-
1
-
-
0029775615
-
The incidence of neutropenia and agranulocytosis in patients treated with clozapine in the UK and Ireland
-
Atkin, K., Kendall, F., Gould, D., Freeman, H., J., L., and D., O. S. (1996) The incidence of neutropenia and agranulocytosis in patients treated with clozapine in the UK and Ireland. Br. J. Psychiatry 169, 483-488.
-
(1996)
Br. J. Psychiatry
, vol.169
, pp. 483-488
-
-
Atkin, K.1
Kendall, F.2
Gould, D.3
Freeman, H.4
Lieberman, J.5
-
3
-
-
0029555342
-
Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells
-
Liu, Z. C., and Uetrecht, J. P. (1995) Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells. J. Pharmacol. Exp. Ther. 275, 1476-1483.
-
(1995)
J. Pharmacol. Exp. Ther
, vol.275
, pp. 1476-1483
-
-
Liu, Z.C.1
Uetrecht, J.P.2
-
4
-
-
0029416850
-
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man
-
Maggs, J. L., Williams, D., Pirmohammed, M., and Park, B. K. (1995) The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J. Pharmacol. Exp. Ther. 275, 1463-1475.
-
(1995)
J. Pharmacol. Exp. Ther
, vol.275
, pp. 1463-1475
-
-
Maggs, J.L.1
Williams, D.2
Pirmohammed, M.3
Park, B.K.4
-
5
-
-
0031770078
-
Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis
-
Guest, I., Sokoluk, B., MacCrimmon, J., and Uetrecht, J. (1998) Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. Toxicology 131, 53-65.
-
(1998)
Toxicology
, vol.131
, pp. 53-65
-
-
Guest, I.1
Sokoluk, B.2
MacCrimmon, J.3
Uetrecht, J.4
-
6
-
-
33747166483
-
Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: A potential in vitro system for the study of agranulocytosis
-
Pereira, A., and Dean, B. (2006) Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis. Biochem. Pharmacol. 72, 783-793.
-
(2006)
Biochem. Pharmacol
, vol.72
, pp. 783-793
-
-
Pereira, A.1
Dean, B.2
-
7
-
-
0033938971
-
Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine
-
Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., and Park, B. K. (2000) Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. Mol. Pharmacol. 58, 207-216.
-
(2000)
Mol. Pharmacol
, vol.58
, pp. 207-216
-
-
Williams, D.P.1
Pirmohamed, M.2
Naisbitt, D.J.3
Uetrecht, J.P.4
Park, B.K.5
-
8
-
-
0031842867
-
A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes
-
Gardner, I., Zahid, N., MacCrimmon, D., and Uetrecht, J. P. (1998) A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes. Mol. Pharmacol. 53, 991-998.
-
(1998)
Mol. Pharmacol
, vol.53
, pp. 991-998
-
-
Gardner, I.1
Zahid, N.2
MacCrimmon, D.3
Uetrecht, J.P.4
-
9
-
-
0032933969
-
The cytotoxicity of clozapine metabolites: Implications for predicting clozapine-induced agranulocytosis
-
Tschen, A. C., Rieder, M. J., Oyewumi, L. K., and Freeman, D. J. (1999) The cytotoxicity of clozapine metabolites: implications for predicting clozapine-induced agranulocytosis. Clin. Pharmacol. Ther. 65, 526-532.
-
(1999)
Clin. Pharmacol. Ther
, vol.65
, pp. 526-532
-
-
Tschen, A.C.1
Rieder, M.J.2
Oyewumi, L.K.3
Freeman, D.J.4
-
10
-
-
33745994905
-
Increased FasL expression correlates with apoptotic changes in granulocytes cultured with oxidized clozapine
-
Husain, Z., Almeciga, I., Delgado, J. C., Clavijo, O. P., Castro, J. E., Belalcazar, V., Pinto, C., Zuniga, J., Romero, V., and Yunis, E. J. (2006) Increased FasL expression correlates with apoptotic changes in granulocytes cultured with oxidized clozapine. Toxicol. Appl. Pharmacol. 214, 326-334.
-
(2006)
Toxicol. Appl. Pharmacol
, vol.214
, pp. 326-334
-
-
Husain, Z.1
Almeciga, I.2
Delgado, J.C.3
Clavijo, O.P.4
Castro, J.E.5
Belalcazar, V.6
Pinto, C.7
Zuniga, J.8
Romero, V.9
Yunis, E.J.10
-
11
-
-
0031814439
-
A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo
-
Gardner, I., Leeder, J. S., Chin, T., Zahid, N., and Uetrecht, J. P. (1998) A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo. Mol. Pharmacol. 53, 999-1008.
-
(1998)
Mol. Pharmacol
, vol.53
, pp. 999-1008
-
-
Gardner, I.1
Leeder, J.S.2
Chin, T.3
Zahid, N.4
Uetrecht, J.P.5
-
12
-
-
0033304007
-
Comparative oxidation of loxapine and clozapine by human neutrophils
-
Jegouzo, A., Gressier, B., Frimat, B., Brunet, C., Dine, T., Luyckx, M., Kouach, M., Cazin, M., and Cazin, J. C. (1999) Comparative oxidation of loxapine and clozapine by human neutrophils. Fundam. Clin. Pharmacol. 13, 113-119.
-
(1999)
Fundam. Clin. Pharmacol
, vol.13
, pp. 113-119
-
-
Jegouzo, A.1
Gressier, B.2
Frimat, B.3
Brunet, C.4
Dine, T.5
Luyckx, M.6
Kouach, M.7
Cazin, M.8
Cazin, J.C.9
-
13
-
-
0027304737
-
Ascorbic acid recycling in human neutrophils
-
Washko, P. W., Wang, Y., and Levine, M. (1993) Ascorbic acid recycling in human neutrophils. J. Biol. Chem. 268, 15531-15535.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 15531-15535
-
-
Washko, P.W.1
Wang, Y.2
Levine, M.3
-
14
-
-
0032977279
-
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans
-
Carr, A. C., and Frei, B. (1999) Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am. J. Clin. Nutr. 69, 1086-1107.
-
(1999)
Am. J. Clin. Nutr
, vol.69
, pp. 1086-1107
-
-
Carr, A.C.1
Frei, B.2
-
15
-
-
0344628603
-
Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: Parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity
-
Sirota, P., Gavrieli, R., and Wolach, B. (2003) Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity. Psychiatry Res. 121, 123-132.
-
(2003)
Psychiatry Res
, vol.121
, pp. 123-132
-
-
Sirota, P.1
Gavrieli, R.2
Wolach, B.3
-
16
-
-
36749104268
-
Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence
-
Gysin, R., Kraftsik, R., Sandell, J., Bovet, P., Chappuis, C., Conus, P., Deppen, P., Preisig, M., Ruiz, V., Steullet, P., Tosic, M., Werge, T., and Do, K. Q. (2007) Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence. Proc. Natl. Acad. Sci. U.S.A. 104, 16621-16626.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A
, vol.104
, pp. 16621-16626
-
-
Gysin, R.1
Kraftsik, R.2
Sandell, J.3
Bovet, P.4
Chappuis, C.5
Conus, P.6
Deppen, P.7
Preisig, M.8
Ruiz, V.9
Steullet, P.10
Tosic, M.11
Werge, T.12
Do, K.Q.13
-
17
-
-
0035033906
-
Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia
-
Mahadik, S. P., Evans, D., and Lal, H. (2001) Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia. Prog Neuropsychopharmacol. Biol. Psychiatry 25, 463-493.
-
(2001)
Prog Neuropsychopharmacol. Biol. Psychiatry
, vol.25
, pp. 463-493
-
-
Mahadik, S.P.1
Evans, D.2
Lal, H.3
-
19
-
-
0031471159
-
Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis
-
Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., and Park, B. K. (1997) Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis. J. Pharmacol. Exp. Ther. 283, 1375-1382.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, pp. 1375-1382
-
-
Williams, D.P.1
Pirmohamed, M.2
Naisbitt, D.J.3
Maggs, J.L.4
Park, B.K.5
-
20
-
-
0001930580
-
: Nutrition, Nutritional Diseases, and Nutrition Research Applications
-
Wagner, J. E, and Manning, P. J, Eds, p, Academic Press,New York
-
Navia, J. M., and Hunt, C. E. (1976) Chapter 17: Nutrition, Nutritional Diseases, and Nutrition Research Applications, In The Biology of the Guinea Pig (Wagner, J. E., and Manning, P. J., Eds.) p 248, Academic Press,New York.
-
(1976)
The Biology of the Guinea Pig
, pp. 248
-
-
Navia, J.M.1
Hunt, C.E.2
-
21
-
-
0022388988
-
Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid
-
Horio, F., Ozaki, K., Yoshida, A., Makino, S., and Hayashi, Y. (1985) Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid. J. Nutr. 115, 1630-1640.
-
(1985)
J. Nutr
, vol.115
, pp. 1630-1640
-
-
Horio, F.1
Ozaki, K.2
Yoshida, A.3
Makino, S.4
Hayashi, Y.5
-
22
-
-
0025195819
-
Regulation of ascorbic acid concentration in embryonic chick brain
-
Wilson, J. X. (1990) Regulation of ascorbic acid concentration in embryonic chick brain. Dev. Biol. 139, 292-298.
-
(1990)
Dev. Biol
, vol.139
, pp. 292-298
-
-
Wilson, J.X.1
-
23
-
-
0003096530
-
: Physiology
-
Wagner, J. E. and Manning, P. J, Eds, pp, Academic Press, New York
-
Sisk, D. B. (1976) Chapter 7: Physiology, In The Biology of the Guinea Pig (Wagner, J. E. and Manning, P. J., Eds.) pp 67-72, Academic Press, New York.
-
(1976)
The Biology of the Guinea Pig
, pp. 67-72
-
-
Sisk, D.B.1
-
24
-
-
0022731886
-
Hematology values for peripheral blood of laboratory rats
-
Leonard, R., and Ruben, Z. (1986) Hematology values for peripheral blood of laboratory rats. Lab. Anim. Sci. 36, 227-231.
-
(1986)
Lab. Anim. Sci
, vol.36
, pp. 227-231
-
-
Leonard, R.1
Ruben, Z.2
-
25
-
-
0025607748
-
Vitamin C status in chronic schizophrenia
-
Suboticanec, K., Folnegovic-Smalc, V., Korbar, M., Mestrovic, B., and Buzina, R. (1990) Vitamin C status in chronic schizophrenia. Biol. Psychiatry 28, 959-966.
-
(1990)
Biol. Psychiatry
, vol.28
, pp. 959-966
-
-
Suboticanec, K.1
Folnegovic-Smalc, V.2
Korbar, M.3
Mestrovic, B.4
Buzina, R.5
-
26
-
-
0025746640
-
Possible role of free radical formation in clozapine (clozaril)-induced agranulocytosis
-
Fischer, V., Haar, J. A., Greiner, L., Lloyd, R. V., and Mason, R. P. (1991) Possible role of free radical formation in clozapine (clozaril)-induced agranulocytosis. Mol. Pharmacol. 40, 846-853.
-
(1991)
Mol. Pharmacol
, vol.40
, pp. 846-853
-
-
Fischer, V.1
Haar, J.A.2
Greiner, L.3
Lloyd, R.V.4
Mason, R.P.5
-
27
-
-
0033610722
-
Myocarditis and cardiomyopathy associated with clozapine
-
Killian, J. G., Kerr, K., Lawrence, C., and Celermajer, D. S. (1999) Myocarditis and cardiomyopathy associated with clozapine. Lancet 354, 1841-1845.
-
(1999)
Lancet
, vol.354
, pp. 1841-1845
-
-
Killian, J.G.1
Kerr, K.2
Lawrence, C.3
Celermajer, D.S.4
-
28
-
-
0142169943
-
Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro
-
Williams, D. P., O'Donnell, C. J., Maggs, J. L., Leeder, J. S., Uetrecht, J., Pirmohamed, M., and Park, B. K. (2003) Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro. Chem. Res. Toxicol. 16, 1359-1364.
-
(2003)
Chem. Res. Toxicol
, vol.16
, pp. 1359-1364
-
-
Williams, D.P.1
O'Donnell, C.J.2
Maggs, J.L.3
Leeder, J.S.4
Uetrecht, J.5
Pirmohamed, M.6
Park, B.K.7
-
29
-
-
0035233822
-
Metabolic cooperation of ascorbic acid and glutathione in normal and vitamin C-deficient ODS rats
-
Wang, Y., Kashiba, M., Kasahara, E., Tsuchiya, M., Sato, E. F., Utsumi, K., and Inoue, M. (2001) Metabolic cooperation of ascorbic acid and glutathione in normal and vitamin C-deficient ODS rats. Physiol. Chem. Phys. Med. NMR 33, 29-39.
-
(2001)
Physiol. Chem. Phys. Med. NMR
, vol.33
, pp. 29-39
-
-
Wang, Y.1
Kashiba, M.2
Kasahara, E.3
Tsuchiya, M.4
Sato, E.F.5
Utsumi, K.6
Inoue, M.7
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