Solvent effects on the microstructure and properties of 75/25 poly(D,L-lactide-co-glycolide) tissue scaffolds

Journal of Biomedical Materials Research - Part A

Volumn 70, Issue 3, 2004, Pages 506-513

  Sander, Edward A ^a   Alb, Alina M ^a   Nauman, Eric A ^a   Reed, Wayne F ^a   Dee, Kay C ^a  

^a Tulane University   (United States)

Author keywords

Compression; Microstructure; Permeability; PLGA; Scaffold

Indexed keywords

ACETONE; BIODEGRADATION; EVAPORATION; LIGHT SCATTERING; MICROSTRUCTURE; STIFFNESS; TISSUE;

EVAPORATION DYNAMICS; TISSUE SCAFFOLDS;

BIOMEDICAL ENGINEERING;

ACETONE; CHLOROFORM; DICHLOROMETHANE; ORGANIC SOLVENT; POLYGLACTIN; POLYMER; SOLVENT;

ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; COMPRESSION; DYNAMICS; EVAPORATION; LIGHT SCATTERING; MATERIALS TESTING; MECHANICS; MICROSTRUCTURE; MOLECULAR INTERACTION; PERMEABILITY; PHYSICAL CHEMISTRY; POLYMER SOLVENT INTERACTION; POROSITY; RIGIDITY; SOLVATION; SOLVENT CASTING PARTICULATE LEACHING TECHNIQUE; TECHNIQUE; TISSUE SCAFFOLD; TISSUE STRUCTURE;

EID: 4344584987     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30109     Document Type: Article

References (33)

1. Ma PX, Schloo B, Mooney D, Langer R. Development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage. J Biomed Mater Res 1995;29:1587-1595.
2. Holy CE, Fialkov JA, Davies JE, Shoichet MS. Use of a biomimetic strategy to engineer bone. J Biomed Mater Res 2003;65A:447-453.
3. Thomson RC, Mikos AG, Beahm E, Lemon JC, Satterfield WC, Aufdemorte TB, Miller MJ. Guided tissue fabrication from periosteum using preformed biodegradable polymer scaffolds. Biomaterials 1999;20:2007-2018.
4. Ouyang HW, Goh JC, Thambyah A, Teoh SH, Lee EH. Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon. Tissue Eng 2003;9:431-439.
5. Gao J, Niklason L, Langer R. Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells. J Biomed Mater Res 1998;42:417-424.
6. Peters MC, Mooney DJ. Synthetic extracellular matrices for cell transplantation. Mater Sci Forum 1997;250:43-52.
7. Gomes ME, Sikavitsas VI, Behravesh E, Reis RL, Mikos AG. Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three-dimensional scaffolds. J Biomed Mater Res 2003;67A:87-95.
8. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-2543.
9. Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 2001;7:679-689.
10. Agrawal CM, Ray RB. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res 2001;55:141-150.
11. Athanasiou KA, Schmitz JP, Agrawal CM. The effects of porosity on in vitro degradation of polylactic acid-polyglycolic acid implants used in repair of articular cartilage. Tissue Eng 1998;4:53-63.
12. Agrawal CM, McKinney JS, Lanctot D, Athanasiou KA. Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering. Biomaterials 2000;21:2443-2452.
13. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R. Preparation and characterization of poly(L-lactic acid) foams. Polymer 1994;35:1068-1077.
14. Wake MC, Gupta PK, Mikos AG. Fabrication of pliable biodegradable polymer foams to engineer soft tissues. Cell Transplant 1996;5:465-473.
15. Hu Y, Grainger DW, Winn SR, Hollinger JO. Fabrication of poly(alpha-hydroxy acid) foam scaffolds using multiple solvent systems. J Biomed Mater Res 2002;59:563-572.
16. Nam YS, Park TG. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J Biomed Mater Res 1999;47:8-17.
17. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly(d,l-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 1996;17:1417-1422.
18. Yoon JJ, Park TG. Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts. J Biomed Mater Res 2001;55:401-408.
19. Whang K, Thomas CH, Healy KE. A novel method to fabricate bioabsorbable scaffolds. Polymer 1995;36:837-842.
20. Niederauer GG, Slivka MA, Leatherbury NC, Korvick DL, Harroff HH, Ehler WC, Dunn CJ, Kieswetter K. Evaluation of multiphase implants for repair of focal osteochondral defects in goats. Biomaterials 2000;21:2561-2574.
21. Liao CJ, Chen CF, Chen JH, Chiang SF, Lin YJ, Chang KY. Fabrication of porous biodegradable polymer scaffolds using a solvent merging/particulate leaching method. J Biomed Mater Res 2002;59:676-681.
22. Widmer MS, Gupta PK, Lu L, Meszlenyi RK, Evans GR, Brandt K, Savel T, Gurlek A, Patrick CW, Jr., Mikos AG. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials 1998;19:1945-1955.
23. Ma PX, Choi JW. Biodegradable polymer scaffolds with well-defined interconnected spherical pore network. Tissue Eng 2001;7:23-33.
24. Agrawal CM, McKinney JS, Huang D, Athanasiou KA. The use of the vibrating particle technique to fabricate highly porous and permeable biodegradable scaffolds. In: Agrawal CM, Parr J, Lin S, editors. STP 1396: synthetic bioabsorbable polymers for implants. Philadelphia: American Society for Testing and Materials; 2000. p 99-114.
25. Lu L, Peter SJ, Lyman MD, Lai HL, Leite SM, Tamada JA, Uyama S, Vacanti JP, Langer R, Mikos AG. In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams. Biomaterials 2000;21:1837-1845.
26. Ochi K et al. Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly-dl-lactic-co-glycolic acid (PLGA)-collagen sponge. J Cell Physiol 2003;194:45-53.
27. Yang J, Shi G, Bei J, Wang S, Cao Y, Shang Q, Yang G, Wang W. Fabrication and surface modification of macroporous poly(L-lactic acid) and poly(L-lactic-co-glycolic acid) (70/30) cell scaffolds for human skin fibroblast cell culture. J Biomed Mater Res 2002;62:438-446.
28. Brousseau J, Catalgil-Giz H, Reed WF. Automatic, simultaneous determination of differential refractive index of a polymer and its corresponding monomer. J Appl Polym Sci 2000;77:3259-3262.
29. Dullien FAL. Porous media: fluid transport and pore structure. New York: Academic Press; 1979.
30. Spain TL, Agrawal CM, Athanasiou KA. New technique to extend the useful life of a biodegradable cartilage implant. Tissue Eng 1998;4:343-352.
31. Strelitzki R, Reed WF. Automated batch characterization of polymer solutions by static light scattering and viscometry. J Appl Polym Sci 1999;73:2359-2368.
32. Wu XS. Synthesis and properties of biodegradable lactic/glycolic acid polymers. In: Wise DL, editor. Encyclopedic handbook of biomaterials and bioengineering: Part A Materials. New York: Marcel Dekker; 1995.
33. Montgomery DC. Design and analysis of experiments. New York: Wiley; 2001.