-
1
-
-
33750579770
-
Drug discovery in jeopardy
-
Cuatrecasas P. Drug discovery in jeopardy. J. Clin. Invest. 116 (2006) 2837-2842
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2837-2842
-
-
Cuatrecasas, P.1
-
2
-
-
29144531173
-
The druggable genome: an update
-
Russ A.P., and Lampel S. The druggable genome: an update. Drug Discov. Today 10 (2005) 1607-1610
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1607-1610
-
-
Russ, A.P.1
Lampel, S.2
-
3
-
-
23044504046
-
How many genomic targets can a portfolio afford?
-
Betz U.A.K. How many genomic targets can a portfolio afford?. Drug Discov. Today 10 (2005) 1057-1063
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1057-1063
-
-
Betz, U.A.K.1
-
4
-
-
27144529964
-
Principles and applications of LC-MS in new drug discovery
-
Korfmacher W.A. Principles and applications of LC-MS in new drug discovery. Drug Discov. Today 10 (2005) 1357-1367
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1357-1367
-
-
Korfmacher, W.A.1
-
5
-
-
32444451730
-
Applications of mass spectrometry in early stages of target based drug discovery
-
Deng G., and Sanyal G. Applications of mass spectrometry in early stages of target based drug discovery. J. Pharm. Biomed. Anal. 40 (2006) 528-538
-
(2006)
J. Pharm. Biomed. Anal.
, vol.40
, pp. 528-538
-
-
Deng, G.1
Sanyal, G.2
-
6
-
-
34248582576
-
Analytical strategies for identifying drug metabolites
-
Prakash C., et al. Analytical strategies for identifying drug metabolites. Mass Spectrom. Rev. 26 (2007) 340-369
-
(2007)
Mass Spectrom. Rev.
, vol.26
, pp. 340-369
-
-
Prakash, C.1
-
7
-
-
37249063120
-
Mass spectrometry analysis of new chemical entities for pharmaceutical discovery
-
Fang A.S., et al. Mass spectrometry analysis of new chemical entities for pharmaceutical discovery. Mass Spectrom. Rev. 27 (2008) 20-34
-
(2008)
Mass Spectrom. Rev.
, vol.27
, pp. 20-34
-
-
Fang, A.S.1
-
8
-
-
33947249054
-
Applications of LC/MS in structure identifications of small molecules and proteins in drug discovery
-
Chen G., et al. Applications of LC/MS in structure identifications of small molecules and proteins in drug discovery. J. Mass Spectrom. 42 (2007) 279-287
-
(2007)
J. Mass Spectrom.
, vol.42
, pp. 279-287
-
-
Chen, G.1
-
9
-
-
30344452615
-
Liquid chromatography-mass spectrometry and related techniques for purity assessment in early drug discovery
-
Molina-Martín M., et al. Liquid chromatography-mass spectrometry and related techniques for purity assessment in early drug discovery. J. Sep. Sci. 28 (2005) 1742-1750
-
(2005)
J. Sep. Sci.
, vol.28
, pp. 1742-1750
-
-
Molina-Martín, M.1
-
10
-
-
71049177058
-
Practical comparison of different approaches to speed up LC separations
-
van de Merbel N.C., et al. Practical comparison of different approaches to speed up LC separations. LCGC Eur. 20 (2007) 32-40
-
(2007)
LCGC Eur.
, vol.20
, pp. 32-40
-
-
van de Merbel, N.C.1
-
11
-
-
4944232688
-
One-minute full-gradient HPLC/UV/ELSD/MS analysis to support high-throughput parallel synthesis
-
Kyranos J.N., et al. One-minute full-gradient HPLC/UV/ELSD/MS analysis to support high-throughput parallel synthesis. J. Comb. Chem. 6 (2004) 796-804
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 796-804
-
-
Kyranos, J.N.1
-
12
-
-
34247256823
-
A systematic approach for the development of liquid chromatographic methods
-
Ceccato A., et al. A systematic approach for the development of liquid chromatographic methods. Org. Process Res. Dev. 11 (2007) 223-228
-
(2007)
Org. Process Res. Dev.
, vol.11
, pp. 223-228
-
-
Ceccato, A.1
-
14
-
-
35948939705
-
Optimization and standardization of liquid chromatography-mass spectrometry systems for the analysis of drug discovery compounds
-
Marin A., et al. Optimization and standardization of liquid chromatography-mass spectrometry systems for the analysis of drug discovery compounds. J. Liq. Chromatogr. Relat. Tech. 31 (2008) 2-22
-
(2008)
J. Liq. Chromatogr. Relat. Tech.
, vol.31
, pp. 2-22
-
-
Marin, A.1
-
15
-
-
33847280899
-
Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis
-
Sajonz P., et al. Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis. J. Chromatogr. A 1145 (2007) 149-154
-
(2007)
J. Chromatogr. A
, vol.1145
, pp. 149-154
-
-
Sajonz, P.1
-
16
-
-
33846043762
-
Hyphenated techniques in drug discovery: purity assessment, purification, quantitative analysis and metabolite identification
-
Rosenfeld J.M. (Ed), Blackwell
-
st edn (2004), Blackwell 114-149
-
(2004)
st edn
, pp. 114-149
-
-
Kingston, J.1
-
17
-
-
22844437343
-
High-throughput purification of single compounds and libraries
-
Schaffrath M., et al. High-throughput purification of single compounds and libraries. J. Comb. Chem. 7 (2005) 546-553
-
(2005)
J. Comb. Chem.
, vol.7
, pp. 546-553
-
-
Schaffrath, M.1
-
18
-
-
20244379289
-
Purifying the masses: integrating prepurification quality control, high-throughout LC/MS purification, and compound plating to feed high-throughput screening
-
Isbell J.J., et al. Purifying the masses: integrating prepurification quality control, high-throughout LC/MS purification, and compound plating to feed high-throughput screening. J. Comb. Chem. 7 (2005) 210-217
-
(2005)
J. Comb. Chem.
, vol.7
, pp. 210-217
-
-
Isbell, J.J.1
-
20
-
-
33750738078
-
Comparison of LC/MS and SFC/MS for screening of a large and diverse library of pharmaceutical relevant compounds
-
Pinkston J.D., et al. Comparison of LC/MS and SFC/MS for screening of a large and diverse library of pharmaceutical relevant compounds. Anal. Chem. 78 (2006) 7467-7472
-
(2006)
Anal. Chem.
, vol.78
, pp. 7467-7472
-
-
Pinkston, J.D.1
-
21
-
-
2342640927
-
Determination of acid dissociation constants by capillary electrophoresis
-
Poole S.K., et al. Determination of acid dissociation constants by capillary electrophoresis. J. Chromatogr. A 1037 (2004) 445-454
-
(2004)
J. Chromatogr. A
, vol.1037
, pp. 445-454
-
-
Poole, S.K.1
-
22
-
-
0036745534
-
Semi-empirical relationships between effective mobility, charge, and molecular weight of pharmaceuticals by pressure-assisted capillary electrophoresis: applications in drug discovery
-
Miller J.M., et al. Semi-empirical relationships between effective mobility, charge, and molecular weight of pharmaceuticals by pressure-assisted capillary electrophoresis: applications in drug discovery. Electrophoresis 23 (2002) 2833-2841
-
(2002)
Electrophoresis
, vol.23
, pp. 2833-2841
-
-
Miller, J.M.1
-
23
-
-
16444376998
-
a estimation using vacuum-assisted multiplexed capillary electrophoresis (VAMCE) with ultraviolet detection
-
a estimation using vacuum-assisted multiplexed capillary electrophoresis (VAMCE) with ultraviolet detection. J. Pharm. Sci. 94 (2005) 576-589
-
(2005)
J. Pharm. Sci.
, vol.94
, pp. 576-589
-
-
Zhou, C.1
-
24
-
-
1842482894
-
Validation and long-term assessment of an approach for the high throughput determination of lipophilicity (log P) values using multiplexed, absorbance-based capillary electrophoresis
-
Wong K.S., et al. Validation and long-term assessment of an approach for the high throughput determination of lipophilicity (log P) values using multiplexed, absorbance-based capillary electrophoresis. J. Pharm. Sci. 93 (2004) 916-931
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 916-931
-
-
Wong, K.S.1
-
25
-
-
0242290999
-
The application of multiplexed microemulsion electrokinetic chromatography for the rapid determination of log P values for neutral and basic compounds
-
Wehmeyer K.R., et al. The application of multiplexed microemulsion electrokinetic chromatography for the rapid determination of log P values for neutral and basic compounds. LCGC N. Am. 21 (2003) 1078-1088
-
(2003)
LCGC N. Am.
, vol.21
, pp. 1078-1088
-
-
Wehmeyer, K.R.1
-
26
-
-
32844464311
-
Development and application of an automated solution stability assay for drug discovery
-
Di L., et al. Development and application of an automated solution stability assay for drug discovery. J. Biomol. Screen. 11 (2006) 40-47
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 40-47
-
-
Di, L.1
-
28
-
-
34249912663
-
High-throughput screening by mass spectrometry: comparison with the scintillation proximity assay with a focused-file screen of AKT1/PKBα
-
Quercia A.K., et al. High-throughput screening by mass spectrometry: comparison with the scintillation proximity assay with a focused-file screen of AKT1/PKBα. J. Biomol. Screen. 12 (2007) 473-480
-
(2007)
J. Biomol. Screen.
, vol.12
, pp. 473-480
-
-
Quercia, A.K.1
-
29
-
-
35848962300
-
Mass spectrometric techniques for label-free high-throughput screening in drug discovery
-
Roddy T.P., et al. Mass spectrometric techniques for label-free high-throughput screening in drug discovery. Anal. Chem. 79 (2007) 8207-8213
-
(2007)
Anal. Chem.
, vol.79
, pp. 8207-8213
-
-
Roddy, T.P.1
-
30
-
-
4644266019
-
High-throughput screening via mass spectrometry: a case study using acethylcholinesterase
-
Özbal C.C., et al. High-throughput screening via mass spectrometry: a case study using acethylcholinesterase. Assay Drug Dev. Technol. 2 (2004) 373-381
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 373-381
-
-
Özbal, C.C.1
-
31
-
-
0033913682
-
Fourier transform ion cyclotron resonance mass spectrometry as a high-throughput affinity screen to identify RNA binding ligands
-
Sannes-Lowery K.A., et al. Fourier transform ion cyclotron resonance mass spectrometry as a high-throughput affinity screen to identify RNA binding ligands. Trends Anal. Chem. 19 (2000) 481-491
-
(2000)
Trends Anal. Chem.
, vol.19
, pp. 481-491
-
-
Sannes-Lowery, K.A.1
-
32
-
-
38049160820
-
From blockbuster medicine to personalized medicine
-
Jørgensen J.T. From blockbuster medicine to personalized medicine. Person. Med. 5 (2008) 55-63
-
(2008)
Person. Med.
, vol.5
, pp. 55-63
-
-
Jørgensen, J.T.1
-
33
-
-
34347235098
-
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
-
Monetti M., et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6 (2007) 69-78
-
(2007)
Cell Metab.
, vol.6
, pp. 69-78
-
-
Monetti, M.1
-
34
-
-
9744283522
-
Proteomics in cancer screening and management in gynecologic cancer
-
Hu W., et al. Proteomics in cancer screening and management in gynecologic cancer. Curr. Onc. Rep. 6 (2004) 456-462
-
(2004)
Curr. Onc. Rep.
, vol.6
, pp. 456-462
-
-
Hu, W.1
-
35
-
-
34248588074
-
Proteomics in neurosciences
-
Drabik A., et al. Proteomics in neurosciences. Mass Spectrom. Rev. 26 (2007) 432-450
-
(2007)
Mass Spectrom. Rev.
, vol.26
, pp. 432-450
-
-
Drabik, A.1
-
36
-
-
27744530843
-
Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 as examples
-
Chernet E., et al. Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 as examples. Life Sci. 78 (2005) 340-346
-
(2005)
Life Sci.
, vol.78
, pp. 340-346
-
-
Chernet, E.1
-
37
-
-
33748416330
-
Applications of nanomaterials in liquid chromatography: opportunities for separation with high efficiency and selectivity
-
Zhang Z., et al. Applications of nanomaterials in liquid chromatography: opportunities for separation with high efficiency and selectivity. J. Sep. Sci. 29 (2006) 1872-1878
-
(2006)
J. Sep. Sci.
, vol.29
, pp. 1872-1878
-
-
Zhang, Z.1
-
38
-
-
33746848049
-
Comparison of multiparallel microfluidic HPLC instruments for high throughput analyses in support of pharmaceutical process research
-
Welch C., et al. Comparison of multiparallel microfluidic HPLC instruments for high throughput analyses in support of pharmaceutical process research. J. Liq. Chrom. Relat. Tech. 29 (2006) 2185-2200
-
(2006)
J. Liq. Chrom. Relat. Tech.
, vol.29
, pp. 2185-2200
-
-
Welch, C.1
-
39
-
-
34547171558
-
Boosting the throughput of separation techniques by multiplexing
-
Trapp O. Boosting the throughput of separation techniques by multiplexing. Angew. Chem. Int. Ed. 46 (2007) 5609-5613
-
(2007)
Angew. Chem. Int. Ed.
, vol.46
, pp. 5609-5613
-
-
Trapp, O.1
-
40
-
-
41149134523
-
Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses
-
Livesay E.A., et al. Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses. Anal. Chem. 80 (2008) 294-302
-
(2008)
Anal. Chem.
, vol.80
, pp. 294-302
-
-
Livesay, E.A.1
-
41
-
-
14944338676
-
Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry
-
Ishihama Y. Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry. J. Chromatogr. A 1067 (2005) 73-83
-
(2005)
J. Chromatogr. A
, vol.1067
, pp. 73-83
-
-
Ishihama, Y.1
-
42
-
-
34447545690
-
The fundamental aspects and applications of Agilent HPLC-Chip
-
Yin H., and Killen K. The fundamental aspects and applications of Agilent HPLC-Chip. J. Sep. Sci. 30 (2007) 1427-1434
-
(2007)
J. Sep. Sci.
, vol.30
, pp. 1427-1434
-
-
Yin, H.1
Killen, K.2
-
43
-
-
4644250523
-
The role of analytical sciences in medical systems biology
-
van der Greef J., et al. The role of analytical sciences in medical systems biology. Curr. Opin. Chem. Biol. 8 (2004) 559-565
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 559-565
-
-
van der Greef, J.1
-
44
-
-
31344457652
-
Micro-separation toward systems biology
-
Liu B.-F., et al. Micro-separation toward systems biology. J. Chromatogr. A 1106 (2006) 19-28
-
(2006)
J. Chromatogr. A
, vol.1106
, pp. 19-28
-
-
Liu, B.-F.1
-
45
-
-
33745753110
-
The role of mass spectrometry in biomarker discovery and measurement
-
Ackermann B.L., et al. The role of mass spectrometry in biomarker discovery and measurement. Curr. Drug Metab. 7 (2006) 525-539
-
(2006)
Curr. Drug Metab.
, vol.7
, pp. 525-539
-
-
Ackermann, B.L.1
-
46
-
-
34247116419
-
Coupling immunoaffinity techniques with MS for quantitative analysis of low-abundance protein biomarkers
-
Ackermann B.L., and Berna M.J. Coupling immunoaffinity techniques with MS for quantitative analysis of low-abundance protein biomarkers. Expert Rev. Proteomics 4 (2007) 175-186
-
(2007)
Expert Rev. Proteomics
, vol.4
, pp. 175-186
-
-
Ackermann, B.L.1
Berna, M.J.2
-
47
-
-
13844254582
-
Modern drug discovery and the progression toward a universal mass spectrometer
-
Volmer D.A., and Sleno L. Modern drug discovery and the progression toward a universal mass spectrometer. Anal. Bioanal. Chem. 381 (2005) 90-92
-
(2005)
Anal. Bioanal. Chem.
, vol.381
, pp. 90-92
-
-
Volmer, D.A.1
Sleno, L.2
-
48
-
-
0038338887
-
Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry
-
Zhang S., et al. Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry. Anal. Chem. 75 (2003) 3010-3018
-
(2003)
Anal. Chem.
, vol.75
, pp. 3010-3018
-
-
Zhang, S.1
-
49
-
-
9644302954
-
A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures
-
Annis D.A., et al. A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures. J. Am. Chem. Soc. 126 (2004) 15495-15503
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 15495-15503
-
-
Annis, D.A.1
-
50
-
-
33745752978
-
Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening
-
Hsieh Y., and Korfmacher W.A. Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening. Curr. Drug Metab. 7 (2006) 479-489
-
(2006)
Curr. Drug Metab.
, vol.7
, pp. 479-489
-
-
Hsieh, Y.1
Korfmacher, W.A.2
|