-
-
Truelove, S.C.1
Witts, L.J.2
-
30
-
-
0026465403
-
High performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-mercaptopurine metabolites in a single sample
-
Lennard L, Singleton HJ. High performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-mercaptopurine metabolites in a single sample. J Chromatogr 1992; 583 (1): 83-90
-
(1992)
J Chromatogr
, vol.583
, Issue.1
, pp. 83-90
-
-
Lennard, L.1
Singleton, H.J.2
-
31
-
-
2542639314
-
Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: Implications for therapy
-
Derijks LJJ, Gilissen LPL, Engels, LGJ, et al. Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy. Ther Drug Monit 2004; 26: 311-8
-
(2004)
Ther Drug Monit
, vol.26
, pp. 311-318
-
-
Derijks, L.J.J.1
Gilissen, L.P.L.2
Engels, L.G.J.3
-
32
-
-
0036001231
-
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: Possible role of concomitant methotrexate
-
Pettersson B, Almer S, Albertioni F, et al. Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate [abstract]. Ther Drug Monit 2002; 24: 351-8
-
(2002)
Ther Drug Monit
, vol.24
, pp. 351-358
-
-
Pettersson, B.1
Almer, S.2
Albertioni, F.3
-
33
-
-
1242314812
-
Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders: The impact of TPMT genotyping in predicting toxicity
-
Reuther LO, Vainer B, Sonne J, et al. Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders: the impact of TPMT genotyping in predicting toxicity. Eur J Clin Pharmacol 2003; 59 (11): 797-801
-
(2003)
Eur J Clin Pharmacol
, vol.59
, Issue.11
, pp. 797-801
-
-
Reuther, L.O.1
Vainer, B.2
Sonne, J.3
-
34
-
-
0042830383
-
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease
-
Gearry RB, Barclay ML, Burt MJ, et al. Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2003; 118: 395-400
-
(2003)
Aliment Pharmacol Ther
, vol.118
, pp. 395-400
-
-
Gearry, R.B.1
Barclay, M.L.2
Burt, M.J.3
-
35
-
-
4344606742
-
No predictive value of TPMT genotyping for leukopenia or hepatotoxicity during azathioprine therapy in inflammatory bowel disease
-
Curvers WL, Derijks LJJ, Stokkers P, et al. No predictive value of TPMT genotyping for leukopenia or hepatotoxicity during azathioprine therapy in inflammatory bowel disease [abstract]. Eur J Gastroenterol Hepatol 2003; 15(12): A29
-
(2003)
Eur J Gastroenterol Hepatol
, vol.15
, Issue.12
-
-
Curvers, W.L.1
Derijks, L.J.J.2
Stokkers, P.3
-
36
-
-
0028832238
-
Intracellular metabolites of 6-mercaptopurine in children with lymphoblastic leukaemia: A possible indicator of non-compliance
-
Lennard L, Welch J, Lilleyman JS. Intracellular metabolites of 6-mercaptopurine in children with lymphoblastic leukaemia: a possible indicator of non-compliance. Br J Cancer 1995; 72: 1004-6
-
(1995)
Br J Cancer
, vol.72
, pp. 1004-1006
-
-
Lennard, L.1
Welch, J.2
Lilleyman, J.S.3
-
37
-
-
0005821465
-
Azathioprine metabolites in inflammatory bowel disease and incidence of noncompliance
-
Webster S, Sanders DS, Lennard L, et al. Azathioprine metabolites in inflammatory bowel disease and incidence of noncompliance [abstract]. Gut 2002; 50 Suppl. II: A71
-
(2002)
Gut
, vol.50
, Issue.2 SUPPL.
-
-
Webster, S.1
Sanders, D.S.2
Lennard, L.3
|