Hypoxia enhances CXCR4 expression favoring microglia migration via HIF-1α activation

Biochemical and Biophysical Research Communications

Volumn 371, Issue 2, 2008, Pages 283-288

  Wang, Xubu ^a   Li, Caixia ^b   Chen, Yang ^a   Hao, Yutong ^a   Zhou, Wen ^a   Chen, Chunhai ^a   Yu, Zhengping ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTHWEST HOSPITAL   (China)

Author keywords

Cell migration; CXCR4 receptor; HIF 1 ; Hypoxia; Microglia

Indexed keywords

CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; HYPOXIA; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANAEROBIOSIS; ANIMALS; CELL LINE; CELL MOVEMENT; CHEMOKINE CXCL12; COBALT; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICROGLIA; RECEPTORS, CXCR4; TRANSCRIPTION, GENETIC;

EID: 43049173715     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.055     Document Type: Article

References (28)

1. Alvarez-Diaz A., Hilario E., de Cerio F.G., Valls-I-Soler A., and Alvarez-Diaz F.J. Hypoxic-ischemic injury in the immature brain-key vascular and cellular players. Neonatology 92 (2007) 227-235
2. Lu D.Y., Liou H.C., Tang C.H., and Fu W.M. Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem. Pharmacol. 72 (2006) 992-1000
3. Gehrmann J., Banati R.B., Wiessner C., Hossmann K.A., and Kreutzberg G.W. Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?. Neuropathol. Appl. Neurobiol. 21 (1995) 277-289
4. Remingto L.T., Babcock A.A., Zehntner S.P., and Owens T. Microglial recruitment, activation, and proliferation in response to primary demyelination. Am. J. Pathol. 170 (2007) 1713-1724
5. Horuk R. Chemokine receptors. Cytokine Growth Factor 12 (2001) 313-335
6. Man S., Ubogu E.E., and Ransohoff R.M. Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol. 17 (2007) 243-250
7. Stumm R., and Hollt V. CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain. J. Mol. Endocrinol. 38 (2007) 377-382
8. Lazarini F., Tham T.N., Casanova P., Arenzana-Seisdedos F., and Dubois-Dalcq M. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia 42 (2003) 139-148
9. Flynn G., Maru S., Loughlin J., Romero I.A., and Male D. Regulation of chemokine receptor expression in human microglia and astrocytes. J. Neuroimmunol. 136 (2003) 84-93
10. Paul S.A.M., Simons J.W., and Mabjeesh N.J. HIF at the crossroad between ischemia and carcinogenesis. J. Cell. Physiol. 200 (2004) 20-30
11. Ziello J.E., Jovin I.S., and Huang Y. Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J. Biol. Med. 80 (2007) 51-60
12. Schioppa T., Uranchimeg B., Saccani A., Biswas S.K., Doni A., Rapisarda A., Bernasconi S., Saccani S., Nebuloni M., Vago L., Mantovani A., Melillo G., and Sica A. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198 (2003) 1391-1402
13. Phillips R.J., Mestas J., Gharaee-Kermani M., Burdick M.D., Sica A., Belperio J.A., Keane M.P., and Strieter R.M. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on nonsmall cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J. Biol. Chem. 280 (2005) 22473-22481
14. Krishnamachary B., Berg-Dixon S., Kelly B., Agani F., Feldser D., Ferreira G., Iyer N., LaRusch J., Pak B., Taghavi P., and Semenza G.L. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63 (2003) 1138-1143
15. Wang G.B., Wang X.Q., Luo G.X., He W.F., Chen X.W., Wu J., and Bian X.W. Design of a multifunction medical experiment platform and its temperature regulation in cell in vitro culture. J. Third Mil. Med. Univ. 29 (2007) 1289-1292
16. Shoshani T., Faerman A., Mett I., Zelin E., Tenne T., Gorodin S., Moshel Y., Elbaz S., Budanov A., Chajut A., Kalinski H., Kamer I., Rozen A., Mor O., Keshet E., Leshkowitz D., Einat P., Skaliter R., and Feinstein E. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol. 22 (2002) 2283-2293
17. Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A.R., Ryan H.E., Johnson R.S., Jefferson A.B., Stokoe D., and Giaccia A.J. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14 (2000) 391-396
18. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., and Semenza G.L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60 (2000) 1541-1545
19. Ran R., Xu H., Lu A., Bernaudin M., and Sharp F.R. Hypoxia preconditioning in the brain. Dev. Neurosci. 27 (2005) 87-92
20. Matteucci E., Locati M., and Desiderio M.A. Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness. Exp. Cell Res. 310 (2005) 176-185
21. Freeman R.S., and Barone M.C. Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Curr. Drug Targets CNS Neurol. Disord. 4 (2005) 85-92
22. Schutyser E., Su Y., Yu Y., Gouwy M., Zaja-Milatovic S., Van Damme J., and Richmond A. Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells. Eur. Cytokine Netw. 18 (2007) 59-70
23. Lavi E., Strizki J.M., Ulrich A.M., Zhang W., Fu L., Wang Q., O'Connor M., Hoxie J.A., and González-Scarano F. CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am. J. Pathol. 151 (1977) 1035-1042
24. Lazarini F., To Nam T., Casanova P., Arenzana-Seisdedos F., and Dubois-Dalcq M. Role of the α-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia 42 (2003) 139-148
25. Ceradini D.J., and Gurtner G.C. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc. Med. 15 (2005) 57-63
26. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
27. Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., Tian Y.M., Masson N., Hamilton D.L., Jaakkola P., Barstead R., Hodgkin J., Maxwell P.H., Pugh C.W., Schofield C.J., and Ratcliffe P.J. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107 (2001) 43-54
28. Boche D., and Nicoll J.A. The role of the immune system in clearance of abeta from the brain. Brain Pathol. 18 (2008) 267-278