A stable isotope-mass spectrometric method for measuring human spermatogenesis kinetics in vivo

Journal of Urology

Volumn 175, Issue 1, 2006, Pages 242-246

  Misell, L M ^a   Holochwost, D ^a   Boban, D ^a,b   Santi, N ^a   Shefi, S ^c   Hellerstein, M K ^b,d   Turek, P J ^c  

^a KINEMED INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Infertility; Male; Spermatogenesis; Spermatozoa; Testis

Indexed keywords

DNA;

ADULT; ARTICLE; CELL CYCLE; CONCENTRATION RESPONSE; DIAGNOSTIC ACCURACY; DISEASE COURSE; EJACULATION; EPIDIDYMIS; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; ISOTOPE LABELING; KINETICS; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; SPERM; SPERMATOGENESIS; SPERMATOZOON;

ADULT; HUMANS; MALE; MASS SPECTROMETRY; MIDDLE AGED; SPERMATOGENESIS; SPERMATOZOA; TIME FACTORS;

EID: 29144471247     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)00053-4     Document Type: Article

References (16)

1. R.P. Amann, R.H. Hammerstedt, D.N. Veeramachaneni The epididymis and sperm maturation a perspective Reprod Fertil Dev 5 1993 361
2. N. Atanassova, C. McKinnell, K.J. Turner, M. Walker, J.S. Fisher, M. Morley Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility evidence for stimulatory effects of low estrogen levels Endocrinology 141 2000 3898
3. R. Busch, D. Cesar, D. Higuera-Alhino, T. Gee, M.K. Hellerstein, J.M. McCune Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling J Immunol Methods 286 2004 97
4. Y. Clermont The cycle of the seminiferous epithelium in man Am J Anat 112 1963 35
5. C.G. Heller, Y. Clermont Spermatogenesis in man an estimate of its duration Science 140 1963 184
6. L.R. Franca, G.F. Avelar, F.F. Almeida Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs Theriogenology 63 2005 300
7. Y. Clermont Kinetics of spermatogenesis in mammals seminiferous epithelium cycle and spermatogonial renewal Physiol Rev 52 1972 198
8. M.K. Hellerstein Measurement of T-cell kinetics recent methodologic advances Immunol Today 20 1999 438
9. L. Hermo, Y. Clermont How are germ cells produced and what factors control their production? K.S. Lawrence Handbook of Andrology. 1995 The American Society of Andrology San Francisco
10. L. Johnson, C.S. Petty, J.C. Porter, W.B. Neaves Germ cell degeneration during postprophase of meiosis and serum concentrations of gonadotropins in young adult and older adult men Biol Reprod 31 1984 779
11. D.C. Macallan, C.A. Fullerton, R.A. Neese, K. Haddock, S.S. Park, M.K. Hellerstein Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose studies in vitro, in animals, and in humans Proc Natl Acad Sci USA 95 1998 708
12. J.M. McCune, M.B. Hanley, D. Cesar, R. Halvorsen, R. Hoh, D. Schmidt Factors influencing T-cell turnover in HIV-1-seropositive patients J Clin Invest 105 2000 R1
13. R.A. Neese, L.M. Misell, S. Turner, A. Chu, J. Kim, D. Cesar Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA Proc Natl Acad Sci USA 99 2002 15345
14. R.A. Neese, S.Q. Siler, D. Cesar, F. Antelo, D. Lee, L. Misell Advances in the stable isotope-mass spectrophotometric measurement of DNA synthesis and cell proliferation Anal Biochem 298 2001 189
15. World Health Organization (WHO) Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 1992 Cambridge University Press Cambridge
16. J.C. Waterlow, P.J. Garlick, D.J. Millward Protein Turnover in Mammalian Tissues and in the Whole Body. 1978 North Holland Publishing Co Amsterdam