Quantifying the effects of co-expressing EGFR and HER2 on HER activation and trafficking

Biochemical and Biophysical Research Communications

Volumn 371, Issue 2, 2008, Pages 220-224

  Shankaran, Harish ^a   Zhang, Yi ^a   Opresko, Lee ^a   Resat, Haluk ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Bootstrap confidence intervals; EGFR; Endocytosis; ErbB; HER; Quantitative network analysis; Receptor pathways; Signal transduction; Systems biology

Indexed keywords

DIMER; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONFIDENCE INTERVAL; CULTURE MEDIUM; DIMERIZATION; ENDOCYTOSIS; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PARAMETER; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

CELL LINE; DIMERIZATION; ENDOCYTOSIS; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 43049178188     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.043     Document Type: Article

References (16)

1. Di Ventura B., Lemerle C., Michalodimitrakis K., and Serrano L. From in vivo to in silico biology and back. Nature 443 (2006) 527-533
2. Wiley H.S., Shvartsman S.Y., and Lauffenburger D.A. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 13 (2003) 43-50
3. Olayioye M.A., Neve R.M., Lane H.A., and Hynes N.E. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19 (2000) 3159-3167
4. Yarden Y., and Sliwkowski M.X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2 (2001) 127-137
5. Slamon D.J., Clark G.M., Wong S.G., Levin W.J., Ullrich A., and McGuire W.L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235 (1987) 177-182
6. Wiley H.S. Trafficking of the ErbB receptors and its influence on signaling. Exp. Cell Res. 284 (2003) 78-88
7. Hendriks B.S., Opresko L.K., Wiley H.S., and Lauffenburger D. Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: Quantitative analysis of HER2 overexpression effects. Cancer Res. 63 (2003) 1130-1137
8. Wang Z., Zhang L., Yeung T.K., and Chen X. Endocytosis deficiency of epidermal growth factor (EGF) receptor-ErbB2 heterodimers in response to EGF stimulation. Mol. Biol. Cell 10 (1999) 1621-1636
9. Band V., and Sager R. Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types. Proc. Natl. Acad. Sci. USA 86 (1989) 1249-1253
10. Resat H., Ewald J.A., Dixon D.A., and Wiley H.S. An integrated model of epidermal growth factor receptor trafficking and signal transduction. Biophys. J. 85 (2003) 730-743
11. Shankaran H., Wiley H.S., and Resat H. Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response. Biophys. J. 90 (2006) 3993-4009
12. Kholodenko B.N., Demin O.V., Moehren G., and Hoek J.B. Quantification of short term signaling by the epidermal growth factor receptor. J. Biol. Chem. 274 (1999) 30169-30181
13. Ozcan F., Klein P., Lemmon M.A., Lax I., and Schlessinger J. On the nature of low- and high-affinity EGF receptors on living cells. Proc. Natl. Acad. Sci. USA 103 (2006) 5735-5740
14. French A.R., Tadaki D.K., Niyogi S.K., and Lauffenburger D.A. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J. Biol. Chem. 270 (1995) 4334-4340
15. Haslekas C., Breen K., Pedersen K.W., Johannessen L.E., Stang E., and Madshus I.H. The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane. Mol. Biol. Cell 16 (2005) 5832-5842
16. Wolf-Yadlin A., Kumar N., Zhang Y., Hautaniemi S., Zaman M., Kim H.D., Grantcharova V., Lauffenburger D.A., and White F.M. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol. Syst. Biol. 2 (2006) 54