Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: An integrated analysis

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 5, 2008, Pages 1774-1783

  Liu, Peter Y ^a,o   Swerdloff, Ronald S ^b   Anawalt, Bradley D ^c   Anderson, Richard A ^d   Bremner, William J ^c   Elliesen, Joerg ^e   Gu, Yi Qun ^f   Kersemaekers, Wendy M ^g   McLachlan, Robert I ^h   Meriggiola, M Cristina ⁱ   Nieschlag, Eberhard ^j   Sitruk Ware, Regine ^k   Vogelsong, Kirsten ^l   Wang, Xing Hai ^m   Wu, Frederick C W ⁿ   Zitzmann, Michael ^j   Handelsman, David J ^a   Wang, Christina ^b  

^a Department of Microbiology and Infectious Diseases   (Australia)

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e BAYER PHARMA AG   (Germany)

^f NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

^g NV ORGANON   (Netherlands)

^h MONASH UNIVERSITY   (Australia)

ⁱ UNIVERSITY OF BOLOGNA   (Italy)

^j UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^k ROCKEFELLER UNIVERSITY   (United States)

^l WORLD HEALTH ORGANIZATION   (Switzerland)

^m Jiangsu Family Planning Institute   (China)

ⁿ UNIVERSITY OF MANCHESTER   (United Kingdom)

^o UNIVERSITY OF SYDNEY   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; GESTAGEN; TESTOSTERONE;

ADULT; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; FERTILITY; HUMAN; HUMAN EXPERIMENT; KAPLAN MEIER METHOD; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SPERMATOGENESIS; WORLD HEALTH ORGANIZATION;

EID: 43249103371     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-2768     Document Type: Article

References (73)

1. WHO Task Force on Methods for the Regulation of Male Fertility Contraceptive efficacy of testosterone-induced azoospermia in normal men Lancet 336 1990 955 959
2. WHO Task Force on Methods for the Regulation of Male Fertility Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men Fertil Steril 65 1996 821 829
3. YQ Gu XH Wang D Xu L Peng LF Cheng MK Huang ZJ Huang GY Zhang A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy chinese men J Clin Endocrinol Metab 88 2003 562 568
4. L Turner AJ Conway M Jimenez PY Liu E Forbes RI McLachlan DJ Handelsman Contraceptive efficacy of a depot progestin and androgen combination in men J Clin Endocrinol Metab 88 2003 4659 4667
5. PY Liu RS Swerdloff PD Christenson DJ Handelsman C Wang Hormonal Male Contraception Summit Group Rate, extent and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis Lancet 367 2006 1412 1420
6. Anonymous Tenth Summit Meeting Consensus: recommendations for regulatory approval for hormonal male contraception Int J Androl 30 2007 63 64
7. PY Liu JD Veldhuis The hypothalamo-pituitary unit, testis and male accessory organs JF Strauss RL Barbieri Yen and Jaffe's reproductive endocrinology: physiology, pathophysiology and clinical management 6th ed. 2008 W. B. Saunders Philadelphia in press
8. RA Anderson DT Baird Male contraception Endocr Rev 23 2002 735 762
9. DJ Handelsman Male contraception LJ DeGroot JL Jameson Endocrinology. 5th ed 2005 Elsevier Saunders Philadelphia 3247 3256
10. C Wang RS Swerdloff Male hormonal contraception Am J Obstet Gynecol 190 2004 S60 S68
11. MC Meriggiola TM Farley MT Mbizvo A review of androgen-progestin regimens for male contraception J Androl 24 2003 466 483
12. E Nieschlag A Henke Hopes for male contraception Lancet 365 2005 554 556
13. JK Amory ST Page WJ Bremner Drug insight: recent advances in male hormonal contraception Nat Clin Pract Endocrinol Metab 2 2006 32 41
14. KL Matthiesson RI McLachlan Male hormonal contraception: concept proven, product in sight? Hum Reprod Update 12 2006 463 482
15. FC Wu Hormonal approaches to male contraception: approaching reality Mol Cell Endocrinol 250 2006 2 7
16. MC Meriggiola G Pelusi Advances in male hormonal contraception Expert Opin Investig Drugs 15 2006 389 397
17. FC Wu TM Farley A Peregoudov GM Waites Effects of testosterone enanthate in normal men: experience from a multicenter contraceptive efficacy study. World Health Organization Task Force on Methods for the Regulation of Male Fertility Fertil Steril 65 1996 626 636
18. RI McLachlan L O'Donnell SJ Meachem PG Stanton K De K Pratis DM Robertson Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive J Androl 23 2002 149 162
19. World Health Organization Task Force on Methods for the Regulation of Male Fertility Rates of testosterone-induced suppression to severe oligozoospermia or azoospermia in two multinational clinical studies. World Health Organization Task Force on Methods for the Regulations of Male Fertility Int J Androl 18 1995 157 165
20. DJ Handelsman TM Farley A Peregoudov GM Waites Factors in nonuniform induction of azoospermia by testosterone enanthate in normal men. World Health Organization Task Force on Methods for the Regulation of Male Fertility Fertil Steril 63 1995 125 133
21. LP Ly PY Liu DJ Handelsman Rates of suppression and recovery of human sperm output in testosterone-based hormonal contraceptive regimens Hum Reprod 20 2005 1733 1740
22. RI McLachlan DM Robertson E Pruysers A Ugoni AM Matsumoto BD Anawalt WJ Bremner C Meriggiola Relationship between serum gonadotropins and spermatogenic suppression in men undergoing steroidal contraceptive treatment J Clin Endocrinol Metab 89 2004 142 149
23. MC Meriggiola A Costantino WJ Bremner AM Morselli-Labate Higher testosterone dose impairs sperm suppression induced by a combined androgen-progestin regimen J Androl 23 2002 684 690
24. Anonymous Sixth Summit Meeting Consensus: recommendations for regulatory approval for hormonal male contraception Int J Androl 25 2002 375
25. GM Waites Development of methods of male contraception: impact of the World Health Organization Task Force Fertil Steril 80 2003 1 15
26. LM Misell D Holochwost D Boban N Santi S Shefi MK Hellerstein PJ Turek A stable isotope-mass spectrometric method for measuring human spermatogenesis kinetics in vivo J Urol 175 2006 242 246 discussion 246
27. Y Clermont Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal Physiol Rev 52 1972 198 236
28. World Health Organization WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction 4th ed. 1999 Cambridge University Press Cambridge, UK
29. CJ Hay BM Brady M Zitzmann K Osmanagaoglu P Pollanen D Apter FC Wu RA Anderson E Nieschlag P Devroey I Huhtaniemi WM Kersemaekers A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception J Clin Endocrinol Metab 90 2005 2042 2049
30. C Wang XH Wang AL Nelson KK Lee YG Cui JS Tong N Berman L Lumbreras A Leung L Hull S Desai RS Swerdloff Levonorgestrel implants enhanced the suppression of spermatogenesis by testosterone implants: comparison between Asian and non-Asian men J Clin Endocrinol Metab 91 2005 460 470
31. RS Swerdloff CJ Bagatell C Wang BD Anawalt N Berman B Steiner WJ Bremner Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) is maintained by TE alone J Clin Endocrinol Metab 83 1998 3527 3533
32. IT Gonzalo RS Swerdloff AL Nelson B Clevenger R Garcia N Berman C Wang Levonorgestrel implants (Norplant II) for male contraception clinical trials: combination with transdermal and injectable testosterone J Clin Endocrinol Metab 87 2002 3562 3572
33. D Kinniburgh H Zhu L Cheng AT Kicman DT Baird RA Anderson Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men Hum Reprod 17 2002 1490 1501
34. JK Amory BD Anawalt WJ Bremner AM Matsumoto Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive development J Androl 22 2001 1053 1060
35. M Meriggiola A Costantino F Saad L D'Emidio AM Labate A Bertaccini W Bremner I Rudolph M Ernst B Kirsch G Martorana G Pelusi Norethisterone enanthate plus testosterone undecanoate for male contraception: effects of various injection intervals on spermatogenesis, reproductive hormones, testis, and prostate J Clin Endocrinol Metab 90 2005 2005 2014
36. A Kamischke T Heuermann K Kruger S von Eckardstein I Schellschmidt A Rubig E Nieschlag An effective hormonal male contraceptive using testosterone undecanoate with oral or injectable norethisterone preparations J Clin Endocrinol Metab 87 2002 530 539
37. BD Anawalt JK Amory KL Herbst AD Coviello ST Page WJ Bremner AM Matsumoto Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial J Androl 26 2005 405 413
38. A Qoubaitary C Meriggiola CM Ng L Lumbreras S Cerpolini G Pelusi PD Christensen L Hull RS Swerdloff C Wang Pharmacokinetics of testosterone undecanoate injected alone or in combination with norethisterone enanthate in healthy men J Androl 27 2006 853 867
39. RA Bebb BD Anawalt RB Christensen CA Paulsen WJ Bremner AM Matsumoto Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach J Clin Endocrinol Metab 81 1996 757 762
40. BD Anawalt RA Bebb WJ Bremner AM Matsumoto A lower dosage levonorgestrel and testosterone combination effectively suppresses spermatogenesis and circulating gonadotropin levels with fewer metabolic effects than higher dosage combinations J Androl 20 1999 407 414
41. S Von Eckardstein G Noe V Brache E Nieschlag H Croxatto F Alvarez A Moo-Young I Sivin N Kumar M Small K Sundaram A clinical trial of 7β-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men J Clin Endocrinol Metab 88 2003 5232 5239
42. YQ Gu JS Tong DZ Ma XH Wang D Yuan WH Tang WJ Bremner Male hormonal contraception: effects of injections of testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in chinese men J Clin Endocrinol Metab 89 2004 2254 2262
43. A Kamischke D Ploger S Venherm S von Eckardstein A von Eckardstein E Nieschlag Intramuscular testosterone undecanoate with or without oral levonorgestrel: a randomized placebo-controlled feasibility study for male contraception Clin Endocrinol (Oxf) 53 2000 43 52
44. RA Anderson D Kinniburgh DT Baird Suppression of spermatogenesis by etonogestrel implants with depot testosterone: potential for long-acting male contraception J Clin Endocrinol Metab 87 2002 3640 3649
45. FC Wu R Balasubramanian TM Mulders HJ Coelingh-Bennink Oral progestogen combined with testosterone as a potential male contraceptive: additive effects between desogestrel and testosterone enanthate in suppression of spermatogenesis, pituitary-testicular axis, and lipid metabolism J Clin Endocrinol Metab 84 1999 112 122
46. MC Meriggiola A Costantino S Cerpolini WJ Bremner D Huebler AM Morselli-Labate B Kirsch A Bertaccini C Pelusi G Pelusi Testosterone undecanoate maintains spermatogenic suppression induced by cyproterone acetate plus testosterone undecanoate in normal men J Clin Endocrinol Metab 88 2003 5818 5826
47. BD Anawalt KL Herbst AM Matsumoto TM Mulders HJ Coelingh-Bennink WJ Bremner Desogestrel plus testosterone effectively suppresses spermatogenesis but also causes modest weight gain and high-density lipoprotein suppression Fertil Steril 74 2000 707 714
48. WM Hair K Kitteridge DB O'Connor FCW Wu A novel male contraceptive pill-patch combination: oral desogestrel and transdermal testosterone in the suppression of spermatogenesis in normal men J Clin Endocrinol Metab 86 2001 5201 5209
49. BM Brady M Walton N Hollow AT Kicman DT Baird RA Anderson Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception Hum Reprod 19 2004 2658 2667
50. MC Meriggiola WJ Bremner CA Paulsen A Valdiserri L Incorvaia R Motta A Pavani M Capelli C Flamigni A combined regimen of cyproterone acetate and testosterone enanthate as a potentially highly effective male contraceptive J Clin Endocrinol Metab 81 1996 3018 3023
51. A Kamischke S Venherm D Ploger S von Eckardstein E Nieschlag Intramuscular testosterone undecanoate and norethisterone enanthate in a clinical trial for male contraception J Clin Endocrinol Metab 86 2001 303 309
52. MC Meriggiola WJ Bremner A Costantino G Di Cintio C Flamigni Low dose of cyproterone acetate and testosterone enanthate for contraception in men Hum Reprod 13 1998 1225 1229
53. MC Meriggiola WJ Bremner A Costantino A Pavani M Capelli C Flamigni An oral regimen of cyproterone acetate and testosterone undecanoate for spermatogenic suppression in men Fertil Steril 68 1997 844 850
54. RA Anderson ZM Van Der Spuy OA Dada SK Tregoning PM Zinn OA Adeniji TA Fakoya KB Smith DT Baird Investigation of hormonal male contraception in African men: suppression of spermatogenesis by oral desogestrel with depot testosterone Hum Reprod 17 2002 2869 2877
55. World Health Organization Task Force on Methods for the Regulation of Male Fertility Comparison of two androgens plus depot-medroxyprogesterone acetate for suppression to azoospermia in Indonesian men Fertil Steril 60 1993 1062 1068
56. YL Gui CH He JK Amory WJ Bremner EX Zheng J Yang PJ Yang ES Gao Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men J Androl 25 2004 720 727
57. P Pollanen V Nikkanen I Huhtaniemi Combination of subcutaneous levonorgestrel implants and transdermal dihydrotestosterone gel for male hormonal contraception Int J Androl 24 2001 369 380
58. ST Page JK Amory BD Anawalt MS Irwig AT Brockenbrough AM Matsumoto WJ Bremner Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonist J Clin Endocrinol Metab 91 2006 4374 4380
59. BM Brady JK Amory A Perheentupa M Zitzmann CJ Hay D Apter RA Anderson WJ Bremner P Pollanen E Nieschlag FC Wu WM Kersemaekers A multicentre study investigating subcutaneous etonogestrel implants with injectable testosterone decanoate as a potential long-acting male contraceptive Hum Reprod 21 2006 285 294
60. DJ Handelsman AJ Conway LM Boylan Pharmacokinetics and pharmacodynamics of testosterone pellets in man J Clin Endocrinol Metab 71 1990 216 222
61. E Nieschlag J Mauss A Coert P Kicovic Plasma androgen levels in men after oral administration of testosterone or testosterone undecanoate Acta Endocrinol 79 1975 366 374
62. U Tauber K Schroder B Dusterberg H Matthes Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone Eur J Drug Metab Pharmacokinet 11 1986 145 149
63. DE Wilson AW Meikle SC Boike AJ Fairless RC Etheredge DK Jorkasky Bioequivalence assessment of a single 5 mg/day testosterone transdermal system versus two 2.5 mg/day systems in hypogonadal men J Clin Pharmacol 38 1998 54 59
64. TM Therneau PM Grambsch Modeling survival data: extending the Cox model 1st ed. 2000 Springer-Verlag New York
65. R Sitruk-Ware New progestagens for contraceptive use Hum Reprod Update 12 2006 169 178
66. E Michel H Bents FB Akhtar W Honigl UA Knuth J Sandow E Nieschlag Failure of high-dose sustained release luteinizing hormone releasing hormone agonist (buserelin) plus oral testosterone to suppress male fertility Clin Endocrinol (Oxf) 23 1985 663 675
67. GF Weinbauer E Gockeler E Nieschlag Testosterone prevents complete suppression of spermatogenesis in the gonadotropin-releasing hormone antagonist-treated nonhuman primate ( Macaca fascicularis ) J Clin Endocrinol Metab 67 1988 284 290
68. GF Weinbauer S Khurshid U Findscheidt E Nieschlag Sustained inhibition of sperm production and inhibin secretion by a gonadotrophin-releasing hormone antagonist and delayed testosterone substitution in non-human primates ( Macaca fascicularis ) Acta Endocrinol 123 1989 303 310
69. DJ Handelsman JA Spaliviero JM Simpson CM Allan J Singh Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation Endocrinology 140 1999 3938 3946
70. E Samojlik MA Kirschner D Silber G Schneider NH Ertel Elevated production and metabolic clearance rates of androgens in morbidly obese women J Clin Endocrinol Metab 59 1984 949 954
71. SR Plymate PC Namkung LA Metej PH Petra Direct effect of plasma sex hormone binding globulin (SHBG) on the metabolic clearance rate of 17 β-estradiol in the primate J Steroid Biochem 36 1990 311 317
72. RP Marwood V Beral Disappearance of spermatozoa from the ejaculate after vasectomy Br J Med 1 1979 87
73. DA Grimes LM Lopez MF Gallo V Halpern K Nanda KF Schulz Steroid hormones for contraception in men Cochrane Database Syst Rev 2007 CD004316