Comparative oxidation of loxapine and clozapine by human neutrophils

Fundamental and Clinical Pharmacology

Volumn 13, Issue 1, 1999, Pages 113-119

  Jegouzo, Anne ^a   Gressier, Bernard ^a   Frimat, Bruno ^a   Brunet, Claude ^a   Dine, Thierry ^a   Luyckx, Michel ^a   Kouach, Mostapha ^a   Cazin, Micheline ^a   Cazin, Jean Claude ^a  

^a UNIV LILLE   (France)

Author keywords

Agranulocytosis; Clozapine; Human polymorphonuclear neutrophils; Loxapine; Myeloperoxidase

Indexed keywords

ASCORBIC ACID; CLOZAPINE; GLUTATHIONE; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; LOXAPINE; MYELOPEROXIDASE; NEUROLEPTIC AGENT;

AGRANULOCYTOSIS; ARTICLE; CHLORINATION; CONTROLLED STUDY; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; GRANULOCYTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATORY BURST; TOXICOKINETICS;

EID: 0033304007     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00329.x     Document Type: Article

References (28)

1. Scavenging of chlorpromazine cation radical by ascorbic acid or glutathione
2. A rapid density gradient technique for separating polymorphonuclear granulocytes
3. N-desmethylclozapine, an insensitive marker of clozapine-induced agranulocytosis and granulocytopenia
4. One-electron oxidations by peroxidases
5. Possible role of free radical formation in clozapine induced agranulocytosis
6. Metabolism of clozapine by human neutrophils: Evidence for a specific oxidation of clozapine by the myeloperoxidase system with inhibition of enzymatic chlorination cycle
7. N-Desmethylclozapine: A clozapine metabolite that suppresses haematopoisis
8. Decrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutrophils: Comparison in vitro of some thiol-containing drugs
9. 1-proteinase inhibitor inactivation by the myeloperoxidase system. Hypothetic study for therapeutic strategy in management of smokers' emphysema
10. Compound I of myeloperoxidase
11. Plasma clozapine and desmethylclozapine levels in clozapine induced agranulocytosis
12. Metabolic activation of chlorpromazine by stimulated human polymorphonuclear leukocytes. Induction of covalent binding of chlorpromazine to nucleic acids and proteins
13. Peroxidase catalysed oxidation of different dibenzazepine derivatives
14. Free radical scavenging enzyme activity and related trace metals in clozapine-induced agranulocytosis: A pilot study
15. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells
16. The metabolic formation of a reactive intermediates from clozapine, a drug associated with agranulocytosis in man
17. Possible role of free radical formation in drug induced agranulocytosis
18. Clozapine induced agranulocytosis: Risk factors, monitoring and management
19. In vitro interaction between dirithromycin or its metabolite, erythromycylamine and oxidative polymorphonuclear metabolism
20. Determination of clozapine in serum with radioreceptor assay versus high performance chromatography: Possible detection of hydroxymetabolites
21. A simple colorimetric methode for the measurement of hydrogen peroxide produced by cells in culture
22. Cytotoxic activity in serum of patients with clozapine-induced agranulocytosis
23. The influence of clozapine treatment on plasma granulocyte colony-stimulating factor (G-CSF) levels
24. Lactate deshydrogenase: A marker of cellular integrity
25. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reaction
26. Chlorination of taurine by human neutrophils
27. Neutrophil cytotoxicity of the chemicaly reactive metabolite(s) of clozapine: Possible role in agranulocytosis
28. Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite