Nutrient-gene interactions: A single nutrient and hundreds of target genes

Biological Chemistry

Volumn 385, Issue 7, 2004, Pages 571-583

  Daniel, Hannelore ^a   tom Dieck, Heike ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Gene expression; Liver; Metabolism; Nutrients; Transcriptome analysis; Zinc deficiency

Indexed keywords

MESSENGER RNA; PROTEIN; ZINC;

ANIMAL MODEL; GENE; GENE INTERACTION; LIVER METABOLISM; METABOLISM; MOUSE; NONHUMAN; NUTRIENT; PLEIOTROPY; PRIORITY JOURNAL; REVIEW; RODENT; ZINC DEFICIENCY;

ANIMALS; DEFICIENCY DISEASES; FATTY ACIDS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSE; LIVER; MODELS, ANIMAL; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; RATS; ZINC;

RODENTIA;

EID: 4344580481     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2004.071     Document Type: Review

References (151)

1. Alfaro, B. and Heaton, F.W. (1974). The subcellular distribution of copper, zinc and iron in liver and kidney. Changes during copper deficiency in the rat. Br. J. Nutr. 32, 435-445.
2. Allen, J.I., Perri, R.T., Mcclain, C.J., and Kay, N.E. (1983). Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency. J. Lab. Clin. Med. 102, 577-589.
3. Andrews, G.K., Gallant, K.R., and Cherian, M.G. (1987). Regulation of the ontogeny of rat liver metallothionein mRNA by zinc. Eur. J. Biochem. 166, 527-531.
4. Andrews, G.K. (2000). Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem. Pharmacol. 59, 95-104.
5. Andrews, G.K., Lee, D.K., Ravindra, R., Lichtlen, P., Sirito, M., Sawadogo, M., and Schaffner, W. (2001). The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J. 20, 1114-1122.
6. Avery, R.A. and Bettger, W.J. (1992). Zinc deficiency alters the protein composition of the membrane skeleton but not the extractability or oligomeric form of spectrin in rat erythrocyte membranes. J. Nutr. 122, 428-434.
7. Ayala, S. and Brenner, R.R. (1983). Essential fatty acid status in zinc deficiency. Effect on lipid and fatty acid composition, desaturation activity and structure of microsomal membranes of rat liver and testes. Acta Physiol. Latinoam. 33, 193-204.
8. Ayala, S. and Brenner, R.R. (1987). Effect of zinc deficiency on the in vivo biosynthesis of fatty acids of the linoleic series in the rat. Acta Physiol. Pharmacol. Latinoam. 37, 321-330.
9. Baltaci, A.K., Ozyurek, K., Mogulkoc, R., Kurtoglu, E., Ozkan, Y., and Celik, I. (2004). Effects of zinc deficiency and supplementation on the glycogen contents of liver and plasma lactate and leptin levels of rats performing acute exercise. Biol. Trace Elem. Res. 96, 27-236.
10. Bao, B., Prasad, A.S., Beck, F.W., and Godmere, M. (2003). Zinc modulates mRNA levels of cytokines. Am. J. Physiol. Endocrinol. Metab. 285, E1095-E1102.
11. Barclay, T.B., Peters, J.M., Sewer, M.B., Ferrari, L., Gonzalez, F.J., and Morgan, E.T. (1999). Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-α dependent. J. Pharmacol. Exp. Ther. 290, 1250-1257.
12. Barthel, A. and Schmoll, D. (2003). Novel concepts in insulin regulation of hepatic gluconeogenesis. Am. J. Physiol. Endocrinol. Metab. 285, E685-E692.
13. Beck, F.W., Prasad, A.S., Kaplan, J., Fitzgerald, J.T., and Brewer, G.J. (1997). Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am. J. Physiol. 272, E1002-E1007.
14. Bettger, W.J. and O'Dell, B.L. (1981). A critical physiological role of zinc in the structure and function of biomembranes. Life Sci. 28, 1425-1438.
15. Beyersmann, D. and Haase, H. (2001). Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals 14, 331-341.
16. 2+ sensors to regulate transcriptional activation domain function. EMBO J. 22, 5137-5146.
17. Blanchard, R.K., Moore, J.B., Green, C.L., and Cousins, R.J. (2001). Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Proc. Natl. Acad. Sci. USA 98, 13507-13513.
18. Boquist, L., Falkmer, S., Havu, N., and Pihl, E. (1968). Insulin biosynthesis, storage and secretion. 8. Pancreatic-islet tissue and heavy metals-some ultrastructural and experimental observations. Lakartidningen. 65, 3603-3607.
19. 2+-binding protein (parathymosin). J. Biol. Chem. 266, 20984-20989.
20. Bray, T.M. and Bettger, W.J. (1990). The physiological role of zinc as an antioxidant. Free Radic. Biol. Med. 8, 281-291.
21. Briefel, R.R., Bialostosky, K., Kennedy-Stephenson, J., McDowell, M.A., Ervin, R.B., and Wright, J.D. (2000). Zinc intake of the U.S. population: findings from the third National Health and Nutrition Examination Survey 1988-1994. J. Nutr. 130, 1367S-1373S.
22. Brocklehurst, K.R., Hobman, J.L., Lawley, B., Blank, L., Marshall, S.J., Brown, N.L., and Morby, A.P (1999). ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli. Mol. Microbiol. 31, 893-902.
23. Churchich, J.E., Scholz, G., and Kwok, F. (1988). Modulation of the catalytic activity of pyridoxal kinase by metallothionein. Biochem. Int. 17, 395-403.
24. Churchich, J.E., Scholz, G., and Kwok, F. (1989). Activation of pyridoxal kinase by metallothionein. Biochim. Biophys. Acta 996, 181-186.
25. Clarke, S.D. and Jump, D. (1997). Polyunsaturated fatty acids regulate lipogenic and peroxisomal gene expression by independent mechanisms. Prostaglandins Leukotr. Essent. Fatty Acids 57, 65-69.
26. Clejan, S., Castro-Magana, M., Collipp, P.J., Jonas, E., and Maddaiah, V.T. (1982). Effects of zinc deficiency and castration on fatty acid composition and desaturation in rats. Lipids 17, 129-135.
27. Coleman, J.E. (1992). Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins. Annu. Rev. Biochem. 61, 897-946.
28. Cousins, R.J., Blanchard, R.K., Popp, M.P., Liu, L., Cao, J., Moore, J.B., and Green, C.L. (2003). A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc. Natl. Acad. Sci. USA 100, 6952-6957.
29. Cowen, L.A., Bell, D.E., Hoadley, J.E., and Cousins, R.J. (1986). Influence of dietary zinc deficiency and parenteral zinc on rat liver fructose-1,6-bisphosphatase activity. Biochem. Biophys. Res. Commun. 134, 944-950.
30. Coyle, P., Philcox, J.C., Carey, L.C., and Rofe, A.M. (2002). Metallothionein: the multipurpose protein. Cell Mol. Life Sci. 59, 627-647.
31. Cui, X., Kawashima, H., Barclay, T.B., Peters, J.M., Gonzalez, F.J., Morgan, E.T., and Strobel, H.W. (2001). Molecular cloning and regulation of expression of two novel mouse CYP4F genes: expression in peroxisome proliferator-activated receptor alpha-deficient mice upon lipopolysaccharide and clofibrate challenges. J. Pharmacol. Exp. Ther. 296, 542-550.
32. Cunnane, S.C., Horrobin, D.F., and Manku, M.S. (1984). Essential fatty acids in tissue phospholipids and triglycerides of the zinc-deficient rat. Proc. Soc. Exp. Biol. Med. 177, 441-446.
33. Cunnane, S.C. (1988). Evidence that adverse effects of zinc deficiency on essential fatty acid composition in rats are independent of food intake. Br. J. Nutr. 59, 273-278.
34. Cunningham, B.A., Moncur, J.T., Huntington, J.T., and Kinlaw, W.B. (1998). 'Spot 14' protein: a metabolic integrator in normal and neoplastic cells. Thyroid 8, 15-825.
35. Dalton, T.P., Li, Q., Bittel, D., Liang, L., and Andrews, G.K. (1996). Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter. J. Biol. Chem. 271, 26233-26241.
36. Daniels, P.J., Bittel, D., Smirnova, I.V., Winge, D.R., and Andrews, G.K. (2002). Mammalian metal response element-binding transcription factor-1 functions as a zinc sensor in yeast, but not as a sensor of cadmium or oxidative stress. Nucleic Acids Res. 30, 3130-3140.
37. DeMoor, J.M. and Koropatnick, D.J. (2000). Metals and cellular signaling in mammalian cells. Cell. Mol. Biol. 46, 367-381.
38. Ducluzeau, P.H., Perretti, N., Laville, M., Andreelli, F., Vega, N., Riou, J.P., and Vidal, H. (2001). Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50, 1134-1142.
39. Ebadi, M., Iversen, P.L., Hao, R., Cerutis, D.R., Rojas, P., Happe, H.K., Murrin, L.C., and Pfeiffer, R.F. (1995). Expression and regulation of brain metallothionein. Neurochem. Int. 27, 1-22.
40. Eder, K. and Kirchgessner, M. (1993). The effect of zinc depletion on the fat content and fatty acid composition of the liver and brain in forcibly fed rats. Z. Ernährungswiss. 32, 187-197.
41. Eder, K. and Kirchgessner, M. (1994a). Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. J. Nutr. 124, 1917-1926.
42. Eder, K. and Kirchgessner, M. (1994b). Levels of polyunsaturated fatty acids in tissues from zinc-deficient rats fed a linseed oil diet. Lipids 29, 839-844.
43. Eder, K. and Kirchgessner, M. (1995a). Zinc deficiency and activities of lipogenic and glycolytic enzymes in liver of rats fed coconut oil or linseed oil. Lipids 30, 63-69.
44. Eder, K., Kirchgessner, M. (1995b). Activities of liver microsomal fatty acid desaturases in zinc-deficient rats force-fed diets with a coconut oil/safflower oil mixture of linseed oil. Biol. Trace Elem. Res. 48, 215-229.
45. Eder, K. and Kirchgessner, M. (1996). Zinc deficiency and the desaturation of linoleic acid in rats force-fed fat-free diets. Biol. Trace Elem. Res. 54, 173-183.
46. El Hendy, H.A., Yousef, M.I., and Abo El-Naga, N.I. (2001). Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats. Toxicology 167, 163-170.
47. Faure, P., Roussel, A.M., Martinie, M., Osman, M., Favier, A., and Halimi, S. (1991). Insulin sensitivity in zinc-depleted rats: assessment with the euglycaemic hyperinsulinic clamp technique. Diabetes Metab. 17, 325-331.
48. Favier, A.E. (1992). The role of zinc in reproduction. Hormonal mechanisms. Biol. Trace Elem. Res. 32, 363-382.
49. Figlewicz, D.P., Forhan, S.E., Hodgson, A.T., and Grodsky, G.M. (1984). 65Zinc and endogenous zinc content and distribution in islets in relationship to insulin content. Endocrinology 115, 877-881.
50. Fischer, A., Pallauf, J., Gohil, K., Weber, S.U., Packer, L., Rimbach, G (2001). Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochem. Biophys. Res. Commun. 285, 470-475.
51. Foretz, M., Guichard, C., Ferre, P., and Foufelle, F. (1999). Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc. Natl. Acad. Sci. USA 96, 12737-12742.
52. Foster, J.D. and Nordlie, R.C. (2002). The biochemistry and molecular biology of the glucose-6-phosphatase system. Exp. Biol. Med. 227, 601-608.
53. Freake, H.C., Govoni, K.E., Guda, K., Huang, C., and Zinn, S.A. (2001). Actions and interactions of thyroid hormone and zinc status in growing rats. J. Nutr. 131, 1135-1141.
54. Frederickson, C.J. (1989). Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 31, 145-238.
55. Frederiksen, K.S., Wulff, E.M., Sauerberg, P., Mogensen, J.P., Jeppesen, L., and Fleckner, J. (2004). Prediction of PPAR-α ligand-mediated physiological changes using gene expression profiles. J. Lipid Res. 45, 592-601.
56. Gaballa, A. and Helmann, J.D. (1998). Identification of a zinc-specific metalloregulatory protein, Zur, controlling zinc transport operons in Bacillus subtilis. J. Bacteriol. 180, 5815-5821.
57. Gaballa, A., Wang, T., Ye, R.W., and Helmann, J.D. (2002). Functional analysis of the Bacillus subtilis Zur regulon. J. Bacteriol. 184, 6508-6514.
58. Gearing, K.L., Crickmore, A., and Gustafsson, J.A. (1994). Structure of the mouse peroxisome proliferator activated receptor α gene. Biochem. Biophys. Res. Commun. 199, 255-263.
59. Goldstein, B.N. and Maevsky, A.A. (2002). Critical switch of the metabolic fluxes by phosphofructo-2-kinase:fructose-2,6-bisphosphatase. A kinetic model. FEBS Lett. 532, 295-299.
60. Gonzalez, F.J. (2002). The peroxisome proliferator-activated receptor α (PPARα): role in hepatocarcinogenesis. Mol. Cell. Endocrinol. 193, 71-79.
61. Hah, J.S., Ryu, J., Lee, W., Jung, C.Y., and Lachaal, M. (2002). The hepatocyte glucose-6-phosphatase subcomponent T3: its relationship to GLUT2. Biochim. Biophys. Acta 1564, 198-206.
62. Hamel, F.G., Upward, J.L., Siford, G.L., and Duckworth, W.C. (2003). Inhibition of proteasome activity by selected amino acids. Metabolism 52, 810-814.
63. Hamer, D.H. (1986). Metallothionein. Annu. Rev. Biochem. 55, 913-951.
64. 2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 33, 935-952.
65. Hashimoto, T., Cook, W.S., Qi, C., Yeldandi, A.V., Reddy, J.K., and Rao, M.S. (2000). Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J. Biol. Chem. 275, 28918-28928.
66. Herzog, A., Kuntz, S., Daniel, H., and Wenzel, U. (2004). Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int. J. Cancer 109, 220-229
67. Hirschi, K.D., Kreps, J.A., and Hirschi, K.K. (2001). Molecular approaches to studying nutrient metabolism and function: an array of possibilities. J. Nutr. 131, 1605S-1609S.
68. Hsu, M.H., Palmer, C.N., Song, W., Griffin, K.J., and Johnson, E.F. (1998). A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding. J. Biol. Chem. 273, 27988-27997.
69. IJpenberg, A., Jeannin, E., Wahli, W., and Desvergne, B. (1997). Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J. Biol. Chem. 272, 20108-20117.
70. Jamieson, A.C., Miller, J.C., and Pabo, C.O. (2003). Drug discovery with engineered zinc-finger proteins. Nat. Rev. Drug Discov. 2, 361-368.
71. Jamison McDaniels, C.P., Jensen, L.T., Srinivasan, C., Winge, D.R., and Tullius, T.D. (1999). The yeast transcription factor Mac1 binds to DNA in a modular fashion. J. Biol. Chem. 274, 26962-26967.
72. Johnson, E.F., Palmer, C.N., Griffin, K.J., and Hsu, M.H. (1996). Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB J. 10, 1241-1248.
73. Jump, D.B. and Oppenheimer, J.H. (1985). High basal expression and 3,5,3′-triiodothyronine regulation of messenger ribonucleic acid S14 in lipogenic tissues. Endocrinology 117, 2259-2266.
74. Jump, D.B., Bell, A., and Santiago, V. (1990). Thyroid hormone and dietary carbohydrate interact to regulate rat liver S14 gene transcription and chromatin structure. J. Biol. Chem. 265, 3474-3478.
75. Jump, D.B., Clarke, S.D., Thelen, A., and Liimatta, M. (1994). Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J. Lipid Res. 35, 1076-1084.
76. Jump, D.B., Ren, B., Clarke, S., and Thelen, A. (1995). Effects of fatty acids on hepatic gene expression. Prostaglandins Leukotr. Essent. Fatty Acids 52, 107-111.
77. Keller, H., Givel, F., Perroud, M., and Wahli, W. (1995). Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol. Endocrinol. 9, 794-804.
78. Kennedy, K.J., Rains, T.M., and Shay, N.F. (1998). Zinc deficiency changes preferred macronutrient intake in subpopulations of Sprague-Dawley outbred rats and reduces hepatic pyruvate kinase gene expression. J. Nutr. 128, 43-49.
79. Kersten, S., Seydoux, J., Peters, J.M., Gonzalez, F.J., Desvergne, B., and Wahli, W. (1999). Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489-1498.
80. Klug, A. and Rhodes, D. (1987). Zinc fingers: a novel protein fold for nucleic acid recognition. Cold Spring Harbor Symp. Quant. Biol. 52, 473-482.
81. Klug, A. (1999). Zinc finger peptides for the regulation of gene expression. J. Mol. Biol. 293, 215-218.
82. Koo, S.H. and Towle, H.C. (2000). Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex. J. Biol. Chem. 275, 5200-5207.
83. Kotzka, J., Muller-Wieland, D., Koponen, A., Njamen, D., Kremer, L., Roth, G., Munck, M., Knebel, B., and Krone, W. (1998). ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway. Biochem. Biophys. Res. Commun. 249, 375-379.
84. Latruffe, N., Malki, M.C., Nicolas-Frances, V., Clemencet, M.C., Jannin, B., and Berlot, J.P. (2000). Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases. Biochem. Pharmacol. 60, 1027-1032.
85. Lefebvre, D., Beckers, F., Ketelslegers, J.M., and Thissen, J.P. (1998). Zinc regulation of insulin-like growth factor-I (IGF-I), growth hormone receptor (GHR) and binding protein (GHBP) gene expression in rat cultured hepatocytes. Mol. Cell. Endocrinol. 138, 127-136.
86. Lefebvre, D., Boney, C.M., Ketelslegers, J.M., and Thissen, J.P. (1999). Inhibition of insulin-like growth factor-I mitogenic action by zinc chelation is associated with a decreased mitogen-activated protein kinase activation in RAT-1 fibroblasts. FEBS Lett. 449, 284-288.
87. Lichtlen, P. and Schaffner, W. (2001). The 'metal transcription factor' MTF-1: biological facts and medical implications. Swiss. Med. Wkly. 131, 647-652.
88. Lichtlen, P., Wang, Y., Belser, T., Georgiev, O., Certa, U., Sack, R., and Schaffner, W. (2001). Target gene search for the metal-responsive transcription factor MTF-1. Nucleic Acids Res. 29, 1514-1523.
89. Lonnerdal, B. (2000). Dietary factors influencing zinc absorption. J. Nutr. 130, 1378S-1383S.
90. Lyons, T.J., Gasch, A.P., Gaither, L.A., Botstein, D., Brown, P.O., and Eide, D.J. (2000). Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Proc. Natl. Acad. Sci. USA 97, 7957-7962.
91. Mamba, K., Taniguchi, K., Kagabu, S., and Makita, T. (1989). Quantitative and morphological studies on the influence of zinc deficiency on the liver of pregnant rats. Nippon Juigaku Zasshi 51, 566-573.
92. Marchesini, G., Bugianesi, E., Ronchi, M., Flamia, R., Thomaseth, K., and Pacini, G. (1998). Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism 47, 792-798.
93. Maret, W. (1994). Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange. Proc. Natl. Acad. Sci. USA 91, 237-241.
94. Maret, W. (1995). Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc. Neurochem. Int. 27, 111-117.
95. Maret, W. and Vallee, B.L. (1998). Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc. Natl. Acad. Sci. USA 95, 3478-3482.
96. Maret, W., Jacob, C., Vallee, B.L., and Fischer, E.H. (1999). Inhibitory sites in enzymes: zinc removal and reactivation by thionein. Proc. Natl. Acad. Sci. USA 96, 1936-1940.
97. Mater, M.K., Thelen, A.P., Pan, D.A., and Jump, D.B. (1999). Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription. J. Biol. Chem. 274, 32725-32732.
98. Matsumoto, M., Ogawa, W., Teshigawara, K., Inoue, H., Miyake, K., Sakaue, H., and Kasuga, M. (2002). Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. Diabetes 51, 1672-1680.
99. Maxwell, K.N., Soccio, R.E., Duncan, E.M., Sehayek, E., and Breslow, J.L. (2003). Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J. Lipid Res. 44, 2109-2119.
100. Mazus, B., Falchuk, K.H., and Vallee, B.L. (1984). Histone formation, gene expression, and zinc deficiency in Euglena gracilis. Biochemistry 23, 42-47.
101. McNall, A.D., Etherton, T.D., and Fosmire, G.J. (1995). The impaired growth induced by zinc deficiency in rats is associated with decreased expression of the hepatic insulin-like growth factor I and growth hormone receptor genes. J. Nutr. 125, 874-879.
102. Meier, C.A. (1997). Regulation of gene expression by nuclear hormone receptors. J. Recept. Signal Transduct. Res. 17, 319-335.
103. Meyer, K., Jia, Y., Cao, W.Q., Kashireddy, P., and Rao, M.S. (2002). Expression of peroxisome proliferator-activated receptor α , and PPARα regulated genes in spontaneously developed hepatocellular carcinomas in fatty acyl-CoA oxidase null mice. Int. J. Oncol. 21, 1175-1180.
104. Miller, R.T., Glover, S.E., Stewart, W.S., Corton, J.C., Popp, J.A., and Cattley, R.C. (1996). Effect on the expression of c-met, c-myc and PPAR-α in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14,643. Carcinogenesis 17, 1337-1341.
105. Miyamoto, T., Sakurai, A., and DeGroot, L.J. (1991). Effects of zinc and other divalent metals on deoxyribonucleic acid binding and hormone-binding activity of human α 1 thyroid hormone receptor expressed in Escherichia coli. Endocrinology 129, 3027-3033.
106. Moon, Y.S., Latasa, M.J., Griffin, M.J., and Sul, H.S. (2002). Suppression of fatty acid synthase promoter by polyunsaturated fatty acids. J. Lipid Res. 43, 691-698.
107. Moore, J.B., Blanchard, R.K., McCormack, W.T., Cousins, R.J. (2001) cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. J. Nutr. 131, 3189-96.
108. Motojima, K. (2000). PPAR-mediated diverse responses in various tissues of mouse. Cell Biochem. Biophys. 32, 205-211.
109. Muller, M. and Kersten, S. (2003). Nutrigenomics: goals and strategies. Nat. Rev. Genet. 4, 315-322.
110. Ninh, N.X., Thissen, J.P., Maiter, D., Adam, E., Mulumba, N., and Ketelslegers, J.M. (1995). Reduced liver insulin-like growth factor-I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (GH) receptors and serum GH-binding protein. J. Endocrinol. 144, 449-456.
111. Ninh, N.X., Maiter, D., Lause, P., Chrzanowska, B., Underwood, L.E., Ketelslegers, J.M., and Thissen, J.P., (1998). Continuous administration of growth hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding. Growth Horm. IGF Res. 8, 465-472.
112. Oliver, J.W., Sachan, D.S., Su, P., and Applehans, F.M. (1987). Effects of zinc deficiency on thyroid function. Drug Nutr. Interact. 5, 113-124.
113. Oteiza, P.I., Olin, K.L., Fraga, C.G., and Keen, C.L. (1995). Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J. Nutr. 125, 823-829.
114. Outten, C.E., Tobin, D.A., Penner-Hahn, J.E., and O'Halloran, T.V. (2001). Characterization of the metal receptor sites in Escherichia coli Zur, an ultrasensitive zinc(II) metalloregulatory protein. Biochemistry 40, 10417-10423.
115. Pallauf, J. and Kirchgessner, K. (1972). Zinc contents in the bones and whole body of growing rats with various zinc supply. 5. Zinc metabolism in the animal model. Z. Tierphysiol. Tierernahr. Futtermittelkd. 30, 193-202.
116. Palmiter,R.D. (1998).The elusive function of metallothioneins. Proc. Natl. Acad. Sci. USA 95, 8428-8430.
117. Park, J.H., Grandjean, C.J., Antonson, D.L., and Vanderhoof, J.A. (1986). Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats. J. Nutr. 116, 610-617.
118. Paski, S.C., Covery, L., Kummer, A., and Xu, Z. (2003). Role of metallothionein in regulating the abundance of histochemically reactive zinc in rat tissues. Can. J. Physiol. Pharmacol. 81, 815-824.
119. Payne, J.C., Rous, B.W., Tenderholt, A.L., and Godwin, H.A. (2003). Spectroscopic determination of the binding affinity of zinc to the DNA-binding domains of nuclear hormone receptors. Biochemistry 42, 14214-14224.
120. Pearce, L.L., Wasserloos, K., St. Croix, C.M., Gandley, R., Levitan, E.S., and Pitt, B.R. (2000). Metallothionein, nitric oxide and zinc homeostasis in vascular endothelial cells. J. Nutr. 130, 1467S-1470S.
121. Peters, J.M., Zhou, Y.C., Ram, P.A., Lee, S.S., Gonzalez, F.J., and Waxman, D.J. (1996). Peroxisome proliferator-activated receptor α required for gene induction by dehydroepiandrosterone-3 β -sulfate. Mol. Pharmacol. 50, 67-74.
122. Powell, S.R. (2000). The antioxidant properties of zinc. J. Nutr. 130, 1447S-1454S.
123. Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.M., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., and Mangelsdorf, D.J. (2000). Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes. Dev. 14, 2819-2830.
124. Rofe, A.M., Philcox, J.C., and Coyle, P. (1996). Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice. Biochem. J. 314, 793-797.
125. Rofe, A.M., Philcox, J.C., and Coyle, P. (2000). Activation of glycolysis by zinc is diminished in hepatocytes from metallothionein-null mice. Biol. Trace Elem. Res. 75, 87-97.
126. Roth, H.P. and Kirchgessner, M. (1975a). Serum and plasma insulin levels in zinc-deficient rats following glucose stimulation. Int. J. Vitam. Nutr. Res. 45, 201-208.
127. Roth, H.P., Schneider, U., and Kirchgessner, M. (1975b). Effect of zinc deficiency on glucose tolerance. Arch. Tierernahr. 25, 545-549.
128. Roth, H.P. and Kirchgessner, M. (1983). Effect of zinc deficiency on 3′,5′-cyclic-AMP content and parameters of energy metabolism in the rat. Z. Ernährungswiss. 22, 116-123.
129. Roth, H.P. and Kirchgessner, M. (1994). Influence of alimentary zinc deficiency on the concentration of growth hormone (GH), insulin-like growth factor I (IGF-I) and insulin in the serum of force-fed rats. Horm. Metab. Res. 26, 404-408.
130. Roth, V.H. (2001). Nitrogen detoxification in artificially-fed zinc-deficient rats. J. Anim. Physiol. Anim. Nutr. 85, 158-163.
131. Sato, S.M., Frazier, J.M., and Goldberg, A.M. (1984). The distribution and binding of zinc in the hippocampus. J. Neurosci. 4, 1662-1670.
132. Seguin, C. and Hamer, D.H. (1987). Regulation in vitro of metallothionein gene binding factors. Science 235, 1383-1387.
133. Shih, H. and Towle, H.C. (1994). Definition of the carbohydrate response element of the rat S14 gene. Context of the CACGTG motif determines the specificity of carbohydrate regulation. J. Biol. Chem. 269, 9380-9387.
134. Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A.H., Osuga, J., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., Gotoda, T., Ishibashi, S., and Yamada, N. (1999). Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J. Biol. Chem. 274, 35832-35839.
135. Southwick, F.S., Li, W., Zhang, F., Zeile, W.L., and Purich, D.L. (2003). Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc. Cell Motil. Cytoskeleton 54, 41-55.
136. Stierum, R., Burgemeister, R., van Helvoort, A., Peijnenburg, A., Schutze, K., Seidelin, M., Vang, O., and van Ommen, B. (2001). Functional food ingredients against colorectal cancer. An example project integrating functional genomics, nutrition and health. Nutr. Metab. Cardiovasc. Dis. 11, 94-98.
137. Sullivan, J.F., Jetton, M.M., Hahn, H.K., and Butch, R.E. (1980). Enhanced lipid peroxidation in liver microsomes of zinc-deficient rats. Am. J. Clin. Nutr. 33, 51-56.
138. Takeda, A., Hirate, M., Tamano, H., Nisibaba, D., and Oku, N. (2003). Susceptibility to kainate-induced seizures under dietary zinc deficiency. J. Neurochem. 85, 1575-1580.
139. Taki, M., Wolford, J.L., and O'Halloran, T.V. (2004). Emission ratiometric imaging of intracellular zinc: design of a benzoxazole fluorescent sensor and its application in two-photon microscopy. J. Am. Chem. Soc. 126, 712-713.
140. tom Dieck, H., Doring, F., Roth, H.P., and Daniel, H. (2003). Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays. J. Nutr. 133, 1004-1010.
141. Trompeter, H.I. and Soling, H.D. (1992). Cloning and characterisation of a gene encoding the 11.5 kDa zinc-binding protein (parathymosin-α). FEBS Lett. 298, 245-248.
142. Vallee, B.L. and Falchuk, K.H. (1993). The biochemical basis of zinc physiology. Physiol. Rev. 73, 79-118.
143. Vallee, B.L. (1995). The function of metallothionein. Neurochem. Int. 27, 23-33.
144. Wang, X., Sato, R., Brown, M.S., Hua, X., and Goldstein, J.L. (1994). SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77, 53-62.
145. White, C.L. (1988). The effect of zinc deficiency on the body composition of rats. Biol. Trace Elem. Res 17, 175-187.
146. Winegar, B.D. and Lansman, J.B. (1990). Voltage-dependent block by zinc of single calcium channels in mouse myotubes. J. Physiol. 425, 563-578.
147. Wolf, S.G., Mosser, G., and Downing, K.H. (1993). Tubulin conformation in zinc-induced sheets and macrotubes. J. Struct. Biol. 111, 190-199.
148. Xu, Z., Squires, E.J., and Bray, T.M. (1994). Effects of dietary zinc deficiency on the hepatic microsomal cytochrome P450 2B in rats. Can. J. Physiol. Pharmacol. 72, 211-216.
149. Xu, Z., Kawai, M., Bandiera, S.M., and Chang, T.K. (2001). Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats. Biochem. Pharmacol. 62, 1283-1291.
150. Yu, S., Rao, S., and Reddy, J.K. (2003). Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis. Curr. Mol. Med. 3, 561-572.
151. Zhao, H. and Eide, D.J. (1997). Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 17, 5044-5052