Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 2, 2008, Pages 648-657

  Lue, Bena Marie ^a   Nielsen, Flemming Seier ^a   Magnussen, Thomas ^b   Schou, Hanne Mette ^b   Kristensen, Kim ^b   Jacobsen, Lene Orup ^b   Müllertz, Anette ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Biorelevant media; Dissolution; In vivo in vitro correlation (IVIVC); Poorly soluble; Solubility

Indexed keywords

ANTIDIABETIC AGENT; BILE SALT; CATIONIC SURFACTANT; CETRIMIDE; GLYCEROL OLEATE; HEMIBENZATHINE; MALEIC ACID DERIVATIVE; NNC 25 0926; OLEIC ACID; PHOSPHATIDYLCHOLINE; SODIUM AZIDE; SODIUM CHLORIDE; TRISMA MALEATE;

ANALYTIC METHOD; ANALYTICAL ERROR; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG FORMULATION; FEMALE; LIPOLYSIS; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NONLINEAR REGRESSION ANALYSIS;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CETRIMONIUM COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DOSAGE FORMS; EXCIPIENTS; FEMALE; KINETICS; MALE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SOLVENTS;

EID: 43249127225     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.12.013     Document Type: Article

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